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Metoclopramide oral solution usp
Read the Medication Guide that comes with Metoclopramide before you start taking it and each time you get a refill. There may be new information. If you take another product that contains metoclopramide (such as REGLAN tablets, REGLAN ODT, or REGLAN injection), you should read the Medication Guide that comes with that product. Some of the information may be different. This Medication Guide does not take place of talking to your doctor about your medical condition or your treatment.
What is the most important information I should know about Metoclopramide?
Metoclopramide can cause serious side effects, including:
Abnormal muscle movements called
tardive dyskinesia (TD).
happen mostly in the face muscles. You can not control these movements. They may not
go away even after stopping metoclopramide. There is no treatment for TD, but
symptoms may lessen or go away over time after you stop taking Metoclopramide
• the longer you take metoclopramide and the more metoclopramide you take. You
should not take metoclopramide for more than 12 weeks.
• if you are older, especially if you are a woman
It is not possible for your doctor to know if you will get TD if you take Metoclopramide.
Call your doctor right away if you get movements you can not stop or control, such as:
• lip smacking, chewing, or puckering up your mouth
• sticking out your tongue • blinking and moving your eyes
See the section “What are the possible side effects of Metoclopramide?”
What is Metoclopramide?
Metoclopramide is a prescription medicine used:
• in adults for 4 to 12 weeks to relieve heartburn symptoms with gastroesophageal
reflux disease (GERD) when certain other treatments do not work. Metoclopramide relieves daytime heartburn and heartburn after meals. It also helps ulcers in the esophagus to heal.
• to relieve symptoms of slow stomach emptying in people with diabetes.
Metoclopramide helps treat symptoms such as nausea, vomiting, heartburn, feeling full long after a meal, and loss of appetite. All these symptoms do not get better at the same time.
It is not known if Metoclopramide is safe and works in children.
Who should not take Metoclopramide?
Do not take Metoclopramide if you: • have stomach or intestine problems that could get worse with Metoclopramide, such
as bleeding, blockage or a tear in the stomach or bowel wall
• have an adrenal gland tumor called a pheochromocytoma
• are allergic to Metoclopramide or anything in it. See the end of this Medication
Guide for a list of the ingredients in Metoclopramide.
• take medicines that can cause uncontrolled movements, such as medicines for mental
What should I tell my doctor before taking Metoclopramide?
Tell your doctor about all your medical conditions
, including if you have:
• high blood pressure • kidney problems. Your doctor may start with a lower dose.
• liver problems or heart failure. Metoclopramide may cause your body to hold fluids.
• diabetes. Your dose of insulin may need to be changed. • breast cancer
• you are pregnant or plan to become pregnant. It is not known if Metoclopramide will
• you are breast-feeding. Metoclopramide can pass into breast milk and may harm your
baby. Talk with your doctor about the best way to feed your baby if you take Metoclopramide.
Tell your doctor about all the medicines you take, including prescription and non-
prescription medicines, vitamins, and herbal supplements.
Metoclopramide and some
other medicines may interact with each other and may not work as well, or cause possible
side effects. Do not start any new medicines while taking Metoclopramide until you talk
with your doctor.
Especially tell your doctor if you take:
• another medicine that contains Metoclopramide, such as REGLAN tablets or
• a medicine for depression, especially an Monoamine Oxidase Inhibitor (MAOI)
• insulin • a medicine that can make you sleepy, such as anti-anxiety medicine, sleep medicines,
If you are not sure if your medicine is one listed above, ask your doctor or pharmacist.
Know the medicines you take. Keep a list of them and show it to your doctor and pharmacist when you get a new medicine.
How should I take Metoclopramide?
• Take Metoclopramide exactly as your doctor tells you.
• You should not take Metoclopramide for more than 12 weeks. • If you take too much Metoclopramide, call your doctor or Poison Control Center right
What should I avoid while taking Metoclopramide?
• Do not drink alcohol while taking Metoclopramide. Alcohol may make some side
effects of Metoclopramide worse, such as feeling sleepy.
• Do not drive, work with machines, or do dangerous tasks until you know how
Metoclopramide affects you. Metoclopramide may cause sleepiness.
What are the possible side effects of Metoclopramide?
Metoclopramide can cause serious side effects, including:
• Abnormal muscle movements.
See “What is the most important information I
• Uncontrolled spasms of your face and neck muscles, or muscles of your body,
arms, and legs
(dystonia). These muscle spasms can cause abnormal movements and
body positions. These spasms usually start within the first 2 days of treatment. These
spasms happen more often in children and adults under age 30.
• Depression, thoughts about suicide, and suicide.
Some people who take
Metoclopramide become depressed. You may have thoughts about hurting or killing yourself. Some people who take Metoclopramide have ended their own lives (suicide).
• Neuroleptic Malignant Syndrome (NMS).
NMS is a very rare but very serious
condition that can happen with Metoclopramide. NMS can cause death and must be treated in a hospital. Symptoms of NMS include: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating.
. Symptoms include slight shaking, body stiffness, trouble moving or
keeping your balance. If you already have Parkinson’s disease, your symptoms may become worse while you are receiving Metoclopramide.
Call your doctor and get medical help right away if you:
• feel depressed or have thoughts about hurting or killing yourself
• have high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and
• have muscle movements you can not stop or control
• have muscle movements that are new or unusual
Common side effects of Metoclopramide include:
• feeling restless, sleepy, tired, dizzy, or exhausted • headache
You may have more side effects the longer you take Metoclopramide and the more Metoclopramide you take.
You may still have side effects after stopping Metoclopramide. You may have symptoms from stopping (withdrawal) Metoclopramide such as headaches, and feeling dizzy or nervous. Tell your doctor about any side effects that bother you or do not go away. These are not all the possible side effects of Metoclopramide. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA 1088.
How should I store Metoclopramide?
Store Metoclopramide at room temperature, 68oF to 77 oF (20oC to 25oC).
Keep Metoclopramide in the bottle it comes in. Keep the bottle closed tightly.
Keep Metoclopramide and all medicines out of the reach of children.
General information about Metoclopramide:
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Metoclopramide for a condition for which it was not prescribed. Do not give your Metoclopramide to other people, even if they have the same symptoms that you have. It may harm them.
This Medication Guide summarizes the most important information about Metoclopramide. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about Metoclopramide that is written for healthcare professionals. For more information, call 1-888-974-5279.
What are the ingredients in Metoclopramide?
Active ingredient: Metoclopramide
Inactive ingredients: Citric acid, FD&C Yellow No. 6, butterscotch flavor, glycerin, methylparaben, propylparaben, propylene glycol, sodium citrate, sorbitol, water.
Silarx Pharmaceuticals, Inc. 19 West Street Spring Valley, NY 10977 Revised June 2009
This Medication Guide has been approved by the U.S. Food and Drug Administration
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