Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
Resumegoogle2012
T: 831.332.4596
Mathematical biologist seeking a career transition towards a data scientist
role with a tech company. Adept with complex data analysis and visualiza-
tion. Experience applying statistical analysis to address practical problems
and to support decision-making. Independent and self-motivated team mem-
ber accustomed to balancing multiple projects and making efficient use of my
time and the time of others. Strong communicator.
UNIV. OF CALIFORNIA SANTA CRUZ — PHD, 2007Emphasis in Mathematical BiologyHonor: Sea Grant/NMFS Graduate Fellowship in Population Dynamics, 2002–2005Honor: U.C. Dean’s Cota-Robles Graduate Fellowship, 2002–2004
COLLEGE OF THE ATLANTIC — BA, 1999Emphasis in Environmental Monitoring and Management
SELECTED ANALYTICAL METHODS APPLIED IN MY RESEARCH
Ordination, Clustering, Linear Regression, Logistic Regression, Generalized
Linear Regression, Multilevel/Hierarchical Modeling, Optimization, Stochastic
Differential Equations, Numerical ODE solvers, ODEs, Time-Series Analysis
STATISTICAL CONSULTANT AND FOUNDERSignal to Noise Consulting, Pasadena, California
POSTDOCTORAL RESEARCHERNorthwest Fisheries Science Center, NOAA, Seattle, Washington
Honor: National Research Council Postdoctoral Fellowship, 2007–2011
GRADUATE STUDENT RESEARCHERDept. of Applied Math and Statistics, Univ. of California Santa Cruz
R FOR BEGINNERSGiven at NOAA-Fisheries in Seattle 2010, 2011Given at PNW-USFS, Corvallis, Oregon 2011A two day workshop developed by myself to introduce biologists to R, and to
INTRODUCTION TO LATEX FOR THESIS WRITINGGiven at ESA annual meeting 2009, 2010A one-day workshop developed by myself to introduce graduate students to
JUVENILE SALMON HABITATSeattle Lab, NOAA-Fisheries/Signal to Noise Consulting
I simulated juvenile distributions in a stream network using a system of sto-
chastic differential equations. I used a k-means clustering algorithm to iden-
tify when the spatial distributions of different juvenile groups merged. In an-
other project, I applied several ordination analyses to a dataset describing
salmon habitat. There were over 32 variates that were expected to organize
into a few multivariate descriptors of habitat quality. Using several ordination
methods, I was able to show that the expected patterns were in fact not pre-
sent, and uncover some of the reasons for this behavior. In another, exten-
sive project, I prepared for analysis a large data set of spatial y distributed
fish and habitat information. I conducted an extensive exploratory analysis
and guided client scientists through a modeling process. Ultimately, I imple-
mented a zero-inflated, multilevel logistic regression model using the lme4
package in R. Model results are being applied to endangered species man-
DATA FLOW IN NATURAL RESOURCES MANAGEMENTSeattle Lab, NOAA-Fisheries
In col aboration with a database manger col eague, we conducted a survey of
natural resource scientists that work with monitoring data. We used the sur-
vey results to il ustrate how problems in data management were negatively
impacting science productivity throughout the natural resources field. Our
final report presented several solutions gleaned from a review of the litera-
MATERNAL EFFECTS IN ROCKFISHUC Santa Cruz/Santa Cruz and Seattle Labs, NOAA-Fisheries
For my PhD, I developed an extensive simulation based on a novel popula-
tion model for maternal effects in rockfish. The model was a non-linear sys-
tem of ODEs. I wrote a numerical solver based on a Predictor-Corrector algo-
rithm. I simulated hundreds of population trajectories and summarized the
outcomes with complex graphics, linear regression and time series analysis.
SPECIES-ABUNDANCE CURVES IN TROPICAL REEF FISHSeattle Lab, NOAA-Fisheries
I supported the work of a col eague by developing a novel model for species-
abundance curves. The model was based on a summation of the probability
density function of the multinomial distribution. This was used to identify sites
with unusual y large diversity from a database of tropical reef fish.
STOCK ASSESSMENTSanta Cruz Lab, NOAA-Fisheries
In Fisheries Science, a stock assessment is an extensive statistical analysis
performed by teams to assess the population status of a managed fish spe-
cies. I supported the assessment of Shortbel y Rockfish by providing several
alternative models and calculations for the rate of natural mortality. I pre-
pared the data for the assessment of California Halibut. Data prep included
several analytical steps, including applying a GLM-based filtering tool. The
initial data for this assessment was too large to load into the R workspace. I
developed several strategies for performing analyses on data subsets and
pooling results together for a summary data set. This was my first experience
Bonificación 90 años de Mutual de Seguros Tercer sorteo zona sur El miércoles 21 de octubre se llevó a cabo el tercer y último sorteo del Beneficio que en virtud de su nonagésimo aniversario entrega Mutual de Seguros a mil de sus asegurados en todo Chile, como premio a su preferencia y permanencia junto a la Corporación. 342 titulares de seguros con domicilio en las regiones sép
818-653-9809 • MELANIEROSE818@YAHOO.COM PROFESSIONAL EXPERIENCE 2013 Prilosec OTC Commercial with Larry the Cable Guy • Omaha, NE • HAIR & MAKE-UP 2012 Prilosec OTC Commercial with Larry the Cable Guy • Omaha, NE • HAIR & MAKE-UP “Generals” Mynabirds/Saddle Creek Records • Omaha, NE • MAKE-UP “Nebraska”/Paramount Pictures • Director: Alexander Payne