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Per sito web inglese t. pietrangelo 15-9-09

Tiziana Pietrangelo, PhD

Department of Basic and Applied Medical Science (BAMS), University “G. d’Annunzio”, Chieti-
Pescara; Lab. Clinical Physiology Clinical Research Center (C.R.C.) on Centre of Excellence for
Research on Ageing (Ce.S.I.);
Via dei Vestini, 29 66013 Chieti (Italy)
Tel: +39 0871 355 4554 Fax +39 0871 355 4563; e-mail
DATE / PLACE OF BIRTH: February 4, 1971 / Pescara, Italy
1990-1995, University of Chieti (Italy) “laurea magna cum laude” in Pharmacy
1996-1998 Research Fellow in Physiology, Faculty of Pharmacy, University “G. d’Annunzio”
Chieti-Pescara (Italy) and visiting research at University of Trieste, Laboratory of Physiology and
1998-2002, PhD course in Cellular and Molecular Biology and Pathology, University of Perugia
From 2003
Senior Researcher
Faculty of Pharmacy
University G. d'Annunzio of Chieti-Pescara, Italy

From 2003
University G. d'Annunzio of Chieti-Pescara
- Faculty of Pharmacy, Degree in Pharmaceutical Chemistry and Tecnologies
Course: General Physiology.

From 2005
University G. d'Annunzio of Chieti-Pescara
- Faculty of Medicine and Surgery, Degree in Tecniques of Biomedical Laboratories
Course: Human Physiology

From 2005
University G. d'Annunzio of Chieti-Pescara
- Faculty of Sport Medicine, Degree in Motor Sciences
Course: Laboratory of Applied Physiology

From 2003 Scientific Manager on Center for the Physical Exercise in Nature of the National Park
of Abruzzo (Valfondillo, AQ, Italy)
1995, 1996, 1997, 1998 Dept Molecular and Cellular Biology University of Perugia
1996, 1998, 1999-2000 Dept Physiology and Pathology, University of Trieste (Italy)

2000 Dept of Surgery (Neurosurgery, Neurobiology), Health Sciences Centre, McMaster
University, Hamilton (CA)

2008 Royal Veterinary College, University of London (UK)
1996 German Cancer Research Center (Heidelberg, Germany)
“Advanced Course on Video Enhanced Microscopy and Fluorescence Techniques in Cell Biology”
School of Physiology and Biophisic
“Image analysis applied to growth factor study”
1998 “Molecular Thecniques in Physiology”
1999 “Electrical signaling in the CNS”
2000 “Eterologous membrane protein expression, transfection and detection methods”
2001 “Phyology of human locomotion”
2004 “Skeletal muscle diversity and plasticity. Physiological and molecular methods to study
skeletal muscle diversity and plasticity”
2006 “Skeletal muscle fibres: morpho-functional aspects and study techniques”
1998 “Molecular techniques in Physiology”, School of Physiology and Biophysic, Italian Society of
1999 “A model to study apoptosis on Nervous System”. University of Trieste. Prof. Fabio Ruzzier

