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Microsoft word - statement about bird flu nov 2005 headed.doc
Bird flu, is a contagious disease caused by avian (bird) influenza virus. It is commonly seen in birds, but on rare occasions, can infect humans. There are 15 types of bird flu viral strains. The most contagious strains are
H5 and H7. The type currently causing concern is the deadly strain H5N1. The widespread persistence of H5N1 in poultry populations poses risks for human health.
Of the few bird flu viruses that have infected humans, H5N1 has caused the largest number of cases of
severe disease and death in humans. The disease caused by H5N1 follows an unusually aggressive clinical course, with rapid deterioration and high fatality. In the present outbreak, more than half of those infected
with the virus have died. Most cases have occurred in previously healthy children and young adults. In the
current outbreak, laboratory-confirmed human cases have been reported in four countries: Cambodia,
Direct contact with infected poultry, or surfaces and objects contaminated by their faeces, is presently considered the main route of human infection. Though more than 100 human cases have occurred in the
current outbreak, this is a small number compared with the huge number of birds affected and the numerous associated opportunities for human exposure, especially in areas where backyard flocks are common. It is not
presently understood why some people, and not others, become infected following similar exposures. The virus does not seem to spread easily from birds to humans. However there are chances that the virus may
change into a form that is highly infectious for humans and may spread easily from person to person. Such a change could lead to a global outbreak (a pandemic). It is estimated that up to 50,000 Britons could die if bird
flu mutates to a form easily passed between humans.
Bird flu usually present with muscle aches, fever, sore throat, and cough. Some patients may subsequently
develop pneumonia, acute respiratory distress syndrome and other severe and life-threatening complications including multi-organ failure, which may be associated with over 50% mortality.
There is no vaccine for prevention of bird flu. Oseltamivir (Tamiflu) and Zanamivir (Relenza) can reduce the severity and duration of illness caused by influenza. So far, most fatal pneumonia seen in cases of H5N1
infection has resulted from the effects of the virus, and cannot be treated with antibiotics. Nonetheless, since influenza is often complicated by secondary bacterial infection of the lungs, antibiotics could be life saving in
Extracorporeal membrane oxygenation (ECMO) in respiratory failure due to bird flu:
Although there have not yet been any reported cases of H5N1 pneumonia being treated with ECMO, our experience of treating other forms of severe pneumonia (including viral pneumonias) with survival rate of
more than 70%, suggest that ECMO may be a useful adjunct in the management of this condition. Please contact the ECMO team at Glenfield hospital, Leicester (01162871471 or 07984 740 111), for further
information or to refer any potential patient. Any referral of an adult patient (18-65 years) with H5N1 pneumonia will be within the framework of the CESAR Trial (www.cesar-trial.org) . Children, however, can
be referred directly for ECMO. Adults >65 years can also be referred directly but are rarely suitable for ECMO treatment. Please see the UHL Glenfield Hospital web site for further information about ECMO
For further information about CESAR see www.cesar-trial.org
Published online May 11, 2004 2594±2597 Nucleic Acids Research, 2004, Vol. 32, No. 8Mapping of the second tetracycline binding site onthe ribosomal small subunit of E.coliMaria M. Anokhina1, Andrea Barta2, Knud H. Nierhaus3, Vera A. Spiridonova4 andAlexei M. Kopylov1,4,*1Department of Chemistry, Moscow State University, 119992 Moscow, Russian Federation, 2Institute ofBiochemistry, Universi
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