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Microsoft word - curriculum vitae_hung-rong yen updated on oct 08, 2011.doc

Curriculum Vitae (Hung-Rong Yen)
Name: Hung-Rong Yen (顏宏融)
Birth date: October 19, 1972.
Birth Place: Changhua County, Taiwan
Citizenship: Taiwan, R.O.C.
Office Address:
Center for Traditional Chinese Medicine, E-mail: coloryen@adm.cgmh.org.tw
Language: Taiwanese, Chinese, English
Education and Post-Graduate Education:
Sep 1990-Jun 1997 M.D., China Medical College, Taichung, Taiwan. Sep 2004-Jun 2010 Ph.D., Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan Feb 2007-Jan 2010 Post-doctoral Research Fellow , Division of Hematopoiesis and Immunology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A. Employment Record:
Jun 1996-May 1997 Internship, Mackay Memorial Hospital, Taipei, Taiwan. Jul 1997-May 1999 Mandatory Military Service(Military Doctor and Secondary Jun 1999-Jun 2000 Residency, Department of Chinese Medicine, Chang Gung Jul 2000-Jun 2003 Residency, Department of Pediatrics, Chang Gung Children’s Jul 2003-Jun 2004 Chief Resident, Department of Gynecology and Pediatrics, Center for Traditional Chinese Medicine, Chang Gung July 2004-Jun 2005 Attending Physician, Department of Gynecology and Pediatrics, Center for Traditional Chinese Medicine, Chang Gung July 2005-Dec 2009 Instructor & Attending Physician, Department of Gynecology and Pediatrics, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Feb 2007-Jan 2010 Post-doctoral Research Fellow, Division of Hematopoiesis and Immunology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A. Jan 2010- Jun2011 Instructor & Attending Physician, Department of Chinese Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Jul 2011-present Assistant Professor & Attending Physician, Department of Chinese Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Aug 2011-present Assistant Professor, Department of Chinese Medicine, School of Medicine, Chang Gung University, Taoyuan, Taiwan. Board Certification:
Specialist of Integration of Chinese and Western Medicine, No. 890057 Licensures:
2. R.O.C. Chinese Medical Physician License No. 006183 3. U.S.A. Passed the Californian Acupuncture Licensure Exam, Acupuncture Board, Professional Affiliations:
1. Membership of Taiwan Pediatric Association 2. Membership of Formosan Medical Association 3. Membership of Medical Association of Integrated Chinese and Western Medicine 4. Membership of Chinese Acupuncture Association 5. Membership of American Society for Microbiology 6. Membership of American Association of Immunologists Awards and Honors:
1990 The Honorable Model Student of the Class, China Medical College 1991 Vice-Class Representative, China Medical College 1992 Chief Editor, School Newspaper, China Medical College 1993 Chief Editor, School Magazine, China Medical College 1994 The Honorable Model Student of the Class, China Medical College 1994 Award for Honorable Youth Model, Taichung City, Taiwan 1995-1997 Class Representative, China Medical College 1997 Award for Excellent Virtue, China Medical College 2007-2008 Taiwan Elite Scholarship for Study Abroad, Ministry of Education, Taiwan (教育部獎助赴國外頂尖大學研修獎學金) 2009 Award for Study Report by Taiwan Elite Scholarship, Ministry of 2009-2010 Taiwan Merit Scholarship by Graduate Students Study Abroad Program, National Science Council, Taiwan (國科會千里馬計畫專案擴增留學 Professional Activities:
2005-2007 Infection Control Committee, Chang Gung Memorial Hospital Teaching Experiences:
1. Lecture in nursing school course “Healthy Issues for Children and Adolescents” for 4th year nursing students on “Traditional Chinese Medicine in Children and Adolescents”. (Chang Gung University, School of Nursing). 2. Lecture in medical school course “Review Courses for Basic and Clinical Medicine” for 8th year medical students on “Traditional Chinese Medicine in Pediatrics”. (Chang Gung University, School of Chinese Medicine). 3. Lecture in medical school course “General Introduction, Gastrointestinal Diseases and Infectious Diseases” for 5th year medical students on “Traditional Chinese Medicine in Pediatrics”. (Chang Gung University, School of Chinese Medicine). Mentoring:
2005-2011 Mentor of undergraduate students in Chang Gung University, School of Research Interest:
Research Project:
Chang Gung Medical Research Project Grant (CMRPG-350821, and Phenotype characterization of in vivo tolerized autoreactive CD8+ T cells--interaction with autoreactive CD4+ T cells. Feb 2007-Jan 2009. Chang Gung Medical Research Project Grant (CMRPG-450091, 450092, Anti-influenza virus activity and mechanism of Chinese medicinal agents. Bibliography:
*Publications:
1. Yen HR, Lin YH*. Experience of learning traditional Chinese medicine. China
Journal of Traditional Chinese Medicine and Pharmacy. 2000;15(4): 68-69&73.
