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BANNED AND DANGEROUS SUBSTANCES COMMONLY GIVEN TO HORSES SENT TO SLAUGHTER
Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
Acepromazine
See also Citak A, Soysal DD, Uçsel R, Karaböcüoglu M, Uzel N., Seizures associated with poisoning in children: tricyclic antidepressant intoxication, PEDIATR INT. 48(6):582-585 (2006) (Two children suffered cardiac arrest from intoxication from Acetazolamide Diuretic
Acetazolamide (sulfonamide) induces metabolic alkalosis and is contraindicated in patients with hyperchloremic acidosis, angle-closure glaucoma, kidney and liver disease, and in patients with Addison’s disease. Fatalities have occurred (rare) due to Stevens-Johnson syndrome (diffuse rash that sloughs), toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Sensitizations may recur when a sulfonamide is readministered irrespective of the route of administration. If signs of hypersensitivity or other serious reactions occur, discontinue use of this drug. Caution is advised for patients receiving concomitant high-dose aspirin and Acetazolamide, as anorexia, tachypnea, lethargy, coma and death have been reported. http://www.drugs.com/pro/acetazolamide.html Acriflavine
Acriflavine is an ingredient found in Blue-Kote, which is itself labeled “not for use on animals intended for food.” The dangers for humans who ingest this substance are blu-kote.html Not for use on animals intended for Altrenogest Regu-Mate
Active harmful ingredients (residue): Progestin. Progestin is used in the mini-pill to prevent contraception so progestin could result in Progestin along with estrogens are pro-thrombotic meaning that they cause deep blood clots, including venous thrombosis and cerebral thrombosis. http://www.nejm.org/doi/full/10.1056/NEJM200105173442007 Combined with estrogens, progestin increases the risk of breast cancer and Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
http://www.whi.org/findings/ht/eplusp_3yr.php Increased stroke risk. http://www.whi.org/findings/ht/ealone_stroke.php HUMAN WARNINGS Skin contact must be avoided as Regu-mate® (altrenogest) Solution 0.22% is readily absorbed through unbroken skin. Protective gloves must be worn by all persons handling this product. Pregnant women or women who suspect they are pregnant should not handle Regu-mate® (altrenogest) Solution 0.22%. Women of child bearing age should exercise extreme caution when handling this product. Accidental absorption could lead to a disruption of the menstrual cycle or prolongation of pregnancy. Direct contact with the skin should therefore be avoided. Accidental spillage on the skin should be washed off immediately with soap and water. http://www.drugs.com/vet/regu-mate-solution.html Aluminum hydroxide
May cause constipation. Caution with renal failure; prolonged use may result in or worsen dialysis osteomalacia. Elevated tissue aluminum levels contribute to the development of dialysis encephalopathy and osteomalacia syndromes. Caution with normophosphatemic patients; prolonged use may result in hypophosphatemia if Constipation, dialysis osteomalacia, hypophosphatemia. http://www.pdr.net/drugpages/concisemonograph.aspx?concise=1544 Can cause constipation, confusion, loss of appetite, and muscle weakness. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001056/ Amikacin
Antibiotics are potentially dangerous to humans who either have allergies or sensitivities to them. Additionally, the use of antibiotics in food animals, and the subsequent ingestion by humans of those animals, has the potential to create antibiotic resistance in humans, which can cause significant problems Amoxicillin
Infections and Infestations: Mucocutaneous candidiasis. Gastrointestinal: Nausea, vomiting, diarrhea, black hairy tongue, and hemorrhagic/pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. Serum sickness-like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis and Liver: A moderate rise in AST (SGOT) and/or ALT (SGPT) has been noted, but the significance of this finding is unknown. Hepatic dysfunction including cholestatic Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
jaundice, hepatic cholestasis and acute cytolytic hepatitis have been reported. Hemic and Lymphatic Systems: Anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be Central Nervous System: Reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and/or dizziness have been reported Miscellaneous: Tooth discoloration (brown, yellow, or gray staining) has been rarely reported. Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases. http://www.drugs.com/sfx/amoxicillin-side-effects.html Ampicillin sodium
Inflammation and redness of the tongue; irritation of mouth or throat; mild diarrhea; Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; severe diarrhea; stomach pain/cramps; vaginal irritation or discharge. http://www.drugs.com/sfx/ampicillin-side-effects.html See also side effects for ampicillin injection: •upset stomach, diarrhea, vomiting, mild skin rash More severe: •severe skin rash, itching, hives, difficulty breathing or swallowing, wheezing, unusual bleeding or bruising, headache, dizziness, seizures, sore mouth or throat http://www.nlm.nih.gov/medlineplus/druginfo/meds/a601133.html Material Safety Data Sheet (“MSDS”) for ampicillin sodium salt: Toxic Effects on Humans: Hazardous in case of ingestion, of inhalation. http://www.sciencelab.com/msds.php?msdsId=9925610 Avoid in children or teenagers for chickenpox or flu symptoms; Reye’s syndrome may occur. May cause severe allergic reaction (hives, facial swelling, asthma, shock) and stomach bleeding. Avoid in asthma, stomach problems that persist or recur, Allergic reaction, hives, facial swelling, asthma, shock. http://www.pdr.net/drugpages/concisemonograph.aspx?concise=195 Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
