Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

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Computed Tomography Inpatient Preparation
1. Clear fluid only for 4hrs before scan (Diabetics – 2hrs). Fluids are encouraged, patient will need to drink oral 2. IP with IV contrast. Need working IV or saline lock or 3. Recent Creatinine/GFR if risk factors for contrast 4. Consent for IV contrast must accompany requisition if 1. Clear fluids encouraged if having IV contrast 2. IP with IV contrast. Need working IV or saline lock or 3. Recent Creatinine/GFR if risk factors for contrast 4. Consent for IV contrast must accompany requisition if 1. No solid food or drink for 4hrs before scan time 2. No caffeine either by coffee, tea or soda pop for 12hrs 4. No smoking for 12hrs before scan time 5. No erectile dysfunction (ED) medication for 24hrs 6. Recent Creatinine/GFR within 2 months documented 7. PT needs working IV (18-20G Nexiva or 20-22G 8. Consent for IV contrast must accompany requisition if 9. Beta Blockers may be prescribed to be taken before the scan to slow heart. Times will be as ordered. 10. Nitroglycerine Beta Blockers may be used during the Computed Tomography Inpatient Preparation
2. PT needs working IV in anticubital vein right arm (18- 20G Nexiva or 20-22G Diffusics) or power PICC 3. Recent Creatinine/GFR if risk factors for contrast 4. Consent for IV contrast must accompany requisition if 1. Clear fluids encouraged if having contrast 2. IP with IV contrast, need working IV or saline lock (18- 20G Nexiva or 20-22G Diffusics) or power PICC 3. Recent Creatinine/GFR if risk factors for contrast 4. Consent for IV contrast must accompany requisition if 1. NPO after midnight. May take meds with sips 2. Signed radiology consent. Family or POA must be available by telephone or present if unable to give 4. Recent CBC, PT, PTT, INR (INR ≤ 1.5, PTT ≤ 40) 5. Off anticoagulants including PLAVIX and ASA x 5 days 7. Send checklist, nursing flowsheet and MAR 1. Clear fluids encouraged if having IV contrast 2. IP with IV contrast, working IV or saline lock 3. Recent Creatinine/GFR if risk factors for contrast 4. Consent for IV contrast must accompany requisition if 1. Clear fluids encouraged if having IV contrast 2. IP with IV contrast, working IV or saline lock 3. Recent Creatinine if risk factors for contrast induced 4. Consent for IV contrast must accompany requisition if Computed Tomography Inpatient Preparation
1. NPO after midnight—may take meds with sips 7. Pre-Procedure checklist, MAR, nursing flow sheet 1. IP with contrast, need working IV or saline lock or 2. Consent for IV contrast must accompany requisition if 4. Recent Creatinine/GFR if risk factors for contrast 3. Working IV or saline lock or power PICC 4. Recent Creatinine/GFR if risk factors for contrast 5. Consent for IV contrast must accompany requisition if 2. Working IV or saline lock or power PICC 3. Recent Creatinine/GFR if risk factors for contrast 4. Consent for IV contrast must accompany requisition if Computed Tomography Inpatient Preparation
1. Clear fluids only for 4hrs before scan 3. Working IV or saline lock or power PICC 4. Consent for IV contrast must accompany requisition if 6. Recent Creatinine/GFR if risk factors for contrast 2. Recent Creatinine within 2 months documented 3. Working IV or saline ock (#18-20G Nexiva or 20-22G 4. Consent for IV contrast must accompany requisition if

Source: http://www.kgh.on.ca/en/specialtiesandservices/Imaging%20Services/Documents/Computed%20Tomography%20Inpatient%20Prep%20sheets.pdf