Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

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Safety data sheet 10020
1 - Identification of the preparation and company
Bio Optica Milano S.p.A. • via San Faustino 58 • I - 20134 Milano Tel. +39-02212713.1 Please contact the nearest Tossicology and Antivenin Center 2 - Composition/information on ingredients
Hazardous ingredients % w/v CAS Classification of pure substances It has been determined that the remaining ingredients are Not Classified as Hazardous (see technical data sheet) 3 - Hazards identification
Preparation classified as Hazardous.
4 - First-aid measures
Eye contact: Immediately flush eyes with plenty of water for at least 15 minutes - call a physician Skin contact: Wash off with soap and water Rinse out mouth with water - drink water - call a physician 5 - Fire fighting measures
Suitable extinguishing media: foam, carbon dioxide, dry powder.
In case of fire the product may develop dangerous combustion gases or vapours. Wear self-contained breathing apparatus.
6 - Accidental release measures
An approved respirator is recommended when vapours/powders/aereosols are generated. Wear suitable protective clothing. Absorb on sand or vermiculite and place in closed containers for disposal. Do not allow to enter ewerage system.
7 - Handling and storage
Keep tightly closed, store in a well ventilated place at 15-25°C.Keep away from sources of ignition.
8 - Exposure controls / personal protection
9 - Physical and chemical properties
Bio Optica Milano s.p.a.
via San Faustino 58 • I - 20134 Milano • tel. +39 02212713.1 • fax +39 022153000 • www.bio-optica.it Safety data sheet 10020
10 - Stability and reactivity
Avoid high temperature which cause evaporation. The fumes are easily flammable. Avoid strong oxidizing agents, alkali metals, peroxides.
11 - Toxicological information
Data on the toxicity of this product are not available. The following information refers to each component which is responsible of the solution toxicity. ETHYL ALCOHOL - INHALATION: may cause irritation to mucous membranes and upper respiratory tract. The typical effects are initial exicitation followed by depression. INGESTION: doses of 30-70 ml of pure alcohol cause euphoria, slight visual impairment, slight muscular incoordination. Doses of 75-150 ml: nausea, vomiting, vertigo, sensory loss, tachicardia. EYE-CONTACT: may cause irritation.
12 - Ecological information
Biodegradability: It is easily biodegradable.
In high concentrationts: harmfull effect on aquatic organisms.Lidus LC50: 8140mg/l/48h; Daphnia EC50: 9268-14221 mg/l 48h.
Use according to good laboratory pratices, avoiding the dispersion of the product in the environment 13 - Disposal considerations
Observe all state and local enviromental regulations regarding waste disposal.
14 - Transport information
15 - Regulatory information
Keep container tightly closed. Keep away from sources of ignition - No smoking. - Hazard labelling according to 2004/73/EC directive- Waste labelling according to 75/442/EEC, 91/689/EEC directives 16 - Other information
This data sheet replaces all the previous editions.
Date of issue: 27/11/2006References:ECDIN - Environment Chemicals Data and Information NewtworkRTECS - Registry of Toxic Effects of Chemical Substances reference Number Bio Optica Milano s.p.a.
via San Faustino 58 • I - 20134 Milano • tel. +39 02212713.1 • fax +39 022153000 • www.bio-optica.it Safety data sheet 10020
The above information is belived to be correct but does not purport to be all inclusive and shall be used only as a guide.
Bio-Optica S.p.A. shall not be held liable for any damage resulting from an inaccurate and illegal handling.
Bio Optica Milano s.p.a.
via San Faustino 58 • I - 20134 Milano • tel. +39 02212713.1 • fax +39 022153000 • www.bio-optica.it

Source: http://tunic.ro/fise/securitate/05-10020L.pdf