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021700 gas embolism

The Ne w E n g l a nd Jo u r n a l o f Me d ic i ne Pathophysiology
The most frequent form of venous gas embolism is the insidious venous aeroembolism, in which a se-ries of gas bubbles resembling a string of pearls en- GAS EMBOLISM
ters the venous system. Rapid entry or large volumesof gas put a strain on the right ventricle because of CLAUS M. MUTH, M.D., AND ERIK S. SHANK, M.D.
the migration of the emboli to the pulmonary circu-lation. The pulmonary arterial pressure increases, andthe increased resistance to right ventricular outflowcauses diminished pulmonary venous return. Because AS embolism, the entry of gas into vascular of the diminished pulmonary venous return, there is structures, is a largely iatrogenic clinical prob- decreased left ventricular preload, resulting in dimin- lem that can result in serious morbidity and ished cardiac output and, ultimately, systemic cardio- even death.1 Since gas embolism can result from pro- vascular collapse.9 Tachyarrhythmias often develop, cedures performed in almost all clinical specialties but bradycardias are possible as well. When large quan- (Table 1), it is important for all clinicians to be aware tities of gas (over 50 ml) are injected abruptly, acute of this problem. In most cases, gas embolism is air cor pulmonale, asystole, or both are likely to occur.2 embolism, although the medical use of other gases, The alteration in the resistance of the lung vessels and such as carbon dioxide, nitrous oxide, and nitrogen, the mismatch between ventilation and perfusion cause can also result in the condition. There are two broad intrapulmonary right-to-left shunting and increased categories of gas embolism, venous and arterial, which alveolar dead space, leading to arterial hypoxia and are distinguished by the mechanism of gas entry and the site where the emboli ultimately lodge.
Diagnosis
VENOUS GAS EMBOLISM
To diagnose venous gas embolism, the physician Venous gas embolism occurs when gas enters the should assess the clinical findings. The so-called mill- systemic venous system.2 The gas is transported to wheel murmur, a splashing auscultatory sound due the lungs through the pulmonary arteries, causing to the presence of gas in the cardiac chambers and interference with gas exchange, cardiac arrhythmias, great vessels, is often present and can be auscultated pulmonary hypertension, right ventricular strain, and by a precordial or esophageal stethoscope. A decrease eventually cardiac failure. Physical preconditions for in the end-tidal carbon dioxide levels, as determined the entry of gas into the venous system are the in- by capnometry, suggests a change in the relation be- cising of noncollapsed veins and the presence of sub- tween ventilation and perfusion due to the obstruc- atmospheric pressure in these vessels. Noncollapsing tion of the pulmonary arteries.10 Doppler ultrasonog- veins include the epiploic veins, the emissary veins, raphy is a sensitive and practical means of detecting and the dural venous sinuses. Air may enter these intracardiac air, and it is often used during neurosur- veins during neurosurgical operations, especially those gical procedures,3,11 procedures with the patient in performed with the patient in the sitting position.3 the sitting position, and other procedures that entail The veins of the throat, and in some cases the veins a high risk of gas embolism. An even more sensitive in the coagulated operative field,4 may also be entry- and definitive method for detecting intracardiac gas ways for air. Air may also enter veins through central is transesophageal echocardiography, although it re- venous and hemodialysis catheters5,6 and may enter quires training in performance and interpretation the veins of the myometrium during pregnancy and Treatment
When venous gas embolism is suspected, further entry of gas must be prevented. In certain cases, From the Druckkammerzentrum Homburg, University Hospital Hom- therapy with catecholamines is required, and, if nec- burg, University of the Saarland, Homburg/Saar, Germany (C.M.M.); and essary, aggressive cardiopulmonary resuscitation is per- the Department of Anesthesiology and Critical Care, Massachusetts Gen-eral Hospital and the Department of Anesthesiology, Harvard Medical formed. Adequate oxygenation is often possible only School — both in Boston (E.S.S.). Address reprint requests to Dr. Muth at with an increase in the oxygen concentration of the the Druckkammerzentrum Homburg, Universitätskliniker des Saarlandes, inspired gas (up to 100 percent oxygen). Supplemen- 66424 Homburg/Saar, Germany, or at cmmuth@aol.com.