(本院認可中國大陸中醫期刊,中國醫藥學報) 2. Yen HR, Chu SM*. Paroxysmal supraventricular tachycardia in neonatal tuberous
sclerosis complex and cardiac rhabdomyoma: report of one case. Acta Paediatrica
Taiwanica. 2003;44(2):112-115. (專科醫學會雜誌,臺兒醫誌)
3. Chao SL, Huang LW*, Yen HR. Pregnancy in premature ovarian failure after
therapy using Chinese herbal medicine. Chang Gung Medical Journal. 2003
4. Yen HR, Lien R*, Fu RH, Chang LY. Hepatic failure in a newborn with maternal
peripartum exposure to echovirus 6 and enterovirus 71. European Journal of
Pediatrics. 2003;162(9): 648-649. (SCI; IF=1.634; Pediatrics 38/94)
5. Yen HR, Lin PY*, Chuang WY, Chang ML, Chiu CH. Skin manifestations of
Kikuchi-Fujimoto disease: case report and literature review. European Journal of
Pediatrics. 2004;163(4-5):210-213. (SCI; IF=1.634; Pediatrics 38/94)
6. Chou CY, Liao LL, Yen HR, Yang RC*. Management of menopausal syndrome
by western and traditional Chinese medicine. Journal of Pharmacy. 2005;21(2):
118-124. (中華民國藥師公會全國聯合會雜誌,藥學雜誌) 7. Chang YC, Shiue HS, Chang HH*, Chang CH, Yang YL, Yen HR. The
therapeutic effect of applying herbal paste onto acupoints for allergic rhinitis during dog days - a preliminary study. Journal of Chinese Medicine. 2006;
17(1-2): 15-24. (本院認可國內中醫期刊,中醫藥雜誌) 8. Lin YK, Yen HR, Wong WR, Yang SH, Pang JH*. Successful treatment of
pediatric psoriasis with indigo naturalis composite ointment. Pediatric
Dermatology. 2006;23(5): 507-510. (SCI; IF=1.031; Pediatrics 63/94)
9. Yen HR*. Evidence-based studies of applying herbal paste onto acupoints for
childhood asthma and allergic rhinitis during dog days. The Taipei Journal of
Chinese Medicine 2006; 12(4):18-25. (台北市中醫師公會會刊)
10. Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL,
Getnet D, Goldberg MV, Maris CH, Housseau F, Yu H, Pardoll DM, Drake CG*. Cutting Edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. Journal of Immunology. 2007;
179(7):4313-4317. (SCI; IF=5.646; Immunology 18/128) 11. Harris TJ, Hipkiss EL, Borzillary S, Wada S, Grosso JF, Yen HR, Getnet D,
Bruno TC, Goldberg MV, Pardoll DM, Deweese TL, Drake CG*. Radiotherapy augments the immune response to prostate cancer in a time-dependent manner. Prostate. 2008; 68(12):1319-1329. (SCI; IF=3.081; Urology& Nephrology 14/63)
12. Getnet D, Maris CH, Hipkiss EL, Grosso JF, Harris TJ, Yen HR, Bruno TC,
Wada S, Adler A, Georgantas RW, Jie C, Goldberg MV, Pardoll DM, Drake CG*. Tumor recognition and self-recognition induce distinct transcriptional profiles in antigen-specific CD4 T cells. Journal of Immunology. 2009; 182(8):4675-4685.
