Epilim approved p i


PROPRIETARY NAME (and dosage form):
Epilim® Liquid Sugar-free (Liquid)
Epilim® CR 200 (Prolonged Release Tablets)
Epilim ® CR 300 (Prolonged Release Tablets)
Epilim ® CR 500 (Prolonged Release Tablets)
Epilim® 100 Crushable (Tablets)
Epilim ® Intravenous (Freeze-dried powder for intravenous injection)
with Water for Injection – Epilim (Solvent ampoule)
1. Epilim Liquid Sugar-free:

each 5 ml contains 200 mg Sodium Valproate Sodium Methylparabenzoate 0,1 % m/v and Sodium Propylparabenzoate 0,04 % m/v. 2. Epilim CR 200: each tablet contains 133,2 mg sodium valproate and 58,0 mg valproic acid
3. Epilim CR 300: each tablet contains 199,8 mg sodium valproate and 87,0 mg valproic acid
4. Epilim CR 500: each tablet contains 333,0 mg sodium valproate and 145,0 mg valproic acid
5. Epilim 100 Crushable: each tablet contains 100 mg Sodium Valproate.
6. Epilim Intravenous: each vial contains 400 mg freeze-dried sodium valproate,
with Water for Injection - Epilim: each ampoule contains 4 ml sterile water for injection.
A 2.5 Anticonvulsants, including anti-epileptics.

Pharmacodynamic properties:
Sodium valproate has anticonvulsant properties. The exact mode of action is unknown. However,
the most likely mode of action for valproate is potentiation of the inhibitory action of gamma amino
butyric acid (GABA) through an action on the further synthesis or further metabolism of GABA.
Pharmacokinetic properties:
Peak plasma concentrations are observed in 1 to 4 hours after sodium valproate liquid, but this can
be delayed for several hours if valproic acid is administered in enteric-coated tablets, in prolonged
release formulation, or is ingested with meals.
Sodium valproate bioavailability is close to 100 % fol owing oral or IV administration.
Valproic acid concentration in cerebrospinal fluid is close to free plasma concentration.
Steady state plasma concentration is reached after 3 to 4 days, fol owing oral administration.
Valproate is highly bound to plasma proteins; protein binding is dose dependent and saturable.
When given in therapeutic doses, most of the medicine is converted to the conjugate ester of
glucuronic acid, while mitochondrial metabolism, principal y by means of beta-oxidation, accounts
for the remainder. Some of the metabolites have anticonvulsant activity.
Sodium valproate is mainly excreted in urine fol owing metabolism via glucuro-conjugation and
Sodium valproate does not increase its own degradation, neither that of other agents such as
oestrogen and progestogen containing medicines.
The elimination half-life of sodium valproate varies from approximately 8 to 20 hours. It is usual y
shorter in children.
In patients with severe renal insufficiency it may be necessary to alter dosage in accordance with
free plasma valproic acid levels.
The reported effective therapeutic range for plasma valproic acid levels in epilepsy is considered to
be between 30 and 100 µg/ml. This reported range may depend on time of sampling and
presence of co-medication. The percentage of free (unbound) drug is usual y between 6 % and
15 % of total plasma levels.
The pharmacological (or therapeutic) effects of Epilim are not clearly correlated with the total or
free (unbound) plasma valproic acid levels.
In cases where measurement of plasma levels is considered necessary, trough plasma levels
should be used for therapeutic monitoring.
In the treatment of generalised epilepsy, particularly with the fol owing patterns of seizures:
• absence • myoclonic • tonic-clonic • atonic • mixed • simple or complex seizures • secondary generalised seizures • specific syndromes (West, Lennox-Gastaut).
Epilim CR: for the treatment and prevention of mania associated with bipolar disorders.
Epilim Intravenous is indicated in patients for whom oral therapy is temporarily not possible.
• Hypersensitivity to sodium valproate.
• Use of Epilim in pregnancy should be avoided (see “Pregnancy and Lactation”).
• Active liver disease, including the fol owing:
Personal or family history of hepatic dysfunction especial y drug related.
Liver dysfunction:

