Microsoft word - cv betti en.doc

Identification
MICHELE BETTI
Tel

Nationality: Italian
Date of birth: 22-05-1969

Educational Background:

2003-2008
Ph.D. January 2008 Biochemistry Sciences: dissertation entitled “Vitamin E cell signalling: a possible chemopreventive role” Department of Internal Medicine, Applied Biochemistry and Nutritional Post-graduate course on emopoietic precursors with a dissertation entitled “TRAIL (Tumor necrosis factor-Related Apoptosis-Inducing Ligand) induces monocytic differentiation on leukemic cells and in myeloid progenitors in caspase-dependent pathway” II level Master on Cytometrical Techniques in Clinical Diagnostic with a dissertation entitled “Vitamin E: antiproliferative effects and cell cycle modulation on glioma C6 rat cell line” I level Master on Experimental and Clinical Cytometry with a dissertation entitled “Evaluation of PCB mixture effects in mytilus haemocytes” Qualification to practise a biologist profession Biological Sciences degree, School of Mathematic, Physic and Natural Sciences Secondary School “L. Laurana” Urbino
Research Experience:

2001-present Effects of vitamin E in cancer cell signalling and in brain development
Institute of physiological sciences, University of Urbino, Department of Internal Medicine, Applied Biochemistry and Nutritional Sciences University of Perugia 1997-present .Immunomodulation and cell signalling in Mytilus haemocytes by hormones, cytokines and pollutants. Institute of physiological sciences, University of Urbino, Department of Biology, University of Genova Identification and characterization of specific protein in truffle Institute of biochemistry sciences, University of Urbino

Teaching Experiences:

2005
Teacher at the University of Perugia, International Master “Biotechnology Medical Application”: module in “Inflammatory Factors” 2003-present Teaching assistant of Physiology at the University of Urbino “Carlo Bo”, School of
Refereed Publications:
1. Canesi, L., Ciacci, C., Betti, M., Malatesta, M., Gazzanelli, G., Gallo, G. (1999). Growth factors stimulate the activity of key glycolytic enzymes in isolated digestive gland cells from mussels (Mytilus galloprovincialis Lam.) through tyrosine kinase mediated signal transduction. Gen. Comp. Endocrinol. 116: 241-248. 2. Canesi, L., Ciacci, C., Betti, M., Gallo, G. (2000). Growth factor-mediated signal transduction and redox balance in isolated digestive gland cells from Mytilus galloprovincialis Lam. Comp. Biochem. Physiol., 125C: 355-363. 3. Canesi, L., Betti, M., Ciacci, C., Gallo, G. (2001). Insuline-like effect of zinc in Mytilus digestive gland cells: modulation of tyrosine kinase-mediated cell signaling. Gen. Comp. Endocrinol., 122, 60-66. 4. Canesi, L., Betti, M., Ciacci, C.,Gallo, G. (2001). Growth factor-mediated cell signalling in bivalve cells. Trends Comp. Biochem. Physiol., 8: 117-27. 5. Canesi, L., Betti, M., Ciacci, C., Scarpato, A., Citterio, B., Pruzzo, C.,Gallo, G. (2002). Signalling pathways involved in the physiological response of mussel hemocytes to bacterial challenge: the role of p38 MAP Kinase. Dev. Comp. Immunol., 488, 26 (4): 1-10. 6. Canesi, L., Scarpato, A., Betti, M., Ciacci, C., Pruzzo, C.,Gallo, G. (2002). Bacterial killing by Mytilus hemocyte monolayers as a model for investigating the signaling pathways involved in mussel immune defence. Mar Environ Res. Sep-Dec;54(3-5):547-51. 7. Canesi, L., Ciacci, C., Betti, M., Scarpato, A., Citterio, B., Pruzzo, C.,Gallo, G. (2003). Effects of PCB congeners on the immune function of Mytilus hemocytes: alterations of tyrosine kinase-mediated cell signaling. Aquat. Toxicol., 63: 293-306. 8. Pruzzo, C., Gallo, G., Betti, M., Canesi, L., (2003). Mechanisms involved in the immune response of the marine mussel Mytilus bacterial challenge: basic studies and future applications. Recent Res. Dev. Microb., 7: 279-287. 9. Zampini, M., Canesi, L., Betti, M., Ciacci, C., Tarsi, R., Gallo, G., Pruzzo, R. (2003). A role for the Mannose-Sensitive Hemagglutinin (MSHA) in promoting the interactions between Vibrio cholerae El Tor and mussel hemolymph. Applied and Environmental Microbiology, 69(9): 5711-5715. 10. Canesi, L., Betti, M., Ciacci, C., Citterio, B., Pruzzo, C., Gallo, G. (2003) Tyrosine kinase-mediated cell signalling in the activation of Mytilus hemocytes: possible role of STAT-like proteins. Biol. Cell, 95: 603-613. 11. Galli F., Stabile A. M., Betti M., Conte C., Floridi A. Azzi A (2004). The effect of alpha and gamma tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation. Archives of Biochemistry and Biophysics, 423: 97-102. 12. Canesi, L., Ciacci, C., Betti, M., Lorusso, LC., Marchi, B., Burattini, S., Falcieri, E., Gallo, Rapid effects of 17-estradiol on cell signaling and function of Mytilus hemocites. Gen. Comp. Endocrinol., 136: 58-71. 13. Canesi, L., Lorusso, LC., Ciacci, C., Betti, M., Zampini, M., Gallo, G. (2004) Environmental estrogens can affect the function of mussel hemocytes through rapid modulation of kinase pathways. Gen. Comp. Endocrinol., 138: 58-69. 14. Canesi, L., Betti, M., Ciacci, C., Lorusso, LC., Gallo, G., Pruzzo, C. (2005) Interactions between Mytilus haemocytes and different strains of Escherichia coli and Vibrio cholerae O1 El Tor: role of kinase-mediated signalling. Cellular Microbiology, 7: 667-674. 15. Canesi, L., Betti, M., Lorusso, LC., Ciacci, C., Gallo, G. (2005) “In vivo” effects of Bisphenol A in Mytilus haemocytes: modulation of kinase-mediated signalling pathways. Aquatic Toxicology, 71: 73-84. 16. Canesi L, Lorusso L C, Ciacci C, Betti M , Gallo G. (2005) Effects of the brominated flame retardant tetrabromobisphenol-A (TBBPA) on cell signaling and function of Mytilus hemocytes: Involvement of MAP kinases and protein kinase C. Aquatic Toxicology, 75: 277-28. 17. Betti M, Ciacci C, Lorusso LC, Canonico B, Falcioni T, Gallo G, Canesi L. (2006) Effects of tumor necrosis factor alpha (TNFalpha) on Mytilus hemocytes: role of stress-activated MAP kinases. Biol. Cell, 98: 233-244. 18. Ferri P, Cecchini T, Ambrogini P, Betti M, Cuppini R, Del Grande P, Ciarloni S (2006) -tocopherol affects neuronal plasticità in adult rat dentate gyrus: the possible role of PKCJ. Neurobiol., 66(8): 793-810. 19. Canesi L, Ciacci C, Lorusso LC, Betti M, Guarnirei T., Tavolari S., Gallo G (2006) Immunomodulation by 17-estradiol in bivalve hemocytes Am J Physiol Regul Integr Comp Physiol., 291(3):R664-73. 20. Betti M, Minelli A, Canonico B, Castaldo P, Magi S, Aisa MC, Di Tomaso V, Galli F Antiproliferative effect of tocopherols (Vitamin E) on murine glioma C6 cells: homologue-specific control of PKC/ERK and cyclin signalling Free Radical Biology & Medicine, 41(3): 464-72. 21. Canesi L, Betti M, Ciacci C, Lorusso LC, Pruzzo C, Gallo G. (2006) Cell signalling in the immune response of mussel hemocytes. Invertebrate Survival Journal, 3: 40-49. 22. Canesi L, Lorusso LC, Ciacci C, Betti M, Rocchi M, Pojana G, Marcomini A (2007) Immunomodulation of Mytilus hemocytes by individual estrogenic chemicals and environmentally relevant mixtures of estrogens: in vitro and in vivo studies. Aquatic Toxicology, 81 (1): 36-44. 23. Canesi L, Ciacci C, Lorusso LC, Betti M (2007) Effects of endocrine disrupting chemicals on the immune system of the edible bivalve mollusc Mytilus. Current Trends in Endocrinology: The Endocrine Disruptors; 1-12. 24. Cuppini R, Sartini S, Agostini D, Guescini M, Ambrogini P, Betti M, Bertini L, Vallasciani M, Stocchi V (2007) BDNF expression in rat skeletal muscle after acute or repeated exercise 25. Canesi, L, Ciacci, C, Lorusso, LC, Betti, M, Gallo, G, Poiana, G, Marcomini, A. (2007) Effects of Triclosan on Mytilus galloprovincialis hemocyte function and digestive gland enzyme activities: possible modes of action on non target organisms. Comp Biochem Physiol C Toxicol Pharmacol., 145(3):464-72. 26. Canesi, L, Ciacci, C, Lorusso, LC, Betti, M, Gallo, G, Poiana, G, Marcomini, A. (2007) Effects of blood lipid lowering pharmaceuticals (bezafibrate and gemfibrozil) on immune and digestive gland functions of the bivalve mollusc, Mytilus galloprovincialis. Chemosphere, 69(6): 994-1002 27. Canesi L., Ciacci C., Betti M., Fabbri R., Canonico B., Fantinati A., Marcomini A., Pojana Immunotoxicity of carbon black nanoparticles to blue mussel hemocytes Environment International 34 (8): 1114-1119 28. Mazzini F, Betti M, Netscher T, Galli F, Salvadori P (2009) Configuration of the vitamin E analogue garcinoic acid extracted from Garcinea Kola seeds Chirality; 21(5): 519-24 29. Luchetti F., Betti M., Canonico B., Arcangeletti M., Galli F., Papa S. (2009) ERK MAPK activation mediates the anti-apoptotic signaling of melatonin in UVB stressed U937 cells Free Radical Biology & Medicine , 46 (3): 339-351 30. Ciacci C, Fabbri R, Betti M, Roch P, Canesi L (2009) Seasonal changes in functional parameters of the hemolymph of Mytilus galloprovincialis Invertebrate Survival Journal, 6: 44-48. 