Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Bop antibiotic profile 2012

2012 ANTIBIOTIC SUSCEPTIBILITY PROFILES

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Number of Isolates
PENICILLIN
FLUCLOXACILLIN
AMOXYCILLIN
AMOX / CLAV
CEFACLOR
COTRIMOXAZOLE
ERYTHROMYCIN
CLINDAMYCIN
TETRACYCLINE
GENTAMICIN
CIPROFLOXACIN
NITROFURANTOIN
TRIMETHOPRIM
The p ercentage of organisms susceptible to an antibiotic is recorded (with the sample size in the first row of the table). (e.g. Staphylococcus aureus vs. flucloxacillin 90% susceptible, n=3874) S = Not specifically tested, but known to be ordinarily susceptible. R = Organism resistant or antibiotic inappropriate V = Variable susceptibility. a. S. aureus susceptible to flucloxacillin can be considered susceptible to amoxycillin-clavulanate and cefaclor. Methicillin resistant Staphylococcus aureus (i.e. MRSA) are resistant to all beta-lactam antibiotics (penicillins, cephalosporins, carbapenems). b. Clindamycin susceptibility is extrapolated from the erythromycin result. c. S. pneumoniae susceptible to penicillin can be considered susceptible to amoxycillin, amoxycillin-clavulanate, cefaclor, cefuroxime, cefotaxime, ceftriaxone, cefpodoxime, imipenem and meropenem. Confirmation of penicillin resistance (reduced susceptibility) in S. pneumoniae requires MIC testing. (Please note this figure includes both penicillin susceptible and intermediately susceptible isolates). S.pneumoniae isolates intermediately susceptible to penicillin are resistant to cefaclor. In 2012 our S. pneumoniae isolates demonstrated the following pattern of susceptibility to penicillin: 81% = Susceptible, 9% = Intermediate, 10% = Resistant. However, of the resistant strains only a few had a penicillin MIC > 4mg/L, and penicillins (amoxycillin) are effective against strains with MIC <= 4mg/L, unless they are causing meningitis. d. Amoxycillin and amoxycillin-clavulanate susceptibility is extrapolated from the penicillin result. e. Erythromycin is not recommended for treatment of infections thought to be due to H. influenzae. f. S. saprophyticus causing urinary tract infections will usually respond to amoxycillin-clavulanate and cephalosporins. (Up to 50% of isolates are resistant to amoxycillin). g. Cotrimoxazole susceptibility is extrapolated from the trimethoprim result. h. Derived from nalidixic acid result. MOST LIKELY BACTERIAL PATHOGENS IN COMMON CONDITIONS 1. RESPIRATORY INFECTIONS
2. URINARY TRACT INFECTION
Pharyngitis - Streptococcus pyogenes (Gp A 3. IMPETIGO / CELLULITIS
Acute exacerbation of Chronic Bronchitis Haemophilus influenzae Moraxella catarrhalis

Source: http://www.pathlab.co.nz/PicsHotel/PathLab/Brochure/BOP%20Antibiotic%20profile%202012.pdf