Conditions of occurrence:
Cases of severe liver damage resulting sometimes in fatalities have been reported.
Experience in epilepsy has indicated that patients most at risk especial y in cases of multiple
anticonvulsant therapy are infants and young children under the age of 3 with severe seizure
disorders, particularly those with brain damage, mental retardation and (or) congenital metabolic or
degenerative disease.
After the age of 3, the incidence of occurrence is reduced and decreases with age.
In most cases, such liver damage occurred during the first 6 months of therapy.
Suggestive signs:
Clinical symptoms are essential for early diagnosis. In particular, the fol owing conditions, which
may precede jaundice, should be taken into consideration, especial y in patients at risk (see above
“Conditions of occurrence”):
- non-specific symptoms, usual y of sudden onset, such as asthenia, anorexia, lethargy, drowsiness, which are sometimes associated with repeated vomiting and abdominal pain. - in patients with epilepsy, recurrence of seizures.
Patients (or their family for children) should be instructed to report immediately any such signs to a
physician should they occur. Investigations including clinical examination and biological
assessment of liver function should be undertaken immediately.

Liver function should be performed before and then periodical y monitored during the first 6 months
of therapy. Amongst usual investigations, tests which reflect protein synthesis, particularly
prothrombin rate, are most relevant. Confirmation of an abnormal y low prothrombin rate,
particularly in association with other biological abnormalities (significant decrease in fibrinogen and
coagulation factors; increased bilirubin level and raised transaminases) requires cessation of
Epilim therapy. As a matter of precaution and in case they are taken concomitantly salicylates
should also be discontinued since they employ the same metabolic pathway.
Severe pancreatitis, which may result in fatalities, has been rarely reported. Young children are at
particular risk. This risk decreased with increasing age. Severe seizures, neurological impairment
or anticonvulsant therapy may be risk factors. Hepatic failure with pancreatitis increases the risk of
fatal outcome.
Effects of Epilim on other medicines:

- Neuroleptics, MAO inhibitors, antidepressants and benzodiazepines
Epilim may potentiate the effect of other psychotropics such as neuroleptics, MAO inhibitors,
antidepressants and benzodiazepines; therefore clinical monitoring is advised and dosage
should be adjusted when appropriate.
- Phenobarbital
Epilim increases phenobarbital plasma concentrations (due to inhibition of hepatic catabolism)
and sedation may occur, particularly in children. Therefore, clinical monitoring is recommended
throughout the first 15 days of combined treatment with immediate reduction of phenobarbital
doses if sedation occurs and determination of phenobarbital plasma levels when appropriate.
- Primidone
Epilim increases primidone plasma levels with exacerbation of its adverse effects (such as
sedation); these signs cease with long-term treatment. Clinical monitoring is recommended
especial y at the beginning of combined therapy with dosage adjustment when appropriate.
- Phenytoin
Epilim decreases phenytoin total plasma concentration. Moreover Epilim increases phenytoin
free form with possible overdosage symptoms (valproic acid displaces phenytoin from its
plasma protein binding sites and reduces its hepatic catabolism). Therefore clinical monitoring
is recommended; when phenytoin plasma levels are determined, the free form should be
- Carbamazepine
Clinical toxicity has been reported when Epilim was administered with carbamazepine as
valproate may potentiate toxic effect of carbamazepine. Clinical monitoring is recommended
especial y at the beginning of combined therapy with dosage adjustment when appropriate.
- Lamotrigine
Epilim may reduce lamotrigine metabolism and increase its mean half-life; dosages should be
adjusted (lamotrigine dosage decreased) when appropriate. There are suggestions, yet to be
proven, that the risk of rash may be increased by co-administration of lamotrigine with Epilim.
- Zidovudine
Epilim may raise zidovudine plasma concentration leading to increase zidovudine toxicity.
Effects of other medicines on Epilim:

