Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Eim_scientific_factsheet

CONTACT
American College of Sports Medicine Why is Exercise Medicine?
EXERCISE IS MEDICINE Physical inactivity is a fast-growing public health problem and contributes to a variety of
chronic diseases and health complications, including obesity, heart disease, diabetes, hypertension, cancer,
depression and anxiety, arthritis, and osteoporosis. In addition to improving a patient’s overall health, increasing
physical activity has proven effective in the treatment and prevention of chronic diseases.
Regular physical activity at the correct intensity:
• Reduces the risk of heart disease by 40% • Reduces the incidence of high blood pressure, by almost 50% • Reduces the incidence of diabetes by almost 50% Just 30 minutes of physical activity per day can: • Reduce mortality and the risk of recurrent breast cancer by almost 50% • Lower the risk of colon cancer by more than 60% • Reduce the risk of developing of Alzheimer’s disease by one-third • Decrease depression as effectively as Prozac or behavioral therapy PHYSICAL INACTIVITY LEADS TO HIGHER RISK OF DEATH
Physical inactivity has a greater effect on the rate of mortality than other major factors, such as smoking, hypertension, diabetes and high cholesterol. Effect of Fitness (CRF*) on Mortality Attributable Fractions (%) for All-Cause Deaths
40,842 Men & 12,943 Women, ACLS Blair SN. Physical inactivity: the biggest public health problem of the 21st century. Br J Sports Med 2009; 43:1-2. CONTACT
American College of Sports Medicine FIT VS. FAT — LEVEL OF FITNESS HAS GREATER EFFECT ON MORTALITY THAN BODY FAT
A low level of fitness is a bigger risk factor for mortality than mild-moderate obesity. It is better to be fit and overweight than unfit with a lower percentage of body fat. Joint Associations of CRF* and % Body Fat with All-Cause Mortality, Adults 60+
Normal
Obese
Rates adjusted for age, sex and exam year PHYSICAL ACTIVITY DECREASES RISK FOR DIABETES PATIENTS WITH CARDIO VASCULAR DISEASE
Fitness levels have a substantial impact on the risk for cardio vascular disease mortality. Those with a moderate or high level of fitness are much less likely to die of cardio vascular disease than those who are less active. CVD* Mortality Risk by Fitness and BMI Categories, 2316 Men with Diabetes, 179 CVD Deaths
lity 8
rta 7
18.5 < BMI <25.0 25.0 ≤ BMI <30.0 30.0 ≤ BMI < 35.0
Rates adjusted for age, sex and exam year Church TS et al. Arch Int Med 2005; 165:2114

Source: http://www.bewegenismedicijn.nl/files/downloads/5._waarom_bewegen_-_exercise_is_medicine.pdf