31. Ciacci C, Citterio B, Betti M, Canonico B, Roch P, Canesi L. (2009) Functional differential immune responses of Mytilus galloprovincialis to bacterial challenge. Comp Biochem Physiol B Biochem Mol Biol. 153(4):365-71 32. Canonico B., Betti M., Luchetti F., Battistelli M., Falcieri E., Ferri P., Zamai L., Barnett D., Papa S. (2010) Flow cytometric profiles, bimolecular and morphological aspects of transfixed leukocytes and red cells Cytometry B Clin Cytom. 78(4): 267-78 33. Mazzini F, Betti M, Canonico B, Netscher T, Luchetti F, Papa S, Galli F (2010) Anticancer activity of Vitamin E derived compounds in murine C6 glioma cells 34. Ciacci C., Citterio B., Betti M., Canonico B., Roch P., Canesi L. (2010) Specificity of anti-Vibrio immune response through p38 MAPK and PKC activation in the hemocytes of the mussel Mytilus galloprovincialis 35. Luchetti F., Canonico B., Betti M., Arcangeletti M., Piroddi M., Pilolli F., Canesi L., Papa S., Galli F. (2010) Melatonin: signaling and cell protection function FASEB J. 24(10): 3603-24 36. Betti M., Ambrogini P., Minelli A., Floridi A., Lattanzi D., Ciuffoli S., Bucherelli C., Prospero E., Frontini A., Santarelli L., Baldi E., Benetti F., Galli F., Cuppini R. (2011) Maternal dietary loads of -Tocopherol depress Protein Kinase C (PKC) signalling and synaptic plasticity in rat postnatal developing hippocampus and promote permanent deficits in adult offspring J Nutr Biochem. 22(1): 60-70 37. Viola V., Pilolli F., Piroddi M., Pierpaoli E., Orlando F., Provinciali M., Betti M., Mazzini Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E Genes Nutr DOI 10.1007/s12263-011-0219-9 (IN PRESS)
Selected Abstract (national and international meetings):

1. Cucchiarini L, Pierotti C, Cardoni P, Vallorani L, Betti M, Stocchi V. (1994). Biochemical characterization of various species of white truffle Biotechnology of ectomycorrhizae: molecular approches. Urbino (Italy), 9-11th November. 2. Canesi L, Betti M, Ciacci C, Gallo G. (1998). Possible role of peptide growth factors in the control of glucose metabolism in mussel cells. Atti XXV Riunione Primaverile Società Italiana di Fisiologia, Firenze (Italy), 16-18th Febbraio. 3. Canesi L, Ciacci C, Betti M, Gallo G. (1998). Effects of growth factors on PFK (phosphofructokinase) activity in isolated mussel digestive gland cells: possible relationship between phosphorylation-mediated signal transduction and cellular redox balance. 19th ESCPB Conference, Turku, (Finland), 23-27th August. 4. Canesi L, Betti M, Ciacci C, Gallo G. (1999). Possible relationship between growth factor-mediated tyrosine kinase signal transduction and cellular redox balance in mussel cells. Atti XXVI Riunione Primaverile Società Italiana di Fisiologia, Firenze (Italy), 15-17th Febbraio. 5. Canesi L, Ciacci C, Betti M, Gallo G. (1999). Tyrosine kinase mediated signal transduction and cellular redox balance in mussel cells. Biochimie, Suppl. 6, June 1999. Abstracts 26th FEBS Meeting, Nice (France), 19-24th June. 6. Canesi L, Ciacci C, Betti M, Gallo G. (1999). Effects of growth factors in isolated Mytilus cells: possible application in the study of growth and metabolism in marine invertebrates. Abstracts CNB3. 3° Congresso Nazionale Biotecnologie, Urbino (Italy), 1-3th Luglio. 7. Canesi L, Betti M, Ciacci C, Gallo G. (2000). Zinc exerts insuline-like effects on carbohydrate metabolism through protein tyrosine phosphorylation in isolated Mytilus cells. 20th Conference of European Comparative Endocrinologists. Faro (Portogallo), 5-9th September. 8. Canesi L, Ciacci C, Betti M, Potenza L, Gallo G. (2001). Epidermal growth factor in Mytilus sp. 14th International Congress of Comparative Endocrinology. Sorrento (Italy), 26-30th Maggio. 9. Canesi L, Ciacci C, Betti M, Gallo G. (2001). Role of differential MAPK activation in mediating the response to both growth and stress stimuli in Mytilus hemocytes. 14th International Congress of Comparative Endocrinology. Sorrento (Italy), 26-30th Maggio. 