13. Wada S, Yoshimura K, Hipkiss EL, Harris TJ, Yen HR, Goldberg MV, Grosso JF,
Getnet D, Demarzo AM, Netto GJ, Anders R, Pardoll DM, Drake CG*. Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model. Cancer Research. 2009; 69(10):4309-4318. (SCI;
14. Grosso JF, Goldberg MV, Getnet D, Bruno TC, Yen HR, Pyle KJ, Hipkiss E,
Vignali DA, Pardoll DM, Drake CG*. Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells. Journal of
Immunology. 2009; 182(11): 6659-6669. (SCI; IF=5.646; Immunology 18/128)
15. Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati
FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL*. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nature Medicine. 2009; 15(9):1016 - 1022. (SCI; IF=27.136;
Medicine-Research & Experimental 1/93) 16. Yen HR, Harris TJ, Wada S, Grosso JF, Getnet D, Goldberg MV, Liang KL,
Bruno TC, Pyle KJ, Chan SL, Anders RA, Trimble CL, Adler AJ, Lin TY, Pardoll DM, Huang CT, Drake CG*. Tc17 CD8 T cells: Functional plasticity and subset diversity. Journal of Immunology. 2009; 183(11):7161-7168. (SCI; IF=5.646;
Immunology 18/128) (Supported by the Taiwan Elite Scholarship from the Ministry of Education and Taiwan Merit Scholarship from the National Science 17. Chang YT, Shen JJ, Wong WR*, Yen HR. Alternative Therapy for
Autosensitization Dermatitis. Chang Gung Medical Journal. 2009;
18. 黃子玶,顏宏融。異位性皮膚炎的中西醫觀點與相關實證研究進展。中醫藥 19. Radojcic V, Yen HR, Pletneva MA, Ivcevic S, Panoskaltsis-Mortari A, Gilliam
AC, Drake CG, Blazar BR, Luznik L*. STAT3 signaling in CD4+ T Cells is critical for the pathogenesis of chronic sclerodermatous Graft-Versus-Host Disease in a murine model. Journal of Immunology. 2010; 184(2):764-774 (2nd
and 3rd authors had equal contribution) (SCI; IF=5.646; Immunology 18/128) 20. Getnet D, Grosso JF, Goldberg MV, Harris TJ, Yen HR, Bruno TC, Durham NM,
Hipkiss EL, Pyle KJ, Wada S, Pan F, Pardoll DM, Drake CG*. A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells. Molecular Immunology. 2010; 47(7-8):1595-600. (SCI; IF=3.202; Immunology
21. Yen HR. Ph.D. Dissertation: Type 17 CD4 (TH17) and CD8 (Tc17) T cells: their
function and role in immunity. Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan. 2010 (長庚大學 臨床醫學研究所醫學博士論文) 22. Wu MS, Yen HR, Peng TY, Hsieh CF, Chen CJ, Lin TY, Horng JT. Mechanism
of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export. Journal of Ethnopharmacology 2011; 134(3):614-23
(SCI; IF=2.226; Integrative & Complementary Medicine 3/14 ) 23. Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV,
Pardoll DM, Pan F. Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1. Cell 2011; 146(5): 772-784.( SCI; IF=32.401; Biochemistry & Molecular Biology
* Symposia and Semina
1. Yen HR, Chen CC, Yen DC, Kong MS, Lai MW, Chang KW, Yen MH, Hsieh WS.
Urachal anomalies associated with gastrointestinal manifestation in children. The 168th Scientific Meeting of the Taiwan Pediatric Association. Taipei, Taiwan, Nov, 2. Yen HR, Chang ML, Jiang-Shieh YF, Wu CH, Wen CY, Chen CC, Yen DC, .