2000, Massachusetts Medical Society.
tal oxygen also reduces the size of the gas embolus P R I M A RY C A R E
TABLE 1. MEDICAL SPECIALTIES WITH DOCUMENTED CASES OF GAS EMBOLISM.
SPECIALTY
MECHANISM OF GAS EMBOLISM
Inadvertent entry of air through peripheral intravenous circuit Intraoperative use of hydrogen peroxide, causing formation of arterial and venous oxygen emboli Entry of air through disconnected intravascular catheter, inadvertent infusion of air through intravascu- Entry of air into extracorporeal-bypass pump circuit, incomplete removal of air from heart after cardio- plegic arrest, carbon dioxide–assisted harvesting of peripheral veins Entry of air through intravascular catheter during angiographic study or procedure Entry of air through disconnected intravascular catheter, pulmonary barotrauma, rupture of intraaortic balloon, entry of air into extracorporeal-membrane-oxygenator circuit Pulmonary barotrauma, paradoxical embolism after decompression injury, entry of gas through discon- Entry of gas into veins or arteries during insufflation of body cavities Entry of gas into veins during upper or lower endoscopy or endoscopic retrograde pancreatography Pulmonary barotrauma in treatment of premature infants Inadvertent entry of air through hemodialysis catheter and circuit on hemodialysis machine Entry of air through incised veins and calvarial bone, especially during craniotomy with the patient in Cesarean section, gas insufflation into veins during endoscopic surgery, intravaginal and intrauterine gas Nd:YAG laser surgery on the larynx, trachea, or bronchi* Gas insufflation into veins during arthroscopy, total hip arthroplasty, or spine surgery with the patient Injection of air or gas as a contrast agent, inadvertent injection of air during angiography Entry of air into pulmonary vasculature during lung biopsy or video-assisted thoracoscopy, chest trauma (penetrating or blunt), lung transplantation Entry of air during transurethral prostatectomy or radical prostatectomy Entry of air during carotid endarterectomy *Nd:YAG denotes neodymium:yttrium–aluminum–garnet.
by increasing the gradient for the egress of nitrogen toms of end-artery obstruction. There are a number from the bubble.13 Rapid resuscitation with volume of mechanisms by which this can occur. One is the expansion is recommended to elevate venous pres- passage of gas across a patent foramen ovale into the sure, thus preventing the continued entry of gas into systemic circulation. A patent foramen ovale, which is detectable in about 30 percent of the general pop- Some authors recommend attempting to evacuate ulation, makes possible right-to-left shunting of gas air from the right ventricle with the use of a central bubbles.16 If there is a patent foramen ovale and if venous catheter (a multiorifice catheter may be more the pressure in the right atrium exceeds the pressure effective than one with a single lumen) or a pulmo- in the left atrium, right-to-left flow through the fo- nary arterial catheter.2,14,15 It may be possible to as- ramen ovale may occur.17 Elevated pulmonary arte- pirate about 50 percent of the entrained air from an rial pressure due to venous gas embolism may result appropriately placed right atrial catheter,2,14 but de- in elevated right atrial pressure, making it possible pending on the placement of the catheter and the for a bubble to be transported through a patent fo- position of the patient, a smaller effect is more like- ramen. Furthermore, the decrease in left atrial pres- ly.2,15 Hyperbaric oxygen therapy is not a first-line sure caused by controlled ventilation and the use of treatment but may be a useful adjunct in severe cas- positive end-expiratory pressure may create a pressure es. It should certainly be considered if there is evi- gradient across the patent foramen ovale, favoring the dence of neurologic changes. In this case, it should passage of gas into the systemic circulation.2,3 be assumed that a paradoxical embolism is present.
In other situations, venous gas may enter the ar- terial circulation by overwhelming the mechanisms Paradoxical Embolism
that normally prevent arterial gas embolism. Studies A paradoxical embolism occurs when air or gas in animals suggest that either a large bolus of gas (20 that has entered the venous circulation manages to ml or more) or small continuous amounts (11 ml enter the systemic arterial circulation and causes symp- per minute) introduced into the venous system may The Ne w E n g l a nd Jo u r n a l o f Me d ic i ne Pathophysiology
The entry of gas into the aorta causes the distri- bution of gas bubbles into nearly all organs. Small em-boli in the vessels of the skeletal muscles or visceraare well tolerated, but embolization to the cerebral orcoronary circulation may result in severe morbidityor death.
