Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Sro 208(i)/2002

http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm GOVERNMENT OF PAKISTAN
MINISTRY OF FINANCE, ECONOMIC AFFAIRS,
STATISTICS & REVENUE
REVENUE DIVISION
NOTIFICATION
(SALES TAX)

Amended via SRO 432(I)/2002
S.R.O. 208(I)/2002.¾ In exercise of the powers conferred under clause (a) of sub-section (2) of
section 13 of the Sales Tax Act, 1990, the Federal Government is pleased to exempt the substances registered as drugs under the Drugs Act, 1976, (XXXI of 1976), specified in the Table below, from the whole Drug/Medicine
ANAESTHETICS
0.25% & 0.5%(hydrochloride) inj.
1% & 2% (hydrochloride) inj.
5% (hydrochloride) inj. for spinalanesthesia 2% & 4% (hydrochloride) topicalsolution , 2% (hydrochloride) gel.
1% (hydrochloride) + epinephrine1:100 000 inj., 2% (hydrochloride) +epinephrine 1:200 000 inj.
2% (hydrochloride) + epinephrine1:80 000 dental cartridge ANALGESICS, ANATIPYRETICS,
NON-STEROIDAL ANTI-INFLAMMATORY
DRUGS AND DRUGS USED TO TREAT
0.216 mg sublingual tab. (as hydrochloride)
http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm 10mg & 30mg slow release tab./ caps.
10mg &15mg/ml inj. (sulfate orhydrochloride).
50 mg/2 ml inj. (hydrochloride)
(sodium , Potassium)75 mg/3ml inj. (sodium) ANTIALLERGICS AND DRUGS USED IN
ANAPHYLAXIS
2mg/5ml syrup (maleate)10mg/ml inj. (maleate).
ANTI-EPILEPTICS
ANTI-INFECTIVE DRUGS.
250 & 500 mg capsule/tablet (as trihydrate).
125 & 250 mg/5ml syrup (as trihydrate)250mg & 500mg Inj http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm anhydrous/trihydrate)125 mg/5ml syrup (as anhydrous/trihydrate)500mg inj.(as sodium salt).
875mg + 125mg tablet100 mg+500 mg, 200mg+1000mg inj. 31 mg+125 mg/5ml syrup.
5 Lac i.u & 10 Lac i.u inj (sodium/potassium) 250, 500mg & 1 gm inj.(as sodium salt).
100 mg/5ml suspension
125 mg/5ml & 250 mg / 5ml syrup 250, 500 mg & 1 gm inj.
125mg/5ml syrup (as palmitate)1% eye ointment0.5% eye drops 250 & 500 mg tablet / cap.(as hydrochloride) Inj. as Clindamycin (as phosphate) 150 mg, 125 mg/5ml syrup (sodium) 250 mg inj. (sodium) 200 mg+40 mg/5ml suspension400mg +80mg/5 ml injection.
200mg/5ml suspension (as ethyl succinate)500mg inj. (as lactobionate) http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm 200 mg/5ml suspension (as benzoate)500 mg/100ml infusion 300 mg + 150 mg tab./cap.
450 mg + 300 mg tab./cap http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm 200 mg (as benzoate)/5ml suspension,500mg/100ml infusion 500mg/600mg tab. & 50mg/5ml, 100mg/5ml Syrup 300 mg tab. (bisulphate)600mg Inj (Dihydrochloride) ANTIPARKINSONISM DRUGS
HAEMATINICS
eq.to 60 mg iron tab., eq.to 25mg iron/ml ANTICOAGULANTS
VITAMIN - K DERIVATIVE
BLOOD PRODUCTS AND PLASMA
SUBSTITUTES
http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm ANTI-HAEMOPHILIC FACTORS
100. polygeline
CARDIOVASCULAR DRUGS
101. amiodarone
102. atenolol
103. bretylium
104. captopril
105. digoxin
500 mcg inj.
250 mcg tab50 mcg/ml oral solution 106. diltiazem
30,60,90 & 180 mg tab. (hydrochloride)10 & 50 mg inj.
107. dobutamine
108. dopamine
109. enalapril
110. hydralazine
111. isoprenaline
112. isosorbide dinitrate
113. lisinopril
114. methyldopa
250 & 500 mg tab.
250 mg inj.
115. nifedipine
116. nitroglycerin (glyceryl trinitrate)
500 mcg tablet sublingual 2.6 & 6.4 mg tab25 mg patches1mg/ml I.V. infusion250 mg inj.
117. prazosin
118. procainamide
119. propranolol
120. quinidine
121. sodium nitroprusside
122. streptokinase
