The toxicology section routinely tests for more than 150 drugs, including common drugs of abuse, volatiles, central nervous sy
DRUG FACT SHEET:
The Toxicology Section routinely tests for more than
Benztropine is a drug used in the treatment of
150 drugs, including common drugs of abuse, volatiles,
Parkinsonism. Medical literature warns that
central nervous system stimulants, depressants,
benztropine may impair mental and/or physical abilities
narcotic analgesics, hallucinogens, psychotropic drugs,
required for performance of hazardous tasks, such as
over the counter medicines, and therapeutic drugs.
Benzylpiperazine (BZP) is a recreational drug with
euphoric, stimulant properties. The effects produced by
11-Hydroxy-Tetrahydrocannabinol (Hydroxy-THC) is
a metabolite of tetrahydrocannabinol (THC), the major
Brompheniramine is an antihistamine available as an 11-Nor-9-Carboxy-Tetrahydrocannabinol (Carboxy-
over-the-counter drug. It may cause central nervous
THC) is a metabolite of tetrahydrocannabinol (THC), the
major psychoactive constituent of marijuana.
Bupivacaine is a long-acting local anesthetic which is 6-Monoacetylmorphine is an active metabolite of
heroin. Its presence in biological samples is indicative
Buprenorphine (Buprenex) is a synthetic opioid
analgesic which is structurally related to morphine. It is
7-Aminoclonazepam is a metabolite of the drug
used for the treatment of moderate to severe pain and
clonazepam (Klonopin) a central nervous system
is approximately 25 to 40 times more potent than
7-Aminoflunitrazepam is a metabolite of flunitrazepam Bupropion (Wellbutrin, Zyban) is an antidepressant
(Rohypnol), a potent central nervous system
drug that is also used for smoking cessation.
Buproprion Metabolite is a byproduct of buproprion
Acetaminophen (Tylenol) is a non-narcotic analgesic
(Wellbutrin, Zyban). Buproprion is an antidepressant
drug that is also used for smoking cessation.
Acetone is a common solvent for plastics, paints, and Buspirone (Buspar) is used therapeutically for the
adhesives. Endogenous acetone may be present as a
Butalbital is a short to intermediate-acting barbiturate Alpha-hydroxyalprazolam is an active metabolite of
commonly compounded with aspirin, caffeine, and
the anti-anxiety benzodiazepine drug alprazolam
occasionally codeine. The drug is prescribed for the
(Xanax). It may cause central nervous system
treatment of tension headaches and may cause central
Alpha-hydroxymidazolam is an active metabolite of Butorphanol (Stadol) is a synthetic narcotic analgesic
the sedative benzodiazepine drug midazolam.
that is structurally related to morphine. Butorphanol is
Alpha-triazolam is a metabolite of the
used for the treatment of moderate to severe pain, and
sedative/hypnotic benzodiazepine drug triazolam.
has a potency of 5 to 8 times that of morphine.
Alprazolam (Xanax) is a benzodiazepine class of Carbamazepine (Tegretol) is structurally related to the
drugs. It is prescribed for management of anxiety
tricyclic antidepressants and is currently used as an
disorders. It may cause central nervous system
anticonvulsant drug. It may cause central nervous
Amitriptyline (Elavil, Endep) is a tricyclic Carisoprodol (soma) is a rapidly acting muscle
antidepressant drug used in the treatment of
relaxant available in prescription form. It may cause
depression. It may cause central nervous system
central nervous system depressant effects.
Cetirizine (Zyrtec)an antihistamine, is a major Amoxapine is an antidepressant drug that may result in
metabolite of hydroxyzine, used in the treatment of
central system depressant effects. Amoxapine may be
allergies, hay fever, angioedema, and urticaria. Chlordiazepoxide (Librium) is a member of the Amphetamine (Benzedrine, Dexedrine) is a central
benzodiazepine class of drugs. It is prescribed as an
nervous system stimulant with a high potential for
anti-anxiety drug. It may cause central nervous system
abuse. It may be detected in biological samples as a
depressant effects. Chlordiazepoxide is metabolized to
Antipyrine is a drug used primarily an analgesic used Chlorpheniramine is an over-the-counter antihistamine
as a component of topical solutions for decongestion
found in many cold and allergy medications. It may
cause central nervous system depressant effects.
