Pii: s0140-6736(02)11208-6

e-mail submissions to correspondence@lancet.com Sir—Björn Dahlöf, in the LIFE study,1 Lars Lindholm and colleagues “to share exciting news” and remind me of the results of the LIFE study.
cardiologists received the same letter. I porosity of liver sinusoids in relation to loss of integrity of the endothelial lining, Dahlöf B, Devereux RB, Kjeldsen SE, et al.
Cardiovascular morbidity and mortality in reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995–1003.
into the analysis of the trial results is Department of Clinical Epidemiology, Leiden The Lancet entirely on its scientific Dahlöf B, Devereux RB, Kjeldsen SE, et al.
Cardiovascular morbidity and mortality in (1·5–1·9 vs 15–25 fenestrae/µm2).
reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995–1003.
Lindholm LH, Ibsen H, Dahlöf B, et al.
Cardiovascular morbidity and mortality in hypertension study (LIFE): a randomised
trial against atenolol. Lancet 2002; 359:
THE LANCET • Vol 360 • October 12, 2002 • www.thelancet.com For personal use. Only reproduce with permission from The Lancet Publishing Group.
Department of Infectious Diseases and Tissue Typing Laboratory, Department of Clinical Roy S, Knox K, Segal S, et al. MBL outside5 the Cleveland Clinic cohorts.
study. Lancet 2002; 359: 1569–73.
Garred P, Madsen HO, Halberg P, et al.
and susceptibility to infection in systemic lupus erythematosus. Arthritis Rheum 1999; 42: 2145–52.
Kronborg G, Weis N, Madsen HO, et al.
Variant mannose-binding lectin alleles are not associated with susceptibility to and infection in randomly included patients. J Infect Dis 2002; 185: 1517–20.
Garred P, Pressler T, Madsen HO, et al.
Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J Clin Invest 1999; 104: 431–37.
Koch A, Melbye M, Sorensen P, et al.
risk (nine [6·4%] of 140 vs seven during early childhood. JAMA 2001; 285:
significant, we took no further notice.
the relevant issue in heart-rate recovery significant (p<0·0001) increased risk athletes, and heart-failure patients.
biologically based hypothesis. Its ability MSL receives research support from theNational Heart, Lung, and Blood Institute of *Michael S Lauer, Victor Froelicher *Clinical Research and Stress Laboratory, Department of Cardiovascular Medicine, DeskF25, Cleveland Clinic Foundation, 9500 Euclid Division of Cardiovascular Medicine, StanfordUniversity Medical Center and the Veterans A=normal MBL allele; O=common designation for variant alleles B (codon 54), C (codon 57), D (codon 52).
Affairs Palo Alto Health Care System, Palo Alto, *Initial patient set. †Confirmatory study.
Combined analysis of three MBL association studies THE LANCET • Vol 360 • October 12, 2002 • www.thelancet.com For personal use. Only reproduce with permission from The Lancet Publishing Group.
recovery after exercise. Lancet 2002; 359:
mediated heart rate recovery after exercise isaccelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol 1994; 24: 1529–35.
Snader CE, Lauer MS. Heart-rate recoveryimmediately after exercise as a predictor of mortality. N Engl J Med 1999; 341:
Pashkow FJ, Lauer MS. Heart rate recovery and treadmill exercise score as predictors ofmortality in patients referred for exercise ECG. JAMA 2000; 284: 1392–98.
Shetler K, Marcus R, Froelicher VF, et al.
mineral riches. It is set to produce 2·5 methodologic issues. J Am Coll Cardiol
2001; 38: 1980–87.
right to explore untapped oil reservesprovide nearly US$1 billion, but Our research was partly funded by the Secure the Future Project of Bristol-Myers Squibb.
much of that is used to finance thewar effort. In the past decade, more Centre for Actuarial Research, and School of Public Health, University of Cape Town, South Africa; *Burden of Disease Research Unit, and Biostatistics Unit, South African Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa; and Centre for Population registrations. It does no such thing.
Fiala C, de Harven E, Herxheimer A, et al.
HIV/AIDS data in South Africa. Lancet 2002; 359: 1782.
1997–2000. Statistical release P0309.1.
Pretoria: Statistics South Africa, 2001.
available for years later than 1996.
http://www.gov.za/speeches/cabinetaids02.
mortality statistics for 1997–2000.3 In that statistics report’s introduction, it THE LANCET • Vol 360 • October 12, 2002 • www.thelancet.com For personal use. Only reproduce with permission from The Lancet Publishing Group.

Source: http://www.cardiology.org/recentpapers/lancet%20letter.pdf