Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Jyu.fi

Scientific Programme
Thursday, November 1st, 2012
Benjamin List
“Asymmetric Counteranion Directed Catalysis: A Remarkably General Approach to Enantioselective Synthesis” Friday, November 2nd, 2012
Pier Giorgio Cozzi
“Stereoselective Organocatalytic SN1-type Reactions” 09.45-10.15 Albrecht Berkessel
“Organocatalysts and Enzymes: Complementary and Cooperative” 10.15-10.30 Yoann Coquerel
“Secondary β-Oxo Amides: a New Class of Pronucleophiles for 11.00-11.45 Peter Schreiner
“Enantioselective Multicatalysis – Retrocatalysis" 11.45-12.15 Marco Bella
“Asymmetric Organocatalysis: from Academia to Industry” 12.15-12.30 Arjen Breman
“Synthesis and Organocatalytic Applications of Nor- and Homo-Quinidine 14.00-14.30 Herbert Mayr
"Structures and Reactivities of Intermediates in Organocatalytic Reactions" 14.30.15.00 Alessandra Lattanzi
“Organocatalytic Stereoselