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Presumptive positive result
D. Interference testing
AccuTest™ THC Test Cassette
The AccuTest™ THC test strip performance at cut
1. Urine testing for drugs of abuse, NIDA Research
not affected when pH and Specific Gravity ranges of urine
2. Steven B. Karch, Drugs of abuse hand book, CRC
specimen are at 4.5 to 9.0 and 1.005 to 1.035.
FOR THE QUALITATIVE ASSESSMENT OFTHCL AND
The following substances were tested and confirmed did not
3. Ray H. Liu and Bruce A. Goldberger, Handbook of
interfere with the AccuTest™ THC test strip at the listed
workplace drug testing, AACC Press, Washington
4. Stephenson, R.L., Department of Health and Human
5. U.S. Department of Transportation, Drug Testing
For in vitro Diagnostic and Forensic Use
Procedures Handbook. p.22, Superintendent of Documents,
The AccuTest™ THC test strip is an immunochromatography based
The specificity for adding various drugs, drug metabolites
6. Lafolie, P., Beck, O., Blennow, G., et al., Importance
one step in vitro test. It is designed for qualitative determination of
tested the AccuTest™ THC test strip, and other compounds
of Creatinine Analyses of Urine When Screening for
drug substances in human urine specimens. This assay may be used
that are likely to be present in urine. All compounds were
Abused Drugs. Clinical Chemistry; 37:1927-31,
in the point of care setting. The cut-off concentration using our test is
prepared in drug -free normal human urine.
The following table lists compounds that are detected by the
7. Goldberger, B.A., Loewenthal, B., Darwin, W.D.,
AccuTest™ THC test strip, which produced positive results
and E.J. Cone, Intrasubject Variation of Creatinine
Cannabinoid (THC) 50 ng/ml of 11-nor- 9-THC-9-COOH
when tested at levels equal or greater than the concentrations
and Specific Gravity Measurements in Consecutive
This assay provides only a preliminary analytical test result. A more
8. Needleman, S.B., Porvaznik, M., Ander, D.,
specific alternative chemical method must be used in order to obtain a
Creatinine Analysis in Single Collection Urine
confirmed analytical result. The Substance Abuse Mental Health
Specimens. Journal of Forensic Science; 37: 1125-
chromatography/ mass spectrometry (GC/MS) as the preferred
9. Mayer, B and Hemphill, G., Evaluation of Urine
confirmatory method. Clinical consideration and professional judgment
Creatinine as a Marker to Identify Dilute Specimens
should be applied to any drug of abuse test result, particularly when
Being Analyzed for Drugs of Abuse. Abstract 313.
preliminary positive results are indicated.
The following compounds show no cross-reactivity at
Note: It is not for use in diagnosing disease or illness; it is for
concentration up to 100 µg/ml unless specified.
Association of Clinical Chemistry, July 1992.
investigational use only.
10. Young, D.S., et al., Clinical Chemistry; 21 (9), 1975.
11. Friedman, R.B., et al., Clinical Chemistry; 26 (4),
SUMMARY AND EXPLANATION
The agents of Marijuana that cause various biological effects in
humans are called cannabinoid. Cannabinoid is a central nervous
stimulant that alters mood and sensory perceptions, produces loss of
coordination, impairs short term memory, and produces symptoms of
1066E Beaufort Street, Unit 6-7, Bedford WA 6052
anxiety, paranoia, depression, confusion, hallucination, and increased
heart rate. Large doses of cannabinoid could cause the development
of tolerances and physiological dependency and lead to abuse. A
tolerance to the cardiac and psychotropic effects can occur and
withdrawal syndrome produces restlessness, insomnia, anorexia and
-THC is the primary active ingredient in cannabinoids. The
main metabolite excreted in the urine is 11-nor -
which are found within hours of exposure and remain detectable in the
The test strip is based on the principle of specific immunochemical
reaction between antibodies and antigen to analyze particular
compound in human urine specimen. The assay relies on the
competition for binding antibody. When drug is present in the urine
specimen, it competes with drug conjugate for the limited amount of
antibody dye conjugate. When the amount of drug is equal or more
than the cut-off, it will prevent the binding of drug conjugate to the
antibody. Therefore, a positive urine specimen will not show a colored
band on the test line zone, indicating a positive result,
while the presence of a colored band indicates a negative
result. A control line is present in the test window to work
as procedural control. This colored band should always
the presence of drug or metabolite. If the control line does not
LIMITATION OF PROCEDURE
appear on the control line zone if the test device is stored in
appear, the test device should be discarded and the obtained
The assay is designed for use with human urine only. A positive result
good condition and the test is performed appropriately.
result is invalid. The presence of this control band in the control
with any of the tests indicates only the presence of a drug/metabolite
region serve as 1) verification that sufficient volume is added, 2)
and does not indicate or measure intoxication. There is a possibility
that technical or processed urine error as well other substances in
The amount of each coated antigen and/or antibody on the
certain foods and medicines may interfere with the test and cause false results. Please refer “SPECIFICITY” secti
strip is less than 1.0 mg for antigen conjugate and is less
than 1.0 mg for goat anti- mouse IgG antibody.
