Microsoft word - cognitive functioning paper.doc

Ageing & Society 30, 2010, 000-000. 2010 Cambridge University Press
DOI: 10.1017/S0144686X09990626 Printed in the United Kingdom
Social involvement, behavioural risks and cognitive functioning among the aged HENRIETTE ENGELHARDT *, ISABELLA BUBER §, VEGARD SKIRBEKK † and
* Department of Population Studies, Otto Friedrich University Bamberg, Germany
§ Vienna Institute of Demography, Vienna, Austria
† Institute for Applied Systems Analysis (IIASA), Laxenburg, Austria
‡ Institute for Mathematical Methods in Economics, Vienna University of Technology, Austria
In this study we analyse the relationship between cognitive performance, social participation and behavioural risks taking into account the influence of age and educational attainment. We examine individual data from 11 European countries and Israel that were collected in the first wave of SHARE. The methodology proposed, a stochastic frontier approach, allows us to identify the effects of the different sources of plasticity on cognitive functioning while explicitly taking into account the age-related decline in cognitive performance. Social involvement variables are employment status, attending educational courses, doing voluntary or charity work, providing help to family, friends or neighbours, participating in a sports, social or other club, participating in a religious organisation and participating in a political or community organisation. We control for age, education, income, physical activity, BMI, smoking and drinking. In the pooled sample, the results clearly show that all kinds of social involvement enhance cognitive functions, in particular the continuation of occupational activities. Moreover, behavioural risks such as physical inactivity, obesity, smoking or drinking are clearly detrimental to cognitive performance. Models for men and women were run separately. For both genders, all social involvement indicators were found to be associated with better cognitive performance. Country-specific results, however, vary across countries with respect to signs for a number of indicators of social involvement and behavioural risks. KEY WORDS – cognitive ageing, cognitive reserve, social involvement, behavioural risks,
social engagement
It is now well accepted that in the future in most industrialised countries, the labour force will become smaller and older. To counteract the shrinkage of the working-age population and to reduce the number of social security beneficiaries, increasing employment at older ages is called for. Senior workers’ productivity levels are important in determining whether policies to extend the length of the working life will be successful. Strategies for encouraging older workers to remain longer in the workforce need to be evaluated in tandem with the development of the productivity profile of older workers. It is well known that workers of different ages have different levels of productivity (as well as learning abilities), although the size of the age effect is still highly disputed and strongly dependent on the occupation, technological progress and possible cohort effects that work through schooling levels. Studies of the influence of age on individual productivity use different measures, including supervisors’ evaluations, piece-rate studies, analyses of employer-employee datasets, age- earnings profiles and entrepreneurial activity (cf. Prskawetz et al. 2005; Prskawetz, Mahlberg and Skirbekk 2007; McEvoy and Cascio 1993; Skirbekk 2008; Warr 1994). An important cause of variability in productivity at higher ages is likely to be the variation in the age-related decline of cognitive abilities. Some abilities, such as perceptual speed, show relatively large decrements from young ages, while others, like verbal abilities, exhibit only small changes throughout the working life. Older individuals learn at a slower pace and have reductions in their memory and reasoning abilities. In particular, senior workers are likely to have difficulties in adjusting to new ways of working (Verhage and Salthouse 1997; Schaie 1996; Skirrbekk 2008; McEvoy and Cascio 1989). Previous studies have indicated the plasticity of ageing by focusing on the role of behavioural risk factors and social involvement on individuals’ cognitive reserves in old age (for a survey see Le Carret et al. 2003). Based on the Survey on Health, Ageing and Retirement in Europe (SHARE), we study the role of these intervening factors on cognitive functioning in old age, and focus on the fluid abilities that are more likely to deteriorate with age. Our approach is to model cognitive abilities as a function of age and education, and to study the loss in efficiency depending on behavioural risk factors (like smoking and obesity) as well as social involvement at old age. Differently from the study by Adam et al. (2006), we study the cognitive decline of a single indicator of fluid abilities that shows clear decline in old age. Moreover, we model the best possible cognitive performance as a function of age and education, and perform country-specific analysis to test the generality of the results. The paper is organised as follows. Theories of cognitive ageing are reviewed in the next section, and the data, methods and variables are discussed in the next. The descriptive univariate and multivariate results based on the stochastic frontier concept are presented in the fourth section, and the fifth sets out our conclusions. Cognitive ageing and cognitive reserve
During the last three decades, a great deal of evidence has accumulated that increased age is accompanied by ‘cognitive ageing’ – the term describes a pattern of age-related variation in cognitive functioning including reasoning, spatial orientation, numerical capabilities, verbal abilities, memory and problem solving. These cognitive abilities are closely correlated with performance in several areas of life, in particular job performance (Schmidt and Hunter 1998; Skirbekk 2008; Warr 1994). Different mental abilities follow different paths across the life cycle. Crystallised abilities tend to increase or remain at a high functional level until late in life, while fluid abilities tend to decline substantially over the adult life span (Blum, Jarvik and Clark 1970; Horn and Cattell 1966, 1967; Schaie 1994; Schwartzman et al. 1987; Verhaegen and Salthouse 1997). Crystallised abilities include accumulated knowledge and skills, such as the meaning of words and size of vocabulary, while fluid abilities concern performance in learning and processing new material—and also comprise perceptual speed A longitudinal study by Schwartzman et al. (1987) found that verbal skills remain virtually unchanged across the life cycle, while reasoning and speed decline with age. The study of twins by Blum et al. (1970) provided similar findings: vocabulary size remained constant from youth to old age, despite a general reduction in other cognitive abilities. Verhaegen and Salthouse (1997) analyses 91 different studies and conclude that important fluid abilities, such as reasoning and speed decline significantly by the age of 50 years. The decline with age in fluid abilities has been shown across countries, for both men and women, and for individuals with different ability levels (Park, Nisbett and Hedden 1999; Deary et al. 2000; Maitland et al. 2000). It is important to stress that intra-individual variations increase with age—following the long-term impact of different lifestyles and health behaviour over the life cycle. Educational, family and occupational choices in addition to behavioural factors such as eating, smoking and drinking habits imply that mental health is increasingly variant at older ages. One example is the greater variation in depression, dementia or activities of daily life in the latter half of life, implying a greater overall variation in mental health at older ages (Christensen et al. 1999; Wilson et al. 2002). The decline in cognitive functioning is associated with structural changes in the brain (Raz 2004). Even early in the ageing process, cerebral atrophy, ventricular enlargement and hippocampal atrophy may be evident in many individuals (Meyer et al. 1999; Coffrey et al. 1992). In addition, the underlying pathologic basis of cognitive decline would be the loss of synapses, neurons, neurochemical inputs and neuronal networks (Honig und Rosenberg 2000). The large variation in cognitive decline implies that many individuals experience strong declines in cognitive functioning, often related to poor health. Fillit et al. (2002) suggested that many individuals have a high functional reserve and therefore the potential to keep learning and adapting in spite of age-related declines in health and mental capacities (Baltes and Baltes 1990). Scarmeas and Stern (2003) developed this view with the concept of cognitive reserve, the notion that innate intelligence or life experience as evinced by educational or occupational attainment creates a cognitive reserve that to some extent counteracts the cognitive decline associated with normal ageing. Hence, as age development is similar for those with high and low abilities, those with higher initial ability levels may simply have ‘more left’—a greater cognitive reserve (Baltes and Mayer 1999; Park, Nisbett Scarmeas and Stern (2003) explored what constituted cognitive reserve and proposed that there are both active and passive components. Active components include the experience acquired from a high level of education, from complex occupations that require continuing education and sustained intellectual involvement. Passive components are the brain structures (synaptic density and number of neurons) that are associated with an enhanced capacity to process information, retrieve memories and solve problems. Recent studies have tried to identify the parameters that contribute to the development of cognitive reserve and influence the cognitive performance of elderly people. Epidemiological studies have established low educational attainment and low occupational status as important risk factors for reduced cognitive functioning and Alzheimer’s disease (Launer et al. 1999; Cullum et al. 2000). A significant effect of education on cognitive ageing was reported by Le Carret et al. (2003) – they found that education protected psychological performance in late life and related this to occupational complexity and the acquisition of a lifelong ability to sustain attention and conceptionalise problems. Bennett et al. (2003) found that (more) education modified the deleterious effect of senile plaque density on cognitive performance. Similarly, lower childhood intelligence (Whalley et al. 2000; Richards et al. 2004) and lower linguistic ability in early life (Snowdon et al. 1996) appear to be a reliable proxy for lower cognitive reserves. Moreover, cognitive training is frequently found to improve cognitive functioning among elderly persons (Schaie and Willis 1986; Ball et al. 2002). Katzman (1993) suggested that educational courses can increase the synaptic density in the neocortical association cortex and therefore delay the onset of dementia by up to five years. A positive association between cognition and participation in intellectual, social and physical activities has been reported by several studies. Low-skilled occupations have been identified as risk factors for age-related cognitive decline (Capurso et al. 2000). On the other hand, individuals who are/were involved in complex work, with freedom to decide how to organise their working day, could be expected to experience less cognitive decline (Schooler, Mulatu and Oates 1999). Salokangas and Joukamaa (1991), Bosse et al. (1987) and Dave, Rashad and Spasojevic (2006) found that working longer associated with better cognitive