10. Rovidati S, Bordoni V, Betti M, Ferraro B, Benedetti S, Galli F, Canestrari F. (2001). Vitamin E inhibits H2O2-induced apoptosis in human lymphocytes by reducing p38 MAPK activation. SFFR 2001. Roma (Italy), 22-24th June. 11. Canesi L, Betti M, Ciacci C, Scarpato A, Pruzzo C, Gallo G. (2001). Bacterial killing by Mytilus hemocytes as a model for investigating the signaling pathways involved in mussel immune defence. 11th International Symposium on Pollutant Responses in Marine Organisms, Plymouth, (U.K.), 10-13th July. 12. Canesi L, Ciacci C, Betti M, Gallo G. (2001). Signaling pathways involved in the response of molluscan hemocytes to extracellular stimuli. 52° Convegno della Società Italiana di Fisiologia. Torrette di Ancona (Italy), 25-28th Settembre. 13. Canesi L, Betti M, Ciacci C, Pruzzo C, Gallo G. (2002). Role of tyrosine kinase-mediated cell signalling in the immune function of mussel hemocytes. Vth scientific meeting of the Italian Association for Developmental and Comparative Immunology (SIICS), Viterbo, Italy, 7 and 8 February. 14. Canesi L, Ciacci C, Betti M, Scarpato A, Gallo G. (2002). Effects oh ortho-substituted PCBs on mussel hemocyte immune function. SETAC (Society of Enivironmental Toxicology and Chemistry) Europe 12th Annual Meeting. Vienna (AUSTRIA), 12-16th May. 15. Canesi L, Ciacci C, Betti M, Marchi B, Gallo G. (2002). Tyrosyne kinase- and Ca2+-mediated signaling pathways as targets for PCB-induced endocrine disruption in bivalve hemocytes. 21th Conference of European Comparative Endocrinologists. Bonn (Germany), 26-30th August. 16. Canesi L, Betti M, Ciacci C, Pruzzo C, Gallo G. (2002). Evidence for activation of a MAPK/STAT signaling pathway in the immune response of molluscan hemocytes. 21th Conference of European Comparative Endocrinologists. Bonn (Germany), 26-30th August. 17. Canesi L, Betti M, Ciacci C, Pruzzo C, Gallo G. (2002). Physiological responses of mussel haemocytes to bacterial challenge. 53° Convegno della Società Italiana di Fisiologia. Ferrara (Italy), 16-19th Settembre. 18. Galli F, Betti M, Pirrodi M, Conte C, Floridi A. (2002) Dual effect of the vitamin E and its carboxyethyl-hydroxychroman metabolites on p38 MAPK activation in inflammatory cells. SIB, Palermo (Italy), 16-19th Settembre. 19. Galli F, Stabile AM, Betti M, Piroddi M, Franceschini M, Conte C, Floridi A, Azzi A. metabolite gamma-carboxyethyl hydroxychroman acid inhibits prostate cancer cell (PC-3) proliferation: a preliminary characterisation. XII Meeting on Fat Soluble Vitamins, Rieti (Italy), 13-15th March. 20. Canesi L, Ciacci C, Lorusso LC, Betti M, Marchi B, Gallo G. (2003). Effects of natural and environmental estrogens on cell signalling in mussel immunocytes. 3rd Federation of European Physiological Societies (FEPS) Meeting, Nizza (France), 28th June-2nd July. 21. Canesi L, Betti M, Ciacci C, Manti A, Gallo G. (2003). IFN stimulates the immune function of Mytilus haemocytes: effects on tyrosine kinase - mediated cell signalling. 9th International Congress of the International society for Developmental and Comparative Immunology. University of St Andrews, Scotland (UK), 29th June- 4th July. 22. Canesi L, Ciacci C, Lorusso LC, Betti M, Gallo G. (2003). Possible mechanisms of immunomodulation of mussel haemocytes by natural and environmental estrogens. 9th International Congress of the International society for Developmental and Comparative Immunology. University of St Andrews, Scotland (UK), 29th June- 4th July. 23. Canesi L, Zampini M, Betti M, Pruzzo C, Gallo G. (2003). Mannose-sensitive interactions between mytilus hemocytes and bacterial surface components. 9th International Congress of the International society for Developmental and Comparative Immunology. University of St Andrews, Scotland (UK), 29thJune- 4th July. 24. Canesi L, Lorusso LC, Ciacci C, Betti M, Burattini S, Battistelli M, Falcieri E. (2003). Effects of estrogens on invertebrate immunocyte morphology and function European Journal of Histochemistry (ISSN 1121-760X, vol. 47/3); Proceedings of the Workshop: “Cell surface: from molecules to shape” Urbino (Italy) 25-27th September. 25. Canesi L, Ciacci C, Lorusso LC, Betti M, Marchi B, Falcieri E, Gallo G. (2003). 17-Estradiol-mediated cell signalling in invertebrate immunocytes. 