Antidepressants and neuroleptics may antagonize the anti-epileptic activity of Epilim by lowering
the seizure threshold. This may require Epilim dosage adjustments.
Anti-epileptics with enzyme inducing effect (including phenytoin, phenobarbital, carbamazepine)
decrease valproate serum concentrations. Dosages should be adjusted according to blood levels
in case of combined therapy.
On the other hand, combination of felbamate and Epilim may increase valproate serum
concentration. Valproate dosage should be monitored.
Mefloquine increases valproic acid metabolism and has a convulsing effect; therefore epileptic
seizures may occur in cases of combined therapy. Chloroquine may also lower the seizure
In case of concomitant use of Epilim and highly protein bound agents (aspirin), valproate free
serum levels may be increased.
Close monitoring of INR should be performed in case of concomitant use of vitamin K dependent
factor anticoagulants
(e.g. warfarin and other coumarin anticoagulants) because the
anticoagulant effect of these agents may be increased due to displacement from plasma protein
binding sites by Epilim.
Valproate serum levels may be increased (as a result of reduced hepatic metabolism) in case of
concomitant use with cimetidine or erythromycin.
Carbapenem antibiotics (panipenem/meropenem): Decrease in valproate blood level sometimes
associated with convulsions has been observed when panipenem or meropenem were combined.
If these antibiotics have to be administered, close monitoring of valproate blood level is
Other interactions:
usual y has no enzyme inducing effect; as a consequence, Epilim does not reduce efficacy
of oestrogen and/or progestogen containing medicines in women receiving hormonal
From experience in treated epileptic mothers, the risk associated with the use of Epilim during
pregnancy has been described as fol ows:
Risk associated with epilepsy and anti-epileptics
In offspring born to mothers with epilepsy receiving any anti-epileptic treatment, the global rate of malformations has been demonstrated to be 2 to 3 times higher than the rate (approximately 3 %) reported in the general population. Although an increased number of children with malformations have been reported in case of multiple drug therapy, the respective part of treatments and disease has not been formal y established. Malformations most frequently encountered are labial clefts and cardiovascular malformations. Developmental delay has been very rarely reported in children born to mothers with epilepsy. It is not possible to differentiate what may be due to genetic, social, environmental factors, maternal epilepsy or anti-epileptic treatment. Notwithstanding those potential risks, no sudden discontinuation in the anti-epileptic therapy should be undertaken as this may lead to breakthrough seizures, which could have serious consequences for both the mother and the foetus.
Risk associated with sodium valproate
In animals: teratogenic effects have been demonstrated in the mouse, rat and rabbit. In humans: cases of facial dysmorphia have been reported. A few cases of multiple malformations, particularly of the limbs have been observed. The frequency of those effects has not been yet clearly established. Nevertheless sodium valproate preferably induces neural tube defects (1 to 2 %): anencephaly, myelomeningocele and spina bifida. • In view of the above data
If a woman plans a pregnancy, it is the opportunity of reviewing the indication for Epilim therapy.
During pregnancy, Epilim treatment should be reviewed and the risks and benefits should be
careful y considered and discussed with the patient. If considered appropriate, folate
supplementation should be started before pregnancy and at relevant dosage as it may minimise
the risk of neural tube defects.
Monotherapy at the minimum effective daily dosage. The administration in several divided doses over the day and the use of a prolonged release formulation is preferable. Specialised prenatal monitoring should be instituted in order to detect the possible occurrence of neural tube defect or another malformation.
Risk in the neonate
Cases of haemorrhagic syndrome have been reported in neonates whose mothers have taken sodium valproate during pregnancy. This haemorrhagic syndrome is related to hypofibrinogenemia; afibrinogenemia has also been reported and may be fatal. Hypofibrinogenemia is possibly associated with decrease of coagulation factors. Therefore, platelet count, fibrinogen plasma level, coagulation tests and coagulation factors should
be investigated in neonates.
crosses the placenta. When given to breast-feeding mothers, Epilim is excreted in breast

Excretion of valproate in breast milk results in a concentration between 1 % and 10 % of maternal
serum levels.
Epilim Liquid Sugar-free and Epilim CR 200, 300 and 500 tablets are for oral administration.
Epilim should preferably be taken with or after food. The tablets should be swal owed whole, if
necessary with a little water (but not with aerated mineral water) and not crushed or chewed.
Epilim Crushable tablets may be crushed and mixed with food or drinks.
Epilim Liquid Sugar-free should not be diluted. Epilim Liquid Sugar-free should be given in
divided doses.
Epilim CR is a control ed release formulation of Epilim, which reduces peak concentration and
ensures a more even plasma concentration throughout the day. Epilim CR may be given once or
twice daily.
Daily dosage requirements vary according to age and body weight.
In patients where adequate control has been achieved, Epilim CR formulations are
interchangeable with other conventional or prolonged release formulations on an equivalent daily
dosage basis.

