Quat.pdf

TECHNICAL REPORT
DESCRIPTION - LYSOL? BRAND I.C.? QUATERNARY DISINFECTANT CLEANER is a highly concentrated, cost-effective germicide based on a blend of quaternaries and detergents. It cleans, disinfects and deodorizes with a neutral pH in dilution. Didecyl dimethyl ammonium chloride …………………………………………….…….……………… 9.22% n-Alkyl (C14 50%, C 12 40%, C 16 10%) dimethyl benzyl ammonium chloride …………………….…. 6.14% ………………………….…………………………………………………………………………………… 84.64% * Includes detergents, and other grease cutting agents. DIRECTIONS FOR USE:

It is a violation of Federal law to use this product in a manner inconsistent with its labeling.
SAFETY REMINDER: Before employees use this or any other product, make sure they read and understand the product
label, Material Safety Data Sheet and facility cleaning / disinfection protocol.
GENERAL USE DIRECTIONS:
For use in Healthcare, Institutional and Industrial Facilities
Recommended for use in: Hospitals, Nursing Homes, Funeral Homes, Schools, Colleges, Veterinary Clinics, Animal Life
Sciences Laboratories, Grooming Establishments, Tack Shops, Pet Shops, Kennels, Breeding Establishments, Equine
Farms.
Disinfects, cleans and deodorizes floors, walls, metal surfaces, glazed porcelain, plastic surfaces (such as polypropylene,
polystyrene, etc.) and other hard, nonporous surfaces.
APPLICATION: Remove heavy soil deposits from surface. Then thoroughly wet surface with a solution of ½ ounce of
concentrate per gallon of water. The solution can be applied with a cloth, mop, sponge, coarse spray or soaking. Let solution remain on surface for a minimum of ten (10) minutes. Rinse or allow to air dry. Rinsing of floors is not necessary unless they are to be waxed or polished. Prepare a fresh solution daily or more often if the solution becomes visibly dirty or diluted. Correct Solution Strength
0.39% (1:256, ½ oz. per gallon)
PRODUCT WATER

*KILLS HIV-1 (AIDS VIRUS) on precleaned, environmental surfaces/objects previously soiled with blood/body fluids in
health care settings or other settings in which there is an expected likelihood of soiling of inanimate surfaces/objects with potential for transmission of Human Immunodeficiency Virus Type 1 (HIV-1) (associated with Aids).
SPECIAL INSTRUCTIONS FOR CLEANING AND DECONTAMINATION AGAINST HIV-1 (AIDS VIRUS) OF SURFACES/
OBJECTS SOILED WITH BLOOD/BODY FLUIDS:
PERSONAL PROTECTION: Disposable latex or vinyl gloves, gowns, face masks, or eye coverings as appropriate must be
worn during all cleaning of blood/body fluids and during decontamination procedures.
CLEANING PROCEDURES: Blood/Body fluids must be thoroughly cleaned from surfaces/objects before application of
disinfectant.
CONTACT TIME: HIV-1 (AIDS VIRUS) is inactivated after a contact time of 4 minutes at 25ºC (room temperature). Use a 10-
minute contact time for other viruses, fungi and bacteria listed.
DISPOSAL OF INFECTIOUS MATERIALS: Blood/Body fluids should be autoclaved and disposed of according to federal,
state, and local regulations for infectious waste disposal.