54° Congresso della Società Italiana di Fisiologia, Chieti (Italy), 29 Settembre-02 Ottobre. 26. Zampini M, Betti M, Canesi L, Tarsi R, Gallo G, Pruzzo C (2003) Adesività di Vibrio Cholerae: ruolo di molecole opsonizzanti. 31° Congresso Nazionale della Società Italiana di Microbiologia, Roma, Italia, 19-22 Ottobre. 27. Canesi L, Ciacci C, Betti M, Lorusso LC, Marchi B, Gallo G. (2003). Non genomic effects of natural and enviromental estrogens in bivalve immunocytes. Biological effects of pullulants: the role of enviromental proteomics and genomics; 22nd conference, Alessandria, Italy, 14-18 December. 28. Canesi L, Ciacci C, Betti M, Lorusso LC, Marchi B, Gallo G. (2003). Effects and mechanisms of action of nonylphenol in Mytilus immunocytes. Biological effects of pullulants: the role of enviromental proteomics and genomics; 22nd conference, Alessandria, Italy, 14-18 December. 29. Canesi L, Zampini M, Betti M, Pruzzo C, Gallo G. (2004). Role of Hemolymph soluble factors in mediating the interactions between Mytilus hemocytes and bacterial surface components VIth scientific meeting of the Italian Association for Developmental and Comparative Immunology (SIICS), University of Padova, Italy, 12 and 13 February. 30. Canesi L, Ciacci C, Lorusso LC, Betti M, Marchi B, Gallo G. (2004). Effects of estrogens on Mytilus hemocytes ISJ, ISSN 1824-307X: VIth scientific meeting of the Italian Association for Developmental and Comparative Immunology (SIICS), University of Padova, Italy, 12 and 13 February. 31. Conte C, Betti M, Aisa MC, Pirrodi M, Floridi A, Galli F. (2004). Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells. Conference on “Vitamin E and Health”, Boston, Massachussetts, USA, 22-24 May. 32. Canesi L, Lorusso LC, Ciacci C, Betti M. Gallo G. (2004). In vivo effects of Bisphenol A in Mytilus hemocytes: modulation of kinase-mediated signaling pathways 23rd ESCPB Conference, Cesenatico, Italy, 23-26 September. 33. Canesi L, Betti M, Ciacci C, Lorusso LC, Pruzzo C, Gallo G. (2004). Signaling pathways involved in the response of Mytilus hemocytes to bacterial challenge: modulation by endogenous and environmental chemicals 23rd ESCPB Conference, Cesenatico, Italy, 23-26 September. 34. Betti M, Ciacci C, Lorusso LC, Canesi L. (2004). Effects of TNF on cell signaling in mussel hemocytes 23rd ESCPB Conference, Cesenatico, Italy, 23-26 September. 35. Canesi L, Lorusso LC, Ciacci C, Betti M, Gallo G. (2004). Estrogens in Mytilus hemocytes: effects on signaling 24° Congresso Nazionale della Società Italiana di Protozoologia, Rapallo, Italy, 1-2 Ottobre. 36. Canesi L, Zampini M, Betti M, Gallo G, Pruzzo C. (2004). Interactions between bacteria and hemolymph components of the edible mussel Mytilus: basic studies and possible applications on human health. Symposium on Food quality and safety to promote health, Urbino, Italy, 8-9 October. 37. Canesi L, Betti M, Ciacci C, Lorusso LC, Pruzzo C, Gallo G. (2005). Kinase-mediated cell signaling in the response of Mytilus hemocytes to bacterial challenge VIIth scientific meeting of the Italian Association for Developmental and Comparative Immunology (SIICS), University of Palermo, Italy, 10 and 12 February. 38. Betti M, Ciacci C, Lorusso LC, Canonico B, Canesi L. (2005). Effects of TNFa in mussel hemocytes: role of kinase pathways VIIth scientific meeting of the Italian Association for Developmental and Comparative Immunology (SIICS), University of Palermo, Italy, 10 and 12 February. 39. Betti M, Galli F, Minelli A, Castaldo P, Magi S, Amoroso S. (2005). -tocopherol exerts antiproliferative effect and modulates cell cycle in murine glioma C6 cell line. 32° Congresso Nazionale della Società Italiana di Farmacologia, Napoli, Italia, 1-4 Giugno. 