Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

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Plastics
Journals, Shafts
Chemical
aterials
Chemical Compatibility Guide
Compatibility Guide
for GPI Flowmeters
r = Recommended
n = Not Recommended
X = Unknown or Not Applicable
Aluminum
PBT Polyester (V
Nylon 6,6
Acetal (Delrin)
PPS (Ryton)
PVDF (Kynar)
Rulon 641
Carbon - Graphite
Ceramic / Sapphire
Tungsten Carbide
Ferrite (MnZn)
Hastelloy-C
FKM/Fluorocarbon (Viton)
Buna-N (Nitrile)
Perfluoroelastomer (FFKM)
Acetic Acid
N R N N R R N X N N R N R R R R N X R R R R N
: reference m
R R R R R R N N R R R N R R R R R R R N R R N
Alcohols: Isobutyl
R R X R R R R X X R X X R R R R R X R R R R R
Alcohols: Isopropyl
R R X R R R R R R R X X R R R R R R R R R R R
Alcohols: Methyl
R R R R R R R X R R R R R R R R R R R N R R R
Ammonia, Anhydrous
N R N R R R R X X N R R R R X R R X R N R R R
section 7
Ammonia, Liquid
N R X R R R R X R N R R R R R R R X R N R R N
Ammonium Hydroxide
N R N R R R R N N N R R R R R R N R R R R R N
Antifreeze
R R X X R X R X X N X X X R X R R R X R X R R
Boric Acid
R N X R R R R R R R R R R X R R R R R R R R R
Butyl Acetate
R R R R R R N R R R R R R R R R R R R N R R N
Calcium Chloride
R N X N R R N X R N R R R R R R R R R R R R R
Calcium Hypochlorite
N N X N R R R X X N R R R R R R N R R R R R N
Carbon Tetrachloride (wet)
R N R R R R X X X R R R R X R R X X R X R N N
Carbonic Acid
R R N R R R R X R R R R R R R R R X R R R R N
Chlorine Water
R N N N N R R X N N N R R N R X R R R R R N N
Chlorine, Anhydrous Liquid
N N N N N N N X X R N R R N R N X N N R R R N
Clorox® Bleach (Sodium Hypochlorite)
X N X R R R R R N N N R R R X R N X R R R R N
Detergents
R R X R R R R R R R R R R R R R X R R R R R R
Diesel Fuel
R R R R R R R R R R R R R R R R R R R R R N R
R R R R R R N X R R X X R R R R R X R R R R N
Ethylene Dichloride
N R R R R R N X X R R R R R R R R X R R R N N
Ethylene Glycol
R R R R R R R R R R R R R R R R R R R R R R R
Ferric Chloride
N N N N N R R X N N R R R R R R N X R R R R R
Freon 113
X X X X X R R X X R R R R R X R R R R R R N R
Fuel Oils (#1 and #2)
R R R R R R R R R R R R R R R R R X R R R N R
Gasoline, Unleaded
R R X R R R N R R R R R R R R R R R R R R N R
R R R R R R N X X R R R R R R R R X R R R N R
Hydraulic Oil (Petro)
R R R R R R R R X R N R R R R R R R R R R N R
Hydraulic Oil (Synthetic)
R R R R R R R R X X X R R R R R R R R R R R N
Hydrochloric Acid 20%
N N X N N R R R N N N R R N R N N R R R R N X
Hydrochloric Acid 37%
N N X N N R R X N N N R R R R N N R R R R R R
Hydrochloric Acid 100%
N N N N N R N N N N N R R R R R N R R R R N N
Hydrofluoric Acid 20%
R N X N N R R R N N R R R N X N N R R R R N N
Hydrofluoric Acid 100%
R N X R R R N N N N N R R N R N N R R R R N N
Hydrogen Peroxide 10%
R R X R R R R R N N R R R R N R N R R R R R N
Hydrogen Peroxide 30%
R R X R R R R X N N R R R R N X N R R R R R N
Hydrogen Peroxide 100%
R R N R R R R X N N N R R R N X N R R R R N N
Isopropyl Acetate
R N X N R R N X X N X N R R R R R X R N R R N
Kerosene
R R R R R R R R R R R R R R R R R R R R R N R
R R X R R R N X X N R N R R R R R X R N R R N
buy smart.buy value.buy
Chemical Compatibility Guide
Plastics
Journals, Shafts
Chemical
Compatibility Guide
for GPI Flowmeters
r = Recommended
n = Not Recommended
X = Unknown or Not Applicable
Aluminum
PBT Polyester (V
Nylon 6,6
Acetal (Delrin)
PPS (Ryton)
PVDF (Kynar)
Rulon 641
Carbon - Graphite
Ceramic / Sapphire
Tungsten Carbide
Ferrite (MnZn)
Hastelloy-C
FKM/Fluorocarbon (Viton)
Buna-N (Nitrile)
Perfluoroelastomer (FFKM)
Lacquer Thinners
R R R R R R N X X N X X R X R X R X R N R N N
Lacquers
R R X R R R N X X N X N R R R R R X R N R N N
Lye: NaOH Sodium Hydroxide
N N N R R N R X X N R N R R X R R X N R R R R
Magnesium Hydroxide
R N N R R R R X R R R R R R R R R X R R R R R
Methanol (Methyl Alcohol)
R R R R R R R X R R R R R R R R R R R N R R R
Methyl Ethyl Ketone
R R R R R R N R R N R N R R R R X R R N R R N
Motor Oil
R R X R R X R R R R R R R R R R R R X X R N R
Nitrating Acid (> 15% H2S04)
X N X N N R N X X N N X R N X R N X R X R R N
Nitric Acid (5-10%)
R R N R R R R X R N R R R N R N N X R R R R N
Nitric Acid (50%)
R N N R R R R X N N N R R N R N N N R R R N N
Nitric Acid (Concentrated)
R N N R R R R R N N N R R N N N N N R R R N N
Oils: Fuel (1, 2, 3, 5A, 5B, 6)
R N R R R R R X R N R R R R R R R X R R R N R
Oils: Hydraulic Oil (Petro)
R R R R R R R R R R N R R R R R R X R R R N R
Oils: Mineral
R R R R R R R R R R R R R R R R R R R R R N R
Oils: Transformer
X R X R R X R R X R X R R R R R R X X R R N R
Phosphoric Acid (< 40%)
R N N N N R R X N N R R R R R R N N R R R R N
Phosphoric Acid (> 40%)
R N N N N R R X N N R R R R R R N X R R R R N
Potassium Chloride
R N N R R R R R R R R R R R R R N X R R R R R
Potassium Hydroxide (Caustic Potash)
N N N R R R R N R R R R R R N N N R R R R R R
Potassium Hypochlorite
N N X N R R R X X X R R R X X N N X R X R R R
Propane (Liquefied)
R R R R R R R X R R X R R R R R R X R R R N R
Propylene Glycol
R R X R R R N R R R X X R R X R R R R R R R R
Salt Brine (NaCI Saturated)
R R X R R R R X X X R R R R R X N X R R R R R
Sea Water
R R N N N R R R X R R R R R R R N X R R R R R
Soap Solutions
R N R R R R R X R R R R R R R R R R R R R R R
Sodium Bicarbonate
R N N R R R R R X R R R R R R R R R R R R R R
Sodium Chloride
R N N R R R R R R R R R R R R R N R R R R R R
Sodium Hydroxide (20%)
R N R R R R R X R R R R R R R R N X R N R R R
Sodium Hydroxide (50%)
N N N R R N R X R R R R R R X R N X N N R R R
Sodium Hydroxide (80%)
N N N N R R R N R N R R R R R R N N R N R R N
Sodium Hypochlorite (< 20%)
N N N N N R R X N N R R R R R R N R R R R R R
Sodium Hypochlorite (100%)
N N N N N R R X N N R R R R N R N R R R R R N
Sulfuric Acid (< 10%)
R N X N R R R X N N R R R R R R N X R R R R R
Sulfuric Acid (75-100%)
R N X N N R N X N X R R R N N R N N R R R R N
Toluene (Toluol)
R R R R R R N N R N R R R R R R R R R N R N N
Trichloroethylene
R N X R R R N X R N R R R R R X R R R R R N N
R N N R R R R R N R R R R R R R R R R R R R R
Water, Deionized
X N R R R R R X X X R R R X R R X X R R R R R
Water, Distilled
R N R R R R R R X R R R R R R R R X R R R R R
Water, Salt
R N N R R R R X X R R R R R R R R X R R R R R
R R R R R R N N R R R R R R R R R X R R R N N
buy smart.buy value.buy

Source: http://www.grisa.com.mx/web/images/pdf/GPI%20Industrial%20Meters/Chemical-Compatibility-Ver-6.pdf