Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
Pediatric intake form
PEDIATRIC INTAKE FORM
Last name:________________________ First name and initial: ___________________ Parent(s)/Guardian(s): ____________________________________________________ Address: ___________________________________ City: __________________ Province: _________________ Postal Code: ____-____ Telephone: (___) ___-____ Date of birth: yyyy/mm/dd
Height: _________________________ Weight: ____________________ Emergency contact: ________________________ Relationship: __________________ Emergency contact phone: (___) ___-____ Name of present MD: _________________________________Phone (___) ____-_____ Address of present MD: __________________________________________________ Chief complaints: ______________________________________________________________________ ______________________________________________________________________ ______________________________________________________________________ ______________________________________________________________________ Date of onset: yyyy/mm/dd Onset was: sudden / gradual / associated with an event: _________________________ Maternal Health and Birth History: Term: premature / full / late
Location: hospital birthing centre home
Delivery: vaginal / C-section / breech / forceps APGAR at birth: _____ APGAR at 5 minutes: _____ Birth weight: _____
Problems patient had at birth: breathing
other:_______________________________________________
Was the infant alert and responsive within 12 hours of delivery?
cord around neck respiratory depression
other: ________________________________________________________________ Item(s) applied to patient at birth: medication
other: ________________________________________________________________
Maternal condition: # pregnancies: _____
maternal age at patient’s birth: _____
paternal age at conception: _______ Maternal complications: hypertension
other: ________________________________________________________________ Maternal health during pregnancy: STDs (herpes/chlamydia/syphilis/trichomonas)
Exercise habits during pregnancy: __________________________________________ Stresses during pregnancy (physical/emotional): _______________________________ ______________________________________________________________________ Cravings during pregnancy: ________________________________________________ Maternal medications during pregnancy: Prescription: ____________________________________________________________ Over the counter: ________________________________________________________ Nutritional supplements: __________________________________________________ Childhood Medical Health of Patient: Past Childhood Illnesses: asthma
thrush (fungal infection in the mouth from a Candida infection)
Vaccination: hepatitis B
varivax (chicken pox vaccine) Any reactions to the vaccines, and if so, what kind? _____________________________ ______________________________________________________________________ Growth and development: At what age did the patient: respond to sound _______________________ follow on object ___________________ hold head up __________________________ vocalize _________________________ sit alone ______________________________ teethe __________________________ crawl _________________________________ walk ___________________________
Do sleeping patterns seem normal to you? Y / N Explain: _______________________________________________________________ Feeding History: Was baby breast fed? Y / N
Introduction of cow’s milk at age ______
Type of solid foods introduced ______________________________________________ Age and type of commercial baby food introduced ______________________________ Any intolerances? Y / N
explain: ________________________________________
Any cravings? __________________________________________________________ Is the child a picky eater? Y / N
explain: __________________________________
Childhood Drug History: Any antibiotics? Y / N
total number of courses of antibiotics: ________________
Other medications? Y / N 1-Medication: ______________
for: _____________________________________
Length of time on drug:___________________________________________________ Reactions to drug? ______________________________________________________ 2-Medication: ______________
for: _____________________________________
Length of time on drug:___________________________________________________ Reactions to drug? ______________________________________________________ Supplements: _________________________________________________________ Past hospitalizations: ____________________________________________________ _____________________________________________________________________ Past surgeries: _________________________________________________________ _____________________________________________________________________ Family Medical History: Please indicate by noting M (mother), F (father), S (sibling), PGM (paternal grandmother), MGM (maternal grandmother), PGF (paternal grand father), MGF (maternal grandfather) Allergy, asthma or eczema _________
Other: _________________________________________________________ Social influences and behaviours: Who lives at home? _____________________________________________________ Any pets? Y / N
If yes, what? _________________ How long? _____________
If yes, who? ______________________________
Any behavioural problems? Y / N Onset: ___________________________________ Any night terrors, sleep walking, difficulty sleeping? Y / N Explain: _______________________________________________________________ Age of child when began daycare: __________________________________________ Average number of hours of television/computer/video games per week: ____________ Any difficulty with social interaction? Y / N explain: ___________________________ Extra-curricular activites / hobbies: __________________________________________
Exercise habits: _________________________________________________________ Do the parent(s) / guardian(s) work? Y / N Who? _____________________________ How many hours a week? _____ Number of hours spent with child per week _____ How old is the home? _________
How is it heated? __________________________
Any recent home renovations? _____________________________________________ How long have you been in the present home? ________________________________ Is it located near: trees
other: _________________________________________________
General Review of Systems: Does your child have any rashes, lumps, sores, itching, dry skin, change in hair or nails? Y / N If yes: ___________________________________________________________________________ Has your child ever been unconscious, had a convulsion, have recurring headaches or had a head injury? Y / N If yes: ___________________________________________________________________________ Any problems with hearing, ringing in the ears, dizziness, ear infections, discharge? Y / N If yes: ___________________________________________________________________________ Any problems with teeth, gums, tongue, sore throats or hoarseness? Y / N If yes: ___________________________________________________________________________ Any problem with their eyes, including vision? Y / N If yes: ___________________________________________________________________________ Has your child ever been cyanotic (turned blue), have a cough, wheeze, or asthma? Y / N If yes: ___________________________________________________________________________ Any recurring problem with vomiting, diarrhea, constipation or stomach pain? Y / N If yes: ___________________________________________________________________________ Any unusual problem on passing urine or any unusual frequency? Any unusual smell or appearance to the urine? Y / N If yes: ___________________________________________________________________________ Does your child complain of any extremity or lower back pain? Y / N Do you notice a limp, or unusual gait pattern? Y / N If yes: ___________________________________________________________________________ Has your child ever had blackouts, seizures, weakness, paralysis, numbness or loss of sensation, tremors, or other involuntary movements? Y / N If yes: ___________________________________________________________________________ Does your child have any thyroid trouble, excessive thirst or hunger, heat or cold intolerance, or diabetes? Y / N If yes: ___________________________________________________________________________ Any allergies, eczema, hay fever, hives or drug reactions? Y / N If yes: ___________________________________________________________________________ Does you child have any intense fears, mood swings, or other sensitivities? Y / N If yes: ___________________________________________________________________________ OTHER HEALTH CONCERNS & ADDITIONAL INFORMATION: ______________________________________________________________________ ______________________________________________________________________ ______________________________________________________________________ ______________________________________________________________________ ______________________________________________________________________
Companion diagnostics and personalized medicine: A review of molecular diagnostic applications Mathew W. Moore1, Deepti Babu2, and Philip D. Cotter1,* ResearchDx, Irvine, California, USA. 2Department of Medical Genetics, University of Alberta, ABSTRACT well established [1, 2]. The advantages of approaching medicine in this way are theoretically Personalized medici
Bundì e buin Carnevâl a duç oms, feminas e frus. Un an a l’è già pasât e come che i vi vevi prometût i soi tornât. Cun dut il cûr i vi àuguri un bon doimilesièt, ma cul gnûf governo no sin partis cul pit drèt. In veretât i stenti a crodi che a capo dal governo al seti inchiamò Romano Prodi. A lu àn sopranomenât mortadèla, ma mi par che al samei plui a una sanganèla: al meri