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April_may-12 [1-2] final by sathyavathi.p65

Code No: R9501
Jawaharlal Nehru Technological University Hyderabad B.Pharmacy III Year II Semester Examinations
April/May-12
April/May - 2012
Answer any FIVE Questions
All Questions carry equal marks
Discuss the role of parameters like lipophilicity, chelation and hydrogen bonding in biological activity ofdrug.
Explain the concept of prodrug with examples.
Write the conjugation reactions in biochemical modification of drugs.
Write the factors affecting drug metabolism.
Classify local anaesthetics. Write the SAR of benzoic acid derivatives on local anaesthetic activity.
Write the synthesis of thiopental sodium.
Write the mechanism of action, uses and synthesis of phenytoin.
Write the SAR of phenothiazine derivatives on antipsychotic activity.
Write a note on adrenergic receptors and give the biosynthesis of catecholamines.
Write the mechanism of action, therapeutic uses of salbutamol.
Classify anticholinergics and write the synthesis, uses of dicyclomine.
Write the biological significance of neuromuscular blockers.
Write a note on anticholinesterases.
Write the synthesis and uses of phenoxybenzamine.
WARNING : Xerox/Photocopying of this book is a CRIMINAL act. Anyone found guilty is LIABLE to face LEGAL proceedings.
[JNTU-Hyderabad] April/May-2012 QP with Solutions SOLUTIONS TO APRIL/MAY - 2012 Q.P.
Discuss the role of parameters like
Write the mechanism of action,
lipophilicity, chelation and hydrogen
therapeutic uses of salbutamol.
bonding in biological activity of drug.
For answer refer Unit-V, Page No. 5.21, Q9, Topic: For answer refer Unit-I, Page Nos. 1.2, 1.7, 1.5, Q3, Q6, Q5, Topics: Lipophilicity, Chelation, Hydrogen Bonding.
Classify anticholinergics and write the
Explain the concept of prodrug with
synthesis, uses of dicyclomine.
examples.
For answer refer Unit-VII, Page Nos. 7.1, 7.16, For answer refer Unit-I, Page No. 1.24, Q18, Topic: Q1, Q11, Topics: Introduction, Dicyclomine.
Concept of Prodrugs.
Q2.
Write the conjugation reactions in
Write the biological significance of
biochemical modification of drugs.
neuromuscular blockers.
For answer refer Unit-II, Page No. 2.29, Q6, Topic: For answer refer Unit-VI, Page No. 6.25, Q14, Phase II/Conjugation/True Detoxification Reactions.
Write the factors affecting drug
Write a note on anticholinesterases.
metabolism.
For answer refer Unit-VI, Page No. 6.15, Q9, Topic: For answer refer Unit-II, Page No. 2.4, Q2, Topic: Write the synthesis and uses of
Classify local anaesthetics. Write the SAR
phenoxybenzamine.
of benzoic acid derivatives on local
anaesthetic activity.

For answer refer Unit-V, Page No. 5.34, Q20, Topic: For answer refer Unit-IV, Page Nos. 4.18, 4.20, Q13, Q14, Topics: Classification, Structure Activity Write a note on the following,
Bioisosterism
Write the synthesis of thiopental sodium.
Structure and chemistry of atropine
Prostaglandin E .
For answer refer Unit-IV, Page No. 4.14, Q10, Bioisosterism
Write the mechanism of action, uses and
For answer refer Unit-I, Page No. 1.14, Q12, Topic: synthesis of phenytoin.
Structure and Chemistry of Atropine
For answer refer Unit-III, Page No. 3.39, Q29, For answer refer Unit-VII, Page No. 7.10, Q9, Write the SAR of phenothiazine
Prostaglandin E1
derivatives on antipsychotic activity.
For answer refer Unit-III, Page No. 3.27, Q16, Topic: Structure Activity Relationship (SAR).
Write a note on adrenergic receptors and
give the biosynthesis of catecholamines.
For remaining answer refer entire Unit-VIII, For answer refer Unit-V, Page Nos. 5.10, 5.8, Q6, Q5, Topics: Adrenergic Receptors, Biosynthesis/Biogenesis.
WARNING : Xerox/Photocopying of this book is a CRIMINAL act. Anyone found guilty is LIABLE to face LEGAL proceedings.

Source: http://www.siaedugroup.com/downloads/pdf/JNTU-HYD-3-2-BPHARM-MEDCHEM-April_May-12.pdf

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