functioning, but because those who experience health impairments retire early (McGarry 2004; Belgrave, Haug and Gomez-Bellenge 1987), it is uncertain to what extent later retirement actually improves health levels. Moreover, a follow-up study by Sugisawa et al. (1997) found that cognitive functions among those who retired early did not differ significantly from their age peers in work, while Mein et al. (2003) found that among British civil servants in high employment grades, an extended career actually worsened the cognitive functions relative to those who had retired. Adam et al. (2006) studied the relationship between cognitive performance and occupational activities, defined in a broad sense that included professional, leisure, physical and other activities. Their results confirmed the positive impact of occupational activities on the cognitive functioning of older people. Several studies have found that a more active lifestyle is protective of late-life cognitive function (Elwood et al. 1999; Dik et al. 2003; Newson and Kemps 2005), consistent with a report that cognitive function in mid-life is associated with greater physical activity in childhood (Richards et al. 2003). Leisure pursuits are often chosen because they require mental effort and are cognitively stimulating. In a study of a religious order (Wilson et al. 2002), longitudinal data were collected from 801 elderly Catholic nuns, priests and brothers without dementia. On recruitment, their cognitive activities were rated and subsequently shown to be associated with retention of cognitive function and reduced risk of dementia after controlling for age, sex and education. The effect sizes in the sub-analysis of cognitive ageing were sufficient to suggest that continued demanding cognitive activity in later life might Leisure activities, irrespective of the extent of cognitive effort involved, surveyed in a non-demented general population sample were also found to have a cumulative effect on the risk of incident dementia (Scarmeas et al. 2001). In the British 1946 cohort study (Richards, Hardy and Wadsworth 2003), leisure activities were associated with better cognitive performance at age 43 years and physical exercise at age 36 years was linked to a significantly slower rate of memory decline from age 43 to 53 years. In a Swedish twin study, Crowe et al. (2003) compared leisure activities between same-sex twin pairs discordant for dementia. Factor analyses of activity reports obtained 20 years earlier identified three activity factors: intellectual/cultural, self-improvement and domestic. The authors concluded that greater participation in intellectual-cultural leisure activities was associated with a lower risk of Alzheimer’s disease in women, but not men. Studies of physical activity find that regular exercise improves the working memory function among older men (James and Coyle 1998; Other risk factors have also been shown to affect cognitive performance among older adults. In a follow-up of Irish smokers and non-smokers, where initial intelligence levels were controlled for, a negative effect of smoking was found (Deary et al. 2003). Excessive alcohol consumption is related to higher morbidity and mortality, but moderate consumption may be weakly positively related to longevity and mental functioning at older ages (Bond et al. 2001; McDougall, Becker and Areheart 2006). Obesity has been found to have negative effects on cognitive performance, net of education, occupation, cigarette smoking, alcohol consumption, total cholesterol and a diagnosis of type II diabetes (Elias et al. 2003). Living arrangements are another factor that might influence cognition, because social isolation is related to more rapid decline in cognitive abilities (Wilson et al. 2007). In more developed countries, the percentage of older people living alone generally rose rapidly between 1960 and the late 1970s; in some North American and European countries the trend continued through the 1990s, but in others it slowed or halted around 1980 (Tomassini et al. 2004; United Nations Organization 2007). In a study of 550 Scots whose IQ was tested in 1932 and retested in 1999-2001, Gow et al. (2005) found that those living with more people in later life, and thus experiencing less loneliness, had higher cognitive performance. Loneliness accounted for three per cent of the variance in later-life cognition (once prior abilities and sex were controlled for), such that those experiencing increased levels of loneliness displayed poorer cognitive performance in later life. A lack of social interaction, as follows retirement for some people, sets off cognitive function problems (Cohen 2004; Cole, Schaninger and Harris 2002; Glass et al. 1999; Melchior et al. 2003). Cognitive decline as a result of reduced socialisation after retirement is most evident among men (Sugisawa et al. 1997). Maier and Klumb (2005) found that in Germany spending time with friends improved health and survival at older ages. Bassuk, Glass and Berkman (1999) used longitudinal United States data from 1982 to 1994 and found that those who had no social contacts suffered from more severe cognitive decline than the rest of the population. A weakening of the degree of activity is related to stronger decline relative to older individuals who manage to uphold their level of cognitive functioning (Mackinnon et al. 2003). Beland et al. (2005) found that participation in community activities mattered for women in a study of community-dwelling older people and that its effects were more significant at advanced ages. Barnes et al. (2004) showed that the level of social involvement and social network size were positively correlated with initial level of cognitive functions and associated with a reduced rate of cognitive decline. A high number of people in a person’s social network reduced the rate of decline by 39 per cent when compared to a low number, and high social involvement reduced decline by 91 per cent. These relationships remained after controlling for socio-economic status, cognitive activity, physical activity, depressive symptoms and chronic medical conditions. Zhang (2006) looked at cognitive impairment over two years, and after controlling for age, activities of daily living disability and rural residence found that women’s disadvantages in social networks and participation in leisure activities partially accounted for gender differentials in impairment. In a longitudinal study of 4,603 Taiwanese from 1989 to 2000, Glei et al. (2005) found that older people who participated in one or two social activities failed 13 per cent fewer cognitive tasks than those with no social activities; while those who engaged in three or more activities failed 33 per cent The findings for the effect of social involvement on cognition are nevertheless contradictory. McGue and Christensen (2007) found in a study of Danish twins that social activity was significantly and moderately heritable, raising the possibility that late-life cognition functioning might reflect selection processes. Aside from this, social activity did not predict changes in functioning, and in monozygotic twins discordant for their levels of social activity, the more socially-active twin was not any less susceptible to age decreases in physical and cognitive functioning and increases in depression symptoms. To summarise, these findings on cognitive reserve may have important implications for the role of continued education, social involvement and structure of retirement at older ages. These factors may indeed help to keep up cognitive abilities at older ages, thus increasing the feasibility and practicability of increasing labour-force participation at higher ages. This literature review has revealed that numerous studies have identified factors that contribute to the development of cognitive reserve and to reduced cognitive decline with increasing age. If this is the case, the impact should be the same in all countries, or at least the sign of the effect should be the same. Using large-scale samples from 12 different countries, we proceed to test the hypothesis that the association between cognition on the one hand and social involvement and behavioural risks on the other hand is the same in each country. Data, method and variables
The empirical analysis is based on data from the Survey of Health, Ageing and Retirement in Europe (SHARE), the overall aim of which is to increase understanding of ageing processes and their implications in Europe. SHARE includes detailed cross-national information, among other things on health, well-being, economic circumstances and social networks for 11 European countries: Austria, Belgium, Denmark, France, Germany, Greece, Italy, The Netherlands, Sweden, Switzerland and Spain, and Israel. The data were collected between 2004 and 2006. SHARE covers the non-institutional population aged 50 or more years. Since the spouses of the respondents were also interviewed, some were younger than 50. Release 2.0.1 of the data was for 31,115 individuals in 21,176 households. The weighted average response rate was 61.6 per cent (Börsch-Supan and Jürges 2005). In order to exclude greater declines in cognitive functioning as a result of poor health, the analysis was restricted to ‘healthy’ respondents aged 50-79 years, and we excluded those who reported a stroke or cerebral vascular disease, Parkinson’s disease or cancer. Anti-cancer drugs decrease cognitive ability levels (Falleti et al. 2006; Wincour et al. 2006), and Parkinson’s disease (Norman et al. 2002; Rasquin et al. 2004), stroke and cerebral vascular disease may severely reduce cognitive functioning (Schatz and Buzan 2006; Schmidt et al. 1993). We also excluded respondents who were taking drugs for anxiety or depression or who had been treated in a mental hospital or psychiatric ward. These selection criteria are similar to those of Adam et al. (2006), but whereas that team excluded only people with brain cancer, we excluded all persons diagnosed with any kind of cancer, because cancer medication is very likely to affect cognitive functioning. Missing or unreliable data for one of the variables retained in the analysis was another criterion for exclusion. The final analysis sample had 22,949 people (10,902 men and 12,047 women), with a mean age for men of 62 We used the ‘stochastic frontier approach’ for the multivariate analysis, which emanates from econometric studies of production functions. It will be helpful to many readers to begin with a short account of the method. There are two ways to estimate a fully efficient production function: (1) Data Envelopment Analysis (DEA), a non-parametric technique that assumes all deviations from the efficient frontier to be a realisation of inefficiency, and (2) Stochastic Frontier Analysis (SFA), a parametric technique which assumes that deviations from the efficient frontier can be either a realisation of inefficiency or a random shock. Aigner, Lovell and Schmidt (1977) and Meeusen and van den Broeck (1977) simultaneously introduced stochastic production frontier models. Their models allow for technical inefficiency but also acknowledge the fact that random shocks outside the control of producers can effect output. The great virtue of stochastic production frontier models is that the impact of shocks on output can, at least in principle, be separated from the influence of variation in technical The application of this terminology to the association between age and cognitive functioning implies that there a stochastic frontier function represents an ‘optimal’ curve (or age relationship) depending on various factors. The basic assumption is that age and educational level are the main explanatory factors of an individual’s cognitive functions. Therefore, the main ‘input factors’ or