Embolization into the coronary arteries induces electrocardiographic changes typical of ischemia andinfarction; dysrhythmias, myocardial suppression, car-diac failure, and cardiac arrest are all possible, depend-ing on the amount of gas embolized.25 Circulatoryresponses may also be seen with embolization to thecerebral vessels.26 Cerebral arterial gas embolization typically involves the migration of gas to small arteries (average diam-eter, 30 to 60 µm).25 The emboli cause pathologic Figure 1. Transesophageal Echocardiogram from a Patient Eval-
uated for the Presence of a Patent Foramen Ovale.
changes by two mechanisms: a reduction in perfusion Saline was agitated and injected rapidly into a central venous distal to the obstruction and an inflammatory response catheter. The bubbles appear as echodense areas in the right atrium (double arrows). If this patient had a patent foramenovale, bubbles would be seen crossing the interatrial septum Symptoms
(thin arrow) and entering the left atrium (arrowhead). (Echocar- The symptoms of cerebral arterial gas embolism diogram provided courtesy of S. Streckenbach.) develop suddenly. The clinical presentation, however,is determined by the absolute quantity of gas and theareas of the brain that are affected. Thus, there may generate intraarterial bubbles.18-20 There have been be minor motor weakness and headache or moderate reports of fatal cerebral arterial gas embolism caused confusion; conversely, complete disorientation, hem- by a large venous gas embolus, although no intracar- iparesis, convulsions, loss of consciousness, and coma diac defects or shunt mechanisms could be demon- may occur.27 Asymmetry of the pupils, hemianopia, strated.21 Various anesthetic agents diminish the ability and impairment of the respiratory and circulatory cen- of the pulmonary circulation to filter out gas embo- ters (manifested as bradypnea, Cheyne–Stokes breath- li.22 Studies in animals have shown that volatile anes- ing, cardiac arrhythmias, and circulatory failure)25,26 thetics, specifically, may raise the threshold for a spill- are other well-known complications. In patients who over of venous bubbles into systemic arteries. This have undergone surgical procedures that carry a risk of finding may have relevance to surgical procedures that gas embolism, a delayed recovery from general anes- carry a substantial risk of venous gas embolism.
thesia or a transitional stage of impaired consciousness The treatment of paradoxical embolism is identi- may be a clue to the occurrence of cerebral arterial cal to that of primary arterial gas embolism (discussed gas embolism. The diagnosis is not easy to establish below). Every venous gas embolism has the poten- in such patients, because complications of anesthesia, tial to evolve into an arterial gas embolism.
such as the central anticholinergic syndrome or thepresence of residual anesthetic or muscle relaxant, can ARTERIAL GAS EMBOLISM
mimic mild cerebral arterial gas embolism.
Arterial gas embolism is caused by the entry of gas into the pulmonary veins or directly into the arteries Diagnosis
of the systemic circulation. Gas may enter the arteries The most important diagnostic criterion is the pa- as a result of overexpansion of the lung by decompres- tient’s history, because the clinical suspicion of em- sion barotrauma or as a result of paradoxical embo- bolism is based on the initial neurologic symptoms lism. Any cardiac surgical operation that uses extracor- and the direct temporal relation between these symp- poreal bypass may also cause arterial gas embolism.23 toms and the performance of an invasive procedure.
Even if only small amounts of gas enter the arterial The procedures that carry the greatest risk of venous system, the flow of gas bubbles into functional end or arterial gas embolism are craniotomy performed arteries occludes these vessels. Although obstruction with the patient in the sitting position, cesarean sec- is possible in any artery, obstruction of either the tion, hip replacement, and cardiac surgery with car- coronary arteries or the nutritive arteries of the brain diopulmonary bypass. All these procedures have in (cerebral arterial gas embolism) is especially serious common an incised vascular bed and a hydrostatic and may be fatal because of the vulnerability of the gradient favoring the intravascular entry of gas.
heart and brain to short periods of hypoxia.24 Cerebral arterial gas embolism can sometimes be P R I M A RY C A R E
Figure 2. Bubble Obstructing End-Arterial Flow in a Cerebral Vessel with a Diameter of 30 to 60 µm, Causing Distal Ischemia.
