Medication Guide
About Using Antidepressants in Children and Teenagers
What is the most important information I should know if my child is being
prescribed an antidepressant?
Parents or guardians need to think about 4 important things when their child is prescribed an antidepressant: 1. There is a risk of suicidal thoughts or actions 2. How to try to prevent suicidal thoughts or actions in your child 3. You should watch for certain signs if your child is taking an antidepressant 4. There are benefits and risks when using antidepressants 1. There is a Risk of Suicidal Thoughts or Actions
Children and teenagers sometimes think about suicide, and many report trying to kill themselves. Antidepressants increase suicidal thoughts and actions in some children and teenagers. But suicidal thoughts and actions can also be caused by depression, a serious medical condition that is commonly treated with antidepressants. Thinking about killing yourself or trying to kill yourself is called suicidality or being suicidal. A large study combined the results of 24 different studies of children and teenagers with
depression or other illnesses. In these studies, patients took either a placebo (sugar pill) or an
antidepressant for 1 to 4 months. No one committed suicide in these studies, but some patients
became suicidal. On sugar pills, 2 out of every 100 became suicidal. On the antidepressants,
4 out of every 100 patients became suicidal.
For some children and teenagers, the risks of suicidal actions may be especially high. These
include patients with
• Bipolar illness (sometimes called manic-depressive illness) • A personal or family history of attempting suicide If any of these are present, make sure you tell your health care provider before your child takes an antidepressant. 2. How to Try to Prevent Suicidal Thoughts and Actions
To try to prevent suicidal thoughts and actions in your child, pay close attention to changes in her or his moods or actions, especially if the changes occur suddenly. Other important people in your child’s life can help by paying attention as well (e.g., your child, brothers and sisters, teachers, and other important people). The changes to look out for are listed in Section 3, on what to watch for. Whenever an antidepressant is started or its dose is changed, pay close attention to your child. After starting an antidepressant, your child should generally see his or her health care provider • After taking the antidepressant for 12 weeks • After 12 weeks, follow your health care provider’s advice about how often to come back • More often if problems or questions arise (see Section 3) You should call your child’s health care provider between visits if needed. 3. You Should Watch for Certain Signs If Your Child is Taking an Antidepressant
Contact your child’s health care provider right away if your child exhibits any of the following
signs for the first time, or if they seem worse, or worry you, your child, or your child’s teacher:
• Acting aggressive, being angry, or violent • An extreme increase in activity and talking • Other unusual changes in behavior or mood Never let your child stop taking an antidepressant without first talking to his or her health care provider. Stopping an antidepressant suddenly can cause other symptoms. 4. There are Benefits and Risks When Using Antidepressants
Antidepressants are used to treat depression and other illnesses. Depression and other illnesses can lead to suicide. In some children and teenagers, treatment with an antidepressant increases suicidal thinking or actions. It is important to discuss all the risks of treating depression and also the risks of not treating it. You and your child should discuss all treatment choices with your health care provider, not just the use of antidepressants. Other side effects can occur with antidepressants (see section below). Of all the antidepressants, only fluoxetine (Prozac®) has been FDA approved to treat pediatric depression. For obsessive compulsive disorder in children and teenagers, FDA has approved only fluoxetine (Prozac®), sertraline (Zoloft®), fluvoxamine, and clomipramine (Anafranil®). Your health care provider may suggest other antidepressants based on the past experience of your child or other family members. Is this all I need to know if my child is being prescribed an antidepressant?
No. This is a warning about the risk for suicidality. Other side effects can occur with antidepressants. Be sure to ask your health care provider to explain all the side effects of the particular drug he or she is prescribing. Also ask about drugs to avoid when taking an antidepressant. Ask your health care provider or pharmacist where to find more information. Prozac® is a registered trademark of Eli Lilly and Company. Zoloft® is a registered trademark of Pfizer Pharmaceuticals. Anafranil® is a registered trademark of Mallinckrodt Inc. This Medication Guide has been approved by the US Food and Drug Administration for


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