predictors for cognition are age and education. Not all individuals attain the optimal cognitive abilities for their age and educational level, however, for some are ‘inefficient’ in that their cognitive functioning is poorer than the optimal value. Moreover, we also consider measurement errors (statistical noise and random shocks) such as the daily constitution of a person. Adam et al. (2006) studied the relationship between cognitive performances and occupational activities using the stochastic frontier approach. They assumed age to be the driving factor (input) and the cognitive test score to be the output. We follow their approach but have specified a different model, and we have run the models Let us consider a production function for the cognitive functioning of an individual i: q = f (x ; β ) (1) where x is a vector of inputs (e.g. age and education), q is the output (e.g. cognitive test score such as ‘number of words recalled’), and β is a [k × ] estimated. We can think of efficiency being measured as ς multiplied by a theoretical norm ς = , individuals are fully efficient and ‘produce’ or recall the highest number of words they can (according to their age and educational level). In this case, their cognitive performance lies exactly on the optimal or frontier curve f (x ;β ) . If ς < 1 then individuals are not fully efficient, their cognitive performance is below the optimal curve. Figure 1 graphically represents the mathematical reasoning. Imagine individual A who is ‘fully efficient’ according to his/her age and educational level. His/her cognitive performance will lie on the optimal or frontier curve f (x ;β ) . Then imagine individual B who is not ‘fully efficient’. His/her cognitive performance will lie below the curve. Put differently, in the stochastic frontier conception, the distance to the optimal or frontier curve is modelled as a function of various explanatory factors. Adding a two-sided error term (Aigner, Lovell and q = f (x ; β )ς exp(v ) (3) ln q = ln f x ; β + ln ς + v (4) ln q = ln f x ; β + v u (5) , where v is the two-sided measurement error (random factors like the daily constitution of a person), and u is the one-sided technical inefficiency. The last is a key term in the frontier analysis method, for it corresponds to the distance to best practice as represented by the stochastic frontier ln( f (x ; β + v . Hence u requires an assumption about the distribution of u . For this analysis, we assumed for the inefficiency component a truncated-normal distribution u ~ iidN + ( non-negative disturbance was specified to be half-normally distributed with u ~ N + ( The estimated coefficients slightly differed but remained stable and comparable to the truncated-normally distributed inefficiency. The inefficiency term can be modelled as a function of other covariates. This idea was first introduced by Battese and Ceolli (1995).1 According to their specification, we modelled the inefficiency term u as u = Z δ where Z is a set of variables thought to influence inefficiency. The applied software provided an extension to the truncated normal model by allowing the mean of the inefficiency term to be modelled as a linear function of a set of covariates. Summing up, the mathematical model applied in the current paper is: where q represents the cognitive performance measured by the number of words recalled, x represents age, the square of age, and educational level, and Zi incorporates the measures of social participation, behavioural risks, economic situation and chronic diseases. The analysis software estimates the coefficients β (effect of age and education) as well asδ (effect of social participation and control variables). SHARE includes five different measures for cognitive functions: orientation, memory, verbal fluency, numeracy and recall. Orientation for time (date, month, year and day of the week) is a basic cognitive functioning indicator, and was not included in the analysis because it shows little variation by age (and is most appropriate for detecting very severe cognitive deficits). Memory indicates the number of words the interviewee can recall from a list of 10 items: butter, arm, letter, queen, ticket, grass, corner, stone, book, stick. Recall is the number of words from this list that the interviewee can recall after a certain delay—dependent on the time to answer another seven questions, but generally about five minutes. The scales for memory and recall both range from ‘0’ to ‘10’. Verbal fluency is the number of different animals that the interviewee can name within one minute, with the values ranging from ‘0’ to ‘80’ in the current sample. Numeracy measures the performance in calculating percentages.2 The respondents achieved scores from ‘1’ to ‘5’—the higher the score, the better the These measures of cognitive functioning are an assessment more of fluid than crystallised intelligence. A measure of crystallised intelligence would not involve any processing of new information, only recall or the performance of learned information and skills. A vocabulary test or a general knowledge test would be more appropriate. Fluency is commonly used as a measure of the efficiency of the central executive of working memory, since it uses the ability to sustain attention on a given task (goal) and to thwart intrusions. The variables memory and recall involve a timing aspect and a processing speed component. We report briefly the descriptive evidence from SHARE on the decline with age of the four measures memory, recall, verbal fluency and numeracy, and then concentrates on recall, as verbal skills might remain unchanged across the life cycle (Schwartzman et al. 1987). For all four dimensions, the decline with age was almost linear, which allows the application of linear regression. The mean number of words remembered declined from 5.5 words at age 50 years to 4.0 words at age 80, and the mean number of words recalled dropped from 4.0 to 2.0. Respondents aged 50 years named on average 21 animals, while those aged 80 named about 15 animals. Finally, the numerical ability score decreased from 3.8 to 3.0. Using standardised scores for memory, recall, verbal fluency and numeracy our results clearly demonstrate that memory and recall decreased more strongly than verbal fluency and numeracy (for more details see Engelhardt et al. 2008). Since the decline of cognitive functioning was most pronounced for memory and recall, further analysis concentrated on those two aspects of cognitive ability. The decline of the standardised scores was almost identical for both and we chose to examine only recall. It might be argued that the number of words recalled reflects a ceiling effect (Rasmussen et al. 2001) since the value of recall cannot exceed 10, as only 10 words were read out and available for recall. A respondent able to remember more words was unable to show their superior cognitive ability. It was found that 97.8 per cent of the respondents recalled up to seven words, another 1.5 per cent eight, 0.5 per cent remembered nine and only 0.2 per cent recalled all the words. Therefore the distribution of recall scores indicates that the distribution was not distorted by a ceiling effect. We selected several indicators that are potential sources of plasticity of cognitive reserve, namely social participation and behavioural risks. The activities of social participation captured in SHARE include voluntary and charity work, care provided for sick or disabled adults, help provided to family, friends and neighbours, educational training, participation in a sports, social or other kind of club, participation in a religious organisation, and participation in a political or community organisation. The corresponding questions referred to activities undertaken within only the previous month and did not elicit how long a person had engaged in these activities. Additionally, SHARE collected information on frequency and on the motivation for taking part in the various activities. Our analysis does not consider those frequencies which are restricted to the preceding month only but might vary during a year. This restriction of activities to the last month before time of interview is certainly a limitation to the quality of our data. Thus, for instance, persons who have been involved in certain activities for many years except for the preceding month would not be Additionally, the following behavioural risks were included in the analyses: being employed, carrying out moderate or vigorous physical activities, being overweight or obese, as well as smoking and drinking habits. If respondents said they engaged in vigorous activity (such as sports, heavy housework or a job that involves physical labour) at least one to three times a month, then we coded them as engaged in vigorous activities. If a respondent answered ‘less than once a month’, he/she was coded as not being engaged in vigorous activities. The same definition was applied for moderate activities: persons who engaged in activities that require a low or moderate level of energy (such as gardening, cleaning the car, or doing a walk) a least one to three times a month were categorised as being engaged in moderate activities. Persons were coded as overweight or obese if their body mass index (BMI) was greater than 25. They were coded as smoking if they had ever smoked cigarettes, cigars, cigarillos or pipes daily for at least one year, and as drinking if they had more than two glasses of any alcohol almost every day of five to six days a week during the last six months. Alternatively, we distinguished people who never smoked, former smokers and current Moreover, we controlled for economic situation and health—specifically, for chronic diseases. As an economic indicator, a measure generated at the household level and adjusted for purchasing power parity (ppp) was included, which is especially appropriate for comparisons of countries with different levels of income. The ppp-adjusted total gross income (i.e. the nominal gross income at the household level divided by the purchasing power parity) was included as a control to quantify the association between economic wealth and cognitive ability. In order to be able to distinguish countries with different income levels, each country’s quartiles of ppp-adjusted total gross income were calculated. Imputations for Israel were not available, so Israel was not included in the final pooled model, but only at the country level, where the final model excluding the income variable was estimated. In order to control for various chronic diseases, a three-level-variable was included that distinguished: (1) no chronic diseases, (2) mild chronic diseases (i.e. high blood pressure, high blood cholesterol, diabetes, asthma, osteoporosis, stomach, duodenal or peptic ulcer, cataracts or hip fracture), and (3) severe chronic diseases (heart attack and chronic lung disease). These categories of ill health might affect cognitive performance and central executive function. Age and education were input factors for the stochastic frontier function. Age was measured in years. The educational level of each respondent was measured by the International Standard Classification of Education (ISCED-97) of the amount received (United Nations Educational, Scientific and Cultural Organization 1997). The ISCED-97 classification has seven levels (0 to 6), ranging from pre-primary level of education (e.g. kindergarten) to the second stage of tertiary education (Ph.D.). We recoded the ISCED codes into four broader education levels: ‘low’ (pre-primary education, ISCED 0 and 1), ‘medium’ (lower secondary education, ISCED 2), ‘high’ (upper secondary or post-secondary non tertiary education, ISCED 3 and 4) and ‘very high’ (first and second stage of tertiary The descriptive results for number of