Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
Affirmation
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fluconazol medicamento genérico - lei nº 9.787, de 1.999 SISTEMA FECHADO Formas farmacêuticas e apresentações: Solução para infusão intravenosa: Embalagem contendo 01 bolsa plástica com 100 mL (2 mg/mL). USO ADULTO E PEDIÁTRICO Solução para infusão intravenosa: USO INTRAVENOSO. Composição: Cada mL de Fluconazol genérico infusão intravenosa contém 2 mg de flu
MANAGEMENT OF THALASSAEMIA-INDUCED OSTEOPOROSIS Ersi Voskaridou, MD, PhD; Evangelos Terpos, MD, PhD Thalassaemia Centre, Laikon General Hospital, Athens, Greece N.B. This is an extract from the presentation given by Dr Voskaridou at our conference on 14.6.05. A complete version, including a full list of references is available on request from the UKTS office. Prevention and general principle