Benzoylecgonine is a hydrolysis product of cocaine Chlorpromazine (Thorazine) is a potent anti-psychotic
without pharmacological activity. Its presence in a
drug. It may cause central nervous system depressant
biological sample is an indication of cocaine use.
DRUG FACT SHEET: Citalopram (Celexa) is a selective serotonin reuptake Diltiazem (Cardiazem) is a calcium channel blocker
inhibitor. It is used therapeutically for the treatment of
that is prescribed for the treatment of angina,
hypertension, and arrhythmias. This cardiovascular
Clomipramine is a tricyclic antidepressant used
primarily in the treatment of obsessive and compulsive
Diphenhydramine (Benadryl) is an antihistamine
behavior. It may cause central nervous system
available in many over-the-counter cold, allergy, and
motion sickness medications. It may cause central
Clonazepam (Klonopin, Clonopin, Rivotril) is a
benzodiazepine derivative used primarily for seizure
Doxepin (Adapin) is a tricyclic antidepressant drug
disorders. It may cause central nervous system
used in the treatment of depression and/or anxiety. It
may cause central nervous system depressant effects.
Clonidine is a potent antihypertensive agent which may Doxylamine (Unisom) is an antihistamine contained in
cause central nervous system depressant effects.
many over-the-counter cold preparations. It is used
Clozapine (Clozaril) is an antipsychotic drug that is
primarily as a sleep-inducing agent. It may cause
used for the treatment of severely ill schizophrenic
patients that do not respond to standard antipsychotic
EDDP is a metabolite of methadone, a synthetic opioid.
drug treatment. It may result in central nervous system
Its presence in a biological sample is an indication of
Cocaethylene is enzymatically produced when cocaine Ephedrine/Pseudoephedrine are used as a nasal
and ethanol are consumed. Cocaethylene is
decongestants and bronchodilators in various over-the-
pharmacologically active and its presence in a
counter cold and allergy medications. These
biological sample is an indication of cocaine use.
substances have stimulant-like effects and are
Cocaine is a potent naturally occurring central nervous
encountered in various dietary supplements and weight-
system stimulant with an extremely high potential for
abuse. Crack cocaine is freebased cocaine which is
Estazolam (ProSom) is a hypnotic drug of the
benzodiazepine class. It is used for the short-term
Codeine is a narcotic analgesic drug prescribed for the
relief of pain or as a cough suppressant. It may cause
Ethanol (ethyl Alcohol, Alcohol) is a central nervous
central nervous system depressant effects.
Cyclobenzaprine (Flexeril) is a centrally-acting muscle Etomidate (Amidate) is a short acting intravenous
relaxant which can produce central nervous system
anaesthetic agent used for the induction of general
anaesthesia and for sedation. It is a central nervous
Desalkylflurazepam is a metabolite of flurazepam
(Dalmane). Flurazepam is a hypnotic drug of the
Fentanyl is a synthetic analgesic with a high potential
benzodiazepine class that may produce central nervous
for abuse. It is used as a surgical anesthetic and is
sometimes found in samples of illicit synthetic heroin
Desipramine is a tricyclic antidepressant used for the
(china white). Fentanyl has a potency approximately
treatment of depression. Desipramine is also used as a
100 to 200 times that of morphine and can cause
metabolite of Imipramine. It may cause central nervous
central nervous system depressant effects.
Fluconazole antifungal drug used in the treatment and Diazepam is a benzodiazepine-type drug prescribed for
prevention of superficial and systemic fungal infections.
its antianxiety, anticonvulsant, and muscle relaxing
Flunitrazepam (Rohypnol) is an extremely potent
properties. It may cause central nervous system
hypnotic drug of the benzodiazepine class. It is not
available therapeutically in the United States.
Difluoroethane (ethylene fluoride) is a gas used as a Fluoxetine (Prozac) is selective serotonin reuptake
propellant in canned air dusters such as “dust off” and
inhibitor which is used for the treatment of depression.
can be abused to get a small and short-lived buzz from
Flurazepam (Dalmane) is a hypnotic drug of the
benzodiazepine class. Due to its rapid metabolism,
Dihydrocodeine is a narcotic analgesic with central
flurazepam is normally not observed in the blood, rather
nervous system depressant effects. It is prescribed for
as a pharmacologically active metabolite, n-
the treatment of mild to moderate pain and has an
desalkylflurazepam. It may cause central nervous
analgesic potency approximately one third that of
morphine. Dihydrocodeine is also a metabolite of the
Fluvoxamine (Luvox) is a selective serotonin reuptake
inhibitor which is used for the treatment of depression.