words recalled clearly indicate a decline of cognitive functioning with increasing age (see Engelhardt et al. 2008). To see whether the association between age and recall was similar in all countries, the mean numbers of words recalled for all countries were plotted separately. Figure 2 depicts the decline with age and shows that the decline was observed in all countries but that the level at age 50 years and the magnitude of the decline varied. The recall score was especially low in Italy, Spain and Greece, which might reflect the relatively low educational level among older people in these countries. Figure 2 shows the greater variation with increasing age in cognitive performance in Austria, Denmark, Sweden and Italy, as well as generally large variation in Switzerland and Denmark. The larger variation is partly explained by the small number of respondents in the corresponding age groups and countries. For example, the Swiss sample was the smallest with 713 respondents, followed by Denmark with 1,171. The country with the largest analysed sample was Belgium, with 2,713 men and women aged 50-79 years. To estimate the basic stochastic frontier function for the variable recall, at the first step we included age-squared and the level of education. The estimated coefficients of this first model (Model 1) are shown in Table 1. Both age and education had a significant effect on the frontier function. As expected, education was an important factor for cognitive performance among the aged. The estimated coefficients were highly significant and indicated that the better the cognitive functioning, the higher the educational level. Summing up, the cognitive reserve frontier estimated as a function of age and educational level can be considered as a good benchmark with respect to which individual cognitive performance can be assessed. The one-sided test for the presence of an inefficiency term detected a statistically significant effect, so inefficiency was modelled as a function of behavioural risks, social participation and control variables for economic circumstances and health, as described above. Model 2 of Table 1 includes a relative income measure and chronic diseases as well as the following four aspects of behavioural risks: physical activities, BMI, smoking and drinking. The additionally included coefficients for relative economic situation and chronic diseases as well as those for behavioural risks were significant. It has to be stressed that estimated negative coefficients can be interpreted as the actual cognitive performance being closer to the stochastic frontier and therefore indicating a better cognitive performance. Conversely, positive coefficients indicate a greater distance to the optimal curve, i.e. to the best practice curve, and thus indicate inferior cognitive performance. Contrary to the notation in regression models, the coefficients of the factors explaining the distance to the optimal curve have different signs. This is because the term Z δ is subtracted in Equation 6. Income was significantly associated with cognitive functioning: the higher the income quartile of a respondent, the better their cognitive ability and the lower the distance to the optimal performance given age and education. As described earlier, the quartiles refer to the ppp-adjusted total gross income within a country and not to quartiles for the total sample of 12 countries. Chronic diseases, especially severe chronic disease were also significantly correlated with lower cognitive performance. Physical activities were associated with better cognitive functioning as individuals who kept up some moderate or even vigorous activities were also closer to the frontier function compared to those with no physical activities. The estimated coefficients for a BMI of 25 or higher and for drinking more than the recommended levels of alcohol (i.e. drinking more than two glasses of any alcohol almost every day or five to six days a week) indicated that being overweight or obese as well as elevated alcohol consumption increased the distance to the frontier function of optimal cognitive functioning. Surprisingly, smoking had a slight positive and even highly significant effect on cognition. This result may be due to selection bias in the cross-sectional dataset. Selection could be caused by an increasingly higher mortality of smokers with age and a positive selection of the smokers in the survey with respect to cognitive ability. With the additional control of social involvement (Model 3), the effect of smoking turned in the expected direction. A different measurement for smoking that distinguished between: (1) people who never smoked over a period of one year at least one cigarette, cigar or pipe, (2) former smokers, and (3) current Finally, different dimensions of social involvement were added. More exactly, we included indicators for being employed, attending educational courses, doing voluntary or charity work, providing help to family, friends or neighbours, participating in a sports, social or other club, participating in a religious organisation and participating in a political or community organisation. The estimated coefficients of the seven dimensions of social involvement were significantly negative and therefore indicated that individuals engaged in social activities were closer to the optimal frontier curve as compared to those not engaged (Table 1, Model 3). In addition, the estimates for the standard deviations of the two error σ indicated that most of the variation was through technical inefficiency u , not measurement error v , as the corresponding standard deviation 2 0 04 . In other words, most of the variation was through systematic inefficiency and not due to measurement errors. In order to detect possible gender differences in the association between behavioural risks as well as social involvement and the variable recall, models for men and women were run separately (Table 2). For both sexes, all coefficients for the social involvement indicators were negative, thus indicating that social involvement is associated with better cognitive performance. Except for being employed and doing voluntary work, the association between social involvement and cognition was stronger among women than among men, the corresponding coefficients being larger in absolute value. Turning to behavioural risks, the estimates indicate that the association between cognitive ability and overweight was stronger among women, whereas the association with excessive consumption of alcohol was more pronounced among men. Moreover, the surprisingly positive association between smoking and cognitive ability was partly neutralised by the findings that it applied only for women. For men, the association between smoking or having smoked over a period of at least one year at least one cigarette, cigar or pipe daily on the one hand and the number of words recalled on the other, was negative in the sense that smoking associated with worse cognitive performance. The estimated coefficient was positive, indicating a greater distance to the optimal frontier for smokers. Interestingly, smoking decreased the distance to the frontier Turning to the control variables for health, mild chronic diseases seem to have a stronger impact among women than men. The diseases included into this category are: high blood pressure, high blood cholesterol, diabetes, asthma, osteoporosis, stomach, duodenal or peptic ulcer, cataracts or hip fracture. The descriptive results show that mild chronic diseases were more frequent among women than men (55 compared to 45 per cent). Severe chronic diseases (heart attack and chronic lung disease) were more frequent among men than women (16 versus 11 per cent) and to a higher degree associated with low cognitive performance. The association between income and cognitive performance was evident among men with a ppp-adjusted total gross income above the median. The stepwise inclusion of the variables showed that part of the effect of income was absorbed by social involvement among men, indicating an interaction between income, social involvement and cognition. Among women, the association between income and cognition was less pronounced in size and direction. Finally, the stochastic frontier approach was run for all countries separately. Unfortunately, the models did not converge for Denmark and Sweden. Nevertheless, the graphs representing the mean number of words recalled (Figure 1) show for Denmark and Sweden a pattern similar to the other countries. Despite the different signs of the coefficients for age and education, we found a decline in cognitive performance with age in all countries. The estimated effects were significant for all countries. Moreover, we found the expected higher cognitive performance with higher educational levels, except in Israel and Switzerland for people in the ISCED 3-4 group. In all countries these coefficients are highly significant. Concerning the potential factors affecting individuals’ sub-optimal performance, or distances to the estimated frontier, we found for all countries with the exception of Israel significant negative effects for being employed. Thus, in almost all countries, being employed reduced the individual distance from the best possible performance given a certain age and educational level. Also the exercise of physical activities, whether vigorously or moderately, had a positive effect on cognitive reserve, again with Israel being the only exception. As regards being overweight or obese, smoking and drinking, the country-specific results were generally consistent with the general expectation. In Austria, a high BMI appeared significantly to favour cognitive performance. For smokers, cognitive performance seemed to be closer to the optimal level in Belgium and Italy, while it appeared significantly In accordance with our expectations, the employed and those with further training showed cognitive performances closer to the optimal level than those who were not employed (with the exception of Israel for employment, where we did not find a significant effect). The other forms of social involvement had more disparate effects on cognitive performance. Voluntary or charity work did not bring about the expected results in Austria, Greece and Switzerland. Giving help to family, friends or neighbours had no positive effect on cognitive reserve in Spain. Taking part in a sports or social club did not seem to help in Spain or Switzerland, and being active in a religious organisation associated with significantly sub- optimal performance in Austria, Spain and Switzerland. Finally, being active in a political organisation increased the distance to the cognitive frontier in Germany, Italy and The Netherlands. Thus although we obtained the expected signs for the pooled sample, the country-specific results differed and need further consideration. Discussion