40. Betti M, Ciacci C, Lorusso LC, Canonico B, Canesi L (2005) Stress signalling in marine invertebrates: the model of mytilus haemocytes Convegno annuale del gruppo SIB biochimica marina e dell’ambiente, Cesenatico, Italy, 9-10 giugno 41. Ferri P, Ciaroni S, Cecchini T, Ambrogini P, Betti M, Del Grande P. (2005). -tocopherol affects neuronal plasticità in adult rat dentate gyrus by inhibing PKC Proceedings of the 31st national congress of Italian Society of Histochemistry, European Journal of Histochemistry, 49/supplement 1, Pisa, Italy, 15-15 June. 42. Canesi L, Ciacci C, Lorusso LC, Betti M, Gallo G. (2005). Effects of brominated flame retardants (BFRs) on mytilus hemocytes: modulation of kinase pathways involved in theimmune function 13° Symposium PRIMO 13, Alessandria, Italy, 19-22 June. 43. Betti M, Galli F, Canonico B, Minelli A, Castaldo P, Aisa MC, Annetti C, Amoroso S. -tocopherol exerts antiproliferative effect and modulates cell cycle in murine glioma C6 cell. 50° Congresso Nazionale della Società Italiana di Biochimica e Biologia Molecolare, Riccione, Italy, 27-30 September. 44. Canesi L, Betti M, Ciacci C, Lorusso LC, Fabbri R, Mancinelli G, Vergani L. Gallo G. Non reproductive functions of estrogens in invertebrates: mechanisms of action in the neuro-immune system. 56° Congresso nazionale della Società Italiana di Fisiologia, Palermo, Italy, 27-30 September. 45. Canesi L, Lorusso LC, Ciacci C, Betti M, Pojana G, Marcomini A. (2006). Immunomodulation in Mytilus hemocytes by individual estrogenic chemicals and estrogenic mixtures of environmental relevance: in vitro and in vivo studies. SETAC Europe 16th Annual Meeting, The Hague, The Netherlands, 7-11 May. 46. Di Tommaso V, Betti M, Aisa MC, Mazzini F, Galli F (2006) Quali-quantitative characterization of gamma-tocopherol anti-proliferative activity in murine glioma C6 cells. XIII Biennal Meeting of the mSociety for Free Radical Research International, Davos, Switzerland, 15-19 August. 47. Canesi L, Lorusso LC, Ciacci C, Betti M, Pojana G, Gallo G, Marcomini A (2006) Immunomodulation in Mytilus hemocytes by individual estrogenic chemicals and estrogenic mixtures of environmental relevance. 23rd Conference of European Comparative Endocrinologists, Manchester, UK, 29 August – 2 September. 48. Canesi L, Ciacci C, Lorusso LC, Betti M, Gallo G (2006) Kinase-mediated 17b-estradiol signalling in bivalve hemocytes. 23rd Conference of European Comparative Endocrinologists, Manchester, UK, 29 August – 2 September. 49. Canesi L, Lorusso LC, Ciacci C, Betti M, Pojana G, Marcomini A (2006) Effetti di composti estrogenici singoli ed in miscele ambientali sulla funzione immunitaria del mitilo. XXII Congresso Nazionale della Società Chimica Italiana, Firenze, Italia, 10-15 Settembre. 50. Ferri P, Ambrogini P, Betti M, Ciarloni S, Cecchini T, Montini M, Cecchini S, Del Grande -Tocoferolo e morfologia delle sinapsi nel giro di ratto adulto. 67° Congresso Nazionale Unione Zoologica Italiana, Napoli, Italia, 12-15 Settembre. 51. Luchetti F, Betti M, Arcangeletti M, Canonico B, Falcieri E, Papa S (2006) Role of melatonin in the regulation of MAPKs in U937 cells. 60TH Meeting of the Italian Society of Anatomy and Histology, Pavia, Italy, 15-17 September. 52. Canesi L, Betti M, Lorusso LC, Ciacci C, Gallo G (2006) Estrogens modulate kinase-mediated cell signaling in mussel hemocytes 57° Congresso nazionale della Società Italiana di Fisiologia, Ravenna, Italy, 25-27 September. 53. Aisa MC, Betti M, Mazzini F, Di Tomaso V, Cipriani S, Galli F (2006) Vitamin E targeting, biotransformation and metabolism: molecular insights into a troublesome story. 51° Congresso Nazionale della Società Italiana di Biochimica e Biologia Molecolare, Riccione, Italy, 28 September-1 October. 54. Betti M, Canonico B, C Ciacci, Lorusso LC, Papa S, Canesi L (2007) Evidence for Stem Cell Factor-induced proliferation/differentiation in bivalve hemocytes VIIIth scientific meeting of the Italian Association for Developmental and Comparative Immunology (SIICS), Area della Ricerca (CNR) Napoli, Italy, 1 and 2 March. 55. Canesi L, Ciacci C, Lorusso LC, Betti M, Gallo G, Pojana G, Marcomini A (2007) Effects of selected pharmaceuticals on immune and digestive gland function of the marine mussel Mytilus spp. Possible modes of action in non target organisms SETAC Europe 17th Annual Meeting, Porto, Portugal, 20-24 May 56. Canesi L, Ciacci C, Betti M, Fabbri R, Pojana G, Marcomini A (2007) Emergine contaminants in the aquatic environment: effects on a sentinel organism, the mussel Mytilus X Congresso Nazionale di Chimica dell’Ambiente e dei Beni Culturali, Vernole (LE), Italia, 11-15 Giugno 57. Canesi L, Ciacci C, Betti M, Fabbri R, Pojana G, Marcomini A (2007) Effects of commercial and purified nanosized carbon black (NCB) on molluscan immunocytes X Congresso