TOILET BOWLS: Swab bowl with brush to remove heavy soil prior to cleaning or disinfecting. Clean by applying diluted
solution around the bowl and under the rim. Stubborn stains may require brushing. To disinfect, first remove or expel over the
inner trap the residual bowl water. Pour in three ounces of the diluted solution. Swab the bowl completely using a scrub
brush or mop, making sure to get under rim. Let stand for 10 minutes or overnight, then flush.
MILDEWSTATIC INSTRUCTIONS: Will effectively control the growth of mold and mildew plus the odors caused by them
when applied to hard, nonporous surfaces such as walls, floors, and table tops. Apply solution (1/2 ounce per gallon of
water) with a cloth, mop, sponge or coarse spray. Make sure to wet all surfaces completely. Let air dry. Repeat application
weekly or when growth reappears.
MICROBIOLOGY DATA
contaminated rings are placed in test tubes that have 10 mls of the diluted product prepared with 400 ppm AOAC synthetic Mechanism of Action for Disinfectant
hard water. After 10 minutes the rings are placed in Antimicrobial Agents
recovery/neutralization media. After a 48-hour incubation period, each tube is examined for growth (+). If the tube shows Generally, disinfectants destroy bacteria by attacking the no growth it is recorded as “0”. The neutralization control is a cytoplasmic membranes or the cellular cytoplasm itself. The positive control conducted to indicate that the recovery medium action of an antimicrobial agent on a bacterial cell involves first will neutralize carryover germicide and support growth of less adsorption to the cell surfaces, then penetration of the outer than 100 bacterium/ml. The phenol resistance is a quality control measure of the resistance of the bacteria against All bacteria contain a cell wall that is unique to this group of organisms. The cell wall gives the cell its shape and rigidity. It Test Conditions: LYSOL® Brand I.C.™ Quaternary
is composed of peptidoglycan which is a polymer consisting of Disinfectant Cleaner diluted 1:256. Test culture with 5% a disaccharide repeating unit of two different N-acetylated organic serum in 400 ppm hard water (CaCO3 equivalent). amino sugars, one of which is attached to a short peptide Contact time 10 minutes at room temperature. chain. Individual glycan strands are cross-linked through peptide bonds between the peptide chains. Gram-negative Test Results:
bacteria contain an outer cytoplasmic membrane consisting of lipopolysaccharide (LPS) molecules that surround the cell wall. The outer membrane is unique to Gram-negative bacteria. In Number of Carriers
addition, these organisms have an inner cytoplasmic Test Organism
membrane on the inside of the cell wall, which is in contact with the cytoplasm. It consists of phospholipids and proteins. The cytoplasmic membrane serves as the selective permeability barrier between the cytoplasm and the cell environment. It is the site at which many of the important cellular functions occur and the target site for many antimicrobial agents. Gram- positive bacteria do not have an outer membrane, only the Chelating agents, such as ethylenediamine tetraacetate (EDTA), are often found in formulated disinfectants. They chelate magnesium (MG++) and calcium (CA++) ions. The LPS- LPS or LPS-protein links are stabilized by Mg in the outer Pseudomonas aeruginosa4 (Clinical Isolate) membrane of Gram-negative bacteria. EDTA destabilizes the membrane by action upon Mg++. This increases permeability of Bacteria cell walls are negatively charged thereby “attracting” positively charged cations such as quaternary ammonium compounds (QAC). QACs adsorb onto the cell surface and diffuse through the cell wall. Once inside the cell, QACs bind to Staphylococcus aureus 6 (Clinical Isolate) the cytoplasmic membrane causing disruption. This results in Staphylococcus epidermidis7 (Clinical Isolate) the release of potassium (K+) ions and other cytoplasmic constituents. Precipitation of the cellular materials results in the Streptococcus faecalis8 (Clinical Isolate) 2Resistant to Antibiotics: Ampicillin, Carbenicillin, Kanamycin, and Tetracycline 3Resistant to Antibiotics: Ampicillin, Carbenicillin, Chloramphenicol, and Tetracycline. GERMICIDAL ACTIVITY
4Resistant to Antibiotics: Amikacin, Ampicillin, Carbenicillin, Cefamandole, Cefazolin, Cefoxitin, Chloramphenicol, Kanamycin, and Tetracycline. Test Method: AOAC Use-dilution test method modified in the
