Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Microsoft word - cattle fact sheet 15 - dermatomycoses.htm

Occupational Health - Zoonotic Disease Fact Sheets #15
[Ringworm (Dermatophytosis, Tinea, Trichophytosis, Microsporosis, Jock Itch, Athlete's SPECIES: Dogs, cats, rodents, domestic animals
AGENT: Organisms are subclassified into: 1. Geophilic - inhabit soil 2. Zoophilic -
parasitic on animals 3. Anthropophilic - Primarily infects humans. All can produce
disease in humans. Grouped in three genera 1. Microsporum 2. Trichophyton 3.
Epidermophyton
RESERVOIR AND INCIDENCE: Fungal spores remain viable for long periods on
carrier animals and fomites. Exposure to reservoir hosts harboring different
dermatophytes determines the type and incidence of infection in humans. Microsporum
canis can be carried by up to 89% of nonsymptomatic cats. Up to 50% of people
exposed to infected cats, both symptomatic and asymptomatic, have acquired
infection. Pets may also acquire disease from humans. **T. mentagrophytes is most
commonly transmitted to man from rodents, M. canis from dogs and cats, and T.
verrucosum from cattle and horses.
TRANSMISSION: Direct or indirect contact with asymptomatic animals or with skin
lesions of infected animals Contaminated bedding Equipment Fungi in air, dust, or on
surfaces of room (spores persist on contaminated surfaces)
DISEASE IN ANIMALS: Disease in rodents is often asymptomatic and not recognized
until people are affected. Infected cats are often asymptomatic. Dogs often show classic
skin lesions. Varying severity of dermatitis occurs with local loss of hair. Deeper
invasion produces a mild inflammatory reaction which increases in severity with the
development of hypersensitivity.
DISEASE IN MAN: Often mild, self limiting; scaling, redness, and occasionally
vesicles or fissures. Thickening & discoloring of nails. May show circular lesions which
clear in the center forming a ring affect. Fungal infections in man are categorized as to
the location on the body: 1. Tinea capitis - Scalp & hair 2. Tinea corporis - Body
(extremities, arm and hand, are most often affected in infections acquired from lab
animals.) 3. Tinea pedis - foot 4. Tinea unguium - Nails
DIAGNOSIS: KOH mount of skin scrapings, Fungal culture
TREATMENT: Macerated (moist softening and fissuring) stage- aluminum subacetate
("Domeboro") solution soaks with potassium permanganate for secondary infections.
Broad spectrum antifungal creams and solutions containing imidazoles or ciclopirox)
instead of tolnaftate and haloprogin help to combat diphtheroids and other gram-positive
organisms present at this stage and alone may be adequate therapy. Dry and scaly stage-
several topical creams, liquids, or lotions are recommended (miconazole, clotrimazole, ketoconazole, econazole, sulconazole, oxiconazole, ciclopirox or naftifine. Betamethasone dipropionate with clotrimazole is recommended for acutely inflamed tinea lesions. For severe cutaneous infections, griseofulvin or ketoconazole is recommended. PREVENTION/CONTROL: Screen newly received animals. Routine sanitization of
contaminated environment, equipment, and caging. Gloves, protective clothing, wash
hands after exposure.
BIOSAFETY LEVEL: BL-2

Source: http://ces.ksu.org/research/comply/iacuc/ohsp/factsheets/factsheet-15-dermatomycoses.pdf