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Sinhamalaria.doc

Malaria: The Unfulfilled Agenda of the Twentieth
ING Chair Professor of Risk Management, ITAM, Mexico Special Professor, University of Nottingham, UK (tapen@itam.mx, Tapen.Sinha@Nottingham.ac.uk) Introduction
Malaria kills between one and three million human beings every year. But, it is Malaria is caused by a family of parasites – the most virulent being Plasmodium falciparum. This particular specie accounts for 80% of infections and 90% of deaths from malaria in the world. The main carrier of this parasite are Anopheles mosquitoes. The most deadly specie of mosquito for malaria is Anopheles gambiae. Thus, any reason that causes the propagation of these species of mosquitoes and the corresponding parasite would lead to the spread of the disease. The disease is not uniformly distributed around the globe. More than 80 percent of malaria sufferers live in Sub-Saharan Africa. Not surprisingly, most deaths occur in that region as well. Prevention of malaria
Malaria has two simple preventions. First, by eradicating Anopheles mosquitoes. Until the turn of the Twentieth Century, malaria was endemic in Europe and the United States. By draining stagnant water and wetland, and thereby eradicating mosquitoes, malaria was practically eliminated from Europe. In the United States, it was virtually wiped out first by draining wetlands and then by killing mosquitoes by spraying DDT. Second, by keeping the mosquitoes from biting. This can be achieved in a number of ways: (1) Wearing insect repellent containing 20% to 35% DEET (N,N-diethylmethyltoluamide) or dimethyl phthalate on exposed skin. (2) Wearing long-sleeved shirts and long trousers if one has to stay outdoors during darkness. (3) Spraying insecticides and using insecticide dispensers that contain tablets impregnated with pyrethroids and burning pyrethroid mosquito coils indoors at night. (4) Sleeping under bed-nets. This method works even better if the bed-net is treated with the insecticide permethrin. Treatment of malaria
In the past, malaria was treated with cheap drugs such as chloroquine and sulfadoxine-pyrimethamine. Unfortunately, the parasite has developed resistance over these drugs. Now, the effective treatment is through artemisinin-based combination therapies (ACTs). However, malaria does not have any vaccine. Economic cost of the disease
Africa, in particular is the home of this disease. Nine out of ten people sick or dying from malaria are from Africa. Of the 720 million people living in 42 countries in sub-Saharan Africa, about 615 million are at risk of contracting malaria. The economic cost of the disease in Africa alone is $12 billion a year. The amount of money required to combat it needs some $3 billion a year for the next two decades. The amount of money spent by various global organizations is around $300 million a year. Thus, we are far away from what is needed to be done Why malaria is neglected
When the avian flu hit in late 2005, governments around the world rallied around to
stop the spread of the disease. No such luck with malaria – even though millions are
dying every year. Unless the rich countries get affected in large numbers, prevention
and cure will not get any financial support. Poor people in poor countries have no voice
because they have no economic clout. For the same reason, vaccine against malaria is
not in the horizon. For pharmaceutical companies, development of vaccine would not
make economic sense.

Source: http://icpr.itam.mx/papers/SinhaMalaria.pdf

Doi:10.1016/j.mehy.2005.11.006

depolarizations, decreased K+ conductance and[6] Gastaut H, Tassinari CA, editors. Handbook of Electro-enhancement of excitatory signals such as Gluta-encephalography and Clinical Neurophysiology, part A, vol. 13. Amsterdam: Elsevier Scientific Publishing Company;mate [12]. Serotonin plays a dual (may be synergis-tic effect) role in increasing susceptibility to[7] Shouse MN, Staba R, Farber

Chemiekaarten_2011.pdf

Met het Koninklijk Besluit van 19 mei 2009 is de lijst van grenswaarden voor blootstelling aan chemi-sche agentia in bijlage I van het KB van 22 maart 2002 aangepast. De nieuwe waarden zijn op1 januari 2010 van kracht geworden. Verklaring van de voetnoten in de titels van de kolommen:(1)het Chemical Abstracts Service Registry Numbergemeten of berekend voor een referentieperiode van 8 uren, tijd

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