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High t (boost testosterone naturally)

High G™ (Muscle Growth Booster)
Overview

HighG™ is a nutritional formulation that sustains muscle health and athletic stamina with
a supportive blend of nutrients. This nutritional combination includes Alphasize,
Arginine Alpha-Ketoglutarate, SustamineTM, L-Arginine, L-Citrulline, L-Glutamine, L-
Isoleucine, L-Leucine, and SerinAid®.
Description
Over 20 clinical studies support the ingredients in HighG™, which is designed to boost
the body’s output of muscle development. HighG™ is formulated to reduce muscle
soreness, increase athletic stamina and capacity, support neuromuscular function during
exercise, reduce fatigue, and reduce both physiological and psychological stress.
Ultimate Muscle: Building and sustaining muscle health requires many things - nutrition,
training, dedication, trusted outcome and the right mix of supplements. Now the High TTM
brand introduces HighG™ - a dynamically formulated, clinically supported product
designed to build muscle.
Research

Alpha-Glyceryl Phosphoryl Choline - Alphasize
As a precursor to acetylcholine, Alpha-Glyceryl Phosphoryl Choline (A-GPC) provides an
immediate release of choline into the bloodstream. Choline is a primary component of
phospholipids and necessary in acetylcholine synthesis, neuron communication, growth
hormone regulation, and exercise capacity.
Prolonged exercise can reduce choline in the body, in which athletes can experience a
choline deficiency. Furthermore as we age, growth hormone levels decline. A-GPC can
help restore choline levels and improve growth hormone secretion by increasing the
production of acetylcholine.
A-GPC was given to younger (32 average age) and older (80 average age) subjects to
understand the influence on growth hormone. The study found that growth hormone
production increased in both younger and older individuals, but had the most significant
effect on older subjects.Researchers gave A-GPC (600 mg) to male subjects
participating in a resistance training program for more than two years. The study was
conducted to determine the effects of A-GPC on growth hormone levels, explosive
performance, and post-exercise oxidation. A-GPC increased post-exercise growth
hormone levels, but had no effect on explosive performance.
Arginine Alpha-Ketoglutarate

Arginine Alpha-Ketoglutarate (AAKG) is a compound that is composed of L-arginine and
alpha-ketoglutarate. As a precursor to nitric oxide production, Arginine Alpha-
Ketoglutarate (AAKG) increases blood flow and transports nutrients to the skeletal
muscles to improve athletic performance. Nitric oxide improves exercise capacity by
relaxing vascular smooth muscles.
AAKG (4,000 mg), or a placebo, was given to 35 adult men that participated in
resistance training for eight weeks. Muscle endurance, anaerobic power, aerobic
capacity, and body composition were analyzed to determine AAKG’s effect on trained
male athletes. It was observed that AAKG increased some measures of strength
training, including maximum bench press repetition and power performance.
To understand the influence on endurance and performance, an AAKG combination
(with creatine, glutamine, taurine, branched-chain amino acids, and medium-chain
triglycerides) was compared to creatine-alone or a placebo. Muscle endurance, body
composition, and power capacity were measured in 35 men recruited for the study. The
AAKG combination significantly increased power capacity and muscle endurance,
creatine-alone increased muscle endurance, and the placebo had no effects.
L-Alanyl-L-Glutamine - SustamineTM
Sustamine™ is a combination of L-glutamine and L-alanine – two amino acids that help
stimulate muscle protein synthesis and restore glycogen. Combining these two amino
acids through an enzymatic process produces a smaller dipeptide that is quickly
absorbed in the body. Research has shown that Sustamine™ increases endurance and
exercise performance by improving time to exhaustion and fluid/electrolyte uptake. The
findings suggest Sustamine™ enhances fluid regulation during prolonged exercise, as
well as improves exercise recovery by reducing inflammatory and oxidative stress
responses associated with physical activity.
L-Alanyl-L-Glutamine (LALG) was compared to L-glutamine or a placebo in exercise-
trained rats. The nutrients were given immediately after and three hours after an
exercise session, in which a higher concentration of glutamine was observed in rats that
were given LALG when compared to L-arginine and the placebo. These improvements
were observed immediately following exercise. Furthermore, LALG or an L-glutamine/L-
alanine solution have both shown to raise glutathione levels in the muscle and liver.
Ten women basketball players were recruited to take LAG in an effort to understand the
effects on jump power, reaction time, shooting accuracy, and fatigue. There were four
different trials that were composed of a 40 minute basketball game. In the first trial,
subjects did not rehydrate. The second trial subjects consumed only water, while in the
last two trials participants consumed LAG with water (either 1 gram/500 ml or 2
grams/500 ml). It was observed that visual reaction time and skill performance were
significantly improved with LAG.