5Resistant to Antibiotics: Gentamicin and Methicillin 6Resistant to Antibiotics: Cefazolin, Clindamycin, Erythromycin, Gentamicin, Kanamycin, presence of 5% organic serum and 400 ppm water hardness Methicillin, Penicillin, Tetracycline, and Tobramycin 7Resistant to Antibiotics: Clindamycin, Erythromycin, Gentamicin, Kanamycin, Methicillin, Penicillin, Tetracycline, and Tobramycin 8Resistant to Antibiotics: Cefazolin, Chloramphenicol, Clindamycin, Erythromycin, Utilizing this method, clean, polished stainless steel Gentamicin, Kanamycin, Methicillin, Tetracycline, and Tobramycin rings/penicylinders are immersed in the test inocula (5% organic serum, and the respective test organism in a nutrient broth) for 15 minutes at room temperature. The contaminated stainless steel rings are dried at 37ºC for 40 minutes. The VIRUCIDAL ACTIVITY
FUNGICIDAL ACTIVITY
Test Method: Virucidal qualification, modified in the presence
Test Method: Use dilution method as described by the Official
of 5% organic serum (moderate amount) in 400 ppm hard Methods of Analysis of the Association of Official Analytical Using hard water, the mixture (virus, disinfectant, serum and The Use-Dilution Method determines disinfectant activity for hard water) is inoculated onto a hard surface in quadruplicate, germicidal solutions. Staphylococcus aureus and Salmonella allowed to dry, and then exposed to the disinfectant which has choleraesuis are tested to support broad spectrum disinfectant been diluted to the proper ratio and modified as stated above. activity claims. Germicides that are intended for use in Neutralization and cytotoxicity controls are performed. To hospitals or other health care facilities must also be tested achieve a virucidal claim, one must demonstrate a 3 log10 against Pseudomonas aeruginosa. This method can also be reduction (titer) on two sample batches above the cytotoxicty used to determine fungicidal activity against pathogenic fungi. produced by the product alone. The results show that LYSOL® Brand I.C.™ Quaternary Disinfectant Cleaner offers a wide The Use-Dilution Method is a qualitative carrier test. Stainless range of virucidal effectiveness against RNA, DNA, and viruses steel penicylinders are soaked for 15 minutes in a yeast broth culture or mold spore suspension. Pathogenic mold spore suspensions are made from 7-10 day old agar plates or slants. Test Conditions: LYSOL® Brand I.C.? Quaternary
The contaminated carriers are then removed and dried for Disinfectant Cleaner diluted 1:256 in the presence of 5% approximately 30 minutes at 37ºC. This now represents a organic serum (moderate amount) in 400 ppm hard water nonporous, hard inanimate surface contaminated with a dried film of fungi. The contaminated carriers are exposed to 10 ml of the diluted germicide for 10 minutes at 20ºC. After treatment, Test Results:
the carriers are removed from the disinfectant and placed in 10 ml subculture broth media containing appropriate neutralizers. TEST VIRUS
TITER REDUCTION (LOG10)
The subculture tubes are incubated under appropriate conditions for the test organisms. The tubes are examined for growth as determined by turbidity of the media. An effective disinfectant for hospital use kills all the organisms on 10 out of Test Conditions: LYSOL® Brand I.C.? Quaternary
Disinfectant Cleaner diluted at 1:256. Test culture with 5% organic serum in 400 ppm hard water (CaCO3 equivalent). Suspension Test Method: Effective against the following fungi
according to the AOAC Fungicidal test, modified in the presence of 5% organic serum (moderate amount) and 400 All viruses treated with LYSOL® Brand I.C.? Quaternary Disinfectant Cleaner were completely inactivated. Complete inactivation indicated at least three logs of virus were Test Results:
inactivated with no residual virus detected within limits allowed Also virucidal against the following animal viruses at 1:256 ?? Feline Leukemia Virus (ATCC VR-717, Strain FL-237) ?? Infectious Bovine Rhinotracheitis Virus (ATCC VR-793) FUNGISTATIC ACTIVITY
NFPA HAZARD RATING - CONCENTRATE
Test Method: Mildewstatic Performance determined by CSMA
fungal/mold/mildew activity method #24. Modified in the presence of 5% organic serum (moderate amount) and 400 ppm water hardness (CaCO3 equivalent) at 20ºC temperature. HMIS HAZARD RATING - CONCENTRATE
Test Conditions: LYSOL® Brand I.C.? Quaternary
Disinfectant Cleaner diluted 1:256. Test culture with 5% blood serum and 400 ppm hard water. Contact time as specified. Test Results:
NFPA HAZARD RATING – DILUTED 1:256
HMIS HAZARD RATING – DILUTED 1:256
PHYSICAL DATA
PHYSICAL PROPERTY/
CHARACTERISTIC
TEST RESULT
NFPA – National Fire Protection Association
HMIS – Hazardous Material Identification System