1.5 IU million inj. & 0.75 million IU inj 123. verapamil
40,80 & 240 mg tab.
5mg inj.
DERMATOLOGICAL DRUGS (TOPICAL)
124. betamethasone + neomycin
125. benzyl benzoate
126. silver sulphadiazine
127. clotrimazole
DIURETICS
128. amiloride
129. bendroflumethiazide
http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm 130. furosemide
131. mannitol
132. spironolactone
GASTROINTESTINAL DRUGS
133. cimetidine
200mg&400mg tab 200mg inj400mg / 5ml susp.
134. ranitidine
150mg, 300mg tablet50mg/2ml inj.
75mg/5ml syrup 135. famotidine
10mg,20mg & 40mg tablet10mg/5ml susp.
136. octreotide acetate
ELECTROLYTES SUPPLEMENTS
137. potassium chloride
138. oral rehydration salt
Components to reconstitute 1 litreglucose/electrolyte solution:sodium chloride 3.5g,trisodium citrate dihydrate 2.9g,potassium chloride 1.5g, glucose 20g.
HORMONES, OTHER ENDOCRINE DRUGS
AND CONTRACEPTIVES
139. bromocriptine
140. carbimazole
141. clomifene
142. glibenclamide
143. human chorionic gonadotrophic hormone
144. hydroxyprogesterone caproate
145. insulin compound, zinc / isophane
146. insulin regular
147. metformine
148. potassium iodide
149. prednisolone
150. propylthiouracil
151. thyroxine
152. vasopressin/ADH
153. erythropoetin
IMMUNOLOGICALS
154. tuberculin PPD
155. anti-D immunoglobulin
156. antivenom sera
157. diphtheria antitoxin inj
http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm 158. hepatitis B Inj
159. immunoglobulin
160. tetanus antitoxin
161. tetanus toxoid
162. BCG (dried) vaccine
163. diphtheria-pertussis
164. tetanus vaccine
165. measles-mump rubella vaccine
166. measles vaccine
167. poliomyelitis vaccine (live attenuated)
168. tetanus vaccine
169. typhoid vaccine
170. hepatitis B vaccine
171. meningococcal vaccine
172. rabies vaccine
173. cyclosporin
OPHTHALMOLOGICAL PREPARATIONS
174. Ketoconazole
175. polymixin B sulphate + .bacitracin zinc
176. sulfacetamide
177. acetazolamide
178. betaxolol
179. levobunalol
180. pilocarpine
181. atropine
182. homatropine
183. phenylepherine
184. tropicamide
185. naphazoline
186. oxybuprocaine
OXYTOCICS AND ANTIOXYTOCICS
188. ergometrine
0.25mg tab. (methyl ergometrine maleate)200 mg inj.
189. oxytocin
PERITONEAL DIALYSIS SOLUTION
http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm 190. intraperitonial dialysis parental solution (of
191. haemodialysis Concentrate
PSYCHOTHERAPEUTIC DRUGS
192. amitryptyline
193. chlorpromazine
10,25,50 &100 mg tab25 mg/5ml syrup50 mg inj.
194. clomipramine
195. diazepam
196. fluphenazine
197. haloperidol
0.25,1.25 & 5 mg tab5mg inj.
2mg/ml oral drops 198. imipramine
199. lithium carbonate
DRUGS ACTING ON THE RESPIRATORY
2 & 4 mg tab.
2mg/5ml syrup100 mcg/dose aerosol50mcg/5ml inj.
5mg (as sulfate)/ml respiratory solution foruse in nebulizers, 180 & 270 mg tab 350 mg tab. (S.R)120 mg/5ml syrup.
SOLUTIONS CORRECTIN WATER
ELECTROLYTE AND ACID BASE
DISTURBANCES`
10%+0.9% IV solution5%+0.45% IV solution4.3%+0.18% IV solution3%+0.3% IV solution http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm ANTIDOTES AND OTHER SUBSTANCES
USED IN POISONING
ANTI-NEOPLASTICS,
IMMUNOSUPPRESSIVES
AND DRUGS USED IN PALLIATIVE CARE
http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm 10 & 50 mg inj. as doxorubicin hydrochoride http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm 2. This notification shall come into force at once and shall be deemed to have taken
[C.No.1/8-STT/2002]

( FALAK SHER )
Additional Secretary

Source: http://softax.com.pk/SRO/2002/salestax/notifications/208.pdf