June 2005

CURRICULUM VITAE
HENRY C. LAI, Ph.D.
Education
B.Sc. (Hon.) (Physiology, 1971), McGill University, Montreal, Quebec, Canada Ph.D. (Psychology, 1977), University of Washington, Seattle, WA, USA
Faculty Positions
Research Associate, Department of Pharmacology, University of Washington, 1980-
Research Assistant Professor, Department of Pharmacology, University of Washington, Adjunct Research Assistant Professor, Center for Bioengineering, University of Research Associate Professor, Department of Pharmacology, University of Washington, Adjunct Research Associate Professor, Center for Bioengineering, University of Research Associate Professor, Center for Bioengineering, University of Washington, Research Professor, Department of Bioengineering, University of Washington, 1997-
Honors
Honorary Professor, Tropical Medicine Institute, Guangzhou University of Traditional
Bibliography

Publications in Refereed Journals
1.
Sweeney, G.D., Janigan, D., Mayman, D. and Lai, H. The experimental porphyrias: a group of distinctive metabolic leisons. In: "The Proceedings of International Conference on Porphyrin Metabolism and Porphyria". South African Journal of Laboratory and Clinical Medicine, South African Medical Journal, Sept. Sweeney, G.D., Freeman, F.B., Rothwell, D. and Lai, H. Decreases in hepatic cytochrome P-450 and catalase following allylisopropylacetamide: the effect of concomitant hemin administration. Biochem. Biophys. Res. Comm. 47:1366-1374, 1972. Horita, A., Carino, M.A. and Lai, H. Influence of catecholamine antagonists and depletors on the CNS effects of TRH in rabbit. Prog. Neuro-Psychopharmacol. 1:107-112, 1977. Lai, H., Quock, R.M., Makous, W.L., Horita, A. and Jen, L.S. Effects of methylazoxymethanol acetate on brain biogenic amines and behavior of the rat. Pharmacol. Biochem. Behav. 8:251-257, 1978. Lai, H., Makous, W.L., Quock, R.M. and Horita, A. Visual deprivation affects serotonin levels in the visual system. J. Neurochem. 30:1187-1189, 1978. Lai, H., Makous, W.L., Horita, A. and Leung, H. Effects of ethanol on turnover and function of striatal dopamine. Psychopharmacology 61:1-9, 1979. Lai, H., Carino, M.A., Sperry, R. and Horita, A. Effects of thioridazine on apomorphine elicited stereotypic behavior and motor activity. Pharmacol. Biochem. Behav. 13:397-401, 1980. Lai, H., Carino, M.A. and Horita, A. Effects of ethanol on central dopamine functions. Life Sci. 29:299-304, 1980. Lai, H., Carino, M.A., Sperry, R. and Horita, A. Effects of microinjection of 2-chloro-11-(2-dimethylaminoethoxy)-dibenzo[b,f] thiepine (zotepine), thioridazine, and haloperidol into the striatum and nucleus accumbens on stereotypic behavior and motor activity. J. Pharm. Pharmacol. 33:252-254, 1981. Lai, H., Carino, M.A. and Horita, A. Chronic treatments with zotepine, thioridazine, and haloperidol affect apomorphine-elicited stereotypic behavior and striatal 3H-spiroperidol binding sites in the rat. Psychopharmacology 75:388-390, 1981. Lai, H., Kazi, M.S., Carino, M.A. and Horita, A. Chronic haloperidol treatment potentiates apomorphine- and ethanol-induced hypothermia in the rat. Life Sci. 30:821-826, 1982. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. Psychoactive drug response is affected by acute low-level microwave irradiation. Bioelectromagnetics 4:204-214, 1983. Yamawaki, S., Lai, H. and Horita, A. Effects of apomorphine on body temperature: involvement of dopamine and serotonin mechanisms. J. Pharmacol. Exp. Ther. 227:383-388, 1983. Lai, H. and Horita, A. Apomorphine-induced hypothermia affected by acute treatment with apomorphine, haloperidol, and ethanol. Psychopharmacology 82:335-337, 1984. Yamawaki, S., Lai, H. and Horita, A. Ethanol induced hypothermia: effects of dopaminergic and serotonergic drugs. Life Sci. 34:467-474, 1984. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. Acute low-level microwave irradiation and the actions of pentobarbital: effects of exposure orientation. Bioelectromagnetics 5:203-212, 1984. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. Low-level microwave irradiation affects ethanol-induced hypothermia and ethanol consumption. Bioelectromagnetics 5:213-220, 1984. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. Microwave-induced postexposure hyperthermia: involvement of endogenous opioids and serotonin. IEEE Tran. Microwave Theory Tech. MTT-32:882-887, 1984. Pae, Y.S., Lai, H. and Horita, A. Effects of acute treatments with apomorphine, haloperidol, and ethanol on apomorphine-induced changes in body temperature. Neuropharmacol. 23:1109-1112, 1984. Pae, Y.S., Lai, H. and Horita, A. Hyperthermia in the rat from handling stress blocked by naltrexone injected into the preoptic anterior hypothalamus. Pharmacol. Biochem. Behav. 22:337-339, 1985. Chou, C.K., Guy, A.W., McDougall, J. and Lai, H. Specific absorption rate in rats exposed to 2450-MHz microwaves under seven exposure conditions. Bioelectromagnetics 6:73-88, 1985. Fatherazi, S., Lai, H., Kazi, M.S. and Horita, A. Intraseptal morphine potentiates pentobarbital narcosis and hypothermia in the rat. Pharmacol. Biochem. Behav. 23:505-507, 1985. Zucker, J.R., Lai, H. and Horita, A. Intraseptal microinjections of substance P and analogues potentiate pentobarbital-induced narcosis and depression of hippocampal cholinergic activity. J. Pharmacol. Exp. Ther. 235:398-407, 1985. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. Low-level microwave irradiation attenuates naloxone-induced withdrawal syndrome in morphine-dependent rats. Pharmacol. Biochem. Behav. 24:151-153, 1986. Liles, W.C., Taylor, S., Finnell, R., Lai, H. and Nathanson, N.M. Decreased muscarinic acetylcholine receptor number in the central nervous system of the tottering (tg/tg) mouse. J. Neurochem. 46:977-982, 1986. Lai, H., Zabawska, J. and Horita, A. Sodium-dependent high-affinity choline uptake in hippocampus and frontal cortex of the rat affected by acute restraint stress. Brain Research 372:366-369, 1986. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. Effects of low-level microwave irradiation on amphetamine hyperthermia are blocked by naloxone and classically conditionable. Psychopharmacology 88:354-361, 1986. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. A review of microwave irradiation and actions of psychoactive drugs. IEEE Engin. Med. Biol. 6(1):31-36, 1987. Lai, H., Bowden, D.M. and Horita, A. Age-related decreases in dopamine receptors in the caudate nucleus and putamen of the rhesus monkey (Macaca mulatta). Neurobiol. Aging 8:45-49, 1987. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. Low-level microwave irradiation affects central cholinergic activity in the rat. J. Neurochem. 48:40-45, 1987. Lai, H., Horita, A., Chou, C.K. and Guy, A.W. Effects of low-level microwave irradiation on hippocampal and frontal cortical choline uptake are classically conditionable. Pharmacol. Biochem. Behav. 27:635-639, 1987. Zabawska, J., Lai, H. and Horita, A. Neural mechanisms mediating the hyperthermia elicited by prostaglandin E2 injected into the preoptic-anterior hypothalamus. Europ. J. Pharmacol. 142:9-16, 1987. Lai, H. Acute exposure to noise affects sodium-dependent high-affinity choline uptake in the central nervous system of the rat. Pharmacol. Biochem. Behav. 28:147-151, 1987. Zucker, J.R., Calkins, D., Zabawska, J., Lai, H. and Horita, A. Effects of intraseptal drug administration on pentobarbita1-induced narcosis and hippocampal choline uptake. Pharmacol. Biochem. Behav. 28:433-436, 1987. Lai, H. Effects of repeated exposure to white noise on central cholinergic activity in the rat. Brain Research 442:403-406, 1988. Lai, H., Horita, A. and Guy, A.W. Acute low-level microwave exposure and central cholinergic activity: studies on irradiation parameters. Bioelectromagnetics 9:355-362, 1988. Lai, H., Carino, M.A., Horita, A. and Guy, A.W. Acute low-level microwave exposure and central cholinergic activity: a dose-response study. Horita, A., Carino, M.A., Zabawska, J. and Lai, H. TRH analog, MK-771, reverses neurochemical and learning deficits in medial septal lesioned rats. Peptides 10:121-124, 1989. Lai, H., Carino, M.A., Horita, A. and Guy, A.W. Low-level microwave irradiation and central cholinergic systems. Pharmacol. Biochem. Behav. 33:131-138, 1989. Lai, H., Carino, M.A. and Wen, Y.F. Repeated noise exposure affects muscarinic cholinergic receptors in the rat brain. Brain Research 488:361-364, 1989. Clarren, S.K., Astley, S.J., Bowden, D.M., Lai, H., Milam, A.N., Rudeen, K. and Shoemaker, W. Neuroanatomic and neurochemical abnormalities in nonhuman primate infants exposed to weekly doses of ethanol during gestation. Alcoholism: Clinical & Expt. Res. 14:674-683, 1990. Lai, H. and Carino, M.A. Acute white noise exposure affects the concentration of benzodiazepine receptors in the brain of the rat. Pharmacol. Biochem. Behav. 36:985-987, 1990. Lai, H. and Carino, M.A. Effects of noise on high-affinity choline uptake in the frontal cortex and hippocampus of the rat are blocked by intracerebroventricular injection of a corticotropin-releasing factor antagonist. Brain Res. 527:354-358, 1990. Lai, H., Carino, M.A., Horita, A. and Guy, A.W. Corticotropin-releasing factor antagonist blocks microwave-induced changes in central cholinergic activity in the rat. Brain Res. Bull. 25:609-612, 1990. Lai, H., Carino, M.A., Wen, Y.F., Horita, A. and Guy, A.W. Naltrexone pretreatment blocks microwave-induced changes in central cholinergic receptors. Bioelectromagnetics 12:27-33, 1991. Lai, H., Carino, M.A., Horita, A. and Guy, A.W. Single vs. repeated microwave exposure: effects on benzodiazepine receptors in the brain of the rat. Bioelectromagnetics 13:57-66, 1992. Lai, H., Carino, M.A., Horita, A. and Guy, A.W. Opioid receptor subtypes that mediate a microwave-induced decrease in central cholinergic activity in the rat. Bioelectromagnetics 13:237-246, 1992. Lai, H. and Carino, M.A. Opioid receptor subtypes mediating the noise-induced decreases in high-affinity choline uptake in the rat brain. Pharmacol. Biochem. Behav. 42:553-558, 1992. Lai, H., Horita, A. and Guy, A.W. Effects of a 60-Hz magnetic field on central cholinergic systems of the rat. Bioelectromagnetics 14:5-15, 1993. Khan, A., Mirolo, M.H., Lai, H., Claypoole, K., Bierut, L., Malik, R. and Bhang, J. ECT and TRH: cholinergic involvement in a cognitive deficit state. Psychopharmacol. Bull. 29:345-352, 1993. Khan, A., Lai, H., Ukai, Y. and Mirolo, M.H. NS-3, a TRH-analog, reverses repeated ECS-induced deficits in water-maze performance in the rat. Pharmacol. Biochem. Behav. 47:477-481, 1994. Lai, H., Horita, A. and Guy, A.W. Microwave irradiation affects radial-arm maze performance in the rat. Bioelectromagnetics 15:95-104, 1994. Lai, H. and Singh, N.P. Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells. Bioelectromagnetics 16:207-210, 1995. Lai, H. and Singh, N.P. Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin. Cancer Letters 91:41-46, 1995. Khan, A., Lai, H., Nishimura, Y., Mirolo, M.H. and Singh, N.P. Effects of ECS on DNA single-strand breaks in rat brain cells. Convulsive Ther. 11:114-121, 1995. Moore, J.C., Lai, H., Li, J.R., Ren, R.L., McDougall, J.A., Singh, N.P. and Chou, C.K. Oral administrations of dihydroartemisinin and ferrous sulfate retarded growth of implanted fibrosarcoma in the rat. Cancer Letters 98:83-87, 1995. Singh, N.P., Lai, H. and Khan, A. Ethanol-induced DNA single-strand breaks in rat brain cells. Mutation Research 345:191-196, 1995. Lai, H., Carino, M.A., Horita, A. and Guy, A.W. Intraseptal β−funaltrexamine injection blocked microwave-induced decrease in hippocampal cholinergic activity in the rat. Pharmacol. Biochem. Behav. 53:613-616, 1996. Lai, H. and Singh, N.P. DNA Single- and double-strand DNA breaks in rat brain cells after acute exposure to low-level radiofrequency electromagnetic radiation. Int. J. Radiat. Biol. 69:513-521, 1996. Lai, H. Spatial learning deficit in the rat after exposure to a 60 Hz magnetic field. Bioelectromagnetics 17:494-496, 1996. Lai, H. and Singh, N.P. Acute exposure to a 60-Hz magnetic field increases DNA strand breaks in rat brain cells. Bioelectromagnetics 18:156-165, 1997. 62. Lai, H. and Singh, N.P. Melatonin and N-tert-butyl-α-phenylnitrone blocked 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells. J. 63. Lai, H. and Singh, N.P. Melatonin and a spin-trap compound blocked radiofrequency radiation-induced DNA strand breaks in rat brain cells. Bioelectromagnetics 18:446-454, 1997. 