Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
Microsoft word - c - banned drug list.docx
2013-14 NCAA Banned Drugs It is your responsibility to check with the appropriate or designated athletics staff before using any substance
The NCAA bans the following classes of drugs:
a. Stimulants b. Anabolic Agents c. Alcohol and Beta Blockers (banned for rifle only) d. Diuretics and Other Masking Agents e. Street Drugs f. Peptide Hormones and Analogues g. Anti-estrogens h. Beta-2 Agonists
Note: Any substance chemically related to these classes is also banned. The institution and the student-athlete shall be held accountable for all drugs within the banned drug class regardless of whether they have been specifically identified. Drugs and Procedures Subject to Restrictions:
a. Blood Doping. b. Local Anesthetics (under some conditions). c. Manipulation of Urine Samples. d. Beta-2 Agonists permitted only by prescription and inhalation. e. Caffeine if concentrations in urine exceed 15 micrograms/ml.
NCAA Nutritional/Dietary Supplements Warning: Before consuming any nutritional/dietary supplement product, review the product with the appropriate or designated athletics department staff!
• Dietary supplements are not well regulated and may cause a positive drug test result. • Student-athletes have tested positive and lost their eligibility using dietary supplements. • Many dietary supplements are contaminated with banned drugs not listed on the label. • Any product containing a dietary supplement ingredient is taken at your own risk. Note to Student-Athletes: There is no complete list of banned substances. Do not rely on this list to rule out any supplement ingredient. Check with your athletics department staff prior to using a supplement.
Some Examples of NCAA Banned Substances in Each Drug Class
amphetamine (Adderall); caffeine (guarana); cocaine; ephedrine; fenfluramine (Fen); methamphetamine; methylphenidate (Ritalin); phentermine (Phen); synephrine (bitter orange); methylhexaneamine, “bath salts” (mephedrone) etc.
exceptions: phenylephrine and pseudoephedrine are not banned.
Anabolic Agents (sometimes listed as a chemical formula, such as 3,6,17-androstenetrione):
Androstenedione; boldenone; clenbuterol; DHEA (7-Keto); epi-trenbolone; etiocholanolone; methasterone; methandienone; nandrolone; norandrostenedione; stanozolol; stenbolone; testosterone; trenbolone; etc.
Alcohol and Beta Blockers (banned for rifle only):
alcohol; atenolol; metoprolol; nadolol; pindolol; propranolol; timolol; etc.
Diuretics (water pills) and Other Masking Agents:
bumetanide; chlorothiazide; furosemide; hydrochlorothiazide; probenecid; spironolactone (canrenone); triameterene; trichlormethiazide; etc.
heroin; marijuana; tetrahydrocannabinol (THC); synthetic cannabinoids (eg. spice, K2, JWH-018, JWH-073)
growth hormone(hGH); human chorionic gonadotropin (hCG); erythropoietin (EPO); etc.
anastrozole; tamoxifen; formestane; 3,17-dioxo-etiochol-1,4,6-triene(ATD), etc.
bambuterol; formoterol; salbutamol; salmeterol; etc.
Additional examples of banned drugs can be found at www.ncaa.org/drugtesting. Any substance that is chemically related to the class, even if it is not listed as an example, is also banned!
Information about ingredients in medications and nutritional/dietary supplements can be obtained by contacting the Resource Exchange Center, REC, 877-202-0769 or www.drugfreesport.com/rec password ncaa1, ncaa2 or ncaa3. It is your responsibility to check with the appropriate or designated athletics staff before using any substance.
The National Collegiate Athletic Association
PATIENT INFORMATION Please complete all 4 pages and return to front desk upon arrival. Email address: _________________________________________________________ Mr/Mrs/Ms: _______________________________________ Date: ______________ Home Phone: ______________________ Work Phone: ________________________ Home Address: ________________________________________________________ City: __________
Similar 96-week Renal Safety Profile of Tenofovir Disoproxil Fumarate (TDF) versus Stavudine (d4T) when used in Combination with Lamivudine (3TC) and Efavirenz (EFV) in Antiretroviral Naïve Patients JE Gallant1, AL Pozniak2, S Staszewski3, B Lu4, J Sayre4 and A Cheng4 for the Study 903 Team 1Johns Hopkins Univ School of Medicine, Baltimore, MD, USA; 2 Chelsea and Westminster
2013-14 NCAA Banned Drugs