Dosage should start at 600 mg/day, where applicable in divided doses, increasing by 200 mg/day
at three day intervals until control is achieved; this is general y within the range of 1 000 to 2 000
mg/day (i.e. 20 – 30 mg/kg body mass). If adequate control has not been achieved after two
weeks, the dose may be further increased, in stages, to a maximum of 2 500 mg/day, or one other
anti-epileptic agent may be added at a low dosage. In patients already receiving other therapy, the
same pattern should be fol owed. If increased sedation is observed, dosage of barbiturates or
benzodiazepines (e.g. lorazepam) should be reduced as that of Epilim is increased; dosage of
both Epilim and other agents should be adjusted, during the stabilization period, to give optimum
control at the lowest possible combined dosage level, and it may be found possible to maintain
optimum control with Epilim alone.
Children over 20 kg:
Initial dosage should be 400 mg/day irrespective of mass, where applicable in divided doses, with
spaced increases until control is achieved. This is usual y within the range of 20 to 30 mg/kg of
body mass per day. Where adequate control is not achieved within this range, the dose may be
increased to 35 mg/kg body mass per day.
Children under 20 kg:
20 mg/kg of body mass per day; in severe cases, this may be increased but only in patients in
whom plasma valproic acid levels can be monitored. Above 40 mg/kg/day, clinical chemistry and
haematological parameters should be monitored.
Epilim CR for the treatment and prevention of mania associated with bipolar disorders:
The recommended initial dose is 1 000 mg/day. The dose should be increased as rapidly as
possible to achieve the lowest therapeutic dose, which produces the desired clinical effect.
Doses should be adjusted according to individual clinical response.
Prophylactic treatment should be established individual y with the lowest effective dose.
Epilim Intravenous:
To reconstitute, inject the solvent provided (4 ml of Water for Injection - Epilim) into the vial, al ow
to dissolve and extract the appropriate dose. Due to displacement of solvent by sodium valproate
the concentration of reconstituted sodium valproate is 95 mg/ml.
Each vial of Epilim Intravenous is for single dose injection only. Epilim Intravenous should be
reconstituted immediately prior to use and infusion solutions containing it used within 24 hours.
Any unused portion must be discarded.
Epilim Intravenous may be given by direct slow intravenous injection or by infusion using a
separate intravenous line in normal saline, dextrose 5 %, or dextrose saline.

