Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
April_may-12 [1-2] final by sathyavathi.p65
Code No: R9501
Jawaharlal Nehru Technological University Hyderabad
B.Pharmacy III Year II Semester Examinations April/May-12 April/May - 2012 Answer any FIVE Questions All Questions carry equal marks
Discuss the role of parameters like lipophilicity, chelation and hydrogen bonding in biological activity ofdrug.
Explain the concept of prodrug with examples.
Write the conjugation reactions in biochemical modification of drugs.
Write the factors affecting drug metabolism.
Classify local anaesthetics. Write the SAR of benzoic acid derivatives on local anaesthetic activity.
Write the synthesis of thiopental sodium.
Write the mechanism of action, uses and synthesis of phenytoin.
Write the SAR of phenothiazine derivatives on antipsychotic activity.
Write a note on adrenergic receptors and give the biosynthesis of catecholamines.
Write the mechanism of action, therapeutic uses of salbutamol.
Classify anticholinergics and write the synthesis, uses of dicyclomine.
Write the biological significance of neuromuscular blockers.
Write a note on anticholinesterases.
Write the synthesis and uses of phenoxybenzamine. WARNING : Xerox/Photocopying of this book is a CRIMINAL act. Anyone found guilty is LIABLE to face LEGAL proceedings.
[JNTU-Hyderabad] April/May-2012 QP with Solutions
SOLUTIONS TO APRIL/MAY - 2012 Q.P. Discuss the role of parameters like Write the mechanism of action, lipophilicity, chelation and hydrogen therapeutic uses of salbutamol. bonding in biological activity of drug.
For answer refer Unit-V, Page No. 5.21, Q9, Topic:
For answer refer Unit-I, Page Nos. 1.2, 1.7, 1.5, Q3,
Q6, Q5, Topics: Lipophilicity, Chelation, Hydrogen Bonding. Classify anticholinergics and write the Explain the concept of prodrug with synthesis, uses of dicyclomine. examples.
For answer refer Unit-VII, Page Nos. 7.1, 7.16,
For answer refer Unit-I, Page No. 1.24, Q18, Topic:
Q1, Q11, Topics: Introduction, Dicyclomine.
Concept of Prodrugs. Q2. Write the conjugation reactions in Write the biological significance of biochemical modification of drugs. neuromuscular blockers.
For answer refer Unit-II, Page No. 2.29, Q6, Topic:
For answer refer Unit-VI, Page No. 6.25, Q14,
Phase II/Conjugation/True Detoxification Reactions. Write the factors affecting drug Write a note on anticholinesterases. metabolism.
For answer refer Unit-VI, Page No. 6.15, Q9, Topic:
For answer refer Unit-II, Page No. 2.4, Q2, Topic:
Write the synthesis and uses of Classify local anaesthetics. Write the SAR phenoxybenzamine. of benzoic acid derivatives on local anaesthetic activity.
For answer refer Unit-V, Page No. 5.34, Q20, Topic:
For answer refer Unit-IV, Page Nos. 4.18, 4.20,
Q13, Q14, Topics: Classification, Structure Activity
Write a note on the following, Bioisosterism Write the synthesis of thiopental sodium. Structure and chemistry of atropine Prostaglandin E .
For answer refer Unit-IV, Page No. 4.14, Q10,
Bioisosterism Write the mechanism of action, uses and
For answer refer Unit-I, Page No. 1.14, Q12, Topic:
synthesis of phenytoin. Structure and Chemistry of Atropine
For answer refer Unit-III, Page No. 3.39, Q29,
For answer refer Unit-VII, Page No. 7.10, Q9,
Write the SAR of phenothiazine Prostaglandin E1 derivatives on antipsychotic activity.
For answer refer Unit-III, Page No. 3.27, Q16,
Topic: Structure Activity Relationship (SAR). Write a note on adrenergic receptors and give the biosynthesis of catecholamines.
For remaining answer refer entire Unit-VIII,
For answer refer Unit-V, Page Nos. 5.10, 5.8, Q6,
Q5, Topics: Adrenergic Receptors, Biosynthesis/Biogenesis. WARNING : Xerox/Photocopying of this book is a CRIMINAL act. Anyone found guilty is LIABLE to face LEGAL proceedings.
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