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______________________________________________________________________________________________________ Material Safety Data Sheet

Zymo Research advises each customer or recipient of this MSDS to study it carefully to become aware of and
understand the hazards associated with the product. The reader should consider consulting reference works or individuals who
are experts in ventilation, toxicology, and fire prevention, as necessary or appropriate to use and understand the data contained
in this MSDS.
To promote safe handling, each customer or recipient should: (1) notify its employees, agents, contractors and others whom it knows or believes will use this material or the information in this MSDS and any other information regarding hazards or safety; (2) furnish this same information to each of its customers for the product; and (3) request its customers to notify their employees, customers, and other users of the product of this information. Section 1 – Product and Company Information

Reagent/Buffer Name:
Tetracycline Hydrochloride (Component A) Catalog Number:
Company:
Street Address:
City, State, Zip Code, Country:
Section 2 – Ingredient Information/Composition

Description: Mixture of the substances listed below with nonhazardous additions.
Dangerous Components Name
Section 3 – Hazard Identification

Toxic Acute Effects: Possible risk or harm to the unborn child. May cause harm to breast feed babies. Harmful if swallowed,
inhaled, or absorbed through skin. May cause irritation. California Prop. 65 reproductive hazard.
Toxic Chronic Effects: Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Target organ(s): liver, teeth, bones.
HMIS Rating: (estimated)
Section 4 – First Aid Measures

In Case of
Eye Contact:
Flush contaminated eye(s) with large volumes of water for at least 15 minutes. Get medical attention. Skin Contact:
Wash contaminated areas with soap and water as contaminated clothing is removed. Do not wear contaminated clothing until after it has been properly cleaned. Ingestion:
If victim is conscious wash out mouth with water. Get medical attention. MSDS: Tetracycline Hydrochloride (Component A) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 1 of 4 Inhalation:
Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Section 5 – Fire Fighting Measures

Extinguishing Media:
Water spray, carbon dioxide, dry chemical powder, or appropriate foam. Special Fire Fighting
Wear self-contained breathing apparatus and protective garments to prevent contact with Procedures:
Unusual Fire And Explosions
Emits toxic fumes under fire conditions. Hazards:
Section 6 – Accidental Release Measures

General Information:
Evacuate spill area. Wear self-contained breathing apparatus, chemical safety goggles, rubber boots, and heavy rubber gloves. Spills / Leaks:
Sweep up, while not raising dust. Place in closed containers for waste disposal. Ventilate area and wash spill site after substance is completely cleared. Section 7 – Handling and Storage

Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Storage:
Store tightly closed. Keep container dry. Keep away from heat. Keep away from sources of ignition. Section 8 – Exposure Controls / Personal Protection

Wear appropriate approved/certified respirator, chemical-resistant gloves, safety goggles, other protective clothing. Safety
shower and eye bath. Use only in a chemical fume hood. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure. Wash thoroughly after handling. Toxic. Keep tightly closed. Light sensitive. Store in a cool dry place. Toxic by
inhalation, in contact with skin and if swallowed. Possible risk of irreversible effects. Target organ(s): Liver, teeth, bones. If you
feel unwell, seek medical advice. Wear suitable protective clothing.
Section 9 – Physical and Chemical Properties

Physical States / Form:
Boiling Point:
Melting Point:
Section 10 – Stability and Reactivity

Chemical Stability:
Conditions To Avoid:
Substances To Be Avoided:
Hazardous, Combustion, Or
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas. Decomposition Products:
MSDS: Tetracycline Hydrochloride (Component A) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 2 of 4 Section 11 – Toxicological Information

RTECS No:
Toxicity Data:
Only selected registry of toxic effects of chemical substances (RTECS) data is presented here. See actual entry in RTECS for complete information. Section 12 – Ecological Information

Products of Biodegradation:
Long term degradation products may arise. The products of degradation are more toxic. Biodegradation: Special Remarks on the Products Section 13 – Disposal Considerations

Observe all federal, state, and local laws. Label Precautionary Statement: Toxic
Section 14 – Transport Considerations

DOT Classification:
Not a DOT controlled material (United States). Section 15 – Regulatory Information

European Information:
R60/61: May impair fertility, may cause harm to the unborn child R23/24/25: Toxic by inhalation, in contact with skin, and if swallowed R36/37/38: Irritating to eyes, respiratory system, and skin S36/37/39: Wear suitable protective clothing and gloves eye/face protection
Federal and State Regulations:
TSCA 8(b) Inventory:

Other Regulations:
Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
California proposition 65:
This product contains the following ingredients for which the state of California found to cause cancer, birth defects or other productive harm which require a warning under the statute: Tetracycline HCl Other Classifications:
DSCL (EEC):
This product is not classified according to the EU regulation. Canada – WHMIS:
Class D2A: Material causing other toxic effects (VERY TOXIC). MSDS: Tetracycline Hydrochloride (Component A) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 3 of 4 Section 16 – Other Information
The above information is believed to be correct, but does not purport to be all-inclusive and should be used only as a guide. Zymo Research shall not be held liable for any damage or other consequences resulting from handling or from contact with the above product. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall Zymo Research be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Zymo Research has been advised or the possibility of such damages. All materials supplied by Zymo Research Corp are intended to be used by trained professionals and are for research use only. MSDS: Tetracycline Hydrochloride (Component A) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 4 of 4 ______________________________________________________________________________________________________ Material Safety Data Sheet

Zymo Research advises each customer or recipient of this MSDS to study it carefully to become aware of and
understand the hazards associated with the product. The reader should consider consulting reference works or individuals who
are experts in ventilation, toxicology, and fire prevention, as necessary or appropriate to use and understand the data contained
in this MSDS.
To promote safe handling, each customer or recipient should: (1) notify its employees, agents, contractors and others whom it knows or believes will use this material or the information in this MSDS and any other information regarding hazards or safety; (2) furnish this same information to each of its customers for the product; and (3) request its customers to notify their employees, customers, and other users of the product of this information. Section 1 – Product and Company Information

Reagent/Buffer Name:
Tetracycline Hydrochloride (Component B) Catalog Number:
Company:
Street Address:
City, State, Zip Code, Country:
Section 2 – Ingredient Information/Composition

Description: Mixture of the substances listed below with nonhazardous additions.
Dangerous Components Name
Section 3 – Hazard Identification
NFPA Ratings (scale 0 - 4) :
HMIS Ratings (scale 0 – 4) :
Hazard Category:
Hazardous Identification
Poison. Danger. Flammable. May be fatal if swallowed. Vapor harmful. Harmful if inhaled or Information:
absorbed through skin. Affects Nervous Central System. Causes eyes, skin and respiratory tract irritation. May affect liver, blood, reproductive system. Route(s) of Entry:
Acute and Chronic Heal
Ingestion: Can cause nausea, vomiting, intoxication, depression of the Central Nervous Hazards:
System, diarrhea. In acute cases can cause death. Inhalation: May cause irritation to the mucous membranes of the upper respiratory tract. MSDS: Tetracycline Hydrochloride (Component B) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 1 of 5 Eyes: Liquid and vapor may cause irritation. Splashes may cause temporary pain and blurred vision. Skin: On prolonged contact, may cause irritation, cracking, flaking and defatting of skin. Section 4 – First Aid Measures

In Case of
Eye Contact:
Flush contaminated eye(s) with large volumes of water for at least 15 minutes. Get medical attention. Skin Contact:
Rinse contaminated areas with large volumes of water for at least 15 minutes as contaminated clothing is removed. Get medical attention if area remains irritated. Do not wear contaminated clothing until after it has been properly cleaned. Ingestion:
If conscious, have victim drink water or milk to dilute. Do NOT induce vomiting unless directed to do so by medical personnel. Get medical aid immediately. Never give anything by mouth to an unconscious person. Inhalation:
Remove victim to fresh air. Give oxygen if breathing becomes difficult. Should breathing stop-give artificial respiration. Get medical aid if cough or other symptoms appear. Section 5 – Fire Fighting Measures

Flash Point:
Lower Explosive Limit:
Upper Explosive Limit:
Extinguishing Media:
Use alcohol foam, dry chemical, CO2. Water may be ineffective, but should be used to keep fire-exposed container cool. Special Fire Fighting
Wear self-contained breathing apparatus and protective garments to prevent contact with Procedures:
Fire Hazards in Presence of
Highly flammable in presence of open flames and sparks, of heat. Slightly flammable to Various Substances:
flammable in presence of oxidizing materials. Non-flammable in presence of shocks, of reducing materials, of combustible materials, of organic materials, of metals, of acids, of alkalis. Products of Combustion:
These products are carbon oxides (CO, CO2). Explosion Hazards:
Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Can release vapors that form explosive mixtures at temperatures above the flashpoint. Containers may explode in the heat of a fire. Section 6 – Accidental Release Measures

