Text Between Well-Being and Protection for Staying in Contact with One’s Skin: ArgiSens®, a biological amplifier of the sensory com- munication ”To communicate or communicat- ern life, especially by developing a ing” – a command that nowadays lasting sensation of well-being and applies everywhere for any situa- well feeling. It is properly the rea- tion in order to be successfully con- son why women and now, more cluded. Communication is, in fact, and more men, are addicted to their at the very heart of all life and or- cosmetic products, item as others ganisational processes, including offering them pleasure! the skin, and creates a transmitting The quest for protection and plea- and receiving system. sure influenced cosmetic science Directly linked to the brain, the skin to better study the relation between is, first and foremost, a powerful, the skin and the nervous system interactive, cell network that is per- leading to the birth of the Neuro- manently exchanging messages. cosmetics, whose main objectives Nevertheless, the interferences are are to soften the skin reactions increasingly varied and manifold against external aggressions, such that, very often, the informa- while soothing and creating sen- tion being conveyed becomes sorial benefits leading to consider blurred and invalid leading many cosmetic products as caress times to sensations of discomfort donors or amplifier of sensory and to ageing speeding up. communication and to ensure that By consequence, it is more than women and men feel at ease both essential to activate the cellular mentally and physically. communication, starting from the upper epidermis and continuing by the rest of the skin, also favouring I. Skin Dialogue: Connected the connection with nervous cells, Cells for Connecting Skin! in order to grant it, as well the whole organism, a daily protection. But human being can’t always and only live for being protected; they also need to counterbalance the stress and the danger of the mod- Text
conscience and fosters thefeeling of being accepted and
responds to one or more stim-uli. And neurones are nerve
combined, form the axon (Fig- ure 1). The dendrites adorn the Figure 1: Sensitive neu- ron structure. Text
tips of the extensions of the sensitive neurone, just like the branches of a tree. The dendrites act as receiver organs from the signal to the neurone, which subsequently sends the signal to other neu- rones via its synapses, thus al- so allowing connections to be made with thousands of other neurones. A neuron may devel- op several hundreds, even thousands, of dendrites. The link ensuring that the nerve message is transmitted – via the axon and dendrites – pass- es via the synapse, which, un- der the influence of a potential action, releases signal mole- cules known as neuromedia- tors (Figure 2). However, this network of neu- ronal connections begins to dwindle after the age of 20! Progressively, the skin is little by little loosing its communica- tive capacities, leading to the synthesis of damaged proteins, destabilizing the skin integrity, as well as to the decrease of its defence systems. So, the skin connection needs absolutely to be amplified and the biological strategy consists in looking for ingredients able to increase the neuron dendricity,
communication and by conse-quence a better protection.
But the neuron stimulationthrough the dendrites length
Text
The first one is from the bio-technology and the amino-acids is vectorized by a physi-
II. Argisens®, A Biological Amplifier of Sensory Communication
The second one is originatedfrom a Brazilian plant, Pfaffiaglomerata or Brazilian ginseng.
active aminoacid essential forimproving cellular exchanges. 1. Arginine-PCA
This property is in particularlinked to its role as precursor
vital formaintainingor changingcertain cellfunctionssuch asneuromedi-ation, skinvasodilata-tion or mel-anisation. Figure 3: Chemical structure of Arginine PCA. Text
so-called ”traditional” ginseng.
