Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
Pest-control-north.co.uk
SAFETY DATA SHEET Permethrin 25% WP Revision Revision date 1. IDENTIFICATION OF THE SUBSTANCE / PREPARATION AND THE COMPANY Product name Permethrin 25% WP Hockley International Ltd Hockley House 354 Park Lane Poynton Stockport SK12 1RL Telephone 01625 878590 01625 877285 2. COMPOSITION / INFORMATION ON INGREDIENTS Hazardous ingredients Symbols/Risk phrases Permethrin (ISO) 52645-53-1 258-067-9 Xn; R20/22 R43 N; R50/53 Suspending Agent 200 7631-86-9 Xi; R36/37/38 Calcium Silicate 1344-95-2 (Calcium silicate respirable) Kaolin China Clay 1332-58-7 (Kaolin, respirable dust) 3. HAZARDS IDENTIFICATION Main hazards Harmful by inhalation and if swallowed. May cause sensitisation by skin contact. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 4. FIRST AID MEASURES Skin contact Wash off immediately with plenty of soap and water. Remove contaminated clothing. May cause irritation to skin. Seek medical attention if irritation or symptoms persist. Eye contact Rinse immediately with plenty of water for 15 minutes holding the eyelids open. Contact lenses should be removed. May cause irritation to eyes. Seek medical attention. Inhalation Move the exposed person to fresh air. If breathing stops, provide artificial respiration. Seek medical attention. Ingestion Immediate medical attention is required. DO NOT INDUCE VOMITING. Drink 1 to 2 glasses of water. Never give anything by mouth to an unconscious person. General information In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Print date 5-Nov-2007 Permethrin 25% WP Revision Revision date 5. FIRE FIGHTING MEASURES Extinguishing media Carbon dioxide (CO2) Dry chemical. Foam. Water spray. Do NOT use . Water jet. Fire hazards Do not release chemically contaminated water into drains, soil or surface water. Take care to retain water used for extinguishing and dispose of according to local regulations. Burning produces compounds of carbon, oxygen and chlorine. Protective equipment Wear: Self-contained breathing apparatus. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Ensure adequate ventilation of the working area. Wear suitable protective equipment. Environmental precautions Do not let product contaminate subsoil. Do not allow product to enter drains. Do not flush into surface water. Prevent further spillage if safe. Clean up methods Avoid raising dust. Sweep up. Transfer to a closable, labelled salvage container for disposal by an appropriate method. 7. HANDLING AND STORAGE Handling Avoid contact with eyes and skin. Do not breathe gas/fumes/vapour/spray. Do not empty into drains. Ensure adequate ventilation of the working area. Wear suitable protective equipment. Do not eat, drink or smoke in areas where this product is used or stored. Keep in a cool, dry, well ventilated area. Keep containers tightly closed. Store at temperatures below 30 °C. Keep away from food, drink and animal feedingstuffs. Keep out of the reach of children. 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Exposure limits Calcium Silicate WEL 8-hr limit ppm: - WEL 8-hr limit mg/m3: 4 (Calcium silicate respirable) WEL 15 min limit ppm: - WEL 15 min limit mg/m3: - Calcium Silicate WEL 8-hr limit ppm: - WEL 8-hr limit mg/m3: 10 (Calcium silicate total inhalable dust) WEL 15 min limit ppm: - WEL 15 min limit mg/m3: - Kaolin China Clay WEL 8-hr limit ppm: - WEL 8-hr limit mg/m3: 2 (Kaolin, respirable dust) WEL 15 min limit ppm: - WEL 15 min limit mg/m3: - Engineering measures Ensure adequate ventilation of the working area. Respiratory protection Suitable half mask respirator with filter P3 (EN 143) Hand protection Chemical resistant gloves (PVC) Eye protection Face shield. Approved safety goggles. Protective equipment Chemical resistant clothing. Rubber boots. Print date 5-Nov-2007 Permethrin 25% WP Revision Revision date 9. PHYSICAL AND CHEMICAL PROPERTIES Description Characteristic. Flash point Flammability limits Not Flammable Explosive Oxidising Relative density 0.60 +/- 0.05 @ 20°C Autoignition temperature > 450°C 10. STABILITY AND REACTIVITY Stability Stable under normal conditions. Decomposition will start at 100°C. Conditions to avoid Direct sunlight. Materials