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This press release is an English-language translation of the original Japanese-language version. To the extent that there are
discrepancies between this translation and the original version, the original version shall be definitive.
Daiichi Sankyo and AstraZeneca Launch NEXIUM 10mg and 20mg Capsules in Japan
TOKYO, Japan (September 15, 2011) − Daiichi Sankyo Co., Ltd. (hereafter, Daiichi Sankyo) and
AstraZeneca KK (hereafter, AstraZeneca) today announced the launch of NEXIUM®
(esomeprazole magnesium) 10mg and NEXIUM®
Capsule 20mg following the NHI (National
Health Insurance) drug price listing received on September 12, 2011.
The NHI reimbursement price is 96.70 yen for NEXIUM®
Capsule 10mg, and 168.90 yen for
Capsule 20mg. (Approval for manufacture and marketing: July 1, 2011; NHI drug price
listing: September 12, 2011)
The active ingredient in NEXIUM® Capsules, esomeprazole magnesium, is one of the two
isomers in omeprazole, the active substance in Omepral®
. Esomeprazole selectively inhibits the
activity of the enzyme H+/K+- ATPase, the acid pump. Esomeprazole thus inhibits the final step
in the regulation of acid secretion and thereby provides effective control of acid-related conditions.
Capsules has been globally approved and is currently sold in more than 120 countries
and regions, backed up by rich and robust clinical evidence/experience. In the phase III clinical
studies for reflux esophagitis patients in Japan, NEXIUM®
Capsules demonstrated a quick relief
of symptoms, endoscopic healing, patient tolerability and a good safety profile.
Under the terms of this agreement, AstraZeneca and Daiichi Sankyo will co-promote NEXIUM®
Capsules in Japan. AstraZeneca will manufacture and develop the product and Daiichi Sankyo
will be responsible for its sales and distribution.
Daiichi Sankyo and AstraZeneca are determined to contribute to the needs of patients with acid-
related conditions in Japan by maximizing the value of NEXIUM®
Capsules through their strong
Product name NEXIUM®
Capsules 10mg, NEXIUM®
Generic name Esomeprazole magnesium
○Gastric ulcer, duodenal ulcer, anastomotic ulcer, reflux esophagitis, non-erosive
reflux disease (NEXIUM®
Capsules 10mg only), Zollinger-Ellison syndrome, and
prevention of recurrence of gastric ulcer and duodenal ulcer in patients treated
with non-steroidal anti-inflammatory drugs ○Adjunct for eradication of Helicobacter pylori in the following diseases Gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura and metachronous development of gastric cancer after endoscopic resection of early gastric cancer ○Gastric ulcer, duodenal ulcer, anastomotic ulcer and Zollinger-Ellison syndromeThe usual adult dosage is 20 mg of esomeprazole given orally once daily. The usual duration of administration is up to 8 weeks for gastric and anastomotic ulcers, and up to 6 weeks for duodenal ulcer. ○Reflux esophagitis Usually the adult dosage is 20 mg of esomeprazole given orally once daily. The usual duration of administration is up to 8 weeks. The dosage for maintenance therapy of repeatedly recurring or relapsing reflux esophagitis is 10 - 20 mg given orally once daily. ○Non-erosive reflux disease Usually the adult dosage is 10 mg of esomeprazole given orally once daily. The usual duration of administration is up to 4 weeks.
○Prevention of recurrence of gastric ulcer and duodenal ulcer in patients treated with non-steroidal anti-inflammatory drugs Usually the adult dosage is 20 mg of esomeprazole given orally once daily. ○Adjunct for eradication of Helicobacter pylori Usually to adults, 20 mg of esomeprazole, 750 mg (potency) of amoxicillin hydrate and 200 mg (potency) of clarithromycin should be given concomitantly via oral route all twice a day for 7 days, provided that the dose of clarithromycin can be increased up to 400 mg (potency) twice a day according to the need. If the triple therapy with proton pump inhibitor, amoxicillin hydrate and clarithromycin for eradication of Helicobacter pylori failed, usually to adults, 20 mg of esomeprazole, 750 mg (potency) of amoxicillin hydrate and 250 mg of metronidazole should be given concomitantly via oral route all twice a day for 7 days as an alternative therapy.
and marketing NHI drug price September 12, 2011
listing Product launch September 15, 2011 Manufacture
distribution For inquiries: AstraZeneca K.K.
Free Radical Biology & Medicine, Vol. 30, No. 7, pp. 803– 808, 2001Copyright © 2001 Elsevier Science Inc. PII S0891-5849(01)00477-4 Fast Track Paper NITROXYL OXIDIZES NADPH IN A SUPEROXIDE DISMUTASENDREAS REIF,* LUIGI ZECCA,*† PETER RIEDERER,* MARTIN FEELISCH,‡ and HARALD H. H. W. SCHMIDT*Clinical Neurochemistry, Department of Psychiatry and Psychotherapy, Julius-Maximil
BELOW MENTION IMPURITIES OF API ARE IN STOCK AND WILL BE READY TO DELIVIER WITH 4-5 WORKING DAYS. OTHER PROCESS RELATED IMPURITIES ALOS SUPPLY AND SYNTHESIS AS PER REQUIRMENT. Azithromycin Clindamycin Cetirizine ATORVASTATIN Omeprazole Fexofenadine Levofloxacin Ranitidine NEBIVOLOL 10. Paliperidone 11. Pramipexole 12. Rizatriptan