Emerging research is increasing our understanding of the potentially modifiable factors associated with cognitive decline in later life, and several interventions for preventing cognitive decline and dementia in old age are being evaluated: early detection, lifestyle factors, management of medical morbidities as well as pharmaceutical approaches (Filit et al. 2002). The idea of lifestyle management is to promote brain reserve through lifelong learning, social involvement and occupational complexity. Social detachment is an independent risk factor for cognitive decline among cognitively intact older people (Bassuk, Glass and Berkman 1999). Berkman et al. (2000) suggested that social involvement most likely challenges individuals to communicate and participate in exchanges that stimulate cognitive capacities. Maintenance of social involvement and avoidance of social isolation may be important in maintaining cognitive vitality in old age. In this paper we have used a parametric stochastic frontier approach to estimate the impact of social involvement as well as behavioural risk factors on cognitive reserve and vitality in ageing among persons aged 50 or more years in 11 European countries and Israel. For this purpose we used the individual data collected during the first wave of SHARE in 2004. Using large-scale samples, we tested the hypothesis that the association between cognitive ability on the one hand and social involvement and behavioural risks on the other hand is the same in different countries. Using comparable data for the 12 different countries, the results support this hypothesis. In this respect, our comparative study adds significantly to In the pooled sample, the results clearly show that individuals’ cognitive reserve is driven mainly by age and by educational level. At the same time, all different forms of social involvement increase cognitive functioning, in particular the continuation of occupational activities. Moreover, behavioural risks such as physical inactivity, being overweight or obese, smoking or drinking clearly do not favour cognitive performances. The country-specific results, however, vary for single countries with respect to signs for most indicators of social involvement and behavioural risks. Cultural differences are clearly important in any international and cross-cultural analysis. Although cross-cultural surveys allow comparative ageing research, problems of comparability of behavioural and psychological phenomena may arise (Tesch-Römer and von Kondratowitz 2006). People from different cultural backgrounds might understand and interpret terms and concepts differently, which might cause variation across the participating countries (Bardage et al. 2005). The current study takes into account various aspects and therefore the differences in cognitive functioning might be due to methodological or cultural biases, but of course they could also indicate true differences between countries. In the context of cross-cultural analysis, Börsch-Supan, Hank and Jürges (2005), and in more detail Jürges (2007), have addressed the role of reporting styles, their impact on cross-country differences in self-assessed health and comparability of health measures. Using a standardised health index, they found that Scandinavians (Danes and Swedes in particular) have a more positive attitude towards their health and tend to systematically overrate their health as compared to the SHARE average. In the current study, the explanatory variable (cognition) but also the control variables (behavioural risks, health) might also be distorted by cultural biases. Tesch-Römer and Kondratowitz (2006) referred to the translation problem and the possibility of transferability of meaning for cross-cultural analyses. Our study focused on cognitive functioning, more exactly on the number of words recalled out of a list of the following ten items: butter, arm, letter, queen, ticket, grass, corner, stone, book, stick. Although these items occur in everyday life, they might be perceived differently in the various countries. It is conceivable that the connotation, occurrence and frequencies, and the associations among these words vary by country (and language). For example, the word ‘queen’ might have distinctive connotations in countries like The Netherlands, Spain and Sweden, where monarchs still have constitutional functions and living exemplars. The association with a living person might make it easier to remember the word ‘queen’ in the cognitive function test. Another example is hat in Spain butter is hardly ever used and therefore the word might be more difficult to recall. Then again, it might have been that when the SHARE data were collected, the price of butter was in the news more in some countries than others, and therefore the word ‘butter’ might be more easily remembered in those countries. Ideally, test conditions should be identical at each session at the same time of day in the same room (Rasmussen et al. 2001), but in an international project involving over 30.000 respondents, such conditions cannot be achieved. There may also be variation at the interviewer level, as through different accents, reading tempos and audibility. Although interviewers had strict instructions in SHARE, total exclusion of personal traits and characteristics was impossible. To sum up, distortions and biases may occur at the level of the respondent, of the interviewer and of the country. The current study might include cohort effects, especially with regard to education. Older cohorts might have lower scores in cognition due to a higher percentage of persons with low education. The increasing access to higher education during recent decades might have resulted in better cognitive performance of younger cohorts. Therefore, it has to be underlined that the study is based on cross-sectional data and not on longitudinal data, the association between age and cognitive performance might partly be explained by cohort effects and the decrease with age might be smaller compared to the current estimation. Given the cross-sectional framework of the study, we have to be careful with causal inferences. Thus we can not say whether socially more active persons have better cognitive performance or whether persons with better cognitive performance are socially more active. Longitudinal studies, however, clearly indicate that the relationship between social participation and cognitive capabilities works in the former way. SHARE is a longitudinal project and further waves will enable us to produce a causal statement regarding social participation and cognitive ageing. Further longitudinal analysis may also help us to disentangle some of the Despite these caveats, the results of the presented analyses clearly indicate that increased variation of cognitive decline at older ages may not be an argument against encouraging older workers to remain longer in the workforce. Our results suggest that social involvement—in particular occupational activities—positively correlate with cognitive ability. Though we cannot discern any causality from the cross-sectional results, the findings encourage a focus on the underlying correlates of cognitive variability in old age. The variation of social involvement and behavioural risk factors will in the end determine the feasibility of more people working to older ages. These results so far indicate that all kinds of social involvement increase cognitive functions. It is in particular the continuation of occupational activities that illustrates the potential effect on personal cognitive functions of reforms trying to encourage aged workers to remain active in most European countries. Besides, behavioural risks such as physical inactivity, obesity, smoking or drinking are clearly detrimental to cognitive performance. A tentative conclusion of our study is that investing in continued education and fostering social involvement at older ages may indeed help to keep up cognitive abilities at older ages, thus increasing the feasibility and practicability of increasing labour force participation at higher Acknowledgements
SHARE data collection was funded primarily by the European Commission through the 5th Framework Research and Development Programme (project QLK6-CT-2001-00360 in the thematic programme Quality of Life). Additional funding came from the United States National Institute on Aging (NIA) (U01 AG09740-13S2, P01 AG005842, P01 AG08291, P30 AG12815, Y1-AG-4553-01 and OGHA 04-064). Data collection in Austria (through the Austrian Science Foundation, FWF, grant number P-15422), Belgium (through the Belgian Science Policy Office) and Switzerland (through BBW/OFES/UFES) was nationally funded. The SHARE data collection in Israel was funded by NIA (R21 AG025169), by the German- Israeli Foundation for Scientific Research and Development (G.I.F) and by the National Insurance Institute of Israel. Further support by the European Commission through the 6th Framework Programme (projects SHARE-I3, RII-CT-2006-062193 and COMPARE, 028857) In the STATA analysis software (see, this option can only be used with the truncated normal which can have a zero mean. A comparison between the basic model (with age and education only) for half-normally distributed and truncated-normally distributed technical inefficiency reveals almost identical results. Therefore the results are stable and do not depend on a specific distribution of the inefficiency. Moreover, in the model with half-normally distributed technical inefficiency we also included heteroscedasticity—for the measurement error v as well as for the technical inefficiency component—based on the log of age in years which implies different variance over age. Both for the error term and for technical inefficiency we found heteroscedasticity in the data, therefore the error term and technical inefficiency have no constant variance and cognitive functioning displays a greater variability with increasing age. In the case of a truncated-normal distribution, Stata does not allow the heteroscedasticity to be specified. The exact wording of the four questions was: (1) ‘If the chance of getting a disease is 10 per cent, how many people out of 1,000 (one thousand) would be expected to get the disease?’ (2) ‘In a sale, a shop is selling all items at half price. Before the sale, a sofa cost €300. How much will it cost in the sale?’ (3) ‘A second-hand dealer is selling a car for €6,000. This is two-thirds of what it costs new. What is the cost of a new car? (4) ‘Let’s say you have €2,000 in a savings account. The account earns 10 per cent interest each year. How much would you have in your account at the end of References
Adam, S., Bay, C., Bonsang, E., Germain, S. and Perelman, S. 2006. Occupational Activities and Cognitive Reserve: A Frontier Approach Applied to the Survey of Health, Ageing and Retirement in Europe (SHARE). Centre de Recherche en Economie Publique et de la Population [Research Centre on Public and Population Economics], Working Paper 0605, HEC-Management School, University of Liège, Belgium. Available online at [Accessed 26 August 2009]. Aigner, D., Lovell K. and Schmidt, P. 1977. Formulation and estimation of stochastic frontier production function models. Journal of Econometrics, 6, 1, 21-37.
Ball, K., Berch, D.B., Helmers, K.F., Jobe, J.B., Leveck, M.D., Marsiske, M., Morris, J.N., Rebok, G.W., Smith, D.M., Tennstedt, S.L., Unverzagt, F.W. and Willis, S.L. 2002. Effects of cognitive training interventions with older adults. Journal of the American Medical Association, 288, 18, 2271-81.
Baltes, P.B. and Baltes, M.M. 1990. Psychological perspectives on successful aging: the model of selective optimization with compensation. In Baltes, P.B. and Baltes, M.M. (eds), Successful Aging: Perspectives from the Behavioral Sciences. Cambridge Baltes, P. B. and Mayer, K. U. (eds) 1999. The Berlin Aging Study: Aging from 70 to 100. Bardage, C., Pluijm, S.M.F., Pedersen, N.L., Deeg, D.J.H., Jylhä, M., Noale, M., Blumstein, T. and Otero, A. 2005. Self-rated health among older adults: a cross-national comparison. European Journal of Ageing, 2, 2, 149-58.
Barnes, L.L., Mendes de Leon, C.F., Wilson, R.S., Bienias, J.L. and Evans, D.A. 2004. Social resources and cognitive decline in a population of older African Americans and whites. Neurology, 63, 12, 2322-26.
Bassuk, S., Glass, T.A. and Berkman, L.F. 1999. Social disengagement and incident cognitive decline in community-dwelling elderly persons. Annals of Internal Medicine, 131, 3, 165-73.
Battese, G.E. and Coelli, T.J. 1995. A model for technical inefficiency effects in a stochastic frontier production function for panel data. Empirical Economics, 20, 2, 325-32.
