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Microsoft word - curriculum vitae _h.cho_

Curriculum Vitae
Hidetsura CHO (長 秀連), Professor, Dr.
Graduate School of Science and Graduate School of Pharmaceutical Sciences,
Tohoku University, Sendai, Japan
Date and Place of Birth: June 4, 1949, Fukuoka, Japan
Nationality: Japanese
Address (Office): 6-3, Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
E-mail: hcho@mail.pharm.tohoku.ac.jp Tel. +81-(0)80-1424-2230 (private) Tel. +81-22-795-5501 (office), Fax. +81-22-795-5502 (office) Address (Home): (1) 1-18-5, Kitakasugaoka, Ibaraki-shi, Osaka, 567-0048, Japan. (2) 405, Kaluo Johzenji-dohri, 1-15-10, Honcho, Aobaku, Sendai, E-mail: kochoran@qj8.so-net.ne.jp, Tel. +81-(0)90-4760-5633 (home) Education: Apr. 1969-Mar. 1973 Kyoto University (Department of Pharmaceutical Sciences) Apr. 1978-Mar. 1978 Kyoto University (Prof. Y. Inubushi, Graduate School of Oct. 1978-Sept. 1979 Iowa State University (Post-doctor, Prof. G. A. Kraus, Oct. 1979-Sept. 1980 Harvard Univerity (Post-doctor, Prof. E. J. Corey, Professional Works: Dec. 1980-Dec. 1992 Suntory Institute (Senior Researcher, Research Institute for Jan. 1993-Jun. 1996 Japan Tobacco Inc. (Group Leader, Medicinal Chemistry Laboratories, Central Pharmaceutical Research Institute) July 1996-May 2000 Japan Tobacco Inc. (Dupty Director, Medicinal Chemistry Laboratories, Central Pharmaceutical Research Institute) Jun. 2000-July 2002 Japan Tobacco Inc. (Director, Product Development Laboratories, Central Pharmaceutical Research Institute) Aug. 2002-Mar. 2008 Japan Tobacco Inc. (Vice-President, Central Pharmaceutical Apr. 2008-now Tohoku University (Professor, Graduate School of Science and Graduate School of Pharmaceutical Sciences) (July 2003-Dec. 2012 Member of Board of Directors in Japanese Society for Process Research Subjects: 1. Development of novel synthetic methods for heterocyclic compounds and molecular 2. Studies on synthesis of RNA-binding small molecules for HCV-IRES (hepatitis C 3. Studies on synthesis of class III-compounds passing through the peptide transporter. Award: The Award for Promotional and Excellent Research of Synthetic Organic Chemistry (The Society of Synthetic Organic Chemistry, Japan, in 1988). “Synthetic Studies on Novel Dihydropyrimidine Derivatives” Representative 29 Publications (Total 41) plus 2 Textbooks: [1] H. Cho, Y. Iwama, K. Okano, H. Tokuyama Construction of Dibenzazocine Skeleton by Regiocontrolled Ring-Expansion Reaction of Cyclic Oxime with DIBAL-H: Facile Synthesis of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibitor SYNLETT, 2013, 24, 813-816.
[2] H. Cho, Y. Iwama, N. Mitsuhashi, K. Sugimoto, K. Okano, H. Tokuyama
Ring-Expansion Reaction of Oximes with Aluminum Reductants
Molecules, 2012, 17, 7348-7355.
[3] Y. Nishimura, Y. Yasui, S. Kobayashi, M. Yamaguchi, H. Cho
Synthesis of novel 2-phenyl-5-substituted dihydropyrimidines using
2-phenyl-1,3-diaza-1,3-butadienes and electron-deficient olefins
Tetrahedron, 2012, 68, 3342-3350.
[4] H. Cho, Y. Nishimura, Y. Yasui, M. Yamaguchi
Construction of Dihydropyrimidine Skeleton Using 1,2,4-Trisubstituted-1,3-Diaza-
Tetrahedron Letters, 2012, 53, 1177-1179
[5] H. Cho, E. Kwon, Y. Yasui, S. Kobayashi, S. Yoshida, Y. Nishimura, M.Yamaguchi
Ring Cleavage of Dihydropyrimidine skeleton
Tetrahedron Letters, 2011, 52, 7185-7188.