Spills / Leaks:
Ventilate area. Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition. Use a spark-proof tool. A vapor suppressing foam may be used to reduce vapors. Wear appropriate personal protective equipment.
Section 7 – Handling and Storage

Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Storage:
Keep container tightly closed in a cool, dry, and well-ventilated place. Keep away from heat, sparks, and flame. MSDS: Tetracycline Hydrochloride (Component B) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 2 of 5 Section 8 – Exposure Controls / Personal Protection

Wear appropriate approved/certified respirator. Chemical resistant gloves. Chemical safety goggles. Lab coat. Safety shower
and eye both. Mechanical exhaust required. Keep tightly closed. Wash thoroughly after handling. Do not get in contact with
eyes, skin or on clothing. Do not inhale vapor. Severe eye irritant.
Chemical Name
Section 9 – Physical and Chemical Properties

Physical States / Form:
Melting/Freezing Point:
Boiling Point:
Flashpoint:
Vapor Pressure:
Specific Gravity:
Solubility In Water:
Section 10 – Stability and Reactivity

Chemical Stability:
Conditions To Avoid:
Incompatible materials, ignition sources, excess heat, oxidizers. Substances To Be Avoided:
Strong oxidants, hydrazine, alkali metals, peroxides, silver salts, acid chlorides, metal hydrates, and others. Hazardous Decomposition
Products:
Hazardous Polymerization:
Section 11 – Toxicological Information
LD50 Oral Rat:
LC50 Inhalation Rat:
LD50 Oral Rabbit:
Carcinogenicity:
Not listed by ACGIH, IARC, NTP, or CA Prop 65 Reproductive Effects:
Ethanol has been linked to birth defects in humans. MSDS: Tetracycline Hydrochloride (Component B) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 3 of 5 Section 12 – Ecological Information
Does not bioaccumulate, readily biodegrades, evaporates to modern extent. Leaches into groundwater, readily biodegrades, quickly evaporates. Readily degrades by reaction with photochemically produced hydroxyl radicals. Readily removed by dry and wet deposition. Section 13 – Disposal Considerations

Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 – Transport Considerations
Domestic (Land, DOT):
Shipping Name: Ethanol Hazard Class: 3 UN/NA: UN3065 Packing Group: II International (Water, I.M.O.):
Shipping Name: Ethanol Hazard Class: 3.2 UN/NA: UN3065 Packing Group: II Section 15 – Regulatory Information
Federal and State Regulations
TSCA Inventory:
CAS# 64-17-5: Listed CAS# 7732-18-5: Listed Health & Safety Reporting List:
Chemical Test Rules:
Section 12b:
TSCA Significant New Use Rule:
CERCLA Hazardous Substances
and corresponding RQs:
SARA Section 302:
SARA Codes:
CAS # 64-17-5: acute, chronic, flammable Section 313:
Clean Air Act:
Hazardous air pollutants: None Class 1 Ozone Depletors: None Class 2 Ozone Depletors: None Clean Water Act:
Hazardous Substances: None Priority Pollutants: None Toxic Pollutants: None MSDS: Tetracycline Hydrochloride (Component B) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 4 of 5 CAS# 64-17-5 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts. CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ. California Prop 65:
WARNING: This product contains Ethyl alcohol, a chemical known to the state of California to cause developmental reproductive toxicity. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations
Hazard Symbols:
Risk Phrases:
Safety Phrases:
Canada - DSL/NDSL:
CAS# 64-17-5: Listed CAS# 7732-18-5: Listed Canada – WHMIS:
Canadian Ingredient Disclosure
Section 16 – Other Information
The above information is believed to be correct, but does not purport to be all-inclusive and should be used only as a guide. Zymo Research shall not be held liable for any damage or other consequences resulting from handling or from contact with the above product. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall Zymo Research be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Zymo Research has been advised or the possibility of such damages. All materials supplied by Zymo Research Corp are intended to be used by trained professionals and are for research use only. MSDS: Tetracycline Hydrochloride (Component B) Creation Date: 3/20/03 Revision Date: 7/16/09 Page 5 of 5

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