Beland, F., Zunzunegui, M.-V., Alvarado, B., Otero, A. and del Ser, T. 2005. Trajectories of cognitive decline and social relations. Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 60, 6, P320-30.
Belgrave, L.L., Haug, M.R. and Gomez-Bellenge, F.X. 1987. Gender and race differences in effects of health and pension on retirement before 65. Comprehensive Gerontology B, 1, 3, 109-17.
Bennett, D.A., Wilson, R.S., Schneider, J.A., Evans, D.A., Mendes de Leon, C.F, Arnold, S.E., Barnes, L.L. and Bienias, J.L. 2003. Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology, 60, 12, 1909-15.
Berkman, L.F., Glass, T., Brissette, I. and Seeman, T.E. 2000. From social integration to health: Durkheim in the new millennium. Social Science and Medicine, 51, 6, 843-57.
Blum, J.E., Jarvik, L.F. and Clark, E.T. 1970. Rate of change on selective tests of intelligence: a twenty-year longitudinal study of aging. Journal of Gerontology, 25, 3,
Börsch-Supan, A. and Jürges, H. (eds) 2005. The Survey of Health, Ageing and Retirement in Europe – Methodology. MEA Eigenverlag, Mannheim, Germany. Börsch-Supan, A., Hank, K. and Jürges, H. 2005. A new comprehensive and international view on ageing: introducing the Survey of Health, Ageing and Retirement in Europe. European Journal of Ageing 2, 4: 245-53.
Bond, G.E., Burr, R., McCurry, S.M., Borenstein Graves, A. and Larson, E.B. 2001. Alcohol, aging and cognitive performance in a cohort of Japanese Americans aged 65 and older: the Kame project. International Psychogeriatrics, 13, 2, 207-23.
Bosse, R., Aldwin, C.M., Levenson, M.R. and Ekerdt, D.J. 1987. Mental health differences among retirees and workers: findings from the Normative Aging Study. Psychology and Aging, 2, 4, 383-9.
Buber, I. 2007. SHARE Codebook. Release 2. Research Report 30a. Vienna Institute of Capurso, A., Panza, F., Solfrizzi, V., Capurso, C., Mastroianni, F. and Del Parigi, A. 2000. Age-related cognitive decline: evaluation and prevention strategy. Recenti Progressi in Medicina, 91, 3, 127-34.
Christensen, H., Mackinnon, A.J., Korten, A.E., Jorm, A.F., Henderson, A.S. and Jacomb, P. 1999. Dispersion in cognitive ability as a function of age: a longitudinal study of an elderly community sample. Aging, Neuropsychology and Cognition, 6, 3, 214-28.
Coffey, C.E., Wilkinson, W.E., Parashos, I.A., Soady, S.A., Sullivan, R.J., Patterson, L.J., Figiel, G.S., Webb, M.C., Spritzer, C.E. and Djang, W.T. 1992. Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging. Neurology, 42, 1, 527-36.
Cohen, S. 2004. Social relationships and health. American Psychologist, 59, 8, 676-84.
Cole, M.S., Schaninger, W.S. and Harris, S.G. 2002. The workplace social exchange network: a multilevel, conceptual examination. Group and Organizational Management, 27, 1, 142-67.
Crowe, M., Andel, R., Pedersen, N. L., Johansson, B. and Gatz, M. 2003. Does participation in leisure activities lead to reduced risk of Alzheimer’s disease? A prospective study of Swedish twins. Journal of Gerontology, Series B, Psychological Sciences and Social Sciences, 58, 5, P249-55
Cullum, S., Huppert, F.A., McGee, M., Dening, T., Ahmed, A., Paykel, E.S. and Brayne, C. 2000. Decline across different domains of cognitive function in normal ageing: results of a longitudinal population-based study using CAMCOG. International Journal of Geriatric Psychiatry, 15, 9, 853-62.
Dave, D., Rashad, I. and Spasojevic, J. 2006. The Effects of Retirement on Physical and Mental Health Outcomes. Working Paper 12123, National Bureau of Economic Research, Cambridge, Massachusetts. Deary, I.J., Pattie, A., Taylor, M.D., Whiteman, M.C., Starr, J.M. and Whalley, L.J. 2003. Smoking and cognitive change from age 11 to age 80. Journal of Neurology, Neurosurgery and Psychiatry, 74, 7, 1006-7.
Deary, I.J., Whalley, L.J., Lemmon, H., Crawford, J.R. and Starr, J.M. 2000. The stability of individual differences in mental ability from childhood to old age: follow-up of the 1932 Scottish mental survey. Intelligence, 28, 1, 49-55.
Dik, M.G., Deeg, D.J.H., Visser, M. and Jonker, C. 2003. Early life physical activity and cognition at old age. Journal of Clinical and Experimental Neuropsychology, 25, 5,
Dolton, P.J. and Vignoles, A.F. 2000. The pay-off to mathematics A-level. In Tikly, C. and Wolf, A. (eds), The Maths We Need Now. Institute of Education, London, 52-73. Dourleijn, E., Liefbroer, A.C. and Beets, G.C.N. 2002. Comparing the 1988 International Standard Classification of Education (ISCED) with retrospective information from educational histories. In Klijzing, E. and Corijn, M. (eds), Dynamics of Fertility and Partnership in Europe: Insights and Lessons from Comparative Research. Volume 2. United Nations Organization, New York, 157-72. Elias, M.F., Elias, P.K., Sullivan, L.M., Wolf, P.A. and D’Agostino, R.B. 2003. Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study. International Journal of Obesity, 27, 2, 260-8.
Elwood, P.C., Gallacher, J.E.J., Hopkinson, C.A., Pickering, J., Rabbitt, P., Stollery, B., Brayne, C., Huppert, F.A. and Bayer, A. 1999. Smoking, drinking and other life style factors and cognitive function in men in the Caerphilly cohort. Journal of Epidemiology and Community Health, 53, 1, 9-14.
Engelhardt, H., Buber, I., Skirbekk, V. and Prskawetz, A. 2008. Social Engagement, Behavioural Risks and Cognitive Functioning Among the Aged. European Demographic Research Paper 2008/1, Österreichische Akademie der Wissenschaften [Austrian Academy of Sciences], Vienna. Available online at [Accessed 26 August 2009]. Falleti, M., Sanfilippo, A., Maruff, P., Weih, L. and Phillips, K.-A. 2006. The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer: A meta-analysis of the current literature. Brain and Cognition, 59,
Fillit, H.M., Butler, R.N., O’Connell, A.W., Albert, M.S., Birren, J.E., Cotman, C.W., Greenough, W.T., Gold, P.E., Kramer, A.F., Kuller, L.H., Perls, T.T., Sahagan, B.G. and Tully, T. 2002. Achieving and maintaining cognitive vitality with aging. Mayo Clinic Proceedings, 77, 7, 681-96.
Glass, T.A., Mendes de Leon, C., Marottoli, R.A. and Berkman, L.F. 1999. Population-based study of social and productive activities as predictors of survival among elderly Americans. British Medical Journal, 319, 7208, 478-83.
Glei, D.A., Landau, D.A., Goldman, N., Chuang, Y., Rodríguez, G. and Weinstein, M. 2005. Participating in social activities helps preserve cognitive function: an analysis of a longitudinal, population-based study of the elderly. International Journal of Epidemiology, 34, 4, 864-71.
Gow, A., Pattie, A., Whiteman, M.C. and Deary, I.J. 2005. Social Support Networks, Loneliness and Cognitive Ageing. Poster presented at the British Psychological Society Quinquennial Conference, Manchester, UK, 30 March-2 April. Available online at [Accessed 10 September Grogger, J.T. and Eide, E. 1993. Changes in college skills and the rise in the college wage premium. Journal of Human Resources, 30, 2, 280-310.
Honig, L.S. and Rosenberg, R.N. 2000. Apoptosis and neurologic disease. American Journal of Medicine, 108, 4, 317-30.
Horn, J.L. and Cattell, R. 1966. Refinement and test of the theory of fluid and crystallized intelligence. Journal of Educational Psychology, 57, 5, 253-70.
Horn, J.L. and Cattell, R. 1967. Age differences in fluid and crystallized intelligence. Acta Psychologica, 26, 2, 107-29.
James, D. and Coyle, C. 1998. Physical exercise, IQ scores and working memory in older men. Education and Ageing, 13, 1, 37-48.
Jürges, H. 2007. True health vs. response styles: exploring cross-country differences in self- reported health. Health Economics, 16, 2, 163-78.
Katzman, R. 1993. Education and the prevalence of dementia and Alzheimer’s disease. Neurology, 43, 6, supplement 3, 13-20.
Launer, L.J., Andersen, K., Dewey, M.E., Letenneur, L., Ott, A., Amaducci, L.A., Brayne, C., Copeland, J.R., Dartigues, J.F., Kragh-Sorensen, P., Lobo, A., Martinez-Lage, J.M., Stijnen T. and Hofman, A. 1999. Rates and risk factors for dementia and Alzheimer’s disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology, 52, 1, 78-84.
Le Carret, N., Lafont, S., Mayo, W. and Fabrigoule, C. 2003. The effect of education on cognitive performances and its implication for the constitution of the cognitive reserve. Developmental Neuropsychology, 23, 3, 317-37.
