It's likely that you or a loved one is taking a medication thatwill be mentioned in our pages over the next 12 months.
And it's definite
that you'll want to
know about it.
new breakthrough or a more effective or affordable treatment).
Now file the issue away. Keep each issue. You'll get an index for the whole
• In the past three years alone, over 400 medications were
year so you can quickly find a reference to any drug you are prescribed later on.
mentioned in Worst Pills, Best Pills News. Many of them were
among the most prescribed in their categories.
It is not our intent for you to discontinue using any drug based on our publica-
• Over the last five years, there were numerous drugs we
tion without first consulting your physician. But you will get the data you need to
warned our readers not to use.months and sometimes
have an informed conversation with your doctor to determine the best course of
years before they were finally withdrawn from the market!
Think of It This Way –
• We want to make sure you know about it when one of your
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Imagine – being treated for a toenail fungus and dying of liver failure!
Now – here's why this is important to you.
There are hundreds of medica-
tions on the market that are extremely dangerous either by themselves, or when
taken in combination with other drugs. There are many others that have not been
tested long enough or thoroughly enough. And there are hundreds more that are
Editor, Worst Pills, Best Pills News
simply a waste of money because they have little or no effect.
P.S. If you're a senior citizen, be sure to use the SENIOR BONUS label to get
That is why Public Citizen's Health Research Group, which I founded with
Ralph Nader over 30 years ago, publishes a newsletter called Worst Pills, Best PillsNews
.to help you do what the FDA doesn't always do – protect yourself from
My name is Dr. Sidney M. Wolfe. I'm a physician. I'm an author. I've testified
before Congress on the very issue I'm speaking to you about now.
And I'm outraged about thousands of people who are needlessly harmed each
What Our Readers Know. And What You SHOULD Know.
year by the very medications that are supposed to be helping them. You should be
In past issues of Worst Pills, Best Pills News
, our readers discovered.
More Importantly, You Should Make Sure
• That so called "super-aspirins" like CELEBREX and VIOXX are much
You Don't Become a Victim.
more expensive, no more effective, no safer on the GI tract and possibly
less safe on the heart than ibuprofen.
That's why I'm offering you the chance to get a full year of Worst Pills, Best
at half price and with no risk whatsoever. I'll come back to that in a
• That despite its FDA approval, the antipsychotic drug GEODON is
moment. First, though, a frankly alarming piece of information.
more dangerous and less effective than previously-available medica-
There Are Drugs on the Market Right Now –
Drugs That YOU May Be Taking – That You Should Simply Not Use.
• That among ACE inhibitors (used to treat high blood pressure), generic
In Worst Pills, Best Pills News
, we don't pull punches, and we don't hedge our
bets. We tell you exactly what drugs you should stay clear of and why. In fact, we
• The 90 oral prescription drugs with "Black Box Warnings" for special
problems, especially those that can lead to death or serious injury.and
often come right out and say, flatly, "DO NOT USE" certain medications. As I
mentioned earlier, our DO NOT USE warnings often come many months, and some-
you have no way of knowing about them unless you specifically ask
times years before drugs are withdrawn from the market. For instance:
your pharmacist (or unless you read Worst Pills, Best Pills News
It Can Happen In So Many Ways.
• LOTRONEX (alosetron). We warned readers in August 2000. It was
Of course, doctors are supposed to know about dangerous drug interactions.