L-Arginine

L-arginine is a semi-essential amino acid that is involved in several physiological processes, including nitric oxide production, protein production, and synthesis of glucose, fatty acids, and amino acids.An inhibition of nitric oxide can cause excessive fat production in insulin-sensitive tissues. One study suggests L-arginine may reduce fat mass by restoring the circulation of nitric oxide. L-arginine has also been suggested to improve exercise training by altering insulin sensitivity and capillary growth in muscle metabolism. Furthermore, adding L-arginine to a resistance exercise training program can augment growth hormone levels. Researchers found that five to nine grams of L-arginine increased growth hormone levels by 200%, when combined with exercise training. L-Citrulline
L-citrulline is a non-essential amino acid that supports exercise recovery and
cardiovascular health. As a precursor to arginine, it helps to remove ammonia from the
body and increase nitric oxide production in the blood vessels. By increasing blood
flow in the body, nutrients and oxygen are transported more efficiently.
The muscles consume oxygen quickly during intense aerobic exercise. Furthermore, the
body uses ATP for continued energy. By using ATP, the muscles produce ammonia,
lactic acid, and inosine monophosphate.These chemicals lead to tired muscles. By
increasing nitric oxide production, L-citrulline helps to reduce ammonia from the body to
provide greater muscle recovery. L-citrulline was shown to improve nutritional status and
nitric oxide levels in aged rats to improve muscle protein metabolism.L-citrulline has
been shown to significantly increase swimming time to exhaustion in mice by reducing
ammonia and lactic acid levels.
Citrulline-malate (6 grams/day), or a placebo, was given to 18 men with fatigue to find
that supplementation reduced fatigue, increased ATP production during exercise, and
enhanced the rate of phosphocreatine recovery after exercise. Researchers concluded
that the nutrient promoted aerobic energy by modulating muscle metabolism.
Additionally, citrulline-malate, or a placebo, was given to 41 males during pectoral
strength training to find a significant decrease in muscle soreness occurred among those
taking the nutrient.
L-Glutamine
As the most abundant amino acid in the body, L-glutamine accounts for over sixty
percent of all free amino acids in the muscle tissue and plasma. It is found in higher
concentrations in the skeletal muscle, lungs, liver, brain, and GI tract. L-glutamine can
maintain muscle mass by inhibiting the breakdown of muscle tissue.
Glutamine levels in the body often decline when the body is under stress. This decline is
especially seen in the skeletal muscle affected by injury, prolonged stress, starvation, or
the use of glucocorticoids. Individuals with chronic immune infections often lose crucial
body mass. A three month study recruited 26 patients with significant weight loss to take
40 grams each day of L-glutamine, or a placebo. The study found that L-glutamine
increased body weight by 3.2%, while the placebo group only gained 0.4%.Preliminary
research suggests L-glutamine is effective in counteracting progressive muscle
weakness by reducing oxidized glutathione levels. L-glutamine’s antioxidant activity
protected the muscles from progressive weakness.
Blood ammonia concentrations increase with endurance exercise and cause greater
fatigue. L-glutamine has been shown to reduce these levels. Fifteen runners (running for
120 mins) took L-glutamine before training. Ammonia levels did not change in the first
hour of training, but they were significantly lower in the second hour of exercise to show
the nutrient lowered ammonia levels during prolonged, strenuous exercise.
L-Isoleucine
L-isoleucine is one of three branched chain amino acids (BCAA), which also include
leucine and valine. L-isoleucine helps to alleviate muscle soreness and regulate
energy. Additionally, BCAA supplementation has been shown to improve VO2 max, a
prime measure of endurance exercise capacity.It has also been observed that
combining BCAA with a high-protein diet can improve energy levels and memory
performance while participating in endurance sports.Researchers recruited 13 male
and female subjects to consume a BCAA beverage, or placebo, every 30 minutes during
cycle training in the heat. Researchers found that BCAA increased moderate exercise
performance in the heat.
Prolonged exercise training often reduces glutamine levels in the body, in which BCAA
supplementation can restore glutamine levels. Twelve elite male triathletes received a
BCAA supplement, or placebo, before and after a competition. Subjects taking BCAA
had higher glutamine concentrations and lower incidences of infection.
L-Leucine
L-leucine is a branched chain amino acid (BCAA) that is predominately found in skeletal
muscle. As a BCAA, it can help reduce muscle soreness after exercise training, as well
as support blood sugar levels and growth hormone production.
Untrained male athletes were given a BCAA beverage before, and 60 minutes into, a 90-
minute cycling routine. Researchers found that subjects consuming the BCAA beverage
had less muscle damage after prolonged endurance exercise. Twelve female subjects
took BCAA or dextrin before participating in squat exercise routine. It was shown that
women taking BCAA had a significantly lower rate of muscle damage when compared to
those taking dextrin. To understand BCAA’s role in exercise metabolism, researchers
inhibited the formation of BCAA in mice. By blocking BCAA metabolism, it was found
that exercise capacity and endurance were limited.
Phosphatidylserine (PS) - SerinAid®