filaggrin maturation, indicatingit as a physiological signal forepidermis differentiation acti-vation. A regular ”apport” of L-PCA al-lows the skin to keep safe its in-tegrity, in particular its barrier,thus diminishing the risk of cu-taneous inflammation and im-proving cell communication. Morever, L-PCA triggers NOproduction by stimulating thetransportation of arginine in thecell. 2. Pfaffia glomerata or Brazilian Ginseng Pfaffia is called Brazilian Gin-seng for its nutritional and pro-
Figure 4: Pfaffia glomerata roots. Text III. Cosmetic Performances
ine). ArgiSens® is a physio-vegetal 1. Tactile perception increase by neuronal dendricity stimulation
oxylic Acid (L-PCA) and sap ofBrasil ginseng (Pfaffia glomera-
Growth Factor), specific la-belling of dendrites and neu-
Figure 5: Neuronal dendricity increase. Text
network labelled with β-tubulinand detected by the Cell ana-
3. Evaluation of Argisens’s activity of the constitutive endothelial NO synthase (NOS3)
control culture. Morever, the chemotactism of
fication of the NOS3 gene ex-pression by quantitative RT-PCR. 2. Evaluation of ArgiSens’s non sensitizing effect ResultsStimulation by 27% of the gene
for control, dexamethasone(anti-inflammatory reference),ArgiSens® 0.5% vs placebo/
IV. Formulation and Application
evaluation and measure in trip-licate of the cytokines release
and sensory communication, ArgiSens opens a new cosmet-
Mean IL1α (pg/mL) Mean IL8 (pg/mL) Text Taste Me [Ref. 292604/4] This very trendy, cherry flavoured gloss brings a brilliant, natural shine to the lips. Its formula moisturises and enhances lip volume thanks to the properties of ArgiSens®, which acts on vasodilatation and tactile perception. The best way to a delicious mouth! Kiss anyone you want…
Mineral Oil (Paraffinum Liquidum) q.s. 100.00
CERAMIDE® (UCIB, Groupe
Solabia)Covapate Unired LC3779 (LCW) CI 15850 (DC Red n°7)/Ricinus
Covapate Unired LC3728 (LCW) CI 45410 (DC Red n°28)/Ricinus
B ARGISENS® (UCIB, Solabia
Aqua/ Pfaffia glomerata/ Arginine PCA 2.00
Procedure: Prepare the phase A at 65°C, under stirring. Add the elements of thephase B. Pour in the wished packaging. Text Nutri Touch [Ref. 193702/4] Description: Nutri Touch is a mixed body milk to use together and play with your body. ArgiSens® and Ω3 Ceramide® are neuronal communi- cation agents to increase tactile perception and to be just fine in order to give your feeling free rein…
Glyceryl Stearate Citrate/Sodium Dicocoamide PEG-15 Sulfate
Ω3 CERAMIDE® (Solabia)
C GLYCOFILM (Solabia)
D PHYSIOGENYL® (UCIB, Solabia Sodium PCA/Magnesium PCA/ ARGISENS® (UCIB, Solabia MARACUJA PULP (CEP, continued next page Text GUARASLIM® (CEP, Solabia
Paullinia Cupana Seed Extract/Ptychopetalum Olacoides Bark Extract
Procedure: Heat water of phase A to 75°C. Add Glycerin/Keltrol premixture at tem- perature, while stirring. Prepare phase B at 75°C, adding Ω3 Ceramide® and Orga- sol at temperature. Realize emulsion pouring B into A, while stirring. Introduce phase C. At 45°C, incorporate ingredients of phase D. At 35°C, add elements of phase E.
Physico-Chemical CharacteristicspH: 5.50 +/- 0.50 at 20°CViscosity: 6,000 to 10,000 cps, 24 h, LVT 3
Scruff & Shoulders [Ref. 002801/2] Description: Under-stressed, your shoulders and your neck are stretched out and make you suffer. Say stop and have a well-being break! Practical and easy to put in a handbag, this roll-on concentrat- ed in beneficial actives, relaxes you in few minutes when you are at work, at home, in subway … Thanks to its double relaxing and ener- gizing action, Mg-Relax® minimizes the effects of the stress by mak- ing muscles less tense. Sensory amplifier, ArgiSens® multiplies plea- sure during the application and offers you a new tactile sensation. continued next page Text
D MG-RELAX® (UCIB, Solabia ARGISENS® (UCIB, Solabia
Pfaffia Glomerata Juice (and) Arginine 3.00
E Spa Lavande Fragrance 0801976 Fragrance 0.20
Procedure: Prepare the phase A at 75°C. Heat the water of the phase B at 75°C, andadd the premixture of Butylene glycol/Keltrol. Realize emulsion by pouring the phaseA into B while speed stirring. After emulsion, add the elements of the phase C. At45°C, add one by one the elements of the phase D. Finally, at 35°C, incorporate thefragrance.
Physico-Chemical CharacteristicspH: 6.00 +/- 0.50 at 20°CViscosity: 3,000 cps +/- 500 at 20°C, LVT 3, 12 tr/min
Jean-François Molina Sales & Marketing Director Solabia Group 29, rue Delizy 93698 Pantin Cedex, France Email: jean-francois.molina@ solabia.fr
THE VALHEIL WORLD SEBASTIAN HAYES SchoolPlay Productions Ltd 15 Inglis Road, Colchester, Essex CO3 3HU www.schoolplayproductions.co.uk This play is fully protected by copyright. It is an infringement of the copyright to give any public performance or reading of this play in its entirety or in the form of excerpts without the prior consent in writing No part of this publication m
Thermodynamics and Kinetics of in situ Nitroxide Mediated Polymerization L. Bentein, M.-F. Reyniers, G.B. Marin University Ghent, Belgium, Laboratory for Chemical Technology Controlled radical polymerization (CRP) is a promising polymerization technique that enables to produce well-defined, end-functionalized polymers at milder experimental reaction conditions than living ionic polymerization. An
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