DRUG FACT SHEET: Gabapentin (Neurontin) It was originally developed for Imipramine (Tofranil) is a tricyclic antidepressant used
the treatment of epilepsy but currently is widely used to
for the treatment of depression. It may cause central
relieve pain, especially neuropathic pain. It can produce
central nervous system depressant effects.
Isopropanol (2-propanol, rubbing alcohol) is a central Gamma butyrolactone (GBL) is a colorless liquid used
nervous system depressant that is metabolized to
in the production of floor strippers, glue removers, paint
acetone in the body. Isopropanol may accumulate in
thinners, pesticides, herbicides, inks, dyes, and other
the body as a result of certain medical conditions.
industrial products. When swallowed, it acts as a
Ketamine (Ketalar, Ketaject) is a rapid-acting veterinary
depressant. It is metabolized in the body into GHB. It is
anesthetic closely related to phencyclidine (PCP).
also considered a "date rape" drug because it can
Lamotrigine (Lamictal) is an anticonvulsant drug which
render a victim unconscious and produce memory loss
is used for the treatment of epilepsy. It may cause
Gamma-Hydroxybutyrate (GHB) can produce
central nervous system depressant effects.
profound central nervous system depression in large
Levorphanol (Dromoran) is potent synthetic narcotic
doses. The drug is encountered illicitly as a
with a high potential for abuse. It is prescribed for the
recreational euphoriant. GHB is also an endogenous
treatment of moderate to severe pain. The analgesic
(Natural) neuromodulator which is present in biological
potency of levorphanol is approximately 4 to 5 times
that of morphine and it can produce central nervous
Guaifenesin is used extensively as an expectorant and
veterinary muscle relaxant. It is present in many over-
Lidocaine is commonly used as a local anesthetic in Haloperidol (Haldol) is used in the treatment of Lorazepam (Ativan) is an antianxiety agent similar to
psychotic disorders. It may cause central nervous
diazepam (Valium). It may cause central nervous
Heroin is a synthetic narcotic analgesic with a high Loxapine is a tricyclic drug used for the treatment of
potential for abuse. It is a common illicit drug and is not
psychosis. It may cause central nervous system
available therapeutically in the United States. It may
cause central nervous system depressant effects.
Maprotiline is a tetracyclic drug used for the treatment Hydrocodone (Vicodin, Lortab, Panacet) is a
of depression. It may cause central nervous system
semisynthetic narcotic analgesic with a high potential
for abuse. It is prescribed as a pain reliever and cough
mCPP (meta-Chlorophenylpiperazine) is an active
suppressant and it is structurally related to morphine.
metabolite of Trazadone as well as a recreational
Hydrocodone has an analgesic potency approximately
psychoactive drug of the piperazine chemical class
1 to 2 times that of morphine and may cause central
reported to produce stimulant and hallucinogenic
Hydromorphone (Dilaudid) is a semisynthetic narcotic Meclizine (Antivert) is an antihistamine used for the
analgesic with a high potential for abuse. It is
treatment of vertigo and motion sickness.
prescribed as a pain reliever and cough suppressant
Meperidine (Demerol) is a synthetic narcotic analgesic
and it is structurally related to morphine.
with a high potential for abuse. The drug is used for the
treatment of moderate severe pain. The analgesic
approximately 7 to 10 times that of morphine and may
potency of meperidine is approximately one tenth that
cause central nervous system depressant effects.
of morphine. It may cause central nervous system
Hydroxybuproprion is a metabolite of Buproprion
(Wellbutrin, Zyban) and antidepressant drug.