Phosphatidylserine (PS) is a phospholipid derived from soy lecithin that helps membrane
function and the transmission of molecular messages between cells. Extensive, intense
physical activity can challenge normal cellular function and affect overall athletic
performance. The body needs to be replenished with nutrients to keep functioning
optimally. PS supplementation can help regulate cortisol levels, improve well-being, and
reduce muscle soreness after exercise.
High intensity cyclists took PS (750 mg/day) for ten days to improve exercise capacity.PS has also been supplemented to reduce elevated cortisol levels and decrease muscle
soreness.PS (750 mg/day) was given to 14 active males for ten days to determine the
effects on exercise capacity. Researchers found subjects taking PS had improvements
in exercise time to exhaustion and exercise capacity.
Researchers have also reviewed the influence of PS supplementation on cortisol,
lactate, and growth hormone levels before, during, and after moderate exercise. Healthy
male subjects took PS (600 mg/day) or a placebo for ten days while participating in a
moderate cycling workout. Cortisol levels were reduced among subjects taking PS to
lower exercise-induced stress on the body. PS supplementation had no effect on lactate
or growth hormone levels.


Additional Information – Dosage, Precautions, Interactions
Suggested Use
Take one (1) serving (4) capsules daily. Workout days: Take two (2) servings - (8)
capsules 90 minutes prior to resistance exercise. (Do not exceed 8 capsules daily).

Dosage
Alpha-Glyceryl Phosphoryl Choline - Alphasize
- Up to 1,200 mg per day
Arginine Alpha-Ketoglutarate –
Up to 20 grams per day
L-Alanyl-L-Glutamine - SustamineTM -
Up to 21 grams per day
L-Arginine -
Up to 15 grams per day
L-Citrulline - Up to 15 grams per day

L-Glutamine - Up to 21 grams per day
L-Isoleucine –
Up to 680 mg per day
L-Leucine –
Up to 1,000 mg per day

Phosphatidylserine (PS) - SerinAid® -
200 mg to 500 mg per day (elemental PS)
Precautions
The maximum safe dosage of this supplement has not been determined for children,
pregnant or nursing women, or those with severe liver or kidney disease. As with all
supplement regimens, please consult your physician prior to use.
Alpha-Glyceryl Phosphoryl Choline - Alphasize - Extremely high doses of choline
(more than 3,000 mg per day) may cause nausea, diarrhea, a fishy body odor, or
excessive sweating.
Arginine Alpha-Ketoglutarate -
There are no known adverse reactions with proper
supplementation.
L-Alanyl-L-Glutamine -
Individuals with Reye’s syndrome, severe kidney or liver
damage, or other illnesses that cause ammonia to build up in the blood should not take
L-Glutamine.