Can cause excessive bleeding in those taking warfarin; http://stroke.ahajournals.org/content/40/5/1944.full Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; dizziness; drowsiness; hearing loss; ringing in the ears; severe or persistent stomach pain; unusual bruising; vomiting. http://www.drugs.com/sfx/aspirin-side-effects.html 10. Avermectin A1a, 5-O-
A hazardous component of the Farnam Ivercare dewormer product. demethyl-25-de(1-
methylpropyl)-22,23-
Links to the toxicological literature here: dihydro-25-(1-
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=14145#x50 methylethyl)-
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+toxline:@term+@rn+65195-51- 11. Benzyl alcohol
Pruritis, erythema, pyoderma, ocular irritation. http://www.pdr.net/search/searchResult.aspx?searchCriteria=Benzyl+alcohol 12. Boldenone undecylenate
Boldenone undecylenate is a steroid ingredient in Equipose (for horses). It is not indicated for use in humans but appears to have off-label uses as a bodybuilding Known side effects consist of: nausea, leukopenia, symptoms resembling a peptic ulcer, acne, excitation (commonly referred to as roid rage), sleeplessness, chills, vomiting, diarrhea, hypertension, prolonged blood clotting time, increase in libido. Females had reported menstrual irregularities, post-menopausal bleeding, increased sex drive, swelling of the breasts, hoarseness or deepening of the voice, and enlargement of the clitoris. Men had reported acne, gynocomastia, and increased general physical condition is desired. aggression. http://www.anabolicsmall.com/equipoise.html Steroids should be taken under a doctor’s supervision and have multiple significant adverse affects including severe allergic reactions, hormonal changes, changes in menstrual functions, mental and mood changes, respiratory problems, nausea and vomiting, joint swelling, vision changes, and unusual weight gain. 13. Butorphanol
Dizziness; drowsiness; dry mouth; light-headedness; nasal irritation; nausea; runny nose; sore throat; stuffy nose; trouble sleeping; unpleasant taste; vomiting. Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; burning, numbness, or tingling; change in the amount of urine produced; chest pain; confusion; ear pain; fainting; fast, slow, or irregular heartbeat; flushing; hallucinations; mental or mood changes (agitation, anxiety, depression); restlessness; ringing in the ears; seizures; severe or persistent dizziness, drowsiness, or light-headedness; severe or persistent headache or trouble sleeping; shortness of breath; slow, shallow, or difficult breathing; tremors; unusual swelling. http://www.drugs.com/sfx/butorphanol-side-effects.html 14. Butoxy Polypropylene
In 2002, a woman in Oklahoma was hospitalized after using Pyranha fly spray on horses. Her face was distorted, and her words slurred. She reportedly had leg problems, tremors, memory problems. The medical toxicologist's conclusion was that the patient, a professional horse trainer, developed a complex neurotoxic movement disorder following sensitization to a product that contained 33% Adverse reactions and side effects of ingestion are unknown. 15. Carbadox
Antibiotic used for growth promotion Not permitted for use in food-producing animals in Australia (http://www.apvma.gov.au/registration/not_permitted.php) Or in Canada, or the European Union. (http://www.hc-sc.gc.ca/dhp- http://www.drugs.com/pro/mecadox.html Chronic health effects, including cancer, mutagenic effect, changes in lung function. Accidental ingestion may cause serious harm or be fatal. MSDS SUPPLIER http://datasheets.scbt.com/sc-204668.pdf 16. Ceftiofur Crystalline Free Excede (antibiotic)
Intended for use in horses which are non-food animals. Because this indication for For the treatment of lower respiratory this new animal drug is not intended for use in food producing animals, there is no data pertaining to drug residues in food (i.e., human food safety). Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
Not for use in humans. For use in animals only. Consult a physician in case of Do not use in horses intended for human consumption. http://animalhealth.pfizer.com/sites/pahweb/US/EN/Products/Documents/Combined %20Full%20PI%20(8_5x11)%20-%20EXEQ0110014.pdf 17. Ceftiofur Sodium
Penicillins and cephalosporins can cause allergic reactions in sensitized individuals. Topical exposure to such antimicrobials, including ceftiofur, may elicit mild to severe allergic reactions in some individuals. Repeated or prolonged exposure may lead to sensitization. Avoid direct contact of the product with the skin, eyes, mouth, and for human consumption.” http://www.drugs.com/vet/ceftiflex.h 18. Chloramphenicol Chlor-500
Some medicines may interact with Chloramphenicol: •Anticoagulants (e.g., warfarin) because side effects, including risk of bleeding, may •Hydantoins (e.g., phenytoin) or sulfonylureas (e.g., glyburide) because the actions and side effects of these medicines may be increased. •Medicines that may decrease your bone marrow (e.g., cancer chemotherapy) because the risk of serious side effects, such as low blood platelet levels and low white blood Chloramphenicol has caused severe and sometimes fatal blood problems (e.g., anemia, low blood platelets, low white blood cell counts). Leukemia has also been reported after use of Chloramphenicol. Blood problems have occurred after both short-term and long-term use of Chloramphenicol. Do not use chloramphenicol if http://www.drugs.com/cdi/chloramphenicol.html http://www.drugs.com/cdi/chloramph Prohibited for use in food-producing animals in the European Union. enicol.html http://www.drugs.com/vet/chloramph 19. Chloroform
The IARC (International Agency for Research on Cancer) classifies chloroform as http://monographs.iarc.fr/ENG/Monographs/vol73/mono73.pdf 20. Cimetidine
Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
Diarrhea, headache, dizziness, somnolence, reversible confusional states, reversible impotence, increased serum transaminases, rash, gynecomastia, blood dyscrasias. WARNINGS/PRECAUTIONS Reversible confusional states reported, especially in severely ill patients. Increased risk of developing confusional states with advancing age (≥50 yrs), renal and/or hepatic impairment. Risk of hyperinfection of strongyloidiasis in http://www.pdr.net/drugpages/concisemonograph.aspx?concise=1440 21. Clenbuterol
