Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Emr.moh.gov.rw

Code review /ProgramOverModule11Purpose of the module: the module displays statistics about a program. All available programs can be selected. The list of indicators is static. The user can select to display a graph.
Maintainability
- JUnit AdminListExtensionTest fails, no other test cases implemented
- Design: org.openmrs.module.programOver.web.controller.ProgramPatientsController is not a Spring controller
- Error org.openmrs.module.programOver.web.controller.PatientGraph.getGraphOfAllARVPatients(PatientGraph.java:94)
- sysout ProgramOverviewDAOimpl >>> see OpenMRS code convention Error Handling
- Exception handling
- SQL without exception handling ProgramOverviewDAOimpl line 159, 194, etc.
Performance
- Report HIV, Number of active patients on ARVs regimen (2004-2008, graph activated)
- How much time is spent on the server side? How much on client side (Javascript)? - problem is on server side - run time 5 minutes on laptop- database table, count patients=2000, count obs=300000- observation: ProgramOverviewDAOimpl.getAllARVPatients() loops over patientIDs, each step executes up to three SQL query Trace log messages
Number of patients died during the chosen period 2004 - 2008
[java] INFO - ProgramOverFormController.handleRequestInternal(60) |2010-10-29 15:52:01,562| TIME check start handleRequestInternal
[java] INFO - ProgramOverFormController.handleRequestInternal(77) |2010-10-29 15:52:01,578| TIME check before getNumberOfMonths [java] INFO - ProgramOverFormController.handleRequestInternal(84) |2010-10-29 15:52:01,578| TIME check after getNumberOfMonths [java] INFO - ProgramOverFormController.handleRequestInternal(129) |2010-10-29 15:52:01,578| TIME check before loop checkTypeController [java] INFO - ProgramOverFormController.handleRequestInternal(144) |2010-10-29 15:52:01,765| TIME check after loop checkTypeController [java] ++++++++++This HIV Programis found [java] INFO - ProgramOverFormController.handleRequestInternal(161) |2010-10-29 15:52:01,765| TIME check before numberOfPatientByYear [java] INFO - ProgramOverFormController.handleRequestInternal(165) |2010-10-29 15:52:01,828| TIME check after numberOfPatientByYear Number of active patients on ARVs 2004 - 2008 [java] INFO - ProgramOverFormController.handleRequestInternal(60) |2010-10-29 15:53:24,171| TIME check start handleRequestInternal [java] INFO - ProgramOverFormController.handleRequestInternal(77) |2010-10-29 15:53:24,171| TIME check before getNumberOfMonths [java] INFO - ProgramOverFormController.handleRequestInternal(84) |2010-10-29 15:53:24,171| TIME check after getNumberOfMonths [java] INFO - ProgramOverFormController.handleRequestInternal(129) |2010-10-29 15:53:24,171| TIME check before loop checkTypeController [java] INFO - ProgramOverFormController.handleRequestInternal(144) |2010-10-29 15:53:53,421| TIME check after loop checkTypeController [java] INFO - ProgramOverFormController.handleRequestInternal(161) |2010-10-29 15:53:53,421| TIME check before numberOfPatientByYear [java] INFO - RegimenHistory.getRegimenList(76) |2010-10-29 15:54:16,015| Running list: 0 [java] INFO - RegimenHistory.getRegimenList(77) |2010-10-29 15:54:16,031| Stavudine(30) from 2004-05-06 to 2004-02-12 [java] INFO - RegimenHistory.getRegimenList(76) |2010-10-29 15:54:46,984| Running list: 0 [java] INFO - RegimenHistory.getRegimenList(77) |2010-10-29 15:54:46,984| Stavudine(30) from 2004-05-06 to 2004-02-12 [java] INFO - RegimenHistory.getRegimenList(76) |2010-10-29 15:55:38,234| Running list: 0 [java] INFO - RegimenHistory.getRegimenList(77) |2010-10-29 15:55:38,234| Stavudine(30) from 2004-05-06 to 2004-02-12 [java] INFO - RegimenHistory.getRegimenList(76) |2010-10-29 15:56:22,609| Running list: 0 [java] INFO - RegimenHistory.getRegimenList(77) |2010-10-29 15:56:22,609| Stavudine(30) from 2004-05-06 to 2004-02-12 [java] INFO - RegimenHistory.getRegimenList(76) |2010-10-29 15:57:14,343| Running list: 0 [java] INFO - RegimenHistory.getRegimenList(77) |2010-10-29 15:57:14,343| Stavudine(30) from 2004-05-06 to 2004-02-12 [java] INFO - RegimenHistory.getRegimenList(76) |2010-10-29 15:58:03,843| Running list: 0 [java] INFO - RegimenHistory.getRegimenList(77) |2010-10-29 15:58:03,843| Stavudine(30) from 2004-05-06 to 2004-02-12 [java] INFO - ProgramOverFormController.handleRequestInternal(165) |2010-10-29 15:58:35,375| TIME check after numberOfPatientByYear - variable listPatientHistory contains a lot of data

Source: http://emr.moh.gov.rw/svn/documentation/code-reviews/code-review-ProgramOverModule11_2-11-2010.pdf