Meprobamate (Miltown, Equanil) is used Hydroxyethylflurazepam is a metabolite of flurazepam
therapeutically as a sedative/hypnotic, antianxiety agent
(Dalmane). Flurazepam is a hypnotic agent of the
and skeletal muscle relaxant. Meprobamate is also a
metabolite of Carisoprodol (Soma). It may cause
Hydroxyzine (Vistaril, Atarax) is a sedative agent with
central nervous system depressant effects.
antihistaminic properties, is used in the treatment of
Mesoridazine (Lidanil, Serentil) is an antipsychotic
anxiety and tension. It may cause central nervous
agent. It may cause central nervous system depressant
Ibogaine is a naturally occurring psychoactive Metaxalone (Skelaxin) is a muscle relaxant used to
substance found in a number of plants. Has been used
relax muscles and relieve pain caused by strains,
to treat opioid addiction. It may cause central nervous
sprains, and other musculoskeletal conditions. It may
cause central nervous system depressant effects.
Ibuprofen (Advil, Motrin) is a non-narcotic analgesic DRUG FACT SHEET: Methadone (Dolophine) is a synthetic opioid which is Morphine is a narcotic analgesic used for the treatment
used for the treatment of pain and opiate dependence.
of moderate to severe pain. It has a high potential for
Methamphetamine (Desoxyn, Methedrine) is a potent
abuse. Morphine may be present as a metabolite of
central nervous system stimulant drug with an
other narcotic analgesics, such as codeine or heroin. It
extremely high potential for abuse. In small doses, the
may cause central nervous system depressant effects.
drug is used for the treatment of obesity.
Naproxen (Aleve, Naprosyn) is a nonsteroidal anti- Methanol (methyl alcohol, wood alcohol) is a central
inflammatory drug with analgesic and antipyretic
nervous system depressant and a common solvent for
Nefazodone is a serotonin reuptake inhibitor used for Methaqualone (Quaalude) is a sedative/hypnotic that
the treatment of depression. It may produce central
was removed from the U.S. market in 1984 due to its
extensive misuse. It may cause central nervous system
Nordiazepam is an active metabolite of several
benzodiazepines, including diazepam (Valium). It may
Methocarbamol (Robaxin) is used therapeutically as a
cause central nervous system depressant effect.
sedative or muscle relaxant that may result in
Nordoxepin is an active metabolite of Doxepin
(Adapin), which is used for the treatment of anxiety or
Methorphan, is chemically related to codeine. It is
depression. It may cause central nervous system
found in several over-the-counter preparations which
are used as cough suppressants. It may cause central
Norfluoxetine is an active metabolite of fluoxetine
nervous system depressant effects as well as
(Prozac), which is used for the treatment of depression.
Normeperidine is an active metabolite of meperidine Methotrimeprazine is an antipsychotic phenothiazine
(Demerol), a narcotic analgesic with a high potential for
derivative similar to chlorpromazine (Thorazine). When
prescribed in this county, however, it is used an as
Norproxyphene is an active metabolite of
analgesic. It is a central nervous system depressant.
propoxyphene, a mildly effective narcotic analgesic
Methyl Ethyl Ketone (MEK) is used as a solvent in
(pain reliever). It may cause central nervous system
household products such as lacquer, varnishes, paint
remover, a denaturing agent for denatured alcohol,
Nortriptyline (Aventyl, Pamelor) is a tricyclic drug used
glues, and as a cleaning agent. Can be abused to get a
for the treatment of depression. It can be present as a
metabolite of amitriptyline (Elavil) and may cause
Methylenedioxyamphetamine (MDA) is a psychedelic,
central nervous system depressant effects.
stimulant and empathogen-enactogen amphetamine
O-Desmethylvenlafaxine is an active metabolite of
derivative also a metabolite of MDMA. It can produce
Venlafaxine (Effexor), an antidepressant drug.
both central nervous system stimulation and
Olanzapine (Zyprexa) is an antipsychotic drug related
to the benzodiazepine class. It may cause central
Methylenedioxymethamphetamine (MDMA) is a
synthetic drug possessing both stimulant and mild
Orphenadrine (Norgesic) is an anticholinergic agent
hallucinogenic properties. On the street it is known as
used in treatment of Parkinsonism. It may produce
central nervous system depressant effects.
Methylphenidate (Ritalin) is a drug used in the Oxazepam is an antianxiety agent of the
treatment of depression, narcolepsy, and childhood
benzodiazepine class. It is also found as an active
hyperkinesis. Overdose can cause drowsiness or
metabolite of several other benzodiazepines. It may
cause central nervous system depressant effects.
