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Quinine figured into America’s history in many ways.
Each year, between 300 and 500 million people become infected
Some say, that, without the quinine, it never would have been
with the disease. Over one million of them die.
possible to build the Panama Canal. Malaria was a leading
cause of death among workers building the canal. Without the
Most of them children … under the age of five … living in Africa.
help of quinine and other insect control measures, the human cost of building the canal would have been too high.
It’s malaria … a disease that has been around at least since man
Two important breakthroughs in the fight against malaria
If you have it, at first you might think that you have the flu.
The first was the discovery that DDT (dichloro-diphenyl-trichlo-
The symptoms are pretty much the same: fever, chills, headache,
roethane) could be an extremely effective pesticide when used
tiredness, sweating, nausea and vomiting.
And the symptoms may go away after a few days … only to return
The second was the development of a synthetic form of
quinine, called chloroquine. It was very effective, had few side
effects, and, most importantly, was very inexpensive.
As the parasites causing the infection grow and invade more and
With these two tools, it looked as if malaria might be headed
And, if the parasites that infect the victim are Plasmodium falci-
, things get pretty serious pretty fast. This form of the parasite
But … not for long. Too many people were using DDT for too
is responsible for about half the cases of malaria in the world.
many other purposes. As a result, it was accumulating in the
environment and causing illness and death for animals such as
Victims of this kind of parasite can suffer a whole array of symp-
falcons and salmon. And people feared that DDT would eventu-
toms: bleeding problems, shock, liver or kidney failure, and coma.
ally cause illness and death for humans.
If they don’t get treatment quickly, they can die.
In 1972, it became illegal to use DDT in the US. Other countries
Even with treatment, about 20 percent will still die.
soon followed in prohibiting the use of DDT.
The other leg of the solution was soon knocked out as well. The
plasmodia that cause malaria have a short life cycle. That
In the past, there were some very reliable options. As early as the
means that it doesn’t take them long to develop a resistance to
1600s, natives of Peru used the bark of the Chinchona tree to cure
threats from disease fighters such as chloroquine. Before long,
this fever. The bark worked because it contained quinine, a sub-
chloroquine was no longer effective in treating malaria,
stance that disrupted the parasite’s reproductive cycle.
especially the most deadly kind. The parasites had mutated
Jesuit missionaries brought word of this remarkable cure to many
other countries where malaria was epidemic, including Italy and other
Malaria came charging back, even in countries like Sri Lanka
countries in Europe. Demand for quinine soared.
and Taiwan, where it had previously been in sharp decline. And
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2010 Maryland Public Television. All rights reserved.
My te: _
Part of the upturn in this lethal disease was due to poverty. Develop-
ing countries –especially in sub-Saharan Africa – did not have the resources to provide their people with needed medical care and
preventive measures such as bed netting.
But, there are many other environmental factors that are increasing the threat of malaria and other diseases carried by animals and
Animals and insects live in habitats that are suited for them. They
prefer a specific range of temperatures, a specific range of precipi-
It doesn’t matter where these conditions occur. Insects and other
animals will leave a place that no longer gives them the right tem-
perature range or the right geographic feature such as a forest.
And they will expand their ranges to include areas that now feature their ―must-haves.‖
When they move to these ―other‖ areas vector animals and insects
(those that carry diseases) bring their diseases with them.
A whole population—the existing residents of that ―other‖ area—
And this population hasn’t had a chance to build immunity to the
To them, their new neighbors are a deadly group.
That’s what’s happening now with malaria. It’s been getting hotter in certain areas of the world, if only by a small fraction of a degree.
But that small fraction is enough for the mosquitoes to expand their
The lethal disease of malaria is on the move.
As are other vector-borne illnesses … diseases such as Lyme Dis-
ease, yellow fever, West Nile virus, and even dengue fever.
Our climate is changing … and so is the risk that more and more people will get new and deadly diseases carried by insects and animals moving into new homes.
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2010 Maryland Public Television. All rights reserved.
SUMMARY OF PRODUCT CHARACTERISTICS NAME OF THE MEDICINAL PRODUCT Citalopram Bluefish 10 mg film-coated tablets Citalopram Bluefish 20 mg film-coated tablets Citalopram Bluefish 40 mg film-coated tablets 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Citalopram Bluefish 10 mg film-coated tablets: Each tablet contains 12.49 mg citalopram hydrobromide, equivalent to 10 mg citalop
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