Mackenzie, C.S., Smith, M.C., Hasher, L., Leach, L. and Behl, P. 2007. Cognitive functioning under stress: evidence from informal caregivers of palliative patients. Journal of Palliative Medicine, 10, 3, 749-58.
Mackinnon, A., Christensen, H., Hofer, S.M., Korten, A.E. and Jorm, A.F. 2003. Use it and still lose it? The association between activity and cognitive performance established using latent growth techniques in a community sample. Aging, Neuropsychology and Cognition, 10, 3, 215-29.
Maier, H. and Klumb, P.L. 2005. Social participation and survival at older ages: is the effect driven by activity content or context? European Journal of Ageing, 2, 1, 31-9.
Maitland, S.B., Intrieri, R.C., Schaie, W.K. and Willis, S.L. 2000. Gender differences and changes in cognitive abilities across the adult life span. Aging, Neuropsychology and Cognition, 7,1, 32-53.
McDougall, G.J., Becker, H. and Areheart, K.L. 2006. Older males, cognitive function and alcohol consumption. Issues in Mental Health Nursing, 27, 4, 337-53.
McEvoy, G. M. and Cascio, W. F. 1989. Cumulative evidence of the relationship between employee age and job performance. Journal of Applied Psychology, 74, 1, 11–7.
McGarry, K. 2004. Health and retirement: do changes in health affect retirement expectations? Journal of Human Resources, 39, 3, 624-48.
McGue, M. and Christensen, K. 2007. Social activity and healthy aging: a study of aging Danish twins. Twin Research and Human Genetics, 10, 2, 255-65.
Meeusen, W. and van den Broeck, J. 1977. Efficiency estimation from Cobb-Douglas production functions with composed error. International Economic Review, 18, 2,
Mein, G., Martikainen, P., Hemingway, H., Stansfeld, S. and Marmot, M. 2003. Is retirement good or bad for mental and physical health functioning? Whitehall II longitudinal study of civil servants. Journal of Epidemiology and Community Health, 57, 1, 46-9.
Melchior, M., Berkman, L.F., Niedhammer, I., Chea, M. and Goldberg, M. 2003. Social relations and self-reported health: a prospective analysis of the French Gazel cohort. Social Science and Medicine, 56, 8, 1817-30.
Meyer, J.S., Rauch, G.M., Crawford, K., Rauch, R.A., Konno, S., Akiyama, H., Terayama, Y. and Haque, A. 1999. Risk factors accelerating cerebral degenerative changes, cognitive decline and dementia. International Journal of Geriatric Psychiatry, 14,12,
Midanik, L.T., Soghikian, K., Ransom, L.J. and Tekawa, I.S. 1995. The effect of retirement on mental health and health behaviors: the Kaiser Permanente Retirement Study. Journals of Gerontology Series B, Psychological Sciences and Social Sciences, 50, 1,
Murnane, R.J., Willett, J.B. and Levy, F. 1995. The growing importance of cognitive skills in wage determination. Review of Economics and Statistics, 77, 2, 251-66.
Newson, R.S. and Kemps, E.B. 2005. General lifestyle activities as a predictor of current cognition and cognitive change. Journals of Gerontology: Psychological Sciences and Social Sciences, 60B, 3, 113-21.
Norman, S., Tröster, A.I., Fields, J.A. and Brooks, R. 2002. Effects of depression and Parkinson’s disease on cognitive functioning. Journal of Neuropsychiatry and Clinical Neurosciences, 14, 1, 31-6.
Park, D.C., Nisbett, R.E. and Hedden, T. 1999. Culture, cognition and aging. Journals of Gerontology: Psychological Sciences and Social Sciences, 54B, 2, 75-84.
Prskawetz, A., Mahlberg, B., Skirbekk, V., Freund, I., Winkler-Dworak, M., Lindh, T., Malmberg, B., Jans, A.-C., Nordström, O.S. and Andersson, F. 2005. The impact of population ageing on innovation and productivity growth in Europe. Report for Tender VT/2004/454, Forschungsbericht 28, Vienna Institute of Demography, Vienna. Prskawetz, A., Mahlberg, B. and Skirbekk, V. 2007. Firm productivity, workforce age and educational structure in Austrian industries in 2001. In Clark, R.L.C., Ogawa, N. and Mason, A. (eds), Population Aging, Intergenerational Transfers and the Macroeconomy. Edward Elgar, Cheltenham, UK, 38-66. Rasquin, S.J., Lodder, R., Ponds, I., Winkens, J., Jolles, J. and Verhey, F.R.J. 2004. Cognitive functioning after stroke: a one-year follow-up study. Dementia and Geriatric Cognitive Disorders, 18, 2, 138-44.
Rasmussen, L.S., Larsen, K., Houx, P., Skovgaard, L.T., Hanning, C.D., Moller, J.T. and the ISPOCD group 2001. The assessment of postoperative cognitive function. Acta Anaesthesiologica Scandinavica, 45, 3, 275-89.
Raz, N. 2004. The aging brain: structural changes and their implications for cognitive aging. In Dixon, R.A., Bäckman, L. and Nilsson, L.-G. (eds), New Frontiers in Cognitive Aging. Oxford University Press, Oxford, 115-33. Richards, M., Hardy, R. and Wadsworth, M.E. 2003. Does active leisure protect cognition? Evidence from a national birth cohort. Social Science and Medicine, 56, 4, 785-92.
Richards, M., Shipley, B., Fuhrer, R. and Wadsworth, M.E. 2004. Cognitive ability in childhood and cognitive decline in mid-life: longitudinal birth cohort study. British Medical Journal, 328, 7439, 552-7.
Salokangas, R.K. and Joukamaa, M. 1991. Physical and mental health changes in retirement age. Psychotherapy and Psychosomatics, 55, 2-4, 100-7.
Scarmeas, N., Levy, G., Tang, M.X., Manly, J. and Stern, Y. 2001. Influence of leisure activity on the incidence of Alzheimer’s disease. Neurology, 57, 12, 2236-42.
Scarmeas, N. and Stern, Y. 2003. Cognitive reserve and lifestyle. Journal of Clinical and Experimental Neuropsychology, 25, 5, 625-33.
Schaie, K.W. and Willis, S.L. 1986. Can decline in intellectual functioning be reversed? Developmental Psychology, 22, 2, 223-32.
Schaie, K.W. 1994. The course of adult intellectual development. American Psychologist, 49, 4, 304-13.
Schaie, K.W. 1996. Intellectual Development in Adulthood. The Seattle Longitudinal Study. Cambridge University Press, New York. Schatz, J. and Buzan, R. 2006. Decreased corpus callosum size in sickle cell disease: relationship with cerebral infarcts and cognitive functioning. Journal of the International Neuropsychological Society, 12, 1, 24-33.
Schmidt, F.L. and Hunter, J.E. 1998. The validity and utility of selection methods in personnel psychology: practical and theoretical implications of 85 years of research findings. Psychological Bulletin, 124, 2, 262-74.
Schmidt, R., Mechtler, L., Kinkel, P.R., Fazekas, F., Kinkel, W.R. and Freidl, W. 1993. Cognitive impairment after acute supratentorial stroke: a 6-month follow-up clinical and computed tomographic study. European Archives of Psychiatry and Clinical Neuroscience, 243, 1, 11-15.
Schooler, C., Mulatu, M.S. and Oates, G. 1999. The continuing effects of substantively complex work in the intellectual functioning of older workers. Psychology and Aging, 14, 3, 483-506.
Schwartzman, A.E., Gold, D., Andres, D., Arbuckle, T.Y. and Chaikelson, J. 1987. Stability of intelligence: a 40 year follow-up. Canadian Journal of Psychology, 41, 2, 244-56.
Skirbekk, V. 2008. Age and productivity capacity: descriptions, causes and policy options. Ageing Horizons (Oxford Institute of Ageing), 8, 4-12.
Snowdon, D.A., Kemper, S.J., Mortimer, J.A., Greiner, L.H., Wekstein, D.R. and Markesbery. W.R. 1996. Linguistic ability in early life and cognitive function and Alzheimer’s disease in later life. Journal of the American Medical Association, 275,
Stern, Y., Albert, S., Tang, M.X. and Tsai, W.Y. 1999. Rate of memory decline in AD is related to education and occupation: cognitive reserve? Neurology, 53, 9, 1942-7.
Sugisawa, A., Sugisawa, H., Nakatani, Y. and Shibata, H. 1997. Effect of retirement on mental health and social well-being among elderly Japanese. Nippon Koshu Eisei Zasshi, 44, 2, 123-30.
Tesch-Römer, C. and von Kondratowitz, H.J. 2006. Comparative ageing research: a flourishing field in need of theoretical cultivation. European Journal of Ageing, 3,3,
Tomassini C., Glaser, K., Wolf, D.A., Broese van Groenou, M.I. and Grundy, E. 2004. Living arrangements among older people: an overview of trends in Europe and the USA. Population Trends, 115, 24-34.