OTHER INFORMATION
Conductive Floors:
Certain areas of a hospital or an industrial plant require that a safe level of conductivity be maintained on the floors. The established levels of safe conductivity are between 25,000 – 1,000,000 ohms. Electric discharges must be dissipated rapidly to avoid static discharges that might affect flammable materials, such as anesthetics. Using improper disinfecta nts or detergents can cause a residue formation which can impair conductivity. LYSOL® Brand I.C.™ Quaternary Disinfectant Cleaner has no effect on the resistant properties of conductive flooring as per the requirements of the National Fire Protection Association, NFPA-99-1993, Chapter 12, Section 12-4.1.3.8. FIRST AID: In case of contact, IMMEDIATELY flush eyes or skin with plenty of water for at least 15 minutes. For eyes or skin, call a
physician. If swallowed, call a doctor or get medical attention. Do no induce vomiting or give anything by mouth to an unconscious
person. Drink promptly a large quantity of milk, egg white, gelatin solution, or if these are not available, drink large quantities of water.
Avoid alcohol.
NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate the use of gastric lavage. Measures against circulatory shock,
respiratory depression and convulsion may be needed.

PRECAUTIONARY STATEMENTS: HAZARDS TO HUMANS AND DOMESTIC ANIMALS.

For Concentrate:
KEEP OUT OF REACH OF CHILDREN
DANGER: CORROSIVE. Causes irreversible eye damage and skin burns. Harmful if swallowed. Do not get in eyes, on skin, or on
clothing. When handling product, protect eyes by wearing goggles or face shield and protect skin by wearing rubber gloves. Wash
thoroughly with soap and water after handling. Remove contaminated clothing and wash before reuse.

ENVIRONMENTAL HAZARD: Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other
waters unless in accordance with the requirements of a National Pollutant Discharge Elimination System (NPDES) permit and the
permitting authority has been notified in writing prior to the discharge. Do not discharge effluent containing this product to sewer systems
without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office
of the EPA.
For 1:256 Dilution:

CAUTION: KEEP OUT OF REACH OF CHILDREN

STORAGE / DISPOSAL

Keep product under locked storage, inaccessible to children. Do not contaminate water, food, or feed by storage or disposal. Open
dumping is prohibited. Do not reuse empty container.
PESTICIDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a
violation of Federal law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or
Environmental Control Agency or the Hazardous Waste representative at the nearest EPA Regional Office for guidance.

CONTAINER DISPOSAL: PLASTIC CONTAINERS – Triple rinse (or equivalent). Then offer for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill or incinerate, or if allowed by state and local authorities, burn. If burned, stay out of smoke. Do not
reuse empty container. Rinse thoroughly, secure wrap in several layers of newspaper, and discard empty container in trash.
MORE INFORMATION
Satisfaction Guaranteed: Careful laboratory control assures materials of uniform quality at all times. All Reckitt Benckiser Professional
products are guaranteed to give complete satisfaction, when used as directed, or they may be returned for credit.
LYSOL® Brand I.C.™ Quaternary Disinfectant Cleaner is part of a system of infection control products provided by Reckitt Benckiser
Professional.
QUESTIONS ? COMMENTS ? CALL 1-800-677-9218
VISIT US AT: www.reckittprofessional.com DISTRIBUTED BY: RECKITT BENCKISER INC. 1655 VALLEY ROAD WAYNE, NEW JERSEY 07474-0977 PACKAGING DESCRIPTION
LYSOL® Brand I.C.™ Quaternary Disinfectant Cleaner
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Source: http://www.detergentsolutions.info/msds/RB-Technical-Report-Lysol-IC-Quanternary.pdf