Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Dysautonomiasos.org

Clinical Trial Information: Pure Autonomic Failure
As of 7/25/12
Title: Magnetic Resonance Spectroscopy in Autonomic Failure Conditions: Pure Autonomic Failure|Multiple System Atrophy Interventions: Procedure: Magnetic Resonance Spectroscopy Imaging URL: http://ClinicalTrials.gov/show/NCT01607268 Title: Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure Conditions: Hypertension|Pure Autonomic Failure|Multiple System Atrophy Interventions: Drug: Losartan|Drug: Captopril|Drug: Placebo URL: http://ClinicalTrials.gov/show/NCT01292694 Title: The Role of Endothelin in the Supine Hypertension of Autonomic Failure Conditions: Hypertension|Pure Autonomic Failure|Multiple System Atrophy Interventions: Drug: BQ123|Drug: BQ123|Drug: Bq123|Drug: BQ123|Drug: Saline URL: http://ClinicalTrials.gov/show/NCT01119417 Title: Treatment of Supine Hypertension in Autonomic Failure Interventions: Drug: Clonidine|Drug: Nitroglycerin transdermal|Drug: Dipyridamole/ Aspirin (Aggrenox)|Drug: Desmopressin (DDAVP)|Drug: Sildenafil|Drug: Nifedipine|Drug: Hydralazine|Drug: Hydrochlorothiazide|Drug: Placebo|Drug: Bosentan|Drug: Diltiazem|Drug: Eplerenone|Drug: guanfacine|Dietary Supplement: L-arginine|Drug: captopril|Drug: carbidopa|Drug: losartan|Drug: metoprolol tartrate|Drug: nebivolol hydrochloride|Drug: prazosin hydrochloride|Drug: tamsulosin hydrochloride|Other: Head-up tilt.
URL: http://ClinicalTrials.gov/show/NCT00223717 Title: Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension Conditions: Orthostatic Hypotension|Pure Autonomic Failure|Multiple System Atrophy|Parkinson's Disease URL: http://ClinicalTrials.gov/show/NCT01316666 Title: Evaluation of Primary Chronic Autonomic Failure Conditions: Autonomic Nervous System Diseases URL: http://ClinicalTrials.gov/show/NCT00059033 Title: Treatment of Orthostatic Hypotension in Autonomic Failure Conditions: Autonomic Failure|Orthostatic Hypotension Interventions: Drug: Atomoxetine|Drug: Acarbose|Drug: Pyridostigmine Bromide|Drug: Yohimbine|Drug: Midodrine HCl|Drug: placebo|Drug: Modafinil|Drug: Octreotide|Other: water intake|Drug: Diphenhydramine Hydrochloride|Drug: Ranitidine HCL|Drug: Tranylcypromine|Drug: Ergotamine/ Caffeine|Drug: Celecoxib|Drug: Pseudoephedrine|Drug: Methylphenidate|Drug: Indomethacin|Drug: Ibuprofen|Drug: Oxymetazoline 0.05% nasal solution|Dietary Supplement: Bovril|Drug: Acetazolamide|Drug: Rivastigmine tartrate|Drug: Carbidopa/levodopa|Device: abdominal binder|Device: abdominal binder (sham) URL: http://ClinicalTrials.gov/show/NCT00223691 Title: Nebivolol in the Supine Hypertension of Autonomic Failure Conditions: Hypertension|Pure Autonomic Failure|Multiple System Atrophy Interventions: Drug: Placebo|Drug: Nebivolol 5 mg|Drug: metoprolol tartrate 50 mg|Drug: URL: http://ClinicalTrials.gov/show/NCT01044693 Title: Mechanisms Responsible for Hypoglycemia Associated Autonomic Failure Conditions: Diabetes Mel itus|Hypoglycemia|Autonomic Failure Interventions: Drug: naloxone|Dietary Supplement: fructose|Behavioral: exercise URL: http://ClinicalTrials.gov/show/NCT00678145 Title: Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mel itus Conditions: Diabetes Mel itus, Insulin-Dependent Interventions: Drug: Dehydroepiandrosterone|Drug: Placebo URL: http://ClinicalTrials.gov/show/NCT00607646 Title: The Autonomic Nervous System and Obesity Conditions: OBESITY|HYPERTENSION|PURE AUTONOMIC FAILURE|SHY-DRAGER SYNDROME Interventions: Drug: Trimethaphan|Drug: Trimethaphan|Drug: Pseudoephedrine URL: http://ClinicalTrials.gov/show/NCT00179023 Title: Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mel itus Interventions: Drug: Fludrocortisone|Drug: Dexamethasone URL: http://ClinicalTrials.gov/show/NCT00608101 Title: Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4 Interventions: Drug: epinephrine|Drug: epinephrine URL: http://ClinicalTrials.gov/show/NCT00608816 Title: Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q5 Interventions: Drug: epinephrine|Drug: epinephrine URL: http://ClinicalTrials.gov/show/NCT00605774 Title: Biomarkers of Risk of Parkinson Disease Conditions: Parkinson Disease|Autonomic Nervous System Diseases|Pure Autonomic Failure URL: http://ClinicalTrials.gov/show/NCT00775853 Title: Abdominal Compression in Orthostatic Hypotension Conditions: Autonomic Failure|Orthostatic Hypotension Interventions: Device: Abdominal binder|Device: No abdominal binder URL: http://ClinicalTrials.gov/show/NCT01223391 Title: Autonomic Phenotype Before and After Akt Inhibition Interventions: Behavioral: Autonomic Function Tests|Other: supine and standing catecholamines URL: http://ClinicalTrials.gov/show/NCT01593579 Title: Assessment of Hand-grip in the Prevention of Postural Orthostatic Hypotension Interventions: Other: Hand grip maneuver URL: http://ClinicalTrials.gov/show/NCT01521221 Title: Intravenous Norepinephrine for Orthostatic Hypotension Interventions: Drug: Intravenous Norepinephrine Infusion URL: http://ClinicalTrials.gov/show/NCT01285908 Title: Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Conditions: Autoimmune Autonomic Ganglionopathy (AAG) Interventions: Drug: Intravenous Immunoglobulin|Drug: Intravenous Immunoglobulin URL: http://ClinicalTrials.gov/show/NCT01522235 Title: Fipamezole in Neurogenic Orthostatic Hypotension Conditions: Symptomatic Neurogenic Orthostatic Hypotension (NOH)|Parkinson's Disease|Multiple System Atrophy Interventions: Drug: Placebo|Drug: Fipamezole URL: http://ClinicalTrials.gov/show/NCT00758849 Title: Risk Prediction in Type II Diabetics With Ischemic Heart Disease Conditions: Type-2 Diabetes Mel itus|Ischemic Heart Disease URL: http://ClinicalTrials.gov/show/NCT01422057 Title: Recurrent Hypoglycaemia in Type 1 Diabetes URL: http://ClinicalTrials.gov/show/NCT01337362 Title: Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cel Transplant in Treating Young Patients With Hematologic Disorders Conditions: Congenital Amegakaryocytic Thrombocytopenia|Diamond-Blackfan Anemia|Leukemia|Myelodysplastic Syndromes|Severe Congenital Neutropenia Interventions: Biological: alemtuzumab|Drug: busulfan|Drug: cyclosporine|Drug: fludarabine phosphate|Drug: methotrexate|Drug: methylprednisolone|Procedure: al ogeneic bone marrow transplantation|Procedure: al ogeneic hematopoietic stem cel transplantation|Procedure: peripheral blood stem cel transplantation|Procedure: umbilical cord blood transplantation URL: http://ClinicalTrials.gov/show/NCT00301834

Source: http://www.dysautonomiasos.org/clinicaltrials/ClinicalTrialsPAF.pdf