64. Lai, H., Carino, M.A., and Singh, N.P. Naltrexone blocked RFR-induced DNA double strand breaks in rat brain cells. Wireless Networks Journal 3:471-476, 1997. Lai, H., Carino, M.A. and Ushijima, I. Acute exposure to a 60 Hz magnetic field affects rats' performance in the water maze. Bioelectromagnetics 19:117-122, 1998. Singh, N.P. and Lai, H. 60 Hz magnetic field exposure induces DNA crosslinks in rat brain cells. Mutation Research 400:313-320, 1998. Lai, H. and Carino, M.A. Intracerebroventricular injections of mu and delta-opiate receptor antagonists block 60-Hz magnetic field-induced decreases in cholinergic activity in the frontal cortex and hippocampus of the rat. Bioelectromagnetics 19:433-437, 1998. Lai, H. and Carino, M.A. 60 Hz magnetic field and central cholinergic activity: effects of exposure intensity and duration. Bioelectromagnetics 20:284-289, 1999. Singh, N.P., Stephens, R.E., Singh, H. and Lai, H. Visual quantification of DNA double-strand breaks in bacteria. Mutation Research 429:159-168, 1999. Wang, B.M. and Lai, H. Acute exposure to pulsed 2450-MHz microwaves affects water maze learning in the rat. Bioelectromagnetics 21:52-56, 2000. Singh, N.P. and Lai, H. Selective toxicity of dehydroartemisinin and holotransferrin on human breast cancer cells. Life Sciences 70:49-56, 2001. Lai, H. and Singh N.P. Magnetic field-induced DNA strand breaks in brain cells of the rat. Environmental Health Perspectives 112:687-694, 2004. Singh N.P. and Lai H. Artemisinin induces apoptosis in human cancer cells. Anticancer Research 24:2277-2280, 2004. Lai, H. Interaction of microwaves and a temporally incoherent magnetic field on spatial learning in the rat. Physiology and Behavior 82:785-789, 2004. Lai, H., Sasaki, T., Singh, N.P., and Messey, A. Effects of artemisinin-tagged holotransferrin on cancer cells. Life Sciences 76:1267-1279, 2005. Lai, H and Singh, N.P. Effects of Microwaves and a Temporally Incoherent Magnetic Field on Single and Double DNA Strand Breaks in Rat Brain Cells. Electromagnetic in Biology and Medicine 24:23-29, 2005. Singh, N.P. and Lai, H. Synergistic cytotoxicity or artemisinin and sodium butyrate on human cancer cells. Anticancer Research 25:4325-4332, 2005. Lai, H., Sasaki, T. and Singh N.P. Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds. Expert Opinion on Therapeutic Targets 9:995-1007, 2005. Lai, H. Biological effects of radiofrequency electromagnetic fields. In G. E. Wnek and G. L. Bowlin, eds. Encyclopedia of Biomaterials and Biomedical Engineering, Marcel Decker, New York, 2005. DOI: 10.1081/E-EBBE-120041846 Lai, H and Singh, N.P. Oral artemisinin prevents and delays the development of 7, 12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in the rat. Cancer Letters 231:43-48, 2006. Nakase, I., Lai, H., Singh, N.P. and Sasaki, T. Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation. International Journal of Pharmaceutics (In Press)
Book Chapters
1.
Lai, H. Neurological effects of microwave irradiation. In: "Advances in Electromagnetic Fields in Living Systems, Vol. 1", J.C. Lin (ed.), Plenum Press, New York, 1994, pp. 27-80. Chandos, B., Khan, A., Lai, H. and Lin, J. C. The application of electromagnetic energy for the treatment of neurological and psychiatric diseases. In:"Biological Effects of Magnetic and Electromagnetic Fields", E. Ueno (ed.), Plenum Press, New York, 1996, pp. 161-169. Feagin, J.E., Wurscher, M.A., Ramon, C. and Lai, H. Magnetic fields and malaria. In "Biologic Effects of Light: Proceedings of the Biologic Effects of Light Symposium" Holick, M.F. and Jung, E. G. (eds.), Kluwer Academic Publishers, Hingham, MA, 1999, pp. 343-349. Lai, H. Biological effects of radiofrequency radiation from wireless transmission towers. In “Cell Towers: Wireless Convenience? Or Environmental Hazard?” Levitt, B.B. (ed.), New Century Publishing, East Canaan, CT, 2001, pp. 65-74. Lai, H. and Singh, N.P. Genetic effects of wireless communication devices. In: "Advances in Electromagnetic Fields in Living Systems, Vol. 5", J.C. Lin (ed.), Springer Press (In press)

Source: http://www.radiationresearch.org/pdfs/cv/henry_lai.pdf