Epilim Intravenous should not be administered via the same IV line as other IV additives.
The intravenous solution is suitable for infusion in PVC, polythene, or glass containers
Patients already satisfactorily treated with Epilim may be continued at their current dosage using
continuous or repeated infusion. Other patients may be given a slow intravenous injection over 3 -
5 minutes, usual y 400 - 800 mg depending on body mass (up to 10 mg/kg) fol owed by
continuous or repeated infusion up to a maximum of 2500 mg/day.
Epilim Intravenous should be replaced by oral Epilim therapy as soon as practicable.
Daily requirement for children is usual y in the range of 20 - 30 mg/kg/day and method of
administration is as above.
Use in the elderly:
Although the pharmacokinetics of Epilim is modified in the elderly, this is of limited clinical
significance and dosage should be determined by seizure control. The volume of distribution is
increased in the elderly, and, because of decreased binding to serum albumin, the proportion of
free drug is increased. This wil affect the clinical interpretation of plasma valproic acid levels.
In patients with renal insufficiency:
It may be necessary to decrease dosage. Dosage should be adjusted according to clinical
monitoring since monitoring of plasma concentrations may be misleading (see “Pharmacokinetic
Combined therapy:
When starting Epilim in patients already on other anticonvulsants, these should be tapered slowly;
initiation of Epilim therapy should then be gradual, with target dose being reached after about 2
weeks. In certain cases it may be necessary to raise the dose by 5 to 10 mg/kg/day when used in
combination with anticonvulsants, which induce liver enzyme activity, e.g. phenytoin,
phenobarbitone and carbamazepine. Once known enzyme inducers have been withdrawn, or if
side-effects, such as tremor, are experienced, it may be possible to maintain seizure control on a
reduced dose of Epilim. When barbiturates are being administered concomitantly and particularly
if sedation is observed (particularly in children) the dosage of barbiturate should be reduced.
General considerations:
The concentration of valproate in plasma that appears to be associated with therapeutic effects is
approximately 30 - 100 µg/ml. Optimum dosage is mainly determined by seizure control and
routine measurement of plasma levels is unnecessary. However, a method for measurement of
plasma levels is available and may be helpful where there is poor control or side-effects are
suspected (see “Pharmacokinetic properties”).
Where applicable, the fol owing frequency rating has been used:
Very common (> 1/10); common (> 1/100; 1/10); uncommon (> 1/1000; 1/100); rare (>
1/10000; 1/1000); very rare ( 1/10000), including “isolated reports”.
Congenital and familial/genetic disorders:
(See “Pregnancy and Lactation”).
Hepato-biliary disorders:
Rare cases of liver dysfunction (see “Warnings”).
Gastrointestinal disorders:
Nausea, gastralgia, diarrhoea frequently occurs in some patients at the start of treatment, but they
usual y disappear after a few days without discontinuing the treatment.
Very rare cases of pancreatitis, sometimes lethal, have been reported (see “Warnings”).
Nervous system disorders:
Confusion; a few cases of stupor or lethargy sometimes leading to transient coma
(encephalopathy) have been described during sodium valproate therapy; they were isolated or
associated with an increase in the occurrence of convulsions whilst on therapy, and they
decreased on withdrawal of treatment or reduction of dosage. These cases have most often been
reported during combined therapy (in particular with phenobarbital) or after a sudden increase in
valproate doses.
Very rare cases of reversible dementia associated with reversible cerebral atrophy have been
reported. Isolated reversible Parkinsonism has been reported. Transient and (or) dose related fine
postural tremor and somnolence have often been reported.
Metabolic disorders:
Cases of isolated and moderate hyperammonemia without change in liver function tests may
frequently occur and should not cause treatment discontinuation. Hyperammonemia associated
with neurological symptoms have also been reported. In such cases further investigations should
be considered (see “Special precautions”).
Blood and lymphatic system disorders:
Frequent occurrences of thrombocytopenia, rare cases of anaemia, leucopenia or pancytopenia
have been reported.
Isolated reduction of fibrinogen or increase in bleeding time has been reported, usual y without
associated clinical signs and particularly with high doses (sodium valproate has an inhibitory effect
on the second phase of platelet aggregation) (see also “Pregnancy”).
Skin and subcutaneous tissue disorders:
The fol owing side-effects have been reported and the frequencies are unknown:
Cutaneous reactions may occur with valproate such as exanthematous rash. In exceptional cases,
toxic epidermal necrolysis, Stevens-Johnson syndrome and erythema multiforme have been
Transient and (or) dose related hair loss has often been reported. Regrowth normal y begins
within six months, although the hair may become curlier than previously.
Reproductive system disorders:
The fol owing side-effects have been reported and the frequencies are unknown:
Amenorrhoea and irregular periods have been reported.
Vascular disorders:
The fol owing side-effects have been reported and the frequencies are unknown:
The occurrence of vasculitis has been reported.
Ear disorders:
Hearing loss, either reversible or irreversible, has been reported rarely; however a cause and effect
relationship has not been established.

Renal and urinary disorders:
There have been isolated reports of a reversible Fanconi’s syndrome (a defect in proximal renal
tubular function) associated with valproate therapy but the mode of action is as yet unclear.
Immune system disorders:
The fol owing side-effects have been reported and the frequencies are unknown:
Al ergic reactions have been reported.
General disorders and administration site conditions:
Very rare cases of non-severe peripheral oedema have been reported.
The fol owing side-effects have been reported and the frequencies are unknown:
Increase in weight may also occur. Weight gain being a risk factor for polycystic ovary syndrome,
it should be careful y monitored (see “Special precautions”).
When using Epilim intravenously, nausea or dizziness may occur a few minutes after injection; it
disappears spontaneously within a few minutes.