The obstruction causes the metabolic processes of neurons to fail. Sodium and water enter the vessel, and cytotoxic edema devel-ops. The surface of the bubble generates a foreign-body response through cellular and humoral immune mechanisms. The bubblealso mechanically irritates the arterial endothelium. Both processes result in vasogenic edema and greater impairment of perfusion.
The neuronal injury extends beyond the area of obstruction.
distinguished from a cerebral infarct or intracerebral diovascular system. Endotracheal intubation should bleeding on a computed tomographic (CT) scan.28 be performed in a somnolent or comatose patient in However, pathologic changes are sometimes very sub- order to maintain adequate oxygenation and ventila- tle and not well visualized on CT, and the diagnosis tion. Oxygen should also be administered, at as high of cerebral arterial gas embolism must be considered a concentration as possible.30 Administration of oxy- early. Magnetic resonance imaging of the cerebrum gen is important not only to treat hypoxia and hypox- can sometimes show an increased volume of water emia but also to eliminate the gas in the bubbles by concentrated in the injured tissue. But this method establishing a diffusion gradient that favors the egress is also not reliable and may fail to detect an embo- It is currently recommended that patients with ar- Gas bubbles in the vessels of the retina can occa- terial gas embolism be placed in the flat supine po- sionally be identified, but their absence does not rule sition.31 The buoyancy of gas bubbles is not sufficient out gas embolism.24 Another finding that is nonspe- to counteract blood flow propelling such bubbles to- cific but that has been described in a number of cases ward the head, even when the patient is placed in a is hemoconcentration with an increase in the hema- head-down position. In addition, the head-down po- tocrit, possibly as a direct consequence of the extravas- sition may aggravate the cerebral edema that develops cular shift of fluid into the injured tissues.29 Treatment
Treatment of Generalized Seizures
The primary goal of treatment is the protection Cerebral gas embolism often causes generalized and maintenance of vital functions. If necessary, car- seizures,27 which may not respond to benzodiaze- diopulmonary resuscitation should be performed, pines. In these cases, it is recommended that the sei- since not only venous but also primary arterial gas zures be suppressed with barbiturates.27,33 Although embolism may lead to serious impairment of the car- there is no proof that barbiturates provide cerebral The Ne w E n g l a nd Jo u r n a l o f Me d ic i ne protection after cerebral ischemia, the use of barbi- turates for ischemic brain lesions has certain advan- tages. They reduce cerebral oxygen consumption, in- tracranial pressure, the production of free radicals, and the release of endogenous catecholamines.34,35 High doses of barbiturates depress respiration; ventilatory support must therefore be available when a patient Hyperbaric-Oxygen Therapy
With hyperbaric-oxygen therapy, the patient breathes 100 percent oxygen at a pressure above that of the atmosphere at sea level. This therapy decreasesthe size of the gas bubble both by raising the ambi- Figure 3. Relation between the Size of the Bubble and Pressure.
ent pressure (Fig. 3) and by causing systemic hyperox- The surface area and volume of the gas bubble are inverselyproportional to pressure at a constant temperature (Boyle’s law).
ia. An arterial partial pressure of oxygen greater than Thus, as the patient is exposed to increasing ambient pressure, 2000 mm Hg is frequently achieved. The hyperoxia produces enormous diffusion gradients for oxygeninto the bubble and for nitrogen out of the bub-ble.31,32 The hyperoxia also allows much larger quan-tities of oxygen to be dissolved in the plasma and in- may become the first choice for volume replacement, creases the extent of oxygen diffusion in tissues.27 but their use is still controversial and therefore can- The improvements in the oxygen-carrying capacity of plasma and in the delivery of oxygen to tissues The goal of infusion therapy is normovolemia.
offset the embolic insult to the microvasculature.
Placement of a central venous catheter is strongly Other benefits of hyperbaric oxygen have been recommended to assess central venous pressure, which proposed. It may help prevent cerebral edema by re- should be maintained at approximately 12 mm Hg.
ducing the permeability of blood vessels while sup- As a further method of ensuring adequate volume porting the integrity of the blood–brain barrier.36,37 status, the urinary output should be monitored with Furthermore, experiments have suggested that hyper- a Foley catheter and maintained above 1 to 2 ml per baric oxygen diminishes the adherence of leukocytes These benefits suggest that all patients with clini- Anticoagulant Therapy
cal symptoms of arterial gas embolism should receive There is evidence that heparin may be beneficial in recompression treatment with hyperbaric oxygen. Al- the treatment of gas embolism.42 Studies have shown though immediate recompression produces the best that the clinical course of arterial gas embolism is response,23 delayed treatment in a hyperbaric cham- less severe if the patient has been treated with hep- ber may still be indicated to ameliorate the patient’s arin before the embolic event occurs. An argument condition.39 Hyperbaric oxygen is the first-line treat- against heparin therapy is the risk it entails of hem- ment of choice for arterial gas embolism.23,25,31,40 Thus, orrhage into the infarcted tissue. At present, the use as soon as cardiopulmonary stabilization has been of heparin for the short-term treatment of cerebral achieved, the patient should be transferred to a hy- arterial gas embolism is not generally recommended.
Corticosteroid Therapy
Infusion Therapy
The use of corticosteroids in patients with arterial There is some evidence that gas embolism may gas embolism remains controversial. Some authors cause hemoconcentration, which increases blood vis- recommend treatment with corticosteroids to com- cosity and impairs the already compromised micro- bat the brain edema43 that results from gas emboliza- circulation.29 Therefore, normovolemia should be tion in the cerebral arteries. Cerebral gas embolism ini- achieved to optimize the microcirculation. Hypovo- tially induces the rapid development of cytotoxic brain lemia is always tolerated less well than relative ane- edema, with diminished extracellular space and en- mia. It is therefore acceptable to decrease the hem- larged intracellular areas. This form of edema does not atocrit, within certain limits. In animals, moderate usually respond to corticosteroids.44 Some authors re- hemodilution to a hematocrit of 30 percent reduces port that corticosteroids aggravate ischemic injury after neurologic damage.41 Colloid solutions are preferable occlusion of the vessels.45,46 Thus, since corticoster- to crystalloid solutions for hemodilution, because the oids appear to offer no benefit in patients with cyto- latter may promote cerebral edema. Hypertonic so- toxic edema and since these drugs may aggravate neu- lutions (e.g., 7.5 percent sodium chloride solution) ronal ischemic injury, we do not recommend them.
P R I M A RY C A R E
TABLE 2. TREATMENT OF GAS EMBOLISM.
TYPE OF TREATMENT
VENOUS GAS EMBOLISM
ARTERIAL GAS EMBOLISM
Measures to increase venous pressure (e.g., Valsalva Identification and shutting down of entryway maneuver or intravenous administration of fluids) Identification and shutting down of entryway for gas Hyperbaric oxygen therapy as soon as patient’s condition is stable enough for transfer to hyperbaric chamber Aspiration with multiluminal central venous catheter (with patient in left lateral decubitus position) Lidocaine, antiepileptic agents, physical therapy Lidocaine Therapy
2. Palmon SC, Moore LE, Lundberg J, Toung T. Venous air embolism:
a review. J Clin Anesth 1997;9:251-7.
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for the treatment of arterial gas embolism are not yet surgery: a critical appraisal. Br J Anaesth 1999;82:117-28.
4. Donlon JV Jr. Anesthesia and eye, ear, nose, and throat surgery. In: Mil-
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CONCLUSIONS
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emboli may lead to cardiovascular collapse or to par- compression bubbles: estimates and significance. Aviat Space Environ Med 1993;64:859-65.
adoxical arterial emboli. Arterial emboli may occlude 14. De Angelis J. A simple and rapid method for evacuation of embolized
end arteries throughout the body and may cause se- rious morbidity or death if they occlude cardiac or 15. Albin MS. Air embolism. In: Albin MS, ed. Textbook of neuroanes-
thesia with neurosurgical and neuroscience perspectives. New York:
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to-left atrial shunting in a healthy population: detection by Valsalva maneu-
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