United Nations Organisation (UNO) 2007. World Population Prospects: The 2006 Revision. United Nations Educational, Scientific and Cultural Organization (UNESCO) 1997. International Standard Classification of Education (ISCED) 1997. UNESCO, Paris. Available online at Verhaegen, P. and Salthouse, T.A. 1997. Meta-analyses of age-cognition relations in adulthood: estimates of linear and nonlinear age effects and structural models. Psychological Bulletin, 122, 3, 231-49.
Vitaliano, P., Echeverria, D., Yi, J., Phillips, P.E.M., Young, H. and Siegler, I.C. 2005. Psychophysiological mediators of caregiver stress and differential cognitive decline. Psychology and Aging, 20, 3, 402-11.
Warr, P. 1994. Age and employment. In Triandis, H., Dunnette, M. and Hough, L. (eds), Handbook of Industrial and Organizational Psychology. Second edition, Consulting Psychologist Press, Thousand Oaks, California, 485–550. Wilson, R.S., Barnes, L.L., Mendes de Leon, C.F., Aggarwal, N.T., Schneider, J.S., Bach, J., Pilat, J., Beckett, L.A., Arnold, S.E., Evans, D.A. and Bennett, D.A. 2002. Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology, 59, 3,
Whalley, L.J., Starr, J.M., Athawes, R., Hunter, D., Pattie, A. and Deary, I.J. 2000. Childhood mental ability and dementia. Neurology, 55, 10, 1455-9.
Wilson, R.S., Mendes De Leon, C.F., Barnes, L.L., Schneider, J.A., Bienias, J.L., Evans, D.A. and Bennett, D.A. 2002. Participation in cognitively stimulating activities and risk of incident Alzheimer disease. Journal of the American Medical Association, 287, 6,
Winocur, G., Vardy, J., Binns, M.A., Kerr, L. and Tannock, I. 2006. The effects of the anti- cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice. Pharmacology Biochemistry and Behavior, 85, 1,66-75.
Wilson, R., Krueger, K.R., Arnold, S.E., Schneider, J.A., Kelly, J.F., Barnes, L.L., Tang, Y. and Bennett, D.A. 2007. Loneliness and risk of Alzheimer disease. Archives of General Psychiatry, 64, 2, 234-40.
Zhang, Z. 2006. Gender differentials in cognitive impairment and decline of the oldest old in China. Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 61B, 2, S107-15.
Henriette Engelhardt-Woelfler, Department of Population Studies, Otto Friedrich University Bamberg, Lichtenhaidestr. 11, D-96045 Bamberg, Germany E-mail: Figure 1. The stochastic frontier function Figure 2. Mean number of words recalled by age and country Source: SHARE 2004 Release 2.0.1, weighted data, own calculations TABLE 1. Estimated coefficients of a stochastic frontier model including behavioural risks and social involvement Frontier:
ln(age) 4.75*** 3.79*** 4.33*** (ln(age))² -0.65*** -0.52*** -0.58*** ISCED 0-1 Factors explaining the distance:
Notes: Reference categories: ISCED 5-6; 1st income quartile; no chronic diseases; hardly ever or never vigorous or moderate activities;
BMI<25; never smoking over a period of one year at least one cigarette, cigar or pipe a day; drinking less than two glasses of alcohol almost
every day or 5-6 days a week; not employed; not attending an educational course; not engaged in voluntary or charity work; no provision of
help to family, friends or neighbours; no involvement in sports or other social club; no participation in a religious organisation; no
participation in a political organisation. * significant at the 5 per cent level, ** significant at the 1 per cent level, *** significant at the 0.1 per
cent level. Since income at the household level is not yet available for Israel, Models 2 and 3 do not include Israel, explaining the lower
number of absolute records in Models 2 and 3.
Significance level: *** p < 0.01
Data source: SHARE 2004 Release 2.0.1, weighted data, own calculations. TABLE 2. Estimated coefficients of a stochastic frontier model, by gender Frontier:
ln(age) 0.26*** 6.62*** 0.58*** 7.16*** (ln(age))² -0.09*** -0.86*** -0.12*** -0.92*** ISCED 0-1 Constant 2.51*** -10.54*** 1.60*** -11.79*** Factors explaining the distance:
Smoking 0.16*** -0.76*** 0.19*** -0.57*** Drinking 0.43*** 0.20*** 0.31*** 0.14*** Constant -1.16*** -1.37*** -0.56*** -0.74*** Notes: Reference categories: ISCED 5-6 (see text); 1st income quartile; no chronic diseases; hardly ever or never vigorous or moderate activities; BMI<25; never smoking over a period of one year at least one cigarette, cigar or pipe a day; drinking less than two glasses of alcohol almost every day or 5-6 days a week; not employed; not attending an educational course; not engaged in voluntary or charity work; no provision of help to family, friends or neighbours; no involvement in sports or other social club; no participation in a religious organisation; no participation in a political organisation. Income at the household level was not available for Israel, which explains the lower number of absolute records in Models 2 and 3. Significance level: *** p < 0.01 Data source: SHARE 2004 Release 2.0.1 (see text). Weighted data, own calculations. TABLE 3. Estimated coefficients of a stochastic frontier approach by country 1.66 3.62 3.54 -2.38 13.60 -4.22 8.38 8.20 18.26 -1.11 -0.27 -0.50 -0.49 0.24 -1.72 0.41 -1.10 -1.02 -2.31 0.10 -1.04 -0.18 -0.16 -0.24 -0.18 0.00 -0.28 -0.18 -0.28 -0.10 -0.13 -0.05 -0.08 -0.16 -0.15 -0.03 -0.21 -0.03 -0.19 -0.04 -0.02 -0.06 -0.05 -0.10 -0.03 0.06 -0.18 -0.01 -0.09 0.01 -4.52 -4.35 7.73 -24.89 12.29 -13.85 -14.40 -33.90 4.82 -0.21 -0.06 -0.07 1.07 0.10 0.18 -0.15 -0.33 -0.04 1.66 0.59 0.23 0.38 1.13 2.01 0.59 -0.02 -0.14 0.17 1.30 -1.90 -0.48 -0.56 -2.53 -1.12 0.40 -0.07 -1.15 -0.20 -3.35 -1.65 -0.57 -1.19 -4.43 -1.44 0.32 -0.23 -1.62 -0.42 -2.48 -0.18 0.11 0.20 1.71 0.77 0.07 0.21 0.43 0.04 3.53 0.17 -0.17 0.26 0.94 0.29 0.06 -0.19 0.52 0.02 4.87 0.33 0.03 0.06 2.09 1.18 0.12 0.10 0.54 -0.00 5.90 -0.43 -0.91 -0.14 -1.85 -1.28 0.00 -0.34 -1.88 -0.17 -10.39 -0.56 -1.85 -0.80 -2.84 -0.13 -0.75 -1.51 -2.52 -0.64 -0.37 -0.53 -0.57 1.48 -1.11 -0.08 -1.65 -0.17 1.57 Help to family, friends or neighbours -0.07 -0.34 -0.53 -0.92 -0.44 -0.06 -0.13 -1.13 -0.01 -3.00 -0.88 -1.09 -0.13 -0.92 -1.78 0.17 -4.69 0.48 -0.75 -0.70 -3.17 0.00 -0.01 -0.89 -1.40 0.10 5.05 -0.93 -0.19 -1.09 1.49 -2.14 -0.75 0.39 1.31 -0.80 -3.52 -1.16 -0.89 -0.77 -5.71 -3.78 -0.92 -0.31 -3.57 0.47 -23.43 1,433 2,612 2,008 2,308 2,120 1,905 1,986 2,146 1,649 685 Notes: D: Germany. NL: Netherlands. CH: Switzerland. Reference categories: ISCED 5-6 (see text); 1st income quartile; no chronic diseases; hardly ever or never vigorous or moderate activities; BMI<25; never smoking over a period of one year at least one cigarette, cigar or pipe a day; drinking less than two glasses of alcohol almost every day or 5-6 days a week; not employed; not attending an educational course; not engaged in voluntary or charity work; no provision of help to family, friends or neighbours; no involvement in sports or other social club; no participation in a religious organisation; no participation in a political organisation. Since income at the household level was not available for Israel, that analysis did not include an economic variable. Significance levels: All non-zero coefficients are significant at p <0.01, except one: the frontier constant for Austria (-0.29) is not significant. Data source: SHARE 2004 Release 2.0.1 (see text and Acknowledgements). Weighted data, own calculations.


In this issue:

Mersey ADR Newsletter Issue 22 Autumn 2003 In this issue: Serious reactions generally… ▼ Fluoroquinolones and tendon disorders ▼ Serious reactions generally… Adverse drug reactions (ADRs) are a major problem, both in ▼ …and serious reactions with NSAIDs hospital and in the community. However, it is estimated that only about 10% of serious

When buying a combi your mains pressure plays a big roll in which size of boiler you should have for the most amount of benefit £590.12 £708.14 £643.06 £771.67 £658.64 £790.37 £628.29 £753.95 £593.28 £711.94 £868.75 £1,042.50 £805.72 £966.86 £740.35 £888.42 £756.69 £908.03 £700.66 £840.79 £665.65 £798.78 £521.

© 2010-2017 Pharmacy Pills Pdf