http://www.deadiversion.usdoj.gov/drugs_concern/clenbuterol.htm producing animal. http://www.farad.org/eldu/prohibit.as 22. Copper Naphthenate
Toxic to central nervous system, blood, and kidneys. May produce vomiting, headache, shock, jaundice, kidney damage, nervous system for human consumption.” http://www.drugs.com/vet/kopertox.h 23. Crude Liver Extract
FDA cautions against the use by humans of any animal organ extract. http://www.healthline.com/natstandardcontent/liver-extract 24. Cupric Sulfate
Harmful if swallowed. May cause gastrointestinal tract irritation with nausea, vomiting, diarrhea, metallic taste, burning sensation in the stomach or epigastrum, abdominal pain, and possible gastrointestinal tract bleeding. May affect metabolism, liver (liver damage, jaundice), blood, urinary system (kidney damage, hematuria, hemoglobinuria, albuminuria), behavior/nervous systems (somnolence, tremor, psychosis, muscle weakness, coma), cardiovascular system (lowering of blood 25. Cypermethrin
“Pyrethroid ingestion gives rise within minutes to a sore throat, nausea, vomiting and abdominal pain. There may be mouth ulceration, increased secretions and/or dysphagia. Systemic effects occur 4-48 hours after exposure. Dizziness, headache and fatigue are common, and palpitations, chest tightness and blurred vision less Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
frequent. Coma and convulsions are the principal life-threatening features. Most patients recover within 6 days. . . .” S.M. Bradberry et al., Poisoning Due to Pyrethroids, Toxicol Rev. 24(2):93-106 (2005) (quoting abstract). Potential organ damage. http://pmep.cce.cornell.edu/profiles/extoxnet/carbaryl-dicrotophos/cypermet-ext.html 26. Dapsone
Adverse effects include agranulocytosis, aplastic anemia, leucopenia, thrombocytopenia, hemolysis, and other blood dyscrasias have been reported after treatment. It may cause significant reduction in leukocytes, platelets, or hemopoiesis. Caution with glucose-6-phosphoate dehydrogenase (G6PD) deficiency, methemoglobin reductase deficiency, or hemoglobin M, and those who are exposed to other agents or conditions such as infection or diabetic ketosis capable of producing hemolysis. Toxic hepatitis and cholestatic jaundice reported after use. Liver function tests must be monitored if there are any abnormalities. Can cause muscle weakness. Peripheral neuropathy, nausea and vomiting, abdominal pain, and pancreatitis may http://www.pdr.net/search/searchResult.aspx?searchCriteria=Dapsone 27. Deodorized Kerosene
Ingestion may cause aspiration hazard, nausea, fatigue, pulmonary edema, central nervous systemepression, convulsions and loss of consciousness. http://www.sciencestuff.com/msds/C1955.html 28. Deslorelin
Deslorelin stops the production of certain sex hormones in horses, and has never been approved for use on humans. If it was approved, it would be for a small targeted complement of the human population with identified diseases related to the production of too much of certain sex hormones, but could otherwise produce unwanted hormonal effects and responses. 29. Detomidine
Can cause hypotension, hypertension, bradycardia, dry mouth, respiratory depression, Hydrochloride
tachycardia, nausea and vomiting, atrial fibrillation, fever, hyperglycemia, anemia, sedation in intensive care and surgery http://www.pdr.net/drugpages/concisemonograph.aspx?concise=2848 for human consumption.” http://www.dormosedan.com/ Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
30. Dexamethasone
Adverse reactions include fluid/electrolyte disturbances, muscle weakness, osteoporosis, peptic ulcer, pancreatitis, ulcerative esophagitis, impaired wound healing, headache, psychic disturbances, growth suppression (pediatrics), glaucoma, hyperglycemia, weight gain, nausea, malaise. - (d)(4) (sterile aqueous solution). http://www.pdr.net/drugpages/concisemonograph.aspx?concise=798 Steroids should be taken under a doctor’s supervision and have multiple significant adverse affects including severe allergic reactions, hormonal changes, changes in menstrual functions, mental and mood changes, respiratory problems, nausea and vomiting, joint swelling, vision changes, and unusual weight gain. for food.” http://www.drugs.com/vet/dexium- 31. Dichloromethane Furall
If eaten, this drug can cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause carboxyhemoglobinemia. Dichloromethane has been treated as a carcinogen in California since 1988 and it may http://www.sciencelab.com/msds.php?msdsId=9948&code=SLM2677 32. Diclazuril
Administered to some AIDS patients, but effects in humans largely unknown. 33. Diclofenac Sodium Surpass
May cause hypertension, edema, or heart failure. Some individuals with prior gastrointestinal disease may be hypersensitive to the drug’s effects. Potential kidney failure and danger for patients with renal disease. May cause anaphylactic reactions; may harm fetus in utero. Maycause liver problems. May cause anemia and affect blood. May cause abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea and vomiting, gastrointestinal ulcers, renal function abnormalities, anemia, dizziness, edema, elevated liver enzymes. http://www.pdr.net/search/searchResult.aspx?searchCriteria=Diclofenac+Sodium Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
34. Diflubenzuron Equitrol
Fly control http://www.drugs.com/vet/equitrol-ii- 35. Dimethylsulfoxide
May cause headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation, breathing problems, vision problems, blood problems, and allergic reactions. Also http://www.webmd.com/vitamins-supplements/ingredientmono-874- DMSO%20(DIMETHYLSULFOXIDE).aspx?activeIngredientId=874&activeIngredi MSDS available here: http://www.sciencelab.com/msds.php?msdsId=9927347 horses slaughtered for food.” 21 CFR § 524.660b horses slaughtered for food.” http://www.webmd.com/vitamins- 36. Dimetridazole (generic)