[6] H. Cho, Y. Yasui, S. Kobayashi, E. Kwon, M. Arisawa, M.Yamaguchi, Synthesis and
Substitution Reactions of 4(6)-Chlorodihydropyrimidines
Heterocycles, 2011, 83 (8), 1807-1818.
[7] H. Cho, Y. Nishimura, Y. Yasui, S. Kobayashi, S. Yoshida, E. Kwon, M. Yamaguchi,
Synthesis of 4-Unsubstituted Dihydropyrimidines. Nucleophilic Substitution at
Position-2 of Dihydropyrimidines., Tetrahedron, 2011, 67, 2661-2669.
[8] H. Cho, K. Sugimoto, Y. Iwama, N. Mitsuhashi, K.Okano, H.Tokuyama,
Regiospecific Rearrangement of Hydroxylamines to Secondary Amines Using
Diisobutylaluminum Hydride, Heterocycles, 2011, 82, 1633-1644.
[9] H. Cho, Y. Iwama, K. Sugimoto, S. Mori, H. Tokuyama, Regioselective Synthesis of
Heterocycles Containing Nitrogen Neighboring an Aromatic Ring by Reductive Ring
Expansion Using Diisobutylaluminum Hydride (DIBALH) and Studies on the Reaction
Mechanism, J. Org. Chem.,2010, 75, 627-636.
[10] H. Cho, Y. Iwama, K. Sugimoto, E. Kwon, H.Tokuyama, Regiospecific synthesis of
unsubstituted basic skeletons of heterocycles containing nitrogen neighboring an
aromatic ring by the reductive ring expansion reaction using diisobutylaluminum
hydride, Heterocycles, 2009, 78, 1183-1190.
[11] H. Ueno, K. Yokota, J. Hoshi, K. Yasue, M. Hayashi, Y. Hase, I. Uchida, K. Aisaka,
S. Katoh, H. Cho, Synthesis of structure-activity relationships of novel selective factor
Xa inhibitors with a tetrahydroisoquinoline ring, J. Med. Chem., 2005, 48, 3586-3604.
[12] H. Ueno, K. Yokota, J. Hoshi, K. Yasue, M. Hayashi, I. Uchida, K. Aisaka, Y. Hase,
S. Katoh, H. Cho, Discovery of novel tetrahydroisoquinoline derivatives as potent and
selective factor Xa inhibitors, Bioorg. & Med. Chem. Lett., 2005, 15, 185-189.
[13] H. Ueno, S. Katoh, K. Yokota, J. Hoshi, M. Hayashi, I. Uchida, K. Aisaka,
Y. Hase, H. Cho, Structure-activity relationships of potent and selective factor Xa
inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of
factor Xa, Bioorg. & Med. Chem. Lett., 2004, 14, 4281-4286.
[14] H. Cho, K. Murakami, H. Nakanishi, A. Fujisawa, H. Isoshima, M. Niwa, K.
Hayakawa, Y. Hase, I. Uchida, H. Watanabe, K. Wakitani, K. Aisaka, Synthesis and
Structure-Activity Relationships of 5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepine
Derivatives: Novel Arginine Vasopressin Antagonists, J. Med. Chem., 2004, 47,
101-109. [15] H. W. Hamilton, G. Nishiguchi, S. E. Hagen, J. D. Domagala, P. C. Weber, S. Gracheck, S. L. Boulware, E. C. Nordby, H. Cho, T. Nakamura, W. Watanabe, S. Ikeda, Novel benzthiodiazepines as antiherpetic agents: SAR improvement of therapeutic index by alternations of the 7-membered ring, Bioorg. & Med. Chem. Lett., 2002, 12, 2981-2983.
[16] T. Inaba, Y. Yamada, H. Abe, S. Sagawa, H. Cho, (1S)-1-[(4R)-2,2-dimethyl-1,3-
dioxolan-4-yl]-2-hydroxyethylammonium benzoate, a versatile building block for chiral
2-aminoalkanols: concise synthesis and application to Nelfinavir, a potent HIV protease
inhibitor, J. Org. Chem., 2000, 65, 1623-1628.
[17] H. Cho, K. Murakami, A. Fujisawa, M. Niwa, H. Nakanishi, I. Uchida,
Synthesis of novel 5,6,7,8-tetrahydro-4H-thieno[2,3-b][1,4]diazepine derivatives,
Heterocycles, 1998, 48, 1555-1566.
