Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Microsoft word - emla disclaimer.docx

Emla Disclaimer
Emla cream contains two medicines called Lidocaine and Prilocaine. These belong to medicines called
local anaesthetics. Emla cream works by numbing the surface of the skin for a short time. It is put on the
skin before certain procedures which can feel uncomfortable; this helps to stop or relieves the pain on
the skin. You cannot have Emla cream allied id you are allergic or hypersensitive to Lidocaine or
procaine or any of the ingredients listed below.
Emla cannot be used on babies aged 0-12 months who are being treated with medicines called
‘sulphonamides’ such as sulfamethoxazole
• Are you anaemic
• Do you have any blood condition where you have reduced red blood cells
• A rare blood disease called glucose 6 phosphate dehdrogenase deficiency
• Blood pigment level changes called ‘ methamoglobinaemia
• Atrophic dermatitis(this condition means the skin does not need as much time to anesthetise )
Have you used medicines called?
• Sulphonamides
• Sulfamthoxazole
• Other local anaesthetics
• Medicines to treat uneven heart beats such as mexiletine or amiodarone
If you are pregnant or breast feeding you must consult your doctor before having Emla cream applied, as
the cream can pass into the breast milk. Emla can have side effects, these include:
• Rash
• Feeling short of breath
• Low blood pressure, which may make you feel faint or dizzy
• Swelling on the face, lips tongue or other parts of the body
• Bluish gray skin in children, which is a very rare effect – due to lack of oxygen – if this happens
the cream must be removed and seek your doctors advise
• Pale skin where the cream has been used
• Mild itching or burning
• Small red dots where the cream is applied
Emla cream 5% contains the following:
• Active substances Lidocaine and Prilocaine, each gram contains 25mg Lidocaine and 25mg
Prilocaine
• Polyoxyethylene hydrogenated castor oil
• Carbomer 974P
• Sodium Hydroxide
Purified water sign to state I have read and fully understood all of the above. I state I have no
known allergies or any of the listed above health problems or using any of the above
medications, or any such medications of the same type. I understand that I may have a reaction
and that I am not holding Profiles responsible, as they have taken all precautions for my safety,
any creams administered are at my own risk.
Signed_____________________________________________________________________
Date ______________________________________________________________________
Name (block) ________________________________________________________________
Address ____________________________________________________________________
Tel Numbers ________________________________________________________________
Therapist comments and signatures

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Source: http://www.profilesbeauty.com/disclaimers/Emla%20Disclaimer/Emla%20Disclaimer.pdf