Withdrawn from European market because of dangers of gastrointestinal problems, http://www.bioagrimix.com/msds/36/36280/3628007.pdf 37. Di-n-propyl
High toxicity – classified as a carcinogenic Pesticide Action Network (PAN) “Bad isocinchomeronate
1 “PAN Bad Actor pesticides” belong to a “most toxic” set of pesticides identified by the Pesticide Action Network and Californians for Pesticide Reform (CPR). These pesticides are at least one of the following: known or probable carcinogens, as designated by the International Agency for Research on Cancer (IARC), U.S. EPA, U.S. National Toxicology Program, and the state of California’s Proposition 65 list; reproductive or developmental toxicants, as designated by the state of Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
www.pesticideinfo.org/Detail_Chemical.jsp?Rec_id=PC2798 Flysect Super-C Mosquito Halt http://www.drugs.com/vet/flysect- super-7.html http://msds.farnam.com/m000811.ht super-c.html http://www.drugs.com/vet/mosquito- 38. Dipropyl
Farnam Roll-On Repellent (fly spray) High toxicity – PAN Bad Actor. isocinchomeronate
www.pesticideinfo.org/Detail_Chemical.jsp?Rec_id=PC2798 39. Domperidone
FDA has warned that this drug passes into breast milk and should not be used in toxicity from fescue grass that affects nursing human mothers. Side effects include dizziness, dry mouth, nervousness, flushing, irritability, insomnia, stomach cramps, hot flashes and leg cramps, chest pain, slow/fast/irregular heartbeat, swelling of the feet or ankles, difficulty urinating, swelling of the breasts or discharge from the nipple in men or women, menstrual changes, sexual difficulties. May affect absorption and action of other drugs, and interact with other drugs. http://www.medicinenet.com/domperidone-oral/article.htm 40. Doxycycline
Dangerous for pregnant women; may cause tooth problems, gastrointestinal symptoms, autoimmune syndrome, renal problems. California’s Proposition 65 list; neurotoxic cholinesterase inhibitors, as designated by California Department of Pesticide Regulation, the Materials Safety Data Sheet for the particular chemical, or PAN staff evaluation of chemical structure (for organophosphorus compounds); known groundwater contaminants, as designated by the state of California (for actively registered pesticides) or from historic groundwater monitoring records (for banned pesticides); pesticides with high acute toxicity, as designated by the World Health Organization (WHO), the U.S. EPA, or the U.S. National Toxicology Program. Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
41. Doxylamine succinate
Not to be combined with other antihistamines. Can cause multiple adverse side 42. Equine Influenza vaccine
Not intended for human use and no testing on human ingestion of this vaccine. 43. Equine Rhinopneumonitis Killed virus vaccine
Not intended for human use and no testing on human ingestion of this vaccine. – Influenza vaccine
Prestige II with Havlogen (vaccine) http://intervetus.naccvp.com/?m=pro 44. Estradiol
Risk of cancer is among the multiple potential negative side effects related to the unapproved and uncontrolled use of this synthetic female hormone. Other side effects for relief of menopausal symptoms in include headaches, dizziness, breast pain, increased risk for yeast infections, flu-like symptoms, arthritic pain, hair loss, gastrointestinal problems including nausea or vomiting, and incidences of spotting in between periods or other menstrual May be unsafe for people with blood disorders, heart disease, obesity, seizure 45. Eucalyptus Oil
Potential side effects include seizures, poisoning, drowsiness, morbidity in children, oil.html Labeled “Not for use on animals 46. Fenbendazole
No human formulation, and adverse effects on humans who eat this dewormer, that directly affects the gastrointestinal tract, are unknown. Panacur Paste Panacur Power Pac Panacur Suspension Safe-Guard Safe-Guard Power-Dose 21 CFR § 520.905a Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
47. Firocoxib Equioxx
There is no approved use of this drug for humans and so any adverse effects on humans who ingest this drug are completely unknown. Firocoxib is one of the NSAIDs, all of which have extensive potential adverse side effects in humans including cardiovascular, gastrointestinal, kidney and eye problems. The NSAIDs can be dangerous for individuals with blood disorders. They are also contraindicated during pregnancy. They also present significant risk for people with a history of ulcers or gastrointestinal bleeding. Can cause nausea, abdominal pain, diarrhea, headaches, excitability, and nervous system problems. 48. Flunixin
Flunixin is one of the NSAIDs, all of which have extensive potential adverse side effects in humans including cardiovascular, gastrointestinal, kidney and eye problems. The NSAIDs can be dangerous for individuals with blood disorders. They are also contraindicated during pregnancy. They also present significant risk for people with a history of ulcers or gastrointestinal bleeding. Can cause nausea, abdominal pain, diarrhea, headaches, excitability, and nervous system problems. Flu-nix D injection Flunixamine 21 CFR § 520.970 49. Flunixin Meglumine
This is also one of the NSAIDs, all of which have extensive potential adverse side effects in humans including cardiovascular, gastrointestinal, kidney and eye problems. The NSAIDs can be dangerous for individuals with blood disorders. They are also contraindicated during pregnancy. They also present significant risk for people with a history of ulcers or gastrointestinal bleeding. Can cause nausea, abdominal pain, diarrhea, headaches, excitability, and nervous system problems. meglumine-injection.html http://www.drugs.com/vet/flunazine- injectable-solution.html http://www.drugs.com/vet/flu-nix-d- Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
ivx.html http://www.drugs.com/vet/flunixami 50. Furaltadone Antibacterial