L-Arginine -
The most common adverse reactions occur at higher doses (15 to 30 g per
day), which include nausea, diarrhea, and abdominal cramps. Pregnant and nursing
mothers should avoid L-Arginine supplementation as it may stimulate growth hormone.
L-Citrulline - In doses higher than 15 grams, L-citrulline may cause gastrointestinal
upset, including diarrhea.

L-Glutamine -
Individuals with Reye’s syndrome, severe kidney or liver damage, or
other illnesses that cause ammonia to build up in the blood should not take L-Glutamine.
L-Isoleucine -
There are no known adverse reactions with proper supplementation.
L-Leucine –
There are no known adverse reactions with proper supplementation.

Phosphatidylserine (PS) - SerinAid® -
There are no known adverse reactions with
proper supplementation.

Drug Interactions
If you are taking the following medications, consult your physician before taking High G.
Alpha-Glyceryl Phosphoryl Choline - Alphasize - Methotrexate
Arginine Alpha-Ketoglutarate -
There are no known interactions with proper
supplementation.
L-Alanyl-L-Glutamine -
Human Growth Hormone, Indomethacin, Methotrexate,
Paclitaxel

L-Arginine -
Diuretics (Aldactone, Midamor, Dyazide, etc.); Estrogen (Premarin,
Estrace, etc.); Ibuprofen; Sildenafil Citrate; Cyclosporine; Organic Nitrates
L-Citrulline - Diuretics (Aldactone, Midamor, Dyazide, etc.); Estrogen (Premarin,
Estrace, etc.); Ibuprofen; Sildenafil Citrate; Cyclosporine; Organic Nitrates
L-Glutamine -
Human Growth Hormone, Indomethacin, Methotrexate, Paclitaxel
L-Isoleucine - Levodopa; Anti-Diabetes Drugs (Amaryl, Glucotrol, Actos, etc.)
L-Leucine –
Levodopa; Anti-Diabetes Drugs (Amaryl, Glucotrol, Actos, etc.)