Nazionale di Chimica dell’Ambiente e dei Beni Culturali, Vernole (LE), Italia, 11-15 Giugno 58. Betti M, Canonico B, Ciacci C, Lorusso LC, Papa S, Canesi L (2007) Effects of Stem Cell Factor (SCF) on molluscan immunocytes 58° Congresso Nazionale della Società Italiana di Fisiologia, Lecce, Italia, 19-21 Settembre 59. Betti M, Minelli A, Ambrogini P, Lattanzi D, Ciuffoli S, Cuppini R (2007) Effects of maternal supplementation with high doses of a-tocopherol on central nervous system (CNS) postnatal development in rats 58° Congresso Nazionale della Società Italiana di Fisiologia, Lecce, Italia, 19-21 Settembre 60. Canonico B, Luchetti F, Betti M, Arcangeletti M, Biagiarelli L, Zamai L, Papa S (2007) Melatonin in the prosurvival function of UV-induced apoptosis in U937 cell line 61° Congresso Nazionale della Società Italiana di Anatomia e Istologia, Sassari, Italia, 19-22 Settembre 61. Betti M, Canonico B, Ciacci C, Arcangeletti M, Papa S, Canesi L (2007) Flow cytometry (FMC) reveals cellular responses to stem cell factor (SCF) in molluscan immunocytes XXV Conferenza Nazionale di Citometria, Roma-Città del Vaticano, Italia, 3-6 Ottobre 62. Ciacci C, Canesi L, Betti M, Poiana G, Marcomini A, Arcangeletti M, Canonico B (2007) Effects of nanosized carbon black (NCB) on molluscan immunocytes XXV Conferenza Nazionale di Citometria, Roma-Città del Vaticano, Italia, 3-6 Ottobre 63. Luchetti F, Canonico B, Betti M, Arcangeletti M, Biagiarelli L, Papa S (2008) Melatonin restores the mitochondrial function and structure Apoptosis World 2008, From mechanisms to applications, Luxembourg, 23th-26th January 64. Ciacci C, Betti M, Roch P, Canesi L (2008) Differential responses of mussel hemocytes to bacterial challenge IXth scientific meeting of the Italian Association for Developmental and Comparative Immunology (SIICS), Varese, Italia, 27-29 Febbraio 65. Canesi L, Ciacci C, Betti M, Fabbri R, Canonico B, Marcomini A, Poiana G (2008) Effects of nanosized particles on bivalve immunocytes nanoECO, Monte Verità, Switzerland, 2-7 March 66. Poiana G, Canesi L, Ciacci C, Betti M, Fabbri R, Canonico B, Marcomini A (2008) Effetti di nanoparticelle di sintesi nei mitili XI congress nazionale di chimica dell’ambiente e dei beni cultutali, Porto San Rocco (TS), Italy, 16-20 giugno 67. Betti M, Canonico B, Ciacci C, Lorusso LC, Papa S, Canesi L (2008) Effects of Stem Cell Factor (SCF) on proliferation and differentiation of bivalve immunocytes 25th ESCPB Congress, Ravenna, Italy, 7-11 September Signal transduction in phagocytosis of the compound ascidian Botryllus schlosseri 25th ESCPB Congress, Ravenna, Italy, 7-11 September 69. Ciacci C, Betti M, Roch p, Fabbri R, Borghi C, Canesi L (2008) Functional response of mussels to bacterial challenge 25th ESCPB Congress, Ravenna, Italy, 7-11 September 70. Ferri P, Ambrogini P, Betti M, Cecchini T, Ciaroni S, Cuppini R, Del Grande P, Papa S Alpha-Tocopherol affects synaptogenesis in adult rat dentate gyrus LXII Congresso della Società Italiana di Anatomia e Istologia, Verona, Italy, 14-16 Settembre 71. Mazzini F, Betti M, Netscher T, Galli F, Salvatori P (2008) New Vitamin E analogues as antitumoral agents XIX National Meeting on Medicinal Chemistry, Verona, Italy, 14-18 September 72. Ferri P, Ambrogini P, Betti M, Ciaroni S, Cecchini T, Biagiotti L, Cuppini R, Papa S, Del L’alfa-tocoferolo promuove la neutitogenesi nel giro dentato di ratto adulto 69° Congresso dell’Unione Zoologica Italiana, Senigallia, Italia, 22-25 Settembre 73. Betti M, Mazzini F, Floridi A, Canonico B, Luchetti F, Piroddi M, Pilolli F, Aisa MC, Galli Structure-function relationship evaluation of synthetic vitamin E analogues in C6 murine glioma cells and peripheral blood leukocytes 53rd National Meeting of Italian Society of Biochemistry and Molecular Biology, Riccione, Italy, 23-26 September 74. Betti M, Floridi A, Minelli A, Cuppini R, Pilolli F, Piroddi M, Galli F (2008) Maternal supplementation with high doses of alpha-tocopherol influences hippocampal PKC activity of rat offspring 53rd National Meeting of Italian Society of Biochemistry and Molecular Biology, Riccione, Italy, 23-26 September 75. Betti M, Mazzini F, Canonico B, Luchetti F, Floridi A, Pilolli F, Piroddi M, Aisa MC, Galli Targeting mitocondriale ed effetti sui processi