Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
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SHERYL WHITE STAFF EXPERIENCE:
SAATCHI HEALTHCARE/GLOW WORM - VP, Group Head Ameriprise Financial, Merial/Frontline & Heartgard (DM & Web); Enbrel;
Nexium; Altace; Sanofi-Aventis (new product launch–Global and US, DM & Web),
Advair, Computer Associates, MCI, Canadian Tire, Volvo, Diageo Liquors (Jose Cuervo,
DRAFT WORLDWIDE - VP, Associate Creative DirectorBank of America; Verizon DSL; AARP/UHG
O&M DIRECT - VP, Creative Supervisor American Express; Reader’s Digest; Time Magazine; AT&T; AT&T Capital Corp.,GBS, Hispanic Market; HBO Video; CSX Transportation; IDS Financial Services; NEBS Office Supplies; Boys Choir of Harlem; Nutri/System; SmithKline Beecham; Merck & Co.; AARP
DOREMUS & COMPANY - Creative SupervisorSalomon Brothers; Pfizer International; Dean Witter Reynolds
J. WALTER THOMPSON - VP, Assoc. Creative DirectorBendix Corp., Selchow & Righter Games; Olivetti; Goodyear; Mellon Bank; Irving Trust; KDKA Radio; Marsh & McLennan; Penn Central
JAMES NEAL HARVEY, INC. - VP Copy SupervisorVolkswagen Bus; Lakeside Games; Wella; Manischewitz Rye & Pumpernickel; Georgia-Pacific; Norwich Eaton; Crayola; National Liberty Insurance; Sterling Drugs; Glenbrook Labs; Cott Beverages
CUNNINGHAM & WALSH - Copy SupervisorJergens; European American Bank; Fox Pharmacals; C.B. Fleet; Southern Railway; Young AmeriClub
WILLIAM DOUGLAS McADAMS - CopywriterBlock Drugs; Reed & Carnick; Johnson & Johnson; Hoechst International; Winthrop Labs; Pfizer International
BBD&O - CopywriterHammermill Paper; General Electric; B.F. Goodrich; Armstrong; Breck Shampoo; Lever Brothers; Playtex; Pillsbury; Sheraton Hotels
SHERYL WHITE FREELANCE:
Automotive: BMW of Manhattan; Mercedes-Benz of North America; CarQuest Auto Parts; BWP Distributors; Braman Honda; Braman Rolls Royce; Avis;
Dotcom: flooz.com; LAA; Microsoft; ClickThings!com; Glaxo Respiratory Institute;
AT&T Wireless; Frontline & Heartgard
Entertainment: USA Network; American Movie Classics; Bravo; Rainbow Programming; The Nostalgia Channel NBC & Cablevision 1992 Olympic Triplecast;
Sports Channel America; CNN; A&E; The History Channel; USSB; HBO; FIT TV; Direct TV; Sirius Satellite Radio, Home Shopping
Fashion: Tumi; Chic Jeans; Lerner Shops; Bobby Brooks
Financial: Citibank: American Cancer Society, Citibank Private Banking, Citibank Mortgage,Manufacturer’s Hanover; Pilgrim Financial Services; Pittock; American Express; GE Credit Card; Prudential Securities; Midlantic Bank Investments; Merrill Lynch; NationsBank; Salomon Smith Barney; First USA; MasterCard; Prudential;Notre Dame Visa; US Airways Visa; Washington Mutual; Bank of America; First National Bank of Omaha
Fitness: Greg Buttles Fitness Centers; Bonaventure Spa; Golden Door Spa; Woodbury Tennis & Fitness
Pharma/Health: GlaxoSmithKline/Advair; Plavix; Zelnorm; Remicaid; Amgen; Baxter; DiaQuest; P&G Attends; Ciba-Geigy; Montifiore; MedFitness; Senior ChoiceCare; Merck; Johnson & Johnson; Hollister; MedAmerica; Blue Cross/Blue Shield; TIAA-Cref Insurance; Pfizer/Aricept; Xalatan; AARP/United HealthCare Group; Aetna Medicare Insurance; Astra-Zeneca/Nexium; Sanofi/Romonabandt; Merial/Frontline;Enbrel; Acomplia
Media: American List Council; PC Magazine; Travel & Leisure; Lears; Modern Maturity; Fast Company
Product: Procter & Gamble: Folger’s, Whirl, Attends, Professional Cleaners; Hills Science Diet; IAM’s; General Foods International Coffees; Empire Berol; Nabisco Brands; Gilson’s Uniforms; Perni Printing; Epson Color Printers; Mayer’s Jewelry; DeBeer’s Diamonds; Continental B-to-B; UPS; Vistacon: 1-Day Acuvue,Acuvue for Monovision; Cracker Barrel Old Country Stores; Tumi; Illy Gourmet Coffee
Pro Bono: Eco-Andes; National Indian Youth Council; The Ms. Foundation for Women; The Boys Choir of Harlem; Cincinnati Chamber of Commerce; National Underground Railroad Freedom Center; Will Power; Mary Cariola
Real Estate: The Heritage on the Garden Condominiums; Coldwell Banker; Citicorp
Services: UPS; UPS Online; Harran Coachways; Allied Carting; Chemtick; Avis Rent-A-Car;Service America; WestTax; Prodigy; Enron Natural Gas & Electric; American Express Mall Promotions; Orlando Promotion, ADU; Gold Card; VISA; MasterCard
Technology: Compaq; Microsoft; Gateway; IBM; Sprint E-Solutions; Dell; Verizon DSL
Telecom: Cellular One; AT&T; MCI; AT&T Wireless Services; Bell Atlantic; NYNEX Mobile;Cincinnati Bell; MCI Online; Ameritech; Iridium Wireless Satellite System; Sprint International; Sprint Business Systems; Sprint Work At Home; Sprint Small Business; Bell South; Frontier
Travel: American Express/AARP Senior Cruises; Majesty Cruise Lines; Golden Door Spa; Bonaventure Resort & Spa, Amelia Island; US Airways; Continental Airlines
Mediterranean Diet Forum, Imperia Working Group 1 – THE MEDITERRANEAN DIET AS UNESCO INTANGIBLE CULTURAL HERITAGE OF HUMANITY Second Part: A BRIEF DEFINITION OF “HOMO MEDITERRANEUS” Pierluigi Ronchetti, Commissione Interministeriale Turismo eno-gastronomico A brief definition of homo mediterraneus is in fact very complex. We shall try to bring it into focus by means