Midazolam (Versed) is a member of the Oxycodone (Oxycontin, Roxicondone, Percodan,
benzodiazepine class of drugs. It is only available for
Percocet, Roxicet, Tylox) is a semisynthetic narcotic
presurgical sedation in the injectable form.
analgesic with a high potential for abuse. It is
Mirtazapine (Remeron) is tetracyclic drug used for the
prescribed for the treatment of moderate to severe pain
and may cause central nervous system depressant
Modafinil (Provigil) is a central nervous system
stimulant medication used for the treatment of
Oxymorphone (Numorphan) powerful semi-synthetic
narcolepsy, shift work sleep disorder and excessive
opioid analgesic and can produce central nervous
daytime sleepiness associated with obstructive sleep
Papaverine is a naturally occurring opium alkaloid. It is
used therapeutically as a vasodilator and
DRUG FACT SHEET: Paroxetine (Paxil) is a serotonin reuptake inhibitor Propoxyphene (Darvon) is a mildly effective synthetic
narcotic analgesic used for the treatment of mild to
Pentazocine is a synthetic narcotic analgesic which is
moderate pain. It may cause central nervous system
prescribed for the treatment of moderate to severe pain.
It may cause central nervous system depressant
Propylhexedrine (Benzedrex, Obesin) is structurally
related to methamphetamine. Propylhexedrine is
Pentobarbital (Nembutal) is a short-acting barbiturate
available over-the-counter for use as a nasal
with sedative, anticonvulsant and central nervous
Protriptyline (Vivactil) is a tricyclic antidepressant drug. Phencyclidine (PCP) is an illicit drug of abuse and a
It may cause central nervous system depressant
veterinary tranquilizer. It produces dissociative
Quetiapine (Seroquel) is a neuroleptic agent, used for Phendimetrazine is an anorexic drug (appetite
suppressant). It possesses central nervous system
Quinidine is an antiarrhythmic agent. It occurs
stimulant properties like amphetamine-type drugs.
naturally with quinine in cinchona bark.
Pheniramine is an antihistamine drug which is found in Quinine is an antimalarial agent. It occurs naturally
combination with decongestants, antitussives,
with Quinidine in cinchona bark and is sometimes used
Phenmetrazine is an anorective agent with a high Sec-Butanol is an important industrial solvent found in
potential for abuse. It may be present as an active
many domestic cleaning agents and paint removers.
metabolite of phendimetrazine. It possesses central
nervous system stimulant properties like amphetamine
Secobarbital is a short-acting barbiturate which is used
therapeutically as a sedative/hypnotic. It may cause
Phenobarbital is a barbiturate with sedative/hypnotic
central nervous system depressant effects.
and anticonvulsant properties. It may cause central
Selegiline (Deprenyl, Eldepryl) is a methamphetamine
derivative used for the treatment of Parkinsonism,
Phentermine is prescribed as an anorexic agent
dementia, and schizophrenia. It may produce central
(appetite suppressant). It may cause central nervous
Sertraline (Zoloft) is a serotonin reuptake inhibitor used Phenylpropanolamine was an over-the-counter cold
medication used as a nasal decongestant and
Strychnine is a potent central nervous system
bronchodilator. It can produce central nervous system
stimulant and convulsant. It is a natural alkaloid found
in the leaves of Strychnos nux-vomica but it is also
Phenytoin (Dilantin) is an anticonvulsant drug used in
the treatment of seizure disorders. It may cause central
Temazepam (Restoril) is a hypnotic drug of the
benzodiazepine class. It is also a metabolite of other
Prazepam is an antianxiety drug of the benzodiazepine
benzodiazepines. It may cause central nervous system
class. Administration of Prazepam may result in central
Terpin Hydrate is an expectorant, commonly used in Primidone is a derivative of Phenobarbital, frequently
the treatment of acute and chronic bronchitis. It is
used for the treatment of seizure disorders. It may
commonly formulated with an antitussive (e.g., codeine)
cause central nervous system depressant effects.
as a combined preparation. It may cause central
Procaine (Novocain) is a local anesthetic used for Tetrahydrocannabinol (THC) is the principal Prochlorperazine (Compazine, Stemetil) is an
psychoactive constituent of marijuana. When smoked,
antipsychotic agent of the phenothiazine class. It is
it is rapidly distributed to various tissues and disappears
Promethazine is a phenothiazine derivative that is Thebaine is a naturally occurring opium alkaloid. It is
widely used as an antihistamine, antiemetic, and
sedative. It may cause central nervous system
Thiopental is an ultra-short-acting barbiturate and has
been used commonly in the induction phase of general
Propofol (Diprivan) is a short-acting, intravenously
anesthesia. It may cause central nervous system
administered hypnotic/sedative agent and supplements
other types of general anesthetics.It will cause central
Thioridazine (Melleril) belongs to the phenothiazine
class of antipsychotic tranquilizers. It may cause central nervous system depressant effects.