May cause cancer in humans, but very little known about effect on humans because the drug has not been tested on humans and the potential side effects upon ingestion 51. Furazolidone Antibacterial:
Contains chemicals known to the state of California to cause cancer. Should only be taken under strict medical oversight; dangerous if taken with alcohol, when pregnant, or for individuals with certain blood disorders. Adverse effects include headache, stomach upset, nausea, vomiting, dizziness or weakness, fever, skin rash, itching, muscle aches, flushing, breathing trouble. This medication may cause the urine to turn brown in color. for food.” http://msds.farnam.com/m000394.ht ne-aerosol-powder.html Federal law prohibits the use of this 52. Furosemide
May cause pancreatitis, jaundice, anorexia, paresthesias, ototoxicity, blood dyscrasias, dizziness, rash, urticaria, photosensitivity, fever, thrombophlebitis, restlessness. http://www.pdr.net/search/searchResult.aspx?searchCriteria=Furosemide 53. Gentamicin sulfate
Can cause severe hearing and kidney problems. May cause dizziness, vertigo, solution
ringing in the ears, hearing loss, numbness, muscle twitching or weakness, difficulty breathing, decreased urination, rash, itching, or sore throat. Interaction and potential harm with other drugs can cause adverse reactions. n-sulfate-solution.html 21 CFR § 529.1044a 54. Gentian violet
Usually used topically on humans. Unknown side effects upon ingestion. Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
protective wound dressing. Not for use on food producing blu-kote.html http://www.drnaylor.com/index.php? gory&id=20&Itemid=47 “Not for use on animals intended for Very hazardous if touched; not fully tested on humans; may be fatal if inhaled or swallowed. Causes irritation and burning, ulceration, or perforation of the gastrointestinal tract and resultant peritonitis, gastric hemorrhage and infection. Can also cause nausea, vomiting (with “coffee ground” emesis), diarrhea, thirst, difficulty swallowing, salivation, chills, fever, uneasiness, shock, strictures and stenosis (esophogeal, gastric, pyloric). May affect behavior (excitement), the cardiovascular system (weak rapid pulse, tachycardia), respiration (shallow respiration), and urinary system (kidneys- renal failure, nephritis). Acute exposure via inhalation or ingestion 56. Hyaluronate sodium Arthritis
May cause gastrointestinal tract information with nausea and vomiting. It may affect blood (normocytic anemia, change in leukocyte count), metabolism, behavior (ataxia, convulsions), respiration (respiratory stimulation), and urinary system. The toxicological properties of this substance have not been fully investigated. http://www.sciencelab.com/msds.php?msdsId=9924276 21 CFR § 522.1145 - “Do not use in horses intended for human consumption.” - “Not for use in horses intended for food.” http://www.bayerdvm.com/products/l egend/legend.cfm http://www.drugs.com/vet/legend- 57. Hyaluronic acid sodium
May cause gastrointestinal irritation, affect blood, metabolism and behavior. The dangers upon ingestion by humans has not been fully investigated. Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
animals not intended for food use. http://www.medi- vet.com/Polyglycan.aspx Also used in race horses prior to a 58. Hydroxyzine Pamoate
May impair mental and physical abilities in elderly, may potentiate other medications, and not for use by pregnant or nursing mothers. http://www.pdr.net/drugpages/concisemonograph.aspx?concise=1096 sedative in animals. http://www.drsfostersmith.com/prod 59. Hyoscine butylbromide Buscopan
Potential adverse effects include blurred vision, severe allergic reactions, confusion, www.drugs.com/sfx/scopolamine-side-effects.html Antispasmodic; colic pain relief. http://www.drugs.com/vet/buscopan- 60. Isoflurane
MSDS reports no information on toxicity upon ingestion. 61. Isoparaffinic Petroleum
Unknown human toxicity and side effects after ingestion. Farnam Bronco Gold (spray) Farnam Wipe http://msds.farnam.com/m001650.ht 62. Ivermectin
Can act for up to twelve months; carcinogenicity not studied; not recommended for pregnant women; distributes into breast milk. Adverse reactions include pruritus, edema, papular/pustular/frank urticarial rash, fever, axillary/cervical/inguinal lymphadenopathy, arthralgia/synovitis, limbitis, tachycardia, peripheral edema, leukopenia, eosinophilia Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
http://www.pdr.net/search/searchResult.aspx?searchCriteria=ivermectin Farnam Ivercare Horse Health Ivermectin Ivercare paste ProMetin E™ Paste Zimecterin Gold Zimecterin Paste Also found in human anthelmintic for human consumption.” 21 CFR § 1194 for human consumption.” 21 CFR § 1195 for human consumption.” http://www.drugs.com/vet/agri- mectin-paste-1-87.html http://www.drugs.com/vet/agri- mectin-paste-1-87.html http://www.davisandlawrence.com/1- x-6-08-g.html http://www.horsehealthusa.com/detai ls/Equell-Paste/37-105.html http://www.equimaxhorse.com/ Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
63. Ketoprofen
Ketoprofen is one of the NSAIDs, all of which have extensive potential adverse side effects in humans including cardiovascular, gastrointestinal, kidney and eye problems. The NSAIDs can be dangerous for individuals with blood disorders. They are also contraindicated during pregnancy. They also present significant risk for people with a history of ulcers or gastrointestinal bleeding. Can cause nausea, abdominal pain, diarrhea, headaches, excitability, and nervous system problems. for food.” http://www.drugs.com/vet/ketofen.ht 64. Levothyroxine Sodium
This artificial thyroid hormone can exacerbate thyroid and hypertension problems in http://www.pdr.net/search/searchResult.aspx?searchCriteria=Levothyroxine+Sodium 65. Luprostiol
Dangerous for children, pregnant and lactating mothers, individuals with respiratory problems. Can cause hormonal effects when taken. 66. Mepivacaine
Because this is an injectable drug, studies have not been done on the dangers of 67. Methocarbamol Robaxin