Special precautions:

- Liver function tests should be carried out before therapy (see “Contra-indications”), and
periodical y during the first 6 months especial y in patients at risk (see “Warnings”). As with most anti-epileptic drugs, mild increased liver enzymes may be noted, particularly at the beginning of therapy; they are transient and isolated, without clinical sign. More extensive biological investigations (including prothrombin rate) are recommended in those patients; an adjustment of dosage may be considered when appropriate and tests should be repeated as necessary.
- Monotherapy is recommended in children under the age of 3 years when prescribing Epilim,
but the potential benefit of Epilim should be weighed against the risk of liver damage or
pancreatitis in such patients prior to initiation of therapy (see “Warnings”).
The concomitant use of salicylates should be avoided in those children under 3 due to the risk
of liver toxicity.
- Blood tests (blood cel count, including platelet count, bleeding time and coagulation tests) are recommended prior to initiation of therapy or before surgery, and in case of spontaneous bruising or bleeding (see ”Side-effects”). - In patients with renal insufficiency, it may be necessary to decrease dosage. As monitoring of plasma concentrations may be misleading, dosage should be adjusted according to clinical monitoring (see “Pharmacokinetic properties”).
- Although immune disorders have been only exceptional y noted during the use of Epilim, the
potential benefit of Epilim should be weighed against its potential risk in patients with systemic
lupus erythematosus.
- Exceptional cases of pancreatitis have been reported; therefore patients experiencing acute abdominal pain should have a prompt medical evaluation. In case of pancreatitis, valproate should be interrupted. - When a urea cycle enzymatic deficiency is suspected, metabolic investigations should be performed prior to treatment because of the risk of hyperammonemia with valproate. - Patients should be warned of the risk of weight gain at the initiation of therapy; and appropriate strategies should be adopted to minimise it (see “Side-effects”).
- Diabetic patients: Epilim is eliminated mainly through the kidneys, partly in the form of
ketone bodies, and this may give false positive readings in the urine testing of possible diabetics.
Effect on ability to drive and use machines:
Patient should be warned of the risk of somnolence especial y in cases of anticonvulsant
polytherapy or association with benzodiazepines (see “Drug interactions”).
Clinical signs of acute massive overdose usual y include a coma, with muscular hypotonia,
hyporeflexia, miosis and impaired respiratory function.
Symptoms may however be variable and seizures have been reported in the presence of very high
plasma levels. Cases of intracranial hypertension related to cerebral oedema have been reported.
Hospital management of overdose should be symptomatic: gastric lavage (which is useful up to 10
to 12 hours fol owing ingestion), cardio-respiratory monitoring, assisted ventilation and other
supportive measures are recommended. Haemodialysis and haemoperfusion have been used
successful y.
Naloxone has been successful y used in a few isolated cases.
Deaths have occurred fol owing massive overdose.

1. Epilim
Liquid Sugar-free:
2. Epilim CR 200:
3. Epilim CR 300:
4. Epilim CR 500:
5. Epilim 100 Crushable:
6. Epilim Intravenous:
Off white, sterile, freeze-dried powder in a clear with Water for Injection - Epilim glass vial, and clear, colourless, aqueous solvent (Water for Injection - Epilim) in a 4 ml clear glass ampoule.

Epilim Liquid Sugar-free is available in amber PET or amber glass bottles of 300 ml.
Epilim CR 200, Epilim CR 300, Epilim CR 500 tablets are available in metal foil in boxes of 100
Epilim 100 Crushable tablets are available in metal foil in boxes of 100 tablets.
Epilim Intravenous: 400 mg of freeze dried Sodium Valproate in a clear glass vial supplied with
an ampoule of 4 ml of solvent (Water for Injection - Epilim).

The tablets, being hygroscopic, must be kept in their protective foil until taken. Where possible,
blister strips should not be cut. Both tablets and liquid should be stored below 25 ºC in a dry place.
Epilim Intravenous freeze-dried powder should be stored below 25 ºC.
For intravenous use, the reconstituted solution should be used immediately and any unused
portion discarded. If the reconstituted solution is further diluted for use as an infusion solution, the
dilute solution may be stored for up to 24 hours if kept at 2 to 8 °C before use, discarding any
remaining solution after 24 hours.


Epilim Liquid Sugar-free:
Epilim CR 200:
Epilim CR 300:
Epilim CR 500:
Epilim 100 Crushable tablets:
Epilim Intravenous:


sanofi-aventis south africa (pty) ltd
2 Bond Street

10 March 2006

Source: http://www.epilepsy.org.za/download/files/17.pdf


I. GENERAL All Physicians and Practitioners All Specialties Section 1. Admission of Patients: Medical Staff members of the Hospital may admit patients for diagnostic, surgical and therapeutic care in accordance with their granted privileges. Exceptions are patients with serious burns and acute psychiatric diagnoses requiring locked facilities. 1.1 Admitting Physician


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