DRUG FACT SHEET: Tizanidine (Zanaflex, Sirdalud) is used as a muscle Xylazine is a phenothiazine derivative that is used as a
relaxant. It is a centrally acting α-2 adrenergic agonist. It
veterinary sedative, analgesic, and anesthetic agent in
may cause central nervous system depressant effects.
large animals. It may cause central nervous system
Toluene is an aromatic solvent present in numerous
paints, thinners, glues. Symptoms of intoxication are
Zaleplon (Sonata) is a sedative/hypnotic, mainly used
similar to ethyl alcohol and often a chemical odor is
for insomnia. may cause hallucinations, abnormal
present in the breath. It may cause central nervous
behavior, severe confusion, day-time drowsiness,
dizziness or lightheadedness, unsteadiness and/or falls,
Topiramate (Topamax) is an adjunctive therapeutic
agent for the treatment of seizure disorders.
Zolpidem (Ambien) is a hypnotic drug used for the Tramadol (Ultram) is a synthetic narcotic analgesic. It
short-term management of insomnia. It may impair
may cause central nervous system depressant effects.
driving skills with a resultant increased risk of road
Trazodone (Desyrel) is used therapeutically for the
traffic accidents. It can be used recreationally for some
treatment of depression. It may cause central nervous
of its side-effects, notably sedation, hallucinations and
Triazolam (Halcion) is a hypnotic drug used for the short-term management of insomnia. It may cause central nervous system depressant effects. Trifluoroperazine (Stelazine) belongs to the phenothiazine class of antipsychotic tranquilizers. It may cause central nervous system depressant effects. Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the piperazine chemical class. Usually in combination with its analogue benzylpiperazine (BZP), it is sold as a legal alternative to the illicit drug MDMA ("Ecstasy") under the name "Legal X" Trihexyphenidyl (Artane) is an antispasmodic used for the treatment of Parkinsonism. Adverse reactions to this drug may include blurring of vision, dizziness, nausea, and nervousness. It is noted in the literature that this type of drug may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Trimethobenzamide (Tebamide, Tigan) is an antiemetic used to prevent nausea and vomiting. It may cause central nervous system depressant effects. Trimethoprim (Trimpex, Proloprim, Primsol) is a bacteriostatic antibiotic used for the treatment and
prevention of urinary tract infections Triprolidine (Actidil, Myidil) is an over-the-counter antihistamine with anticholinergic properties. The most common side effect is drowsiness. Valproic Acid (Depakote) is an anticonvulsant and has been used for the treatment of the manic phase of bipolar disorder. Possible side effects include nausea, vomiting, sedation, and weakness. Venlafaxine (Effexor) is an antidepressant drug which inhibits serotonin and norepinephrine. Verapamil (Calan, Isoptin, Verelan) is a cardiovascular drug used for the management of angina, arrhythmia, and hypertension.
Department of Psychology Lakehead University Psychology 5311 – Cognitive-Behaviour Therapy 2004-05 Winter Course Outline Instructor: Ron Davis, Ph.D. Office: SN 1042, 343-8646, ron.davis@lakeheadu.caClass: Tuesdays, 1:00-4:00pm, Evans HouseOffice hours: by appointment Course Description: This course provides an overview of the science and practice of cognitive-behaviour therapy (CB
Seasonal timing and pre-hibernation 32 fattening in breeding and non-breeding European Ground Squirrels EVA MILLESI, ANITA DIVJAK & ANNA STRAUSSDepartment of Behavioural Biology, University of Vienna, Althanstr. 14, 1090 Vienna, Austria; eva.millesi@univie.ac.at Abstract We compared seasonal timing, body mass changes and plasma progesterone secretion in breeding and non-breeding fe