Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Microsoft word - acutely hazardous waste.doc

California Code of Regulations
Title 22, Division 4.5, Chapter 11, Article 4, §66261.33
List of Acutely Hazardous Wastes
Substance
Acetamide, N-(aminothioxomethyl) Acetamide, 2-fluoro Acetic acid, fluoro-, sodium salt 1-Acetyl-2-thiourea Acrolein Aldicarb Aldicarb sulfone Aldrin Allyl alcohol Aluminum phosphide (RT) 5-(Aminomethyl)-3-isoxazolol 4-Aminopyridine Ammonium picrate (R) Ammonium vanadate Argentate (1-), bis (cyano-C)-, potassium Arsenic acid H3AsO4 Arsenic oxide As203 Arsenic oxide As205 Arsenic pentoxide Arsenic trioxide Arsine, diethyl Arsonous dichloride, pheny Aziridine Aziridine, 2-methyl Barium cyanide Benzenamine, 4-chloro Benzenamine, 4-nitro Benzene, (chloromethyl) 1,2-Benzenediol, 4-[1-hydroxy- (methylamino)ethyl]-, (R)- Benzeneethanamine, alpha,alpha dimethyl Benzenethiol 7-Benzofuranol, 2,3-dihydro-2,2 dimethyl-, methylcarbamate Benzoic acid,2-hydroxy,compd.with(3aS-cis)-1,2,3,3a,8, 8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3 b] indol 2H-1-Benzopyran-2-one,4-hydroxy-3 (3-oxo-1-phenylbutyl)-, and salts when present at concentrations Benzyl chloride Beryllium powder Bromoacetone Brucine 2-Butanone, 3,3-dimethyl-1 (methylthio)-, o-[(methylamino) carbonyl] oxime Calcium cyanide Ca(CN) Carbamic acid, [(dibutylamino) thio]methyl-,2,3-dihydro-2,2 dimethyl- 7-benzofuranyl ester Carbamic acid, dimethyl-,1 [(dimethyl-amino)carbonyl] 5-methyl-1H-pyrazol-3-yl ester. Carbamic acid, dimethyl-, 3-methyl-1 (1-methylethyl)-1H-pyrazol-5-yl ester. Carbamic acid, methyl-, 3-methylphenyl ester. Carbofuran Carbon disulfide Carbonic dichloride Carbosulfan Chloroacetaldehyde p-Chloroaniline 1-(o-Chlorophenyl) thiourea 3-Chloropropionitrile Copper cyanide Cu(CN) m-Cumenyl methylcarbamate. Cyanides (soluble cyanide salts), not otherwise specified Cyanogen Cyanogen chloride (CN)Cl 2-Cyclohexyl-4,6-dinitrophenol Dichloromethyl ether Dichlorophenylarsine Dieldrin Diethylarsine Diethyl-p-nitrophenyl phosphate O,O-Diethyl O-pyrazinyl phosphorothioate\ Diisopropyl fluorophosphate (DFP) 1,4,5,8-Dimethanonaphthalene,1,2,3,4-10,10-hexachloro-1,4,4a,5,8,8ahexahydro, (1alpha,4alpha,4abeta,5alpha,8alpha,8abeta) 1,4,5,8-Dimethanonaphthalene,1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8ahexahydro-,(1alpha,4alpha,4abeta, 2,7:3,6-Dimethanonaphth[2,3-b]oxirene,3,4,5,6,9,9-hexachlorola,2,2a,3,6,6a,7,7a-octahydro-, (1aalpha,2beta,2aalpha,3beta,6beta,6a alpha, 7beta,7aalpha)- 2,7:3,6-Dimethanonaphth[2,3-b] oxirene 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a- octahydro-, (1aalpha,2beta,2abeta,3alpha,6 alpha,6abeta,7beta,7aalpha)-, and metabolites Dimetilan Dimethoate alpha, alpha-Dimethylphenethylamine 4,6-Dinitro-o-cresol and salts 2,4-Dinitrophenol Dinoseb Diphosphoramide, octamethyl Diphosphoric acid, tetraethyl ester Disulfoton Dithiobiuret 1,3-Dithiolane-2-carboxaldehyde, 2,4 dimethyl-, O-[(methylamino)-carbonyl]oxime. Endosulfan Endrin, and metabolites Epinephrine Ethanedinitrile Ethanimidothioic acid, N-[(methylamino) carbonyl] oxy]-, methyl ester Ethanimidothioc acid, 2-(dimethylamino) N-[[(methylamino) carbonyl]oxy]-2oxo-, methyl ester. Ethyleneimine Famphur Fluorine Fluoroacetamide Fluoroacetic acid, sodium salt Formetanate hydrochloride. Formparanate Fulminic acid, mercury (2+) salt (R,T) Heptachlor Hexaethyl tetraphosphate Hydrazinecarbothioamide Hydrazine, methyl Hydrocyanic acid Hydrogen cyanide Hydrogen phosphide Isodrin Isolan 3-Isopropylphenyl N-methylcarbamate. 