[18] H. Cho, K. Murakami, H. Nakanishi, H. Isoshima, K. Hayakawa, I. Uchida,
Regioselective synthesis of several heterocyclic fused azepines using
diisobutylaluminum hydride, Heterocycles, 1998, 48, 919-927.
[19] H. Cho, S. Matsuki, A. Mizuno, H. Annoura, T. Tatsuoka, Synthesis of
pyrroloazepines. Facile synthesis of 2-substituted pyrrole derivatives by the phosgene
method, J. Heterocyclic Chem., 1997, 34, 87-91.
[20] H. Cho, S. Kato, S. Sayama, K. Murakami, H. Nakanishi, Y. Kajimoto, H. Ueno,
H. Kawasaki, K. Aisaka, I. Uchida, Synthesis and selective coronary vasodilative
activity of JTV-506 and 3,4-dihydro-2,2-bis(methoxymethyl)-2H-1-benzopyran-3-ol
derivatives, potassium channel openers, J. Med. Chem., 1996, 39, 3797-3805.
[21] H. Cho, S. Matsuki, Ring construction of several heterocycles with phosphorus
pentoxide-methanesulfonic acid (PPMA), Heterocycles, 1996, 43, 127-131.
[22] H. Cho, M. Ueda, M. Tamaoka, M. Hamaguchi, K. Aisaka, Y. Kiso, T. Inoue,
R. Ogino, T. Tatsuoka, T. Ishihara, T. Noguchi、 I. Morita, S. Murota, Novel caffeic acid
derivatives: Extremely potent inhibitors of 12-lipoxygenase, J. Med. Chem., 1991, 34,
1503-1505.
[23] H.Cho, M. Ueda, K. Shima, A. Mizuno, M. Hayashimatsu, Y. Ohnaka, Y. Takeuchi,
M. Hamaguchi, K. Aisaka, T. Hidaka, M. Kawai, M. Takeda, T. Ishihara,K. Funahashi, F.
Satoh, M. Morita, T. Noguchi, Dihydropyrimidines: Novel calcium antagonists with
potent and long-lasting vasodilative and antihypertensive activity, J. Med. Chem., 1989,
32, 2399-2406. [24] H. Cho, T. Iwashita, M. Ueda, A. Mizuno, K. Mizukawa, M. Hamaguchi, On the tautomerism of dihydropyrimidines: The influence of the 2- and 5-substituents on the observation of tautomers, J. Am. Chem. Soc., 1988, 110, 4832-4834.
[25] H. Cho, K. Shima, M. Hayashimatsu, Y. Ohnaka, A. Mizuno, Y. Takeuchi,
Synthesis of novel dihydropyrimidines and tetrahydropyrimidines, J. Org. Chem., 1985,
50, 4227-4230.
[26] G. A. Kraus, H. Cho, S. Crowley, B. Roth, H. Sugimoto, S. Prugh, Phthalide
annulation: The synthesis of kalafungin, pachybasin, and chrysophanol,
J. Org. Chem., 1983, 48, 3439-3444.
[27] E. J. Corey, H. Cho, C. Rucker, D. H. Hua, Studies with trialkylsilyltriflates: new
syntheses and applications, Tetrahedron Lett., 1981, 22, 3455-3458.
[28] E. J. Corey, L. O. Weigel, A. R. Chamberlin, H. Cho, D. H. Hua, Total synthesis of
Maytansine, J. Am. Chem. Soc., 1980, 102, 6613-6615.
[29] T. Harayama, H. Cho, Y. Inubushi, Total synthesis of dl-chamaecynone, a
termiticidal norsesquiterpene, Tetrahedron Lett., 1977, 3273-3276.
[Textbook]
[1] Pharmaceutical Process Chemistry (Kagakudoujin INC/The Japanese Society for
Process Chemistry, <in Japanese>, published in April 1, 2005, for beginners of Process
Chemistry Division)
[2] Pharmaceutical Sciences; Discovery and Development of New Medicines
(Nanzandou INC, August 25, 2012)
Hobby:
Classic music, Opera, Operetta, Musical, Kabuki, Golf, Go.

Source: http://www.cais.upatras.gr/sites/www.cais.upatras.gr/files/Curriculum%20Vitae%20%20H.Cho_.pdf

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