Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

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HEALTH HISTORY-TO BE COMPLETED BY PATIENT Medical Problems- Please indicate if you are currently experiencing any of the following: □ Anemia □ Chronic lung disease □ Fibromyalgia □ Irritable bowel syndrome □ Stomach/duodenal ulcer Surgeries/Procedures- Please indicate if you have previously had a surgery or procedure: □ NONE Marital Status: □ Single □ Married □ Divorced If you’ve smoked previously, when did you stop? History of Heart Disease (heart attack, heart failure)? □ Yes □ No who: History of High blood pressure? □ Yes □ No who: History of Diabetes? □ Yes □ No who: History of Crohn’s disease or ulcerative colitis? □ Yes □ No who: Copyright 2009 Advanced Gastroenterology Allergies: NONE Aspirin Morphine Penicillin Sulfa Versed Valium Other:
GI Medications- Please indicate if you are currently taking any of the following: NONE

Other Medications- Please include the STRENGTH & DOSAGE:

Review of Systems- Please indicate if you are currently experiencing the following:
General: □ fevers, □ chills, □ sweats, □ anorexia, □ fatigue, □ malaise, □ weight loss
Eyes: □ blurring, □ diplopia (double vision), □ irritation, □ discharge, □ vision loss, □ eye pain
Ears/Nose/Throat: □ earache, □ ear discharge, □ tinnitus (ringing in ear), □ decreased hearing, □ nasal congestion,
□ nosebleeds, □ sore throat, □ hoarseness, □ dysphagia (difficult swallowing)
Cardiovascular: □ chest pains, □ palpitations, □ syncope (passing out), □ dyspnea on exertion (shortness of breath),
□ orthopnea (shortness of breath when lying down), □ peripheral edema (leg swelling)
Respiratory: □ cough, □ dyspnea (shortness of breath), □ excessive sputum, □ hemoptysis (coughing up blood),
□ wheezing
Gastrointestinal: □ nausea, □ vomiting, □ diarrhea, □ constipation, □ change in bowel habits, □ abdominal pain, □ melena
(black stool), □ hematochezia (rectal bleeding), □ jaundice (yellow skin) □ heart burn
Genitourinary: □ vaginal discharge, □ incontinence, □ dysuria (painful urination), □ hematuria (bloody urination), □ urinary
frequency, □ amenorrhea (no menstruation), □ menorrhagia (heavy menstruation), □ abnormal vaginal bleeding, □ pelvic
pain
Musculoskeletal: □ back pain, □ joint pain, □ joint swelling, □ muscle cramps, □ muscle weakness, □ stiffness, □ arthritis
Skin: □ rash, □ itching, □ dryness, □ tattoo
Neurologic: □ transient paralysis, □ weakness, □ seizures, □ syncope (passing out), □ tremors, □ vertigo

Psychiatric: □ depression, □ anxiety, □ memory loss, □ suicidal ideation, □ hallucinations, □ paranoia
Endocrine: □ cold intolerance, □ heat intolerance, □ polydipsia (excessive thirst), □ polyuria (excessive urination)
Heme/Lymphatic: □ abnormal bruising, □ bleeding, □ enlarged lymph nodes
Allergic/Immunologic: □ urticaria (itching), □ hay fever, □ HIV exposure, □ eczema
Copyright 2009 Advanced Gastroenterology

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