3(2H)-Isoxazolone, 5-(aminomethyl) Manganese, bis(dimethylcarbamodithioato-S,S') Manganese dimethyldithiocarbamate Mercury, (acetato-O)phenyl Mercury fulminate (R,T) Methanamine, N-methyl-N-nitroso Methane, isocyanato Methane, oxybis[chloro Methane, tetranitro- (R) Methanethiol, trichloro Methanimidamide, N,N-dimethyl-N' [3-[[(methylamino)-carbonyl]oxy]phenyl]-, monohydrochloride. Methanimidamide, N,N-dimethyl-N'-2[methyl-4-[[methylamino)carb onyl]oxy] 6,9-Methano-2,4,3-benzodioxathiepen,6,7,8,9,10,10—hexachloro 1,5,5a,6,9,9a-hexahydro-, 3-oxide 4,7-Methano-1H-indene, 1,4,5,6,7,8,8 heptachloro- 3a,4,7,7a-tetrahydro- Methiocarb Methomyl Methyl hydrazine Methyl isocyanate 2-Methyllactonitrile Methyl parathion Metolcarb Mexacarbate alpha-Naphthylthiourea Nickel carbonyl, Ni(CO)4, (T-4) Nickel cyanide Ni(CN)2 Nicotine and salts Nitric oxide p-Nitroaniline Nitrogen dioxide Nitrogen oxide NO Nitrogen oxide NO2 Nitroglycerine (R) N-Nitrosodimethylamine N-Nitrosomethylvinylamine Octamethylpyrophosphoramide Osmium oxide OsO, (T-4) Osmium tetroxide 7-Oxabicyclo[2.2.1]heptane-2,3 dicarboylic acid Oxamyl Parathion Phenol, 2-cyclohexyl-4,6-dinitro Phenol, 2,4-dinitro Phenol, 2-methy1-4,6-dinitro- and salts Phenol, 2-(1-methylpropyl)-4,6-dinitro Phenol, 2,4,6-trinitro-, ammonium salt (R) Phenol, 4-(dimethylamino)-3,5-dimethyl methylcarbamate (ester). Phenol, (3,5-dimethyl-4-(methylthio) methylcarbamate Phenol, 3-(1-methylethyl)-, methyl carbamate. Phenol, 3-methyl-5-(1-methylethyl) methyl carbamate Phenylmercury acetate Phenylthiourea Phorate Phosgene Phosphine Phosphoric acid, diethyl 4-nitrophenylester Phosphorodithioic acid, O,O-diethyl S-[2-(ethylthio)ethyl] ester Phosphorodithioic acid, O,O-diethyl S- [(ethylthio)methyl] ester Phosphorodithioic acid, O,O-dimethyl S-[2--(methylamino)-2-oxoethyl] ester Phosphorofluoridic acid, bis(1 methylethyl) ester Phosphorothioic acid, O,O-diethyl 0 (4-nitrophenyl) ester Phosphorothioic acid, O,O-diethyl O-pyrazinyl ester Phosphorothioic acid, 0-[4- [(dimethylamino) sulfonyl]phenyl] O,O-dimethyl ester Phosphorothioic acid, O,O-dimethyl 0-(4-nitrophenyl) ester Physostigmine Physostigmine salicylate Plumbane, tetraethy Potassium cyanide K(CN) Potassium silver cyanide Promecarb Propanal, 2-methyl-2-(methylthio) 0- [(methylamino)carbonyl]oxime Propanal, 2-methyl-2-(methyl-sulfonyl) O-[(methylamino)carbonyl] oxime. Propanenitrile Propanenitrile, 3-chloro Propanenitrile, 2-hydroxy-2-methyl 1,2,3-Propanetriol, trinitrate (R) 2-Propanone, 1-bromo Propargyl alcohol 2-Propenal 2-Propen-1-ol 1,2-Propylenimine 2-Propyn-1-ol 4-Pyridinamine Pyridine, 3-(1-methyl-2 pyrrolidinyl)-, (S) and salts Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-. Selenious acid, dithallium (1+) salt Selenourea Silver cyanide Ag(CN) Sodium azide Sodium cyanide Na(CN) Strychnidin-10-one, and salts Strychnidin-10-one, 2,3-dimethoxy Strychnine and salts Sulfuric acid, dithallium (1+) salt Tetraethyldithiopyrophosphate Tetraethyl lead Tetraethyl pyrophosphate Tetranitromethane (R) Tetraphosphoric acid, hexaethyl ester Thallic oxide Thallium oxide Tl2O3 Thallium (I) selenite Thallium (I) sulfate Thiodiphosphoric acid, tetraethyl ester Thiofanox Thioimidodicarbonic diamide [(H2N)C(S)]2NH Thiophenol Thiosemicarbazide Thiourea, (2-chlorophenyl) Thiourea, 1-naphthalenyl Thiourea, phenyl Tirpate Toxaphene Trichloromethanethiol Vanadic acid, ammonium salt Vanadium oxide V2O5 Vanadium pentoxide Vinylamine, N-methyl-N-nitroso Warfarin, and salts, when present at concentrations greater than 0.3% Zinc, bis(dimethylcarbamodithioato S,S') Zinc cyanide Zn(CN)2 Zinc phosphide Zn3P2, when present at concentrations greater than 10% (R,T) Ziram

Source: http://www.ci.santa-maria.ca.us/3120-AcutelyHazardousWaste.pdf