substances that will produce either positive results, or that do not
1. Bring all materials and specimens to room temperature.
Test zone: contains drug bovine protein antigen conjugates
interfere with test performance. If a drug/metabolite is found present in
2. Remove the test cassette and pipette from sealed foil
Control zone: contains Goat anti-mouse IgG antibody
the urine specimen, the assay does not indicate frequency of drug use
Conjugate pad: contains mice monoclonal anti-drug antibody.
or distinguish between drug of abuse and certain foods and
3. Place the cassette kit onto a flat surface, face up.
4. Suck up the urine specimen with the pipette.
5. Holding the dropper vertically, dispense 3 drops (110µL)
The AccuTest™ THC test strip is a qualitative assay. It identifies the
MATERIAL REQUIRED BUT NOT PROVIDED
drug in human urine at its cut-off concentration or higher. The
concentration of the drug cannot be determined by this assay. The
test is intended to distinguish negative result from presumptive
WARNINGS AND PRECAUTIONS
positive result. All positive results must be confirmed using an
1. For in vitro diagnostic and professional use only.
2. Do not use the test strip beyond the expiration date.
3. Urine specimens may be infectious; properly handle and
dispose of all used reaction devices in a biohazard
The accuracy of the AccuTest™ THC test strip was evaluated in
comparison to GC/MS method at the following concentration: 11-nor-
4. Visually inspect the foil package to insure it is intact. If the
9-THC-9-COOH 50ng/ml (THC). The results of the component strip is
package is not intact, the integrity of the device might be
6. Read the result after 3 minutes but within 10 minutes.
Do not interpret the result after 10 minutes. Waiting more
THC The accuracy of the THC test was evaluated in comparison to
5. Use a new urine specimen cup for each sample to avoid
than ten minutes may cause the reading to be inaccurate.
GC/MS at a cut-off of 50 ng/ml of 11-nor-?9-THC-9-COOH. Eighty-
To avoid confusion, discard the test cassette after
eight (88) urine specimens with GC/MS confirmed 11-nor-?9-THC-9-
STORAGE AND STABILITY
interpreting the result.
COOH concentration were evaluated in this study. The results are
The test device should be stored at 2°C to 28°C; do not
INTERPRETATION OF RESULTS
and will be effective until the expiration date stated on
Positive % agreement: 95, Negative % agreement: 100
the package. The product is humidity-sensitive and should be
Two colored bands form on any strip of the card. The
Two specimens were found discrepant between the Rapid THC and
used immediately after being open. Any improperly sealed
appearance of two colored bands, one in test line zone and the
GC/MS method. When compared those data, 50% (1 out of 2) of the
other in control line zone, indicates negative result for that
discrepancy specimens were found between –25% and cut-off
SPECIMEN COLLECTION AND PREPARATION
particular test(s). The negative result does not indicate the
Fresh urine does not require any special handling or
absence of drug in the specimen; it only indicates the level of
pretreatment. Specimen should be collected in a clean, dry,
tested drug in the specimen is less than cut-off level.
The cut-off concentrations (sensitivity level) of AccuTest™ THC test
plastic or glass container. If the assay is not performed
immediately, urine specimen may be refrigerated at 2- 8 °C or
One colored band appears in control line zone. No coloured
frozen up to 7 days. Specimens should be brought to room
band is found in test line zone. This is an indication the level of
temperature before testing. Urine specimens exhibiting a
tested drug(s) in the specimen is above the cut- off level.
The precision of the AccuTest™ THC test strip was determined by
large amount of precipitate or turbidity should be centrifuged
conducting the test with spiked controls and interpreted the results by
or allowed to settle before testing. Avoid contact with skin by
If there is no colored band in control line zone of any strip, the
three individuals to verify the random error of visual interpretation. The
wearing gloves and proper laboratory attire.
test result is invalid. Retest the sample with a new device.
results of 50% above and 50% below cut-off specimens are 100%
Good Laboratory practice recommends the daily use of
control materials to validate the reliability of device. Control
materials should be assayed as clinical specimen and
challenging to the assay cutoff concentration, e.g., 25%
above and below cutoff concentration. If control values do not
fall within establish range, assay results are invalid. Control
materials that are not provided with this test kit are
The Rapid Drugs of Abuse Test provides a built-in process
control with a different antigen/antibody reaction at the control
Note: A borderline (+/-) in test line zone should be
region (C). This control line should always appear regardless
considered negative result.
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Prof. Dr. med. Hans Hölschermann Chefarzt der Medizinischen Klinik I Kardiologie, Angiologie, Internistische Intensivmedizin und Stroke Unit Urseler Straße 33, 61348 Bad Homburg Tel. 06172/14-3133 Fax 06172/14-4915 firstname.lastname@example.org PATIENTENINFORMATION WARUM UND WELCHE MEDIKAMENTE BEI KORONARER HERZKRANKHEIT? Liebe Patientin, lieber Patient, be