Phosphatidylserine (PS) - SerinAid® -
There are no known interactions with proper
supplementation.
* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
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Nutrition. 2006 Sep; 22(9):872-881. 6 Campbell B, Baer J, Roberts M, et al. Effects of arginine alpha-ketoglutarate supplementation on body composition and training adaptations. Sports Nutr Rev J 2004:1:S10. 7 Little JP, Forbes SC, Candlow DG, Cornish SM, Chilibeck PD. Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance. Int J Sport Nutr Exerc Metab. 2008 Oct; 18(5):493-508. 8 Hoffman JR, Ratamess NA, Kanh J, Rashti SL, et al. Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise. J Int Soc Sports Nutr. 2010; 7:8. 9 Rogero MM, Tirapegui J, Pedrosa RG, Castro IA, Pires IS. Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exercise. Nutrition. 2006 May; 22(5):564-571. 10 Cruzat VF, Tirapegui J. Effects of oral supplementation with glutamine and alanyl-glutamine on glutamine, glutamate, and glutathione status in trained rats and subjected to long-duration exercise. Nutrition. 2009 Apr; 25(4):428-435. 11 Hoffman JR, Williams DR, Emerson NS, Hoffman MW, et al. L-alanyl-L-glutamine ingestion maintains performance during a competitive basketball game. J Int Soc Sports Nutr. 2012 Mar;9(1):4. 12 L-Arginine. Monograph. Alter Med Rev. 2005;10(2):139-147. 13 Johgen, WS, Fried, SK, Fu, WJ, et al. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. J Nutr Biochem. 2006 Sep; 17(9):571-588. 14 McConnel, GK. Effects of L-Arginine supplementation on exercise metabolism. Curr Opin Clin Nutr Metab Care. 2007 Jan; 10(1):46-51. 15 Kanaley JA. Growth hormone, Arginine and exercise. Curr Opin Clin Nutr Metab Care. 2008 Jan; 11(1):50-54. 16 Collier SR, Collins E, Kanaley JA. Oral arginine attenuates the growth hormone response to resistance exercise. J Appl Physiol. 2006 Sep; 101(3):848-852. 17 Kanaley, JA. Growth hormone, arginine and exercise. Curr Opin Clin Nutr Metab Care. 2008 Jan; 11(1):50-54. 18 Flam BR, Eichler DC, Solomonson LP. Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle. Nitric Oxide. 2007 Nov;17(3-4):115-121. 19 Borsheim E, Bahr R. Effect of exercise intensity, duration and mode on post-exercise oxygen consumption. Sports Med. 2003;33(14):1037-1060. 20 Osowska S, Duchemann T, Walrand S, Paillard A, et al. Citrulline modulates muscle protein metabolism in old malnourished rats. AJP – Endo. 2006;291(3):E582-E586. 21 Takeda K, Machida M, Kohara A, Omi N, Takemasa T. Effects of citrulline supplementation on fatigue and exercise performance in mice. J Nutr Sci Vitaminol. 2011;57(3):246-250. 22 Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, et al. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. 2002 Aug;26(4):282-289. 23 Perez-Guisado J, Jakerman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010 May;24(5):1215-1222. 24 Walsh NP, Blannin AK, Robson PJ, Gleeson M. Glutamine, exercise and immune function. Links and possible mechanisms. Sports Med. 1998 Sep; 26(3):177-191. 25 L-Glutamine. Monograph. Alt Med Rev. 2001;6(4):406-410. 26 Shabert, JK, Winslow, C, et al. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition. 1999; 15(11-12): 860-864. 27 Mok, E, Constantin, B, et al. L-Glutamine administration reduces oxidized glutathione and MAP kinase signaling in dystrophic muscle of mdx mice. Pediatr Res. 2008 Mar; 63(3):268-273. 28 Carvalho-Peixoto J, Alves RC, Cameron LC. Glutamine and carbohydrate supplements reduce ammonemia increase during endurance field exercise. Appl Physiol Nutr Metab. 2007 Dec; 32(6):1186-1190. 29 Jackman SR, Witard OC, Jeukendrup AE, Tipton KD. Branched-chain amino acid ingestion can ameliorate soreness from eccentric exercise. Med Sci Sports Exerc. 2010 May; 42(5):962-970. 30 Matsumoto K, Koba T, Hamada K, Tsujimoto H, Mitsuzono R. Branched-chain amino acid supplementation increases the lactate threshold during an incremental exercise test in trained individuals. J Nutr Sci Vitaminol. 2009 Feb; 55(1):52-58. 31 Portier H, Chatard JC, Filaire E, Jaunet-Devienne MF, et al. Effects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing race. Eur J Appl Physiol. 2008 Nov; 104(4): 787-794. 32 Mittleman KD, Ricci MR, Bailey SP. Branched-chain amino acids prolong exercise during heat stress in men and women. Med Sci Sports Exerc. 1998 Jan; 30(1):83-91. 33 Bassit RA, Sawada LA, Bacurau RF, et al. The effect of BCAA supplementation upon the immune response of triathletes. Med Sci Sports Exerc. 2000; 32:1214-1219. 34 Greer BK, Woodard JL, White JP, Arguello EM, Haymes EM. Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise. Int J Sport Nutr Exerc Metab. 2007 Dec; 17(6):595-607. 35 Shimomura Y, Inaguma A, Watanabe S, Yamamoto Y, et al. Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness. Int J Sport Nutr Exerc Metab. 2010 Jun; 20(3):236-244. 36 She P, Zhou Y, Zhang Z, Griffin K, Gowda K, Lynch CJ. Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance. J Appl Physiol. 2010 Apr; 108(4):941-949. 37 Jager R, Purpura M, Kingsley M. Phospholipids and sports performance. J Int Soc Sports Nutr. 2007 Jul; 4:5. 38 Kingsley M. Effects of phosphatidylserine supplementation on exercising humans. 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Drug safety 25 a/w

3 2 n d E D I T I O N Carbapenems: Interaction with sodium valproate Doripenem monohydrate (marketed as Doribax), 4.4 Special warnings and precautions for use a synthetic antibiotic, is a new chemical entity The concomitant use of doripenem and valproic that belongs to the carbapenem class of beta-lac- acid/sodium valproate is not recommended (see section tams. Doripenem is administer

Doi:10.1016/s1473-3099(11)70035-4

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