Clinical features and management of urachal anomalies in children. The 19th Joint Annual Conference of Biomedical Sciences. Mar, Taipei, Taiwan, 2004. (Poster 3. Yen HR, Chiu CH, Huang YC, Horng JT, Lin TY. The complete genome
sequence of enterovirus 71 isolated in Taiwan in 2004. The Scientific Meeting of the Taiwan Pediatric Association, Taipei, Taiwan, Nov, 2005. (Oral Presentation) 4. Huang TY, Lien R, Huang HR, Yang PH, Yen HR, Lin TY, Chang ML, Huang CC.
Neonatal enteroviral infection of northern Taiwan in 2005. The Scientific Meeting of the Taiwan Pediatric Association, Taipei, Taiwan, Nov, 2005. (Oral 5. Yen HR, Chang HH. From Experience-Based Toward Evidence-Based —
Application of evidence-based traditional Chinese medicine in Chang Gung Memorial Hospital, Taiwan. North American Conference on Systematic Reviews, Baltimore, U.S.A., Jul, 2006 (Poster Presentation) 6. Yen HR, Lin TY, Chen CL, Lo CS, Yang RC, Chang HH. Screening of Chinese
herbal formulas against H1N1 Influenza virus. Fifth Meeting of Consortium for Globalization of Chinese Medicine cum International Forum (Zhuhai) on Chinese Medicine, Zhuhai, Guangdong, China, September 20, 2006 (Poster Presentation) 7. Yen HR, Chang HH: In vitro antiviral activity against influenza H1N1 virus of
Chinese herbal formulas. 3rd HHRI Conference on Traditional Medicine Research – from Bench to Clinic. National Health Research Institutes, Miaoli, Taiwan, September 29, 2006 (Oral presentation) 8. Rabizadeh S, Wu S, Albesiano E, Wu X, Mirviss L, Rhee K, Huso D, Yen HR,
Harris TJ, Pardoll DM, Sears C. Stat3 is activated throughout the gastrointestinal tract in enterotoxigenic Bacteroides fragilis colitis. Digestive Disease Week 2008, San Diego, U.S.A., May, 2008. (Poster Presentation) 9. Radojcic V, Pletneva MA, Yen HR, Harris TJ, Pardoll DM, Drake CG, Luznik L.
STAT3 signaling in donor-derived CD4+ T-cells plays a critical role in the induction of acute and chronic GVHD in murine models of alloBMT. (published in Blood, Nov 2007; 110: 2179). The 49th American Society of Hematology Annual Meeting, Atlanta, U.S.A., December, 2007 (Poster Presentation) 10. Wada S, Yoshimura K, Hipkiss EL, Harris TJ, Yen HR, Goldberg MV, Grosso JF,
Getnet D, Netto G, Anders R, DeMarzo AM, Pardoll DM, Drake CG. Dendritic and T cell functions in patients with metastatic hormone-refractory prostate cancer treated with GVAX immunotherapy for prostate cancer and ipilimumab. The 2008 American Association for Cancer Research (AACR) Annual Meeting, San Diego, U.S.A., April, 2008(Poster Presentation) 11. Harris TJ, Wada W, Yen HR, Wong JW, Pardoll DM, Drake CG, DeWeese TL.
Adjuvant vaccine therapy in combination with radiation for treatment of prostate cancer: preclinical validation in a mouse model of prostate cancer. The 50th American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, Boston, U.S.A., September, 2008. (Oral presentation) 12. Grosso JF, Goldberg MV, Getnet D, Yen HR, Pardoll DM, Drake CG. Functional
distinct LAG-3 and PD-1 subsets on activated and tolerized CD8 T cells. Keystone Symposia on Molecular and Cellular Biology-Mobilizing Cellular Immunity for Cancer Therapy. Snowbird, Utah, U.S.A. January, 2009. (Poster Presentation) 13. Bruno TC, Kelleher CC, Grosso JF, Goldberg MV, Netto G, Yen HR, Wada S,
Getnet D, Hipkiss EL, Pardoll DM, Drake CG. Simultaneous accumulation of functionally impaired anti-tumor CD8 T cells and reduced tumor growth in a double transgenic system. Keystone Symposia on Molecular and Cellular Biology-Mobilizing Cellular Immunity for Cancer Therapy. Snowbird, Utah, U.S.A. January, 2009. (Poster Presentation) 14. Getnet D, Grosso JF, Goldberg MV, Harris TJ, Bruno TC, Yen HR, Wada S,
Pardoll DM, Drake CG. A novel role for Helios in induced regulatory T cells. Keystone Symposia on Molecular and Cellular Biology-Mobilizing Cellular Immunity for Cancer Therapy. Snowbird, Utah, U.S.A. January, 2009. (Poster 15. Wada S, Yoshimura K, Hipkiss EL, Harris TJ, Yen HR, Goldberg MV, Grosso JF,
Getnet D, Netto G, Anders R, DeMarzo AM, Pardoll DM, Drake CG. Cyclophosphamide augments anti-tumor immunity: studies in an autochthonous prostate cancer model. Keystone Symposia on Molecular and Cellular Biology-Mobilizing Cellular Immunity for Cancer Therapy. Snowbird, Utah, U.S.A. January, 2009. (Poster Presentation) 16. Yen HR, Solomon A, Abi-Habib R, Buckley JT, Drake CG, Denmeade SR.
PRX303 is an IL-2 proaerolysin fusion protein toxin that selectively targets and kills foxp3 regulatory T cells: potential role as a vaccine adjuvant. Keystone Symposia on on Molecular and Cellular Biology-Targeted Cancer Therapies. Whistler, British Columbia, Canada. March, 2009. (Poster Presentation) 17. Wu S, Rhee KJ, Rabizadeh S, Albesiano E, Yen HR, Wu X, Huso D, Housseau F,
Pardoll DM, Sears CL. Enterotoxigenic Bacteroides fragilis colonic infection promotes colon tumorigenesis in Apc+/min mice via activation of Th17 T cell responses. Digestive Disease Week 2009, Chicago, U.S.A., May, 2009. (Poster 18. Yen HR, Harris TJ, Wada S, Grosso JF, Getnet D, Goldberg MV, Bruno TC, Pyle
KJ, Lin TY, Pardoll DM, Huang CT, Drake CG. Tc17 CD8 T cells: functional plasticity, subset diversity and anti-tumor activity. The 2009 Scientific Retreat, Prostate Cancer Foundation, New York, U.S.A. Sep, 2009. (Poster Presentation) 19. Yen HR, Harris TJ, Radojcic V, Huang DD, Grosso JF, Getnet D, Wada S,
Goldberg MV, Bruno TC, Durham N, Khazaie K, Luznik L, Lin TY, Pardoll DM, Huang CT, DrakeCG. Adoptive transfer of Tc17 CD8 T cells leads to tumor inhibition and anti-tumor response. The 97th Annual Meeting of The American Association of Immunologists, Baltimore, Maryland, U.S.A. May, 2010. (Poster 20. Chen S, Zhang A, Yen HR, Lin A. OMM and TCM: comparisons of manipulative
treatment. American Osteopathic Association OMED 2010. The 115th Osteopathic Medical Conference & Exposition, San Francisco, California, U.S.A., October, 21. Yen HR. TCM treatment for asthma in children. Harmonizing the ancient wisdom
into a modern concept –sharing practical TCM experiences with experts from Taiwan. New Cavendish Campus, University of Westminster, London, U.K.,

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