Microsoft word - donatus dreher - curriculum vitae - 2013.doc

DREHER Donatus Stefan, MD, PhD, FMH Respiratory Medicine
Professional positions
Clinical experience
Scientific research
Education track
Personal data
1. Professional positions
Co-founder and Owner, TOTZKE & DREHER SCIENTIFIC SA Clinical Consulting and Medical Writing Senior Medical Director, Clinical Group Head, Global Clinical Development Unit, Rheumatology - Autoimmune and Inflammatory Diseases, Merck Serono SA Geneva Medical Director, Clinical Development, Autoimmune, Dermatology and Emerging Therapies, Merck Serono SA Senior Manager, Clinical Research, Novartis Consumer Health, Nyon, Switzerland Clinical Project Manager, Health Project Management (HPM) SA, Geneva, Switzerland Senior Physician, Respiratory Medicine, University Hospital of Geneva Resident Physician, Internal Medicine and Respiratory Medicine, University Hospital of Geneva Postgraduate MD-PhD, University of Geneva 2. Clinical experience
3 years Director/Group Head Clinical Development (Merck Serono Geneva) · Clinical development of a new recombinant biological drug · Protocol and medical lead of international multicenter Phase I-II trials in 3 years Senior Manager in Clinical Research (Novartis Nyon) · Protocol and medical lead of US and EU multicenter Phase III trials in · Support of post-marketing regulatory and marketing activities · Clinical lead in NDA submission 2 years Clinical Project Manager (HPM Geneva) · CTDs, scientific overviews, and expert reports · Management of Phase IV trials in rheumatoid arthritis and hepatitis · Drug safety: PSURs, signal detection, causality assessment 5 years Senior physician / resident in Respiratory Medicine (HUG) 3 years Resident in Internal Medicine (HUG - University Hospital of Geneva) 3. Scientific research
Main investigator in Swiss National Foundation Priority project PhD Thesis in Cell Physiology and Proteome Research Participation in International Breast Cancer trial & other clinical studies 4. Education track
Certification by European Center of Pharmaceutical Medicine (ECPM) Swiss Board Exam Specialist Respiratory Medicine (FMH) Swiss Board Exam Specialist Internal Medicine (FMH) PhD Thesis, Faculty of Biology, University of Geneva MD Thesis, Institute of Physiology, University of Zurich Federal Diploma in Medicine, University of Zurich Training in Biostatistics and Clinical Trials, Harvard School of Public Health, Boston Matura Mathematisch-Naturwissenschaftliches Gymnasium Zürcher Oberland, Switzerland Schiller Gymnasium, Frankfurt a/M, Germany 5. Personal data
Born in Amersham UK, December 6, 1962 British, Swiss, and French nationality Full proficiency: English, German, French Limited proficiency: Italian, Spanish 6. Publications
I. Respiratory medicine & Immunology Kiama SG, Dreher D, Cochand L, Kok M, Obregon C, Nicod L, Gehr P. Host cell responses of Salmonella typhimurium infected human dendritic cells. Immunol Cell Biol 2006;84:475-81. Obregon C, Dreher D, Kok M, Cochand L, Kiama GS, Nicod LP. Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18. Infect Immun 2003;71:4382-8. Tailleux L, Schwartz O, Herrmann JL, Pivert E, Jackson M, Amara A, Legres L, Dreher D, Nicod LP, Gluckman JC, Lagrange PH, Gicquel B, Neyrolles O. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med 2003;197:121-7. Dreher D, Kok M, Obregon C, Kiama SG, Gehr P, Nicod LP. Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells. J Leukocyte Biol 2002;72:743-51. Erni C, Suard C, Freitas S, Dreher D, Merkle HP, Walter E. Evaluation of cationic solid lipid microparticles as synthetic carriers for the targeted delivery of macromolecules to phagocytic antigen-presenting cells. Biomaterials 2002;23:4667-76. Dreher D, Nicod LP. Dendritic cells in the mycobacterial granuloma are involved in acquired immunity. Am J Respir Crit Care Med 2002;165:1577-8. Walter E, Dreher D, Kok M, Thiele L, Kiama SG, Gehr P, Merkle HP. Hydrophilic poly(DL-lactide- co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells. J Control Release 2001;76:149-68. Dreher D, Kok M, Cochand L, Kiama SG, Gehr P, Pechere JC, et al. Genetic background of attenuated Salmonella typhimurium has profound influence on infection and cytokine patterns in human dendritic cells. J Leukoc Biol 2001;69:583-9. Dreher D, Kok M, Pechere JC, Nicod LP. New strategies against an old plague: genetically engineered tuberculosis vaccines. Schweiz Med Wochenschr 2000;130:1925-9. Nicod LP, Cochand L, Dreher D. Antigen presentation in the lung: dendritic cells and macrophages. Sarcoidosis Vasc Diffuse Lung Dis 2000;17:246-55. Dreher D, Junod AF. Role of oxygen free radicals in cancer development. Eur J Cancer Jacquier-Sarlin MR, Dreher D, Polla BS. Selective induction of the glucose-regulated protein grp78 in human monocytes by bacterial extracts (OM-85): a role for calcium as second messenger. Biochem Biophys Res Commun 1996;226:166-71. Dreher D, Vargas JR, Hochstrasser DF, Junod AF. Effects of oxidative stress and Ca2+ agonists on molecular chaperones in human umbilical vein endothelial