“Specific GTP effect on [Ca2+]i in C2C12 cells, a skeletal muscle cell line”
McMaster University, Hamilton Ontario, Canada.
Journal of Applied Physiology
Open Longevity Science
MEMBERSHIPS (at present):
Italian Physiological Society (SIF)
Interuniversity Institute of Myology (IIM)
Italian Motor and Sport Sciences Society (SISMES)
MAJOR RESEARCH INTERESTS: - Role of non conventional growth factors as guanine based purine in myogenesis process of skeletal muscle - Role of oxidative stress during human satellite cell differentiation derived from young and elderly subjects. - Effects of different physical activities in human skeletal muscles: functional characterization and identification of specific training-activated signaling. -Human skeletal muscle: correlation between oxidative stress and functional capacity in different physiological and pathological conditions Awarded 2007 by University “G. d’Annunzio” for the project: “Transcriptional profile analysis and
genic modulation during myogenic differentiation induced by guanosin 5’trifosfato (GTP)”
Awarded 2008 by University “G. d’Annunzio” for the project: “Transcriptional, functional and
regenerative profile of human sarcopenic volunteers treated with specific physical therapies”
Awarded 2009 by University “G. d’Annunzio” for the project: ““Study of regenerative aspects and
modulation of vastus lateralis skeletal muscle under chronic hypoxia/hyperoxia””
Partecipates at Grant PRIN-MIUR: 2001-2002 “Synthetic peptides change functional parameters of
adhesion molecule n-Cam” - Scientific national coordinator Prof. Giorgio Fanò
2002-2004 “The effects of aging on functional capacity of human skeletal muscle: a biochemical
and morphological study on satellite cells cultures” – Scientific Coordinator of local unit: Prof.ssa
Stefania Fulle
2007-2008 “Electrostimulation, muscle disuse and oxidative stress as determinants of age-
dependent changes in regenerative properties of muscle satellite cells” – Scientific Coordinator of
local unit: Prof.ssa Stefania Fulle
PEER REVIEWED PAPERS from 2000 1.Fulle S, Pietrangelo T, Mariggiò MA, Lorenzon P, Racanicchi L, Mozrzymas J, Guarnieri S, Zucconi-Grassi G, Fanò G. Calcium and Fos involvement in brain-derived Ca2+-binding protein (S100)-dependent apoptosis in rat phaeochromocytoma cells (2000) Experimental Physiology, 85 (3), pp. 243-253. 2.Gysbers JW, Guarnieri S, Mariggiò MA, Pietrangelo T, Fanò G, Rathbone MP Extracellular guanosine 5' triphosphate enhances nerve growth factor- induced neurite outgrowth via increases in intracellular calcium (2000) Neuroscience, 96 (4), pp. 817-824. 3.Castellano S, Mariggiò MA, Guarnieri S, Stefancich G, Pietrangelo T. New structural analogues of tubulozole induce apoptosis, [Ca2+]i modifications and cytoskeletal disorganization in glial (GL15) and neuronal-like (PC12) cell lines (2000) Archiv der Pharmazie, 333 (11), pp. 373-380. 4.Mariggio MA, Mazzoleni G, Pietrangelo T, Guarnieri S, Morabito C, Steimberg N, Fano G. Calcium-mediated transductive systems and functionally active gap junctions in astrocyte-like GL15 cells (2001) BMC Physiology, 1, art. no. 4, pp. 1-15. 5.Pietrangelo T, Mariggiò MA, Lorenzon P, Fulle S, Protasi F, Rathbone M, Werstiuk E, Fanò G. Characterization of specific GTP binding sites in C2C12 mouse skeletal muscle cells (2002) Journal of Muscle Research and Cell Motility, 23 (2), pp. 107-118. 6.Lorenzon P, Bandi E, De Guarrini F, Pietrangelo T, Schaሷfer R, Zweyer M, Wernig A, Ruzzier F. Ageing affects the differentiation potential of human myoblasts (2004) Experimental Gerontology, 39 (10), pp. 1545-1554. 7.Fulle S, Protasi F, Di Tano G, Pietrangelo T, Beltramin A, Boncompagni S, Vecchiet L, Fanò G. The contribution of reactive oxygen species to sarcopenia and muscle ageing (2004) Experimental Gerontology, 39 (1), pp. 17-24. 