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MEDIA RELEASE
April 15 2009
ACRF $5 million grant supports breast stem cell discovery


Scientists at the Walter & Eliza Hall Institute (WEHI) are now able to explain the links between breast
cancer risk and exposure to female hormones, paving the way for breast cancer preventions and
treatments. The research, led by Dr Jane Visvader and Dr Geoff Lindeman, was partially supported by a $5 million grant from The Australian Cancer Research Foundation (ACRF). The new discovery was published in the international journal Nature on 12 April 2010. The research team at the Institute discovered that breast stem cells, despite lacking receptors for oestrogen and progesterone, are still extra sensitive to sustain exposure to the female hormones oestrogen and progesterone. “Our research also revealed that during pregnancy there is a profound increase in breast stem cell numbers,” Dr Lindeman said. “This might account for the short-term increase in cancer risk associated with pregnancy.” This groundbreaking research comes just months after the two leading Australian scientists discovered new clues to treating an aggressive form of breast cancer. “The ACRF support for our research has been pivotal to the success of our work. We are heavily dependent on our ACRF Centre-funded equipment for our ongoing research efforts in breast cancer", said Professor Lindeman. “The sort of research that has led to our discovery was necessarily a team effort. We are grateful for their foresight in being a strong supporter of the multi-disciplinary team effort - these maximize translational cancer research outcomes.” In 2005 ACRF awarded its largest ever grant of $5 million grant to an alliance comprising the Walter & Eliza Hall Institute, Royal Melbourne Hospital, the Royal Women's Hospital, the Ludwig Institute for Cancer Research, and The University of Melbourne (Faculty of Medicine, Dentistry and Health Sciences). Led by Dr Lindeman, the consortium is an Australian-first integrated cancer research project, and currently focuses on specific diseases including bowel and breast cancer. For more information contact: Lucas Knight (ACRF) 0425 232 342 or 02 9223 7833 lknight@acrf.com.au A u s t r a l i a n Ca n c e r R es e a r c h F o u n d a t i o n ABN 27 076 461 360 ACN 002 774 727 CFN 13585 GPO Box 9989, Sydney NSW 2001 Suite 409, The Strand Arcade, 412 George Street, Sydney NSW 2000 Telephone: 61 2 9223 7833 Facsimile: 61 2 9223 1800 Email: info@acrf.com.au Web:www.acrf.com.au Founding Chairman the Late Sir Peter Abeles AC Board of Trustees Mr T S Dery (Chairman), Mr A J Boettcher OAM, Mr G J Camm, Mr T Crommelin, Mr C Gantner AO, Mr S Gerlach, Mr P A Jones, Lady McMahon, Mr J M Millar, Mr S J Perrott, Mr S R Rix, Sir Ian Turbott AO CMG CVO HonDLitt, Dr J Yu AC. Chief Executive Mr D Brettell Medical Research Advisory Committee Prof I Frazer (Chairman), Prof J Adams, Prof G Chenevix-Trench, Prof D Hilton, Prof P Hogg, Prof P Klinken, A/Prof G J Lindeman, Prof T J Martin AO, Prof C R Parish, Prof J Stow, Prof J A Trapani, Prof G P Young, Prof M A Vadas.

Source: https://acrf.com.au/wp-content/uploads/2010/04/acrf_5_million_grant_supports_breast_stem_cell_discovery1.pdf

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