• PROPULSID (cisapride). We warned readers in August, 1998. It was
And they usually do. But there are just so many interactions. And what if you get
one medication from Doctor A and another from Doctor B? That's what happened
often with an allergy drug called Seldane, which caused life-threatening abnormal
• REZULIN (troglitazone). We warned readers in January, 1998. It was
heart rhythm when taken in combination with erythromycin. (Seldane is now off
• BAYCOL (cerivastatin). We warned readers in March 1998. It was
We've also seen cases where one doctor was prescribing a medication
withdrawn in August of 2001 – over 3 years later!
to treat symptoms that were being caused by another medication prescribed by
Think of how many people were affected by taking these drugs after our warn-
Same thing with pharmacies. One pharmacy may catch a dangerous interac-
tion, but if you use more than one pharmacy, it could be a problem.especially since
there are so many dangerous drug combinations, like insulin and Inderal; Prozac and
It’s still going on. Consider something that’s been in the news recently—
Desyrel; Tagamet and Dilantin; Demerol and Nardil; and Calan Sr. and Quinidine or
Ephedra. In February 2000—over three years ago—we warned readers about thedangers of Ephedra. In September, 2001, we petitioned the FDA to ban it. And peo-
ple (like Baltimore Orioles pitcher Steve Bechler) are still dying from its use.
And then there are the medications that are just plain dangerous. And if
And in February, 2001 – over two years ago – we reported what has since
you're thinking, "Well, that's what the FDA is for – to make sure drugs are safe," just
become accepted fact: the value of postmenopausal hormone replacement
remember the drugs I mentioned earlier that were withdrawn from the market after
therapy is not only greatly exaggerated, but it can actually increase the risk of a
they had been used by patients.and after they had caused irreparable harm and
In recent issues, we issued DO NOT USE warnings for MERIDIA, AVANDIA,
Bottom Line – Look Out For Yourself.
LOZOL, MACROBID, and SPECTROCEF. We issued important warnings about
Worst Pills, Best Pills News Makes It Easy.
RELENZA, DIABINESE, BEXTRA, VIOXX, CELEBREX, and ST. JOHN’S
WORT. We reported on the dangerous effects of ZYBAN, and PLAVIX.
Here's how it works. Each issue of Worst Pills, Best Pills News
has an index
right on the front page. Scan it to see if any medication you take is on it. Then look
How long will it be before these drugs are withdrawn? How many people will
through the issue and see if any condition you have is discussed (you may discover a
they injure before they are? And will you or a loved one be one of them?
(more important drug information on next page)
America has a drug problem, but it's not the one you think.
We are one of the biggest drug-consuming countries in the world -- of
prescription drugs, over-the-counter drugs, legal drugs.
The druggies in our culture are not necessarily the 17-year-olds you
imagine. They're our parents, our grandparents, us!
That's the shocking truth I learned from Dr. Sidney Wolfe, Director of
Public Citizen's Health Research Group and Editor of WORST PILLS, BESTPILLS NEWS.
Every time Dr. Wolfe appeared on my TV show, the audience
response was phenomenal. Viewers wanted to know how to protect their loved ones -- and themselves -- from the dangers of adverse drugreactions.
That's why Dr. Wolfe started this newsletter, filled with the latest life-
saving information drawn from hundreds of published medical referencesand sources.
In WORST PILLS, BEST PILLS NEWS, you'll learn which popular drugs
not to use, adverse effects of new drugs, and the combinations of medi-cines you should never, never take!
You don't know when you or a loved one will be affected by this
Believe me, this is a non-profit group with nothing to gain but your
well-being. Why not try a risk-free subscription now. You'll thank me for it.
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Positive Feedback And Self-Esteem Introduction According to self-enhancement theory individuals are influenced to maintain their self-esteem in an optimistic way (Ryckman, 2004). Rogers (1959) explained that an individual’s self-concept may be viewed in both the experience of self and the ideal self . Self-discrepancy theory implies that individuals become distressed when our ‘a
Countercurrent chromatography: a worthy technique for the direct measurement of liquid-liquid partition coefficients 1 Area de Quimica Analitica, CCEE, ESTCE, Universitat Jaume I, 12080, Castello, Spain 2 Laboratoire des Sciences Analytiques, CNRS, Université de Lyon 1, Bat CPE-308, 69622 Abstract chromatography are: (i) a high loading capability, (ii) a very simple solute retention