to avoid Strong oxidising agents. Hazardous decomposition Burning produces compounds of carbon, oxygen and chlorine. products 11. TOXICOLOGICAL INFORMATION Toxicological information Permethrin 25% WP Oral Mouse LD50 = 2,160 mg/kg Dermal Rat LD50 = > 10,000 mg/kg Oral Rat LD50 = 1,750 mg/kg Dermal Rabbit LD50 = > 8,000 mg/kg Inhalation Rat LC50/ 4 h = > 25.0 mg/l Permethrin (ISO) Oral Mouse LD50 = 2,160 mg/kg Dermal Rat LD50 = > 10,000 mg/kg Oral Rat LD50 = 1,750 mg/kg Dermal Rabbit LD50 = > 8,000 mg/kg Inhalation Rat LC50/ 4 h = > 25.0 mg/l Suspending Agent 200 Oral Mouse LD50 = 2,160 mg/kg Dermal Rat LD50 = > 10,000 mg/kg Oral Rat LD50 = 1,750 mg/kg Dermal Rabbit LD50 = > 8,000 mg/kg Inhalation Rat LC50/ 4 h = > 25.0 mg/l Corrosivity May cause irritation to eyes. May cause irritation to skin. Sensitization May cause sensitisation by skin contact. Repeated or prolonged Prolonged or repeated exposure may cause irritation to skin and mucous membranes. exposure May cause allergic reactions in susceptible people. Mutagenic effects Carcinogenic effects Reproductive toxicity Print date 5-Nov-2007 Permethrin 25% WP Revision Revision date 12. ECOLOGICAL INFORMATION Ecotoxicity Permethrin 25% WP Daphnia LC50/48h = 2.40 ug/l Rainbow trout LC50/96h = 10.0 ug/l Bluegill sunfish LC50/96h = 7.20 ug/l Quail LC50/8 days = > 10,000 mg/kg Permethrin (ISO) Daphnia LC50/48h = 2.40 ug/l Rainbow trout LC50/96h = 10.0 ug/l Bluegill sunfish LC50/96h = 7.20 ug/l Quail LC50/8 days = > 10,000 mg/kg Suspending Agent 200 Daphnia LC50/48h = 2.40 ug/l Rainbow trout LC50/96h = 10.0 ug/l Bluegill sunfish LC50/96h = 7.20 ug/l Quail LC50/8 days = > 10,000 mg/kg Mobility Mobile in most soils. Degradability Water endangering. 13. DISPOSAL CONSIDERATIONS General information Do not empty into drains. NB: The user's attention is drawn to the possible existence of regional or national regulations regarding disposal. Disposal methods Can be incinerated if in compliance with local and national regulations. Can be sent to landfill if in compliance with local and national regulations. Disposal of packaging Empty containers can be sent to landfill after cleaning, if in compliance with local and national regulations. 14. TRANSPORT INFORMATION Packing group III Hazard ID 90 Proper Shipping ENVIRONMENTALLY Name HAZARDOUS SUBSTANCE, SOLID, N.O.S, (contains Permethrin). Packing group III Marine pollutant YES EmS Code F-A S-F Packing group III Subsidiary risk - Packing Instruction 911 Maximum quantity 400 kg Packing Instruction 911 Maximum quantity 400 kg (Passenger) Print date 5-Nov-2007 Permethrin 25% WP Revision Revision date 15. REGULATORY INFORMATION Xn - Harmful; N - Dangerous for the environment Risk phrases R36/38 - Irritating to eyes and skin. R20/22 - Harmful by inhalation and if swallowed. R43 - May cause sensitisation by skin contact. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Safety phrases S23 - Do not breathe gas/fumes/vapour/spray. S24 - Avoid contact with skin. S29 - Do not empty into drains. S37 - Wear suitable gloves. S42 - During fumigation/spraying wear suitable respiratory equipment. S51 - Use only in well-ventilated areas. 16. OTHER INFORMATION Text of risk phrases in R20/22 - Harmful by inhalation and if swallowed. Section 2 R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitisation by skin contact. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Print date 5-Nov-2007
A Washington Toxics Coalition Fact Sheet Getting Ahead of Lice by Shamra Harrison E ach year in the United States, as many as 6 million children will be treated for pediculosis, or head lice. Many parents, sometimes on the advice of theirchild’s school or even their pediatrician, turn to pesticidal products as asolution. Before using a pesticidal shampoo as a first-line treatment,
Anne-Marie Lizin Bericht über Guantánamo1 Einführung Auf ihrer Rotterdamer Jahrestagung im Juli 2003 hob die Parlamentarische Versammlung der OSZE (OSZE PV) besonders hervor, dass die Bekämpfung von Terrorismus mit demokratischen Werten und der Achtung der Men-schenrechte in Einklang zu bringen sei. In ihrer dort verabschiedeten „Ent-schließung über die von den Vereinigten Staaten am
SAFETY DATA SHEET
Permethrin 25% WP