Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

20130116-program-nhf-vintermöte-2013

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Program'for'the'Scientific'meeting'of'the'Norwegian'Hypertension'Society'
Place:!Auditoriom!Rødt!(Lab5Bygget)!OUS!Ullevål!sykehus!Date:!8/2!–!2013! '
09:00'–'09:05'Opening:'Ingrid'Toft'–'NHF'president'
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09:05'–'10:20'Session'1'–'Free'communications'
Chair:!Ingrid!Toft!
09:05!–!09:20! Fadl'Elmula'M.'Fadl'Elmula:!Effect!of!Renal!Sympathetic!
Denervation!(RDN)!on!treatment!resistant!hypertension!and!cardiovascular!hemodynamic!in!comparison!to!intensive!medical!therapy!utilizing!Impedance!Cardiography.! 09:20!–!09:35! Sverre'E.'Kjeldsen:!European!Network!on!COordinating!
Research!on!renal!Denervation!(ENCORED).! 09:35!–!09:50! Eivind'Berge:!Effects!of!candesartan!on!blood!pressure!
variability!in!acute!stroke:!Is!it!important!for!prognosis?!Results!from!the!Scandinavian!Candesartan!Acute!Stroke!Trial.! 09:50!–!10:05! Trude'Skogstrand:!Identification!of!an!SPP15connected!common!
genetic!pathway!in!hypertensive!renal!damage:!Meta5analysis!of!gene!expression!microarrays.! 10:05!–!10:20! Michael'Hultström:!Genomics!of!cardiorenal!syndrome!in!mice:!
SNPs!and!gene!expression!in!heart!and!kidney.! '
10:20'–'10:35'Coffee–break'
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10:35'–'11:55'Session'2'–'Free'communications'
Chair:!Tonje!Aksnes!
10:35!–!10:55! Åshild'E.'Rieck:!Impact!of!hypertension!on!cardiac!function!and!
10:55!–!11:10! Helga'Midtbø:!Does!Rheumatoid!Arthritis!Predispose!to!
11:10!–!11:25! Ingeborg'Eskerud:!Coronary!artery!plaque!burden!is!a!predictor!
of!severe!myocardial!ischemia!in!non5ST!elevation!myocardial!infarction.! 11:25!–!11:40! Mai'Tone'Lønnebakken:!Vascular!structure!and!function!in!
11:40!–!11:55! Anne'Cecilie'Larstorp:!The!Beauty!Study!5!hypothesis,!conduct!
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12:00'–'12:50'Lunch'
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13:00'–'14:40'Session'3'–'Invited'speakers'
Chair:!Sverre!Kjeldsen!
13:00!–!13:45! Ingar'Holme:!Utvikling!av!prognostiske!modeller!i!biomedisin;!
13:45!–!14:30! Knut'Liestøl:!Over–adjustment!bias!i!klinisk!epidemiologi.!
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14:40'–'15:00'Coffee–break'
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15:00'–'16:45''Session'4'–'Free'communications'
Chair:!Eva!Gerdts!
15:00!–!15:15! Dag'Olav'Dahle:!Hyperuricemia!in!renal!transplant!recipients!is!
associated!with!graft!loss!and!all5cause!mortality.! 15:15!–!15:30! Svetlana'Zykova:!Dietary!factors!and!serum!uric!acid!levels!in!
Caucasian!subjects!with!or!without!abdominal!obesity.!Cross5sectional!analyses!from!two!population5based!surveys:!The!Australian!Diabetes,!Obesity!and!Lifestyle!Study!and!The!Tromsø!study! 15:30!–!15:45! Hilde'Merete'Storhaug:!Uric!Acid!and!Development!of!
Hypertension!and!Decline!in!GFR!in!the!general!population!during!12!years!of!follow!up.!The!Tromsø!Study.! 15:45!–!16:00! Sigrid'Nordang'Skårn:!Impact!of!INsulin!Sensitivity!on!
Cardiovascular!Risk!Markers!During!10520!Years!of!FOllow5up!“INFO”! 16:00!–!16:15! Per'Torger'Skretteberg:!Seven5Year!Increase!in!Exercise!
Systolic!Blood!Pressure!at!Moderate!Workload!Predicts!Long5Term!Risk!of!Coronary!Heart!Disease!and!Mortality!in!Healthy!Middle5Aged!Men! 16:15!–!16:30! Kristian'Engeseth:!High!Heart!Rate!Reserve!Predicts!Reduced!
Risk!of!Death!from!Cardiovascular!Disease!in!Healthy!Men!with!Low!but!Not!with!High!Physical!Fitness! 16:30!–!16:45! Irene'Grundvold:!Low!Heart!Rates!Predict!Incident!Atrial!
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16:45'–'17:00'General'discussion'and'closing'of'the'meeting.'
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17:10'–'17:45'Annual'meeting'of'the'Norwegian'Hypertension'Society'
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18:00'–'19:30'Dinner!

Source: http://hypertensjonsforeningen.no/Program-vintermote-2013.pdf

Specific clinical issues:

Specific Clinical Risk Factors: GI Problems in People with Developmental Disabilities Specific Clinical Risk Factors: GI Problems in People with Developmental Disabilities Dysphagia, esophageal disorders & GE reflux OPENING COMMENTS: Don’t confuse “usual” with “normal” Don’t ignore the signs that a problem exists (“I told ya and I told ya”) It’s important to

galton.uchicago.edu

Meta-Analysis (or Overview) Clinical Scenario • Mrs BW 64 y.o. • Hysterectomy • Dx of osteoporosis (Spinal BMD < 2SD below Dx of osteoporosis (Spinal BMD < 2SD below • ? aminobisphosphonate (etidronate, ? aminobisphosphonate (etidronate, alendronate) • Pt concern: cost Osteoporosis • Affects 30-40% of postmenopausal women • 1.5M fracture

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