cells. Electrophoresis 1995;16:1205-14. Dreher D, Jornot L, Junod AF. Effects of hypoxanthine-xanthine oxidase on Ca2+ stores and protein synthesis in human endothelial cells. Circ Res 1995;76:388-95. Dreher D, Junod AF. Differential effects of superoxide, hydrogen peroxide, and hydroxyl radical on intracellular calcium in human endothelial cells. J Cell Physiol 1995;162:147-53. Feraille E, Barlet-Bas C, Cheval L, Rousselot M, Carranza ML, Dreher D, Arystarkhova E, Doucet A, Favre H. Presence of two isoforms of Na, K-ATPase with different pharmacological and immunological properties in the rat kidney. Pflugers Arch 1995;430:205-12. Brandli O, Dreher D, Morger D. Results of short-term tuberculosis therapy with isoniazid, rifampicin and pyrazinamide Schweiz Med Wochenschr 1993 26;123:1300-06. Dreher D, Rochat T. Hyperoxia induces alkalinization and dome formation in MDCK epithelial cells. Dreher D, Koller EA. Circadian rhythms of specific airway conductance and bronchial reactivity to histamine: the effects of parasympathetic blockade. Eur Respir J 1990;3:414-20. Schmid T, Dreher D, Karrer W. Oxygen saturation during sleep in chronic obstructive lung diseases before and after bronchodilator therapy. A controlled, prospective study in 36 patients. Schweiz Med Wochenschr 1988;118:1645-50. Brandli O, Langloh P, Plangger M, Dreher D. Course and prognosis of chronic obstructive lung disease over 5 and 10 years. Schweiz Med Wochenschr 1988;118:1314-20. Scherer O, Schwab R, Dreher D, Brandli O. Quality of life and time of survival following diagnosis of a bronchus carcinoma in 267 patients from 1977 to 1984. Schweiz Med Wochenschr 1987;117:1506-13. Buck RJ, Wirth W, Dreher D, Nevitt M, Eckstein F. Frequency and spatial distribution of cartilage thickness change in knee osteoarthritis and its relation to clinical and radiographic covariates - data from the osteoarthritis initiative. Osteoarthritis Cartilage 2013;21:102-9. Haugen IK, Cotofana S, Englund M, Kvien TK, Dreher D, Nevitt M, Lane NE, Eckstein F. Hand joint space narrowing and osteophytes are associated with magnetic resonance imaging-defined knee cartilage thickness and radiographic knee osteoarthritis: Data from the Osteoarthritis Initiative. J Rheumatol 2012;39:161-6. Eckstein F, Cotofana S, Wirth W, Nevitt M, John MR, Dreher D, Frobell R; Osteoarthritis Initiative Investigators Group. Greater rates of cartilage loss in painful knees than in pain-free knees after adjustment for radiographic disease stage: data from the osteoarthritis initiative. Arthritis Rheum 2011;63:2257-67. Wirth W, Buck R, Nevitt M, Le Graverand MP, Benichou O, Dreher D, Davies RY, Lee JH, Picha K, Gimona A, Maschek S, Hudelmaier M, Eckstein F; OAI Investigators. MRI-based extended ordered values more efficiently differentiate cartilage loss in knees with and without joint space narrowing than region-specific approaches using MRI or radiography--data from the OA initiative. Osteoarthritis Cartilage 2011;19:689-99. Eckstein F, Nevitt M, Gimona A, Picha K, Lee JH, Davies RY, Dreher D, Benichou O, Le Graverand MP, Hudelmaier M, Maschek S, Wirth W; for the OA Initiative investigators Group. Rates of change and sensitivity to change in cartilage morphology in healthy knees and in knees with mild, moderate, and end stage radiographic osteoarthritis. Arthritis Care Res 2011;63:311-9. Frobell RB, Nevitt MC, Hudelmaier M, Wirth W, Wyman BT, Benichou O, Dreher D, Davies R, Lee JH, Baribaud F, Gimona A, Eckstein F; Osteoarthritis Initiative Investigators. Femorotibial subchondral bone area and regional cartilage thickness: a cross-sectional description in healthy reference cases and various radiographic stages of osteoarthritis in 1,003 knees from the Osteoarthritis Initiative. Arthritis Care Res 2010;62:1612-23. Frobell RB, Wirth W, Nevitt M, Wyman BT, Benichou O, Dreher D, Davies RY, Lee JH, Baribaud F, Gimona A, Hudelmaier M, Cotofana S, Eckstein F; OA Initiative investigators. Presence, location, type and size of denuded areas of subchondral bone in the knee as a function of radiographic stage of OA - data from the OA initiative. Osteoarthritis Cartilage 2010;18:668-76. Wirth W, Nevitt M, Hellio Le Graverand MP, Benichou O, Dreher D, Davies RY, Lee J, Picha K, Gimona A, Maschek S, Hudelmaier M, Eckstein F; OAI investigators. Sensitivity to change of cartilage morphometry using coronal FLASH, sagittal DESS, and coronal MPR DESS protocols--comparative data from the Osteoarthritis Initiative (OAI). Osteoarthritis Cartilage 2010;18:547-54. Altman RD, Dreiser RL, Fisher CL, Chase WF, Dreher DS, Zacher J: Diclofenac sodium gel in patients with primary hand osteoarthritis: a randomized, double-blind, placebo-controlled trial. J Rheumatol 2009;36:1991-9. Hurny C, Bernhard J, Gelber RD, Coates A, Castiglione M, Isley M, Dreher D, Peterson H, Goldhirsch A, Senn HJ. Quality of life measures for patients receiving adjuvant therapy for breast cancer: an international trial. The International Breast Cancer Study Group. Eur J Cancer 1992;28:118-24.


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