di morte cellulare di analoghi naturali e di sintesi della vitamina E Società Italiana di Nutrizione Umana, Roma, Italia, 11-12 Dicembre 76. Canesi L, Betti M, Ciacci C, Pruzzo C, Gallo G (2009) 1999-2009: 10-year apprenticeship in comparative immunology. The immunocytes as leading actors in the responses of the bivalve Mytilus to environmental challenge X Meeting of Italian Association of Developmental and Comparative Immunobiology, Urbino, Italy, 18-20 February 77. Ciacci C, Citterio B, Fabbri R, Barmo C, Betti M, Roch P, Canesi L (2009) Effects of bacterial challenge on Mytilus digestive gland biomarkers X Meeting of Italian Association of Developmental and Comparative Immunobiology, Urbino, Italy, 18-20 February 78. Canonico B, Betti M, Ciacci C, Arcangeletti M, Papa S, Canesi L Flow cytometry as a tool for analysing invertebrate cells: our experience on mussel hemocytes X Meeting of Italian Association of Developmental and Comparative Immunobiology, Urbino, Italy, 18-20 February 79. Betti M, Gobbi P, Canonico B, Ciaci C, Papa S, Canesi L (2009) Proliferation of mussel haemocytes: effects of Stem Cell Factor (SCF) X Meeting of Italian Association of Developmental and Comparative Immunobiology, Urbino, Italy, 18-20 February 80. Ciacci C, Canonico B, Betti M, Pojana G, Marcomini A, Canesi L (2009) Mytilus hemocytes as a model for nanoparticle toxicology in marine invertebrates X Meeting of Italian Association of Developmental and Comparative Immunobiology, Urbino, Italy, 18-20 February 81. Canesi L, Ciacci C, Fabbri R, Betti M, Marcomini A, Pojana G (2009) Bivalve molluscs as a target for nanoparticle toxicity: in vitro and in vivo effects of nanosized carbon black, C60 Fullerene, TiO2 and SiO2 in mytilus PRIMO 15°, Bordeaux, France, 17-20 May 82. Ciacci C, Canonico B, Betti M, Pojana G, Marcomini A, Canesi L (2009) Immunociti di mitilo come modello per lo studio degli effetti di nanoparticelle sugli invertebrati marini Il Mediterraneo: aspetti emergenti e risposte dalle scienze del mare, Cesenatico, Italy, 8-10 luglio 83. Betti M, Ciacci C, Canonico B, Papa S, Canesi L (2009) Proliferation of mussel haemocytes: effects of Stem Cell Factor (SCF) Il Mediterraneo: aspetti emergenti e risposte dalle scienze del mare, Cesenatico, Italy, 8-10 luglio 84. Canonico B, Betti M, Ciacci C, Arcangeletti M, Manti A, Papa S,Canesi L (2009) Analisi di immunociti di invertebrati mediante citometria a flusso Il Mediterraneo: aspetti emergenti e risposte dalle scienze del mare, Cesenatico, Italy, 8-10 luglio 85. Mazzini F, Betti M, Netscher T, Floridi A, Galli F (2009) New vitamin E analogues as proapoptotic and antiproliferative agents on C6 glioma cells SFRR-Europe Meeeting, Rome, Italy, 26-29 August 86. Betti M, Ambrogini P, Minelli A, Floridi A, FLattanzi D, Ciuffoli S, Galli F, Cuppini R Maternal dietary loads of -Tocopherol can affect PKC signaling and synaptic plasticity in postnatal developing hippocampus thereby affecting spatial memory in adult offspring SFRR-Europe Meeeting, Rome, Italy, 26-29 August 87. Ferri P, Ambrogini P, Betti M, Ciaroni S, Cecchini T, Cuppini R, Cecchini S, Papa S, Del Correlati molecolari di rimodellamento sinaptico in condizioni di supplementazione con -Tocoferolo 70° Congresso dell’Unione Zoologica Italiana, Rapallo, Italia, 21-24 Settembre 88. C Ciacci, B Citterio, M Betti, B Canonico, P Roch, L Canesi (2010) Responses of Mytilus galloprovincialis hemocytes to heat killed Vibrio splendidus LGP32: role of p38 MAPK and PKC XI Meeting of Italian Association of Developmental and Comparative Immunobiology, Modena, Italy, 24-26 February 89. B Canonico, C Ciacci, M Arcangeletti, M Betti, B Citterio, P Roch, S Papa, L Canesi (2010) Changes in hemocyte subpopulations and immunoreactivity to anti-integrins and -progenitors antibodies of Mytilus galloprovincialis after bacterial challenge XI Meeting of Italian Association of Developmental and Comparative Immunobiology, Modena, Italy, 24-26 February 90. M Betti, C Ciacci, P Gobbi, B Canonico, S Papa, L Canesi (2010) Proliferation and differentiation of mussel hemocytes are conserved from molluscs to mammals XI Meeting of Italian Association of Developmental and Comparative Immunobiology, Modena, Italy, 24-26 February

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