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Drug-Related Changes of Condition:
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Antiarrhythmics
Anticonvulsants
Antidepressants – Selective Serotonin Reuptake Inhibitors
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Antidepressants – Tricyclics
Antidepressants – Miscellaneous
Antidiabetics
Antihistamines
Antihypertensives – Angiotensin-Converting Enzyme Inhibitors
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Antihypertensives – Angiotensin-Converting Enzyme Inhibitors (continued)
Antihypertensives – Angiotensin Receptor Blockers
Antihypertensives – ß-Blockers
Antihypertensives – Calcium Channel Blockers
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Antihypertensives – Diuretics
Antihypertensives – Miscellaneous
Anti-Infectives
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Anti-Infectives (continued)
Antiparkinsonians
Antipsychotics – Atypicals
Antipsychotics – Typicals
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Anxiolytics
Corticosteroids
Dementia Medications
Gastrointestinal – H2-Receptor Antagonists
Gastrointestinal – Proton Pump Inhibitors
Hormonal Agents
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Hormonal Agents (continued)
Lipid-Lowering Agents
Migraine Medications
5-9% <1% <1% <1% ≤2% 3-9% Hyperkinesia <1% Muscle Relaxants
Nitrates/Anti-Anginals
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Nitrates/Anti-Anginals (continued)
Osteoporosis Medications
Pain Medications
2-16% 2% 0.1-2% 0.1-2% <0.1% 0.1-2% <0.1% 0.1-2% 0.1-2% Respiratory Medications
Sedatives/Hypnotics
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Sedatives/Hypnotics (continued)
Urinary Incontinence Medications
Miscellaneous Medications
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Copyright 2012, Omnicare, Inc.
Drug-Related Changes of Condition: Falls
Medications Associated with Falls*
Abnormal Accidental
Coordination Trauma/
Extremity Nerve
Tendon Vascular
Medication
Dizziness Edema Discomfort Changes Syncope Changes Changes Vertigo Weakness
Miscellaneous
Miscellaneous Medications (continued)
N/S = Adverse effect was reported but the rate of occurrence was not specified.
*The above table is not all-inclusive of agents that have been associated with falls.
Similar to the article by R. Smith, some of the 12
Vascular changes include thrombophlebitis, venous broad categories are further defined as follows:
thrombus and thromboembolic events. This category should be viewed as a sign of a more serious event than • Abnormal coordination/gait identifies adverse effects that interfere with the ability to keep one’s center of gravity The weakness category includes both weakness and within the pelvic area during normal ambulation.
• Dizziness is a sensation of unsteadiness accompanied by a References:
feeling of movement within the head.
Package Inserts obtained at various commercial Web sites and from Drugs@FDA. Available at: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/. Accessed • Edema is an abnormal excess accumulation of serous fluid in connective tissue that, when occuring in the lower extremi- Clinical Pharmacology Online. Available at: http://www.clinicalpharmacology.
ties, may cause a patient to choose inappropriate footwear.
com. Accessed 7/17/09.
Lexi-Comp Online. Available at: http://online.lexi.com/crlsql/servlet/crlonline. • Lower-extremity discomfort is localized physical suffering, such as pain, cramps and claudication.
French, D.; Campbell, R.; Spehar, A.; et al. Drugs and falls in community-dwelling older people: a national veterans study. Clin. Ther. 28:619-30; 2006.
• Nerve changes include both neuropathy and paresthesia.
French, D.; Campbell, R.; Spehar, A.; et al. Outpatient medications and hip fractures in the U.S. — a national veterans study. Drugs Aging 22:877-85; 2005.
Syncope is defined as loss of consciousness resulting Neutel, C.I.; Perry, S.; Maxwell, C. Medication use and risk of falls. from insufficient blood flow to the brain. This category Pharmacoepidemiol. Drug Saf. 11:97-104; 2002.
Smith, R. Fall-contributing adverse effects of the most frequently prescribed includes fainting and orthostatic or postural hypotension.
drugs. J. Am. Podiatr. Med. Assoc. 93:42-50; 2003.
Ziere, G.; Dieleman, J.P.; Hofman, A.; et al. Polypharmacy and falls in the middle • Tendon changes include tendinitis, tenosynovitis, synovitis age and elderly population. Br. J. Clin. Pharmacol. 61:218-23; 2005.
Copyright 2012, Omnicare, Inc.

Source: http://www.lynchburg.edu/sites/default/files/documents/centers/Beard/stephen-anderson-falls.pdf

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