8.Fulle S, Pietrangelo T, Bellomo R, Sagnella D, Belia S. The relationship between oxidative stress and the functional capacity of skeletal muscle Basic Applied Myology (ISSN: 0194-5793) 14(1): 33-36, 2004 9.Fulle S, Pietrangelo T, Di Tano G, Fanò G. Sarcopenia: caratteri, genesi, rimedi Medicina dell’Esercizio Fisico e dello Sport N.2: 15-19, 2004 10.Di Tano G, Fulle, S, Pietrangelo T, Bellomo R, Fanò G. Sarcopenia: Characteristics, genesis, remedies (2005) Sport Sciences for Health, 1 (2), pp. 69-74. 11.Fulle S, Di Donna S, Puglielli C, Pietrangelo T, Beccafico S, Bellomo R, Protasi F, Fanò G. Age-dependent imbalance of the antioxidative system in human satellite cells (2005) Experimental Gerontology, 40 (3), pp. 189-197. 12.Fioretti B, Pietrangelo T, Catacuzzeno L, Franciolini F. Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis (2005) American Journal of Physiology - Cell Physiology, 289 (1 58-1), pp. C89-C96. 13.Pietrangelo T, Guarnieri S, Fulle S, Fanò G, Mariggiò MA Signal transduction events induced by extracellular guanosine 5′ triphosphate in excitable cells (2006) Purinergic Signalling, 2 (4), pp. 633-636. 14.Pietrangelo T, Fioretti B, Mancinelli R, Catacuzzeno L, Franciolini F, Fanò G, Fulle S. Extracellular guanosine-5′-triphosphate modulates myogenesis via intermediate Ca2+-activated K+ currents in C2C12 mouse cells (2006) Journal of Physiology, 572 (3), pp. 721-733. 15.Fulle S, Pietrangelo T, Mancinelli R, Saggini R, Fanò G. Specific correlations between muscle oxidative stress and chronic fatigue syndrome: A working hypothesis (2007) Journal of Muscle Research and Cell Motility, 28 (6), pp. 355-362. 16.Beccafico S, Puglielli C, Pietrangelo T, Bellomo R, Fanò G, Fulle S. Age-dependent effects on functional aspects in human satellite cells (2007) Annals of the New York Academy of Sciences, 1100, pp. 345-352. 17.Maccallini C, Pietrangelo T, Mancinelli R, Amoroso R, Bettoni G, Fulle S. The excitation-contraction coupling on C2C12 skeletal muscle myotubes was modulated by NO-donor ester of gemfibrozil (2008) Nitric Oxide - Biology and Chemistry, 18 (3), pp. 168-175. 18. Nurowska E, Constanti A, Dworakowska B, Mouly V, Furling D, Lorenzon P, Pietrangelo T, Dolowy K and Ruzzier F. Potassium currents in human myogenic cells from healthy and congenital myotonic dystrophy foetuses. (2009) Cellular & Molecular Biology Letters, 14(2):336-346. 19. Pietrangelo T, Puglielli C, Mancinelli R, Beccafico S, Fanò G, Fulle S. Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation (2009) Experimental Gerontology, 44(8):523-531. 20. Pietrangelo T, Toniolo L, Paoli A, Fulle S, Puglielli C, Fanò G and Reggiani C. Functional characterization of muscle fibers from patients with Chronic Fatigue Syndrome: case-control study. (2009) International Journal of Immunopathology and Pharmacology, 22(2):427-436. 21. Pietrangelo T, Mancinelli R, Toniolo L, Cancellara L, Paoli A, Puglielli C, Iodice P, Doria C, Bosco G, D’Amelio L, Di Tano G, Fulle S, Saggini R, Fanò G and Reggiani C. Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events. (2009) International Journal Molecular Medicine, 24(4):503-512. 22. Doria C, Veicsteinas A , Limonta E, Maggioni MA, Aschieri P, Eusebi F, Fanò G and Pietrangelo T. Energetics of karate (kata and kumite techniques) in top-level athletes. (2009) European Journal Applied Physiology, Epub ahead of print. 23. Pietrangelo T, Mancinelli R, Toniolo L, Montanari G, Vecchiet J, Fanò G and Fulle S. Transcription profile analysis of vastus lateralis muscle from patients with Chronic Fatigue Syndrome. Accepted to International Journal of Immunopathology and Pharmacology 24. Squecco R, Carraro U, Kern H, Pond A, Adami N, Biral D, Vindigni V, Boncompagni S, Pietrangelo T, Bosco G, Fanò G, Marini M, Abruzzo PM, Germinario E, Danieli-Betto D, Protasi F, Francini F, Zampieri S. A sub-population of rat muscle fibers maintains an assessable excitation-contraction coupling mechanism after long-standing denervation, despite lost contractility Accepted to Journal of Neuropathology and Experimental Neurology


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