Potential adverse reactions include lightheadedness, dizziness, drowsiness, nausea, urticaria, pruritus, rash, conjunctivitis, nasal congestion, blurred vision, headache, http://www.pdr.net/search/searchResult.aspx?searchCriteria=Methocarbamol Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
68. Methyl Salicylate
“When ingested, the highly concentrated liquid methyl salicylate in the form of wintergreen oil, as with other volatile oils, can induce vomiting and is a notorious source for severe, often fatal poisonings.” http://www.drugs.com/npp/wintergreen.html Dangerous if used in conjunction with other analgesics, anticoagulants, steroids, http://www.pdr.net/search/searchResult.aspx?searchCriteria=Methyl+Salicylate 69. Methylandrostenediol
Can cause estrogenic (female hormone) and androgenic (male hormone) effects. Steroids should be taken under a doctor’s supervision and have multiple significant adverse affects including severe allergic reactions, hormonal changes, changes in menstrual functions, mental and mood changes, respiratory problems, nausea and vomiting, joint swelling, vision changes, and unusual weight gain. 70. Methylprednisolone
Steroids should be taken under a doctor’s supervision and have multiple significant adverse affects including severe allergic reactions, hormonal changes, changes in menstrual functions, mental and mood changes, respiratory problems, nausea and vomiting, joint swelling, vision changes, and unusual weight gain. 71. Metronidazole
This drug can cause gastrointestinal problems, serious allergic reactions in sensitive individuals, flu-like symptoms, seizures, encephalopathy, aseptic meningitis, peripheral neuropathy, nausea and vomiting, headache, anorexia and neutropenia. http://www.pdr.net/search/searchResult.aspx?searchCriteria=Metronidazole 72. Moxidectin
Very limited testing on humans – potential adverse effects still unknown. Quest Plus Antiparasitic (dewormers) Not for horses or ponies intended for Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
.htm 21 CFR § 520.1452; 520.1463 - Gel - “Not for use in horses and ponies intended for food.” http://www.drugs.com/vet/quest- 73. N-(2-Ethylhexyl)-5-
“Harmful if ingested.” Bug Block fly control has multiple adverse effects if norbornene-2,3-
dicarboximide
http://www.statelinetack.com/ContentFiles/Associated_Content/absorbinebugblockM 74. N-acetyl-D-glucosamine
Ingredient in Polyglycan, which includes warning: “For use only as a surgical lavage in animals not intended for food use.” are to be slaughtered for food.” www.arthrodynamic.com/polyglycan 75. Neomycin Sulfate
May cause nausea and vomiting, diarrhea, malabsorption syndrome, nephrotoxicity, ototoxicity, neuromuscular blockage, neurotoxicity, fetal harm. Especially dangerous for individuals with certain diseases of the muscles. http://www.pdr.net/drugpages/concisemonograph.aspx?concise=3174 76. Nitrofurantoin
Adverse effects include hypersensitivity reactions, pulmonary/hepatic/psychotic reactions, peripheral neuropathy, nausea and vomiting, anorexia, dizziness, exfoliative dermatitis, anaphylaxis, hematologic abnormalities, cyanosis, angioedema, asthenia. This drug is not to be administered to http://www.pdr.net/drugpages/concisemonograph.aspx?concise=383 use in food. http://www.drugs.com/vet/equifur- Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
77. Nitrofurazone
http://www.sciencelab.com/msds.php?msdsId=9926271 intended for consumption as food. http://www.drugs.com/vet/niderm- 78. N-Octyl Bicycloheptene
According to the manufacturer, Farnam Roll-On Repellent is “harmful if swallowed.” Dicarboximide
Fly spray http://msds.farnam.com/m000018.ht 79. Nystatin
Antimicrobial, antifungal and steroid Adverse reactions include oral irritation, sensitization, diarrhea, nausea and vomiting, Animax ointment gastrointestinal disturbances, rash, urticaria, Stevens-Johnson syndrome. http://www.pdr.net/search/searchResult.aspx?searchCriteria=Nystatin http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000767/ http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682758.html 80. Omeprazole Treatment
Adverse reactions include headache, diarrhea, abdominal pain, nausea and vomiting, fever, respiratory disorders, severe allergic reactions, irregular heartbeat, bruising and http://www.pdr.net/search/searchResult.aspx?searchCriteria=Omeprazole for human consumption.” http://gastrogard.us.merial.com/faq.s 81. Oxibendazole
“Do not allow product to enter drinking water supplies, waste water or soil.” Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
http://www.seqchem.com/safetysheet.php?SQIndex=SRP012491o for human consumption.” 21 CFR § 520.1638 human consumption. http://www.drugs.com/vet/anthelcide 82. Parachlorometaxylenol
May cause burning of mouth, throat and stomach, if ingested. http://surfactantsinc.com/pdf/Surcide%20PCMX-USP%20MSDS.pdf 83. Phenol
Phenol is considered to be quite toxic to humans via oral exposure. Anorexia, progressive weight loss, diarrhea, vertigo, salivation, a dark coloration of the urine, and blood and liver effects have been reported in chronically (long-term) exposed humans. Animal studies have reported reduced fetal body weights, growth retardation, and abnormal development in the offspring of animals exposed to phenol http://www.epa.gov/ttn/atw/hlthef/phenol.html 84. Phenylbutazone NSAID:
Serious and fatal adverse effects have been reported from ingestion of Phenylbutazone, including bone marrow suppression and aplastic anemia. Banned in America for human use. Nicholas Dodman, Nicolas Blondell, Ann M. Marini, “Association of phenylbutazone usage with horses bought for slaughter: A public health risk”, FOOD AND CHEMICAL TOXICOLOGY 48 (2010) 1270–74. “Phenylbutazone is known to induce blood dyscrasias, including aplastic anemia, leukopenia, agranulocytosis, thrombocytopenia and deaths. Hypersensitivity reactions of the serum-sickness type have also been reported. In addition, phenylbutazone is a carcinogen, as determined by the National Toxicology Program.” http://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm12407 Phenylbutazone is especially problematic for patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
can aggravate both conditions. Phenylbutazone is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of an increased risk of bleeding. Patients taking lithium can develop toxic blood lithium levels. Additionally, patients taking cyclosporine http://horsebackmagazine.com/hb/arc (Sandimmune) can develop kidney toxicity. hives/13184 http://www.farmvet.com/pc-1500- 163-bute-paste-12-gm.aspx http://www.drugs.com/vet/butequine- can.html http://tuesdayshorse.wordpress.com/t 85. Piperonyl Butoxide
Potential dangers to humans are unknown: “Data are not available from accidental poisonings, occupational exposures, or epidemiological studies regarding the reproductive and developmental toxicity of piperonyl butoxide.” Ingestion can cause vomiting and diarrhea. Pesticide Action Network North http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33240 The EPA classifies piperonyl butoxide as a group C carcinogen, a possible human carcinogen. Environmental Protection Agency. Reregistration Eligibility Decision http://www.epa.gov/opp00001/reregistration/REDs/piperonyl_red.pdf 86. Polysulfated
Data on human safety, pertaining to consumption of drug residues in food, were not Glycosaminoglycan
required for approval of this supplemental new animal drug. The drug is approved for use only in horses that are not to be used for food and is to be labeled “’Not for use in http://www.fda.gov/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOI ADrugSummaries/ucm054846.htm Based on the formulation of the drug, humans could develop anaphylaxis or excessive bleeding as the sulfated proteoglycans are anticoagulants. 87. Ponazuril Antiprotozoal
Unknown side effects and adverse reactions in humans ingesting Ponazuril. “Data on human safety, pertaining to consumption of drug residues in food, were not required for approval of this supplemental new animal drug. The drug is approved for use only in horses that are not to be used for food and is to be labeled ‘Not for use in horses intended for food.’” Freedom of Information Summary, Original New Animal Drug Application, NADA Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
141-188 (Marquis), www.fda.gov/downloads/AnimalVeterinary/./ucm117581.pdf food.” http://www.drugs.com/vet/marquis- 88. Prallethrin
Potential poisoning, headache, dizziness, nausea, and seizure. http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC35755 “Pyrethroid ingestion gives rise within minutes to a sore throat, nausea, vomiting and abdominal pain. There may be mouth ulceration, increased secretions and/or dysphagia. Systemic effects occur 4-48 hours after exposure. Dizziness, headache and fatigue are common, and palpitations, chest tightness and blurred vision less frequent. Coma and convulsions are the principal life-threatening features. Most patients recover within 6 days. . . .” S.M. Bradberry et al., Poisoning Due to Pyrethroids, Toxicol Rev. 24(2):93-106 (2005) (quoting abstract). 89. Praziquantel
Available by prescription only and to be taken only under the monitoring of a Contraindicated for people with pre-exiting conditions involving the liver, kidney, or Praziquantel may cause side effects including headache, dizziness, stomach pain, nausea, fever, itching, hives (especially serious). http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000474/ http://www.rxlist.com/biltricide-drug/patient-images-side-effects.htm plus-equine-oral-gel.html “Not for use in humans.” 90. Prednisone
Steroids should be taken under a doctor’s supervision and have multiple significant adverse affects including severe allergic reactions, hormonal changes, changes in menstrual functions, mental and mood changes, respiratory problems, nausea and vomiting, joint swelling, vision changes, and unusual weight gain. 91. Prostaglandin Lutalyse
Can cause unknown and unwanted hormonal effects, including termination of pregnancy, to individuals who ingest without knowing. Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
female reproduction and other uses. This drug is not to be administered to use in food. http://www.drugs.com/vet/lutalyse- 92. Pseudoephedrine HCl Tri-Hist
Can cause central nervous stimulation, insomnia, anxiety, dizziness, blurred vision, colitis, and psychosis when combined with other drugs. 93. Pyrantel Pamoate
Adverse reactions include abdominal cramps, nausea and vomiting, diarrhea, http://www.pdr.net/drugpages/concisemonograph.aspx?concise=2985 for human consumption.” 21 CFR § 520.2043 for human consumption.” http://www.drugs.com/vet/exodus- 94. Pyridoxine HCl
Potential health effects after ingestion unknown. http://www.sciencelab.com/msds.php?msdsId=9924765 95. Pyrilamine Maleate USP Tri-Hist
Many individuals with identified health conditions have hypersensitivities to Antihistamine (human and horse use) antihistamines and the use of antihistamines is contraindicated in that portion of the http://www.drugs.com/pro/poly-hist-pd.html for food purposes.” Not for use in horses intended for Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
96. Rabies vaccination
The dangers of human ingestion are unknown. 97. Ractopamine
A January 2012 article reported that ractopamine hydrochloride is “[f]ed to an hydrochloride
estimated 60 to 80 percent of pigs in the United States, [and has] has sickened or killed more of them than any other livestock drug on the market.” While the FDA has approved the drug for use in cows and pigs, many countries have banned it from food-producing animals, and the drug has never been tested on horses intended for human consumption. http://bottomline.msnbc.msn.com/_news/2012/01/25/10220221-dispute-over-drug-in- 98. Rhinopneumonitis
99. Ronidazole
Does not appear to have any human applications. Dangerous side effects in animals. Toxicity information and potential health effects are unknown. https://www.reagentworld.com/products/msds2.asp?proid_2=23072 100. Selenium
Rare but potential side effects include nausea, vomiting, abdominal pain, hearing loss, fatigue, weight loss, muscle tenderness, heart failure, and allergic reactions. 101. Stanozolol Anabolic
Potential side effects of anabolic steroids are well-documented. Steroids should be taken under a doctor’s supervision and have multiple significant adverse affects including severe allergic reactions, hormonal changes, changes in menstrual functions, mental and mood changes, respiratory problems, nausea and vomiting, joint swelling, vision changes, and unusual weight gain for food.” http://www.petplace.com/drug- 102. Stilbenes
Animals treated with these drugs are banned from meat production in the European lex.europa.eu/smartapi/cgi/sga_doc?smartapi!celexplus!prod!CELEXnumdoc&lg=EN 103. Strangles vaccine
Vaccination for streptococcus equi (Streptococcus Equi
vaccine)
Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
104. Sucralfate
Adverse reactions include constipation, diarrhea, nausea and vomiting, pruritus, rash, dizziness, insomnia, back pain, headache, dry mouth, flatulence, gastric discomfort, indigestion, sleepiness. http://www.pdr.net/search/searchResult.aspx?searchCriteria=Sucralfate 105. Sulfadiazine
Sulfadiazine has potential cross-sensitivity with other drugs in the same class. Some individuals will have blood cell destruction from the drug. It can also cause transient leukopenia, skin necrosis, skin discoloration, burning sensation, rash, interstitial nephritis, and other systemic reactions. http://www.pdr.net/search/searchResult.aspx?searchCriteria=Sulfadiazine for human consumption.” http://www.drugs.com/vet/tribrissen- 106. Sulfamethoxazole
While these drugs are approved for human use, unnecessary ingestion of antibiotics is Trimethoprim
medically contraindicated. Additionally, adverse reactions include nausea and vomiting, anorexia, allergic skin reactions (e.g., rash, urticaria), agranulocytosis, aplastic anemia, hepatitis, renal failure, hyperkalemia, aseptic meningitis, arthralgia, 107. Sunscreens
While sunscreens are used by humans, there is no substantial literature or studies on ingestion of sunscreens or their byproducts and metabolites. 108. Testosterone enanthate
The ingestion of male hormones, when not medically indicated, can create hormonal imbalances. Additionally, use may cause dangerous reactions in hypersensitive individuals or those with other illnesses. Can increase prostate and other problems in Can also cause hormone-mediated reactions, fluid and electrolyte disturbances, nausea, cholestatic jaundice, alterations in liver function, headache, and anxiety. It is also designated as “not for use” in nursing mothers. http://www.pdr.net/drugpages/concisemonograph.aspx?concise=2017 109. Thiamine HCl
http://www.sciencelab.com/msds.php?msdsId=9925232 Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
110. Thyrostats
Animals treated with these drugs are banned from meat production in the European lex.europa.eu/smartapi/cgi/sga_doc?smartapi!celexplus!prod!CELEXnumdoc&lg=EN 111. Topazone Aerosol Powder Antibacterial
Contains chemicals known to the state of California to cause cancer. Should only be taken under strict medical oversight; dangerous if taken with alcohol, when pregnant, or for individuals with certain blood disorders. Adverse effects include headache, stomach upset, nausea, vomiting, dizziness or weakness, fever, skin rash, itching, muscle aches, flushing, breathing trouble. This medication may cause the urine to turn brown in color. 112. Triamcinolone Acetonide
Steroids should be taken under a doctor’s supervision and have multiple significant adverse affects including severe allergic reactions, hormonal changes, changes in menstrual functions, mental and mood changes, respiratory problems, nausea and vomiting, joint swelling, vision changes, and unusual weight gain. for human consumption.” 21 CFR § 522.2483 113. Trimethoprim
Trimethoprim is a strong antibiotic with multiple potential adverse reactions, adverse interactions with other drugs and hypersensitivities noted in individuals with various http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000813/ for human consumption.” 21 CFR § 520.2613 powder - “Not for use in horses intended for food.” “Do not use in horses intended for Product/Type/Warnings
Potential problems from human ingestion of residue or metabolites
400-oral-paste.html http://www.drugs.com/vet/uniprim- 114. West Nile virus
This vaccine has only been approved for use in horses and no data exists with respect to the safety of humans eating it, or meat from animals who have received it. 115. Xylazine
Xylazine poisoning causes hypotension, bradycardia, and respiratory depression. Ocular administration can cause sinus bradycardia, hypotension and decreased mental Velez LI, Shepherd G, Mills LD, Rivera W., Systemic toxicity after an ocular exposure to xylazine hydrochloride, J. EMERG. MED. 30(4):407-10 (2006).

Source: http://www.frontrangeequinerescue.org/documents/drug.chart.pdf

Efp

• Sanieren von feuchten und salzbefallenen Mauern! • Keine Schimmelbildung und kein Modergeruch! • Einfache Verarbeitung, die Zeit und Geld spart! • Auch als Sanierputz geeignet durch WTA Zertifizierung • Einsetzbar auf kritische Untergründe Eigenschaften: renovacoll EFP ist ein weißer Werktrockenmörtel mit hoher Wasserdampfdurchlässigkeit und einem großen Porenvolumen. ren

This segment of our website is designed to give the interested participant more information about the nature of our experimental malaria vaccine study

Eligibility Criteria and Visit Schedule (SLVP website link) Immune Senescence in the Elderly: Comparison of Immune Responses to Influenza Vaccine in Adults of Different Ages This segment of the Vaccine Program website is designed to provide more detailed information to volunteers who are interested in participating in the influenza vaccine study. There are three sections. In the first secti

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