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Curriculum Vitae
Chang-Hoon Woo, D.V.M., Ph.D.

Office Address:
Department of Pharmacology

Tel. 82-53-620-4355 (Office) 82-10-4368-4355 (Cell)
Fax. 82-53-656-7995
E-mail: changhoon_woo@yu.ac.kr
Home Address:
3200 Lenox Rd NE Apt E409
Atlanta, GA 30324
Tel. 404-983-1488 (Cell)
EDUCATION:

 Ph.D. Biomedical Science, Korea University, South Korea, 2005
 M.S. Microbiology & Immunology, Chonnam National University, South Korea, 2002
 D.V.M. Veterinary Medicine, Chonnam National University, South Korea, 1997

RESEARCH & PROFESSIONAL EXPERIENCE:


2010 – Present
Assistant Professor

2009 – 2010
Research Assistant Professor

2005 – 2008
Postdoctoral Research Associate

2005 – 2005
Postdoctoral Research Fellow
School of Life Science and Biotechnology Chang-Hoon Woo, D.V.M., Ph.D.

TEACHING EXPERIENCE:

2010 – Present
Instructor

GRANTS AND FELLOWSHIPS:

1. Korean Research Foundation Postdoctoral Fellowship (03/2005 – 08/2005)
P.I.: Chang-Hoon Woo
2. AHA/National Center Postdoctoral Fellowship (07/2006 – 06/2008)
P.I.: Chang-Hoon Woo
3. AHA/National Center Scientist Development Grant (01/2009 – 12/2009)
“ERK5-SUMOylation, CHIP and ICER”
P.I.: Chang-Hoon Woo
4. Korean National Research Foundation (NRF) (09/2010 – 08/2013)
“The role of ERK5 and NRF2 in atheroscleorosis”
P.I.: Chang-Hoon Woo
5. Korea Science and Engineering Foundation (KOSEF)/MRC (01/2011 – 12/2013)
“Hypertension in Aging”
P.I.: Chang-Hoon Woo
6. The Ministry of Health and Welfare (11/2011 – 10/2014)
“Activated protein C in cardiovascular disease”
P.I.: Chang-Hoon Woo

AWARDS AND HONORS:

1. Postdoctoral Fellow Travel Award, Experimental Biology, ASBMB, 2007
2. Postdoctoral Fellow Travel Award, Vasculata, NAVBO, 2007
3. New Investigator Travel Award, AHA-BCVS, AHA, 2008

RESEARCH PUBLICATIONS:

Chang-Hoon Woo, D.V.M., Ph.D.
1: Jang TH, Lee SJ, Woo CH, Lee KJ, Jeon JH, Lee DS, Choi K, Kim IG, Kim YW, Lee TJ,
Park HH. Inhibition of genotoxic stress induced apoptosis by novel TAT-fused peptides targeting
PIDDosome. Biochem Pharmacol. 2011 (in press)
2: Kim JE, Sung JY, Woo CH, Kang YJ, Lee KY, Kim HS, Kwun WH, Choi HC. Cilostazol
Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production
through Activation of AMP-activated Protein Kinase Induced by Heme Oxygenase-1. Korean J
Physiol Pharmacol. 2011 Aug;15(4):203-10.
3: Lim JH, Woo CH*, Li JD*. Critical role of type 1 plasminogen activator inhibitor (PAI-1) in
early host defense against nontypeable Haemophilus influenzae (NTHi) infection. Biochem
Biophys Res Commun. 2011 Oct 14;414(1):67-72 (*Corresponding author)
4: Sung JY, Woo CH, Kang YJ, Lee KY, Choi HC. AMPK induces vascular smooth musclecell
senescence via LKB1 dependent pathway. Biochem Biophys Res Commun. 2011 Sep
16;413(1):143-8.
5: Lee K, Kim H, Kim JM, Chung YH, Lee TY, Lim HS, Lim JH, Kim T, Bae JS, Woo CH,
Kim KJ, Jeong D. Nacre-driven water-soluble factors promote wound healing of the deep burn
porcine skin by recovering angiogenesis and fibroblast function. Mol Biol Rep. 2011 (in press)
6: Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King
MR, Berk BC, Fujiwara K, Woo CH*, Abe J*. PKCζ mediates disturbed flow-induced
endothelial apoptosis via p53 SUMOylation. J Cell Biol. 2011 May 30;193(5):867-84
(*Corresponding author)
7: Lim SK, Park MJ, Lim JC, Kim JC, Han HJ, Kim GY, Cravatt BF, Woo CH, Ma SJ, Yoon
KC, Park SH. Hyperglycemia induces apoptosis via CB(1) activation through the decrease of
FAAH 1 in retina pigment epithelial cells. J Cell Physiol. 2011 Mar 25. doi: 10.1002/jcp.22756.
8: Chang E, Heo KS, Woo CH, Lee H, Le NT, Thomas TN, Fujiwara K, Abe J. MK2
SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells
by inhibiting MK2 kinase and HSP27 phosphorylation. Blood. 2011 Feb 24;117(8):2527-37.
9: Lee SA, Kim EY, Jeon WK, Woo CH, Choe J, Han S, Kim BC. The inhibitory effect of
raloxifene on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells is mediated
through a ROS/p38 MAPK/CREB pathway to the up-regulation of heme oxygenase-1
independent of estrogen receptor. Biochimie. 2011 Feb;93(2):168-74.
10: Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C,
Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe J. Novel role of C terminus of
Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and
dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.
FASEB J. 2010 Dec;24(12):4917-28.
Chang-Hoon Woo, D.V.M., Ph.D.
11: Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS,
Fujiwara K, Berk BC. PKCzeta decreases eNOS protein stability via inhibitory phosphorylation
of ERK5. Blood. 2010 Sep 16;116(11):1971-9.
12: Woo CH, Abe J. SUMO--a post-translational modification with therapeutic potential? Curr
Opin Pharmacol. 2010 Apr;10(2):146-55.
13: Abe J, Woo CH. NADPH oxidase in vascular injury: a new insight about its regulation and
role in T cells. Circ Res. 2009 Jan 30;104(2):147-9.
14: Ishinaga H, Jono H, Lim JH, Komatsu K, Xu X, Lee J, Woo CH, Xu H, Feng XH, Chen LF,
Yan C, Li JD. Synergistic induction of nuclear factor-kappaB by transforming growth factor-beta
and tumour necrosis factor-alpha is mediated by protein kinase A-dependent RelA acetylation.
Biochem J. 2009 Jan 15;417(2):583-91.
15: Lim JH, Ha U, Sakai A, Woo CH, Kweon SM, Xu H, Li JD. Streptococcus pneumoniae
synergizes with nontypeable Haemophilus influenzae to induce inflammation via upregulating
TLR2. BMC Immunol. 2008 Jul 29;9:40.
16: Lim JH, Ha UH, Woo CH, Xu H, Li JD. CYLD is a crucial negative regulator of innate
immune response in Escherichia coli pneumonia. Cell Microbiol. 2008 Nov;10(11):2247-56.
17: Shishido T*, Woo CH*, Ding B*, McClain C, Molina CA, Yan C, Yang J, Abe J. Effects of
MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for
diabetic ventricular dysfunction after myocardial infarction. Circ Res. 2008 Jun 6;102(11):1416-
25 (*contributed equally)
18: Kim H, Hwang JS, Woo CH, Kim EY, Kim TH, Cho KJ, Kim JH, Seo JM, Lee SS. TNF-
alpha-induced up-regulation of intercellular adhesion molecule-1 is regulated by a Rac-ROS-
dependent cascade in human airway epithelial cells. Exp Mol Med. 2008 Apr 30;40(2):167-75.
19: Woo CH, Shishido T, McClain C, Lim JH, Li JD, Yang J, Yan C, Abe J. Extracellular
signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory
response and endothelial nitric oxide synthase expression in endothelial cells. Circ Res. 2008
Mar 14;102(5):538-45.
20: Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P, Xu H, Ha UH, Xu H, Li JD.
Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-
induced inflammation in the middle ear and lung of mice. PLoS One. 2007 Oct 10;2(10):e1032.
21: Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H,
Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE,
Davis RJ, Flavell RA, Li JD. Tumor suppressor CYLD regulates acute lung injury in lethal
Streptococcus pneumoniae infections. Immunity. 2007 Aug;27(2):349-60.
Chang-Hoon Woo, D.V.M., Ph.D.
22: Shin Y, Yoon SH, Choe EY, Cho SH, Woo CH, Rho JY, Kim JH. PMA-induced up-
regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial
cells. Exp Mol Med. 2007 Feb 28;39(1):97-105.
23: Yan C*, Ding B*, Shishido T*, Woo CH*, Itoh S, Jeon KI, Liu W, Xu H, McClain C,
Molina CA, Blaxall BC, Abe J. Activation of extracellular signal-regulated kinase 5 reduces
cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP
early repressor feedback loop. Circ Res. 2007 Mar 2;100(4):510-9 (*contributed equally)
24: Woo CH, Kim TH, Choi JA, Ryu HC, Lee JE, You HJ, Bae YS, Kim JH. Inhibition of
receptor internalization attenuates the TNFalpha-induced ROS generation in non-phagocytic
cells. Biochem Biophys Res Commun. 2006 Dec 29;351(4):972-8.
25: Woo CH, Massett MP, Shishido T, Itoh S, Ding B, McClain C, Che W, Vulapalli SR, Yan C,
Abe J. ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated
receptor delta (PPARdelta) stimulation. J Biol Chem. 2006 Oct 27;281(43):32164-74.
26: You HJ, Woo CH, Choi EY, Cho SH, Yoo YJ, Kim JH. Roles of Rac and p38 kinase in the
activation of cytosolic phospholipase A2 in response to PMA. Biochem J. 2005 Jun 1;388(Pt
2):527-35.
27: Woo CH, Lim JH, Kim JH. Lipopolysaccharide induces matrix metalloproteinase-9
expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway
in Raw 264.7 cells. J Immunol. 2004 Dec 1;173(11):6973-80.
28: Cho SH, Woo CH, Yoon SB, Kim JH. Protein kinase Cdelta functions downstream of Ca2+
mobilization in FcepsilonRI signaling to degranulation in mast cells. J Allergy Clin Immunol.
2004 Nov;114(5):1085-92.
29: Yoo MH, Song H, Woo CH, Kim H, Kim JH. Role of the BLT2, a leukotriene B4 receptor,
in Ras transformation. Oncogene. 2004 Dec 9;23(57):9259-68.
30: Woo CH, Lim JH, Kim JH. VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade
mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway
epithelium. Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L307-16.
31: Cho SH, You HJ, Woo CH, Yoo YJ, Kim JH. Rac and protein kinase C-delta regulate ERKs
and cytosolic phospholipase A2 in FcepsilonRI signaling to cysteinyl leukotriene synthesis in
mast cells. J Immunol. 2004 Jul 1;173(1):624-31.
32: Woo CH, Yoo MH, You HJ, Cho SH, Mun YC, Seong CM, Kim JH. Transepithelial
migration of neutrophils in response to leukotriene B4 is mediated by a reactive oxygen species-
extracellular signal-regulated kinase-linked cascade. J Immunol. 2003 Jun 15;170(12):6273-9.
Chang-Hoon Woo, D.V.M., Ph.D.
33: Lee SS*, Woo CH*, Chang JD, Kim JH. Roles of Rac and cytosolic phospholipase A2 in the
intracellular signalling in response to titanium particles. Cell Signal. 2003 Mar;15(3):339-45
(*contributed equally)
34: Woo CH, Jeong DT, Yoon SB, Kim KS, Chung IY, Saeki T, Kim JH. Eotaxin induces
migration of RBL-2H3 mast cells via a Rac-ERK-dependent pathway. Biochem Biophys Res
Commun. 2002 Nov 1;298(3):392-7.
35: Woo CH, Kim JH. Rac GTPase activity is essential for lipopolysaccharide signaling to
extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts. Mol
Cells. 2002 Jun 30;13(3):470-5.
36: Lee M, You HJ, Cho SH, Woo CH, Yoo MH, Joe EH, Kim JH. Implication of the small
GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6
astroglioma cells. Biochem J. 2002 Sep 15;366(Pt 3):937-43.
37: Park SH, Woo CH, Kim JH, Lee JH, Yang IS, Park KM, Han HJ. High glucose down-
regulates angiotensin II binding via the PKC-MAPK-cPLA2 signal cascade in renal proximal
tubule cells. Kidney Int. 2002 Mar;61(3):913-25.
38: Woo CH, You HJ, Cho SH, Eom YW, Chun JS, Yoo YJ, Kim JH. Leukotriene B(4)
stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis. J
Biol Chem. 2002 Mar 8;277(10):8572-8.
INTERNATIONAL ORAL PRESENTATION:

1: Woo CH, Kim JH. Transepithelial migration of neutrophils in response to leukotriene B4 is
mediated by a ROS-ERK-linked cascade. The 2nd Japan-Korea Conference on Cellular Signaling
for Young Scientist 2003. 7.14 – 17 at Kyushu University, Fukuoka, Japan.
2: Woo CH, Massett M, Shishido T, Itoh S, Ding B, McClain C, Che W, Yan C and Abe J.
Heme oxygenase-1 and a carbon monoxide releasing compound, [Ru(CO)3Cl2]2,-induced ERK5
activation inhibits inflammatory responses via peroxisome proliferators-activated receptor delta
stimulation in skeletal muscle. The AHA 2006 Scientific Sessions at Chicago, USA
3: Woo CH, Takahashi H, Shishido T, McClain C, Spangenberg T, Yan C, Blaxall BC, Patterson
C and Abe J. Novel role of E3 ubiquitin ligase, C terminus of Hsc70-interacting protein (CHIP),
on myocyte apoptosis via regulating ERK5-mediated inducible early repressor (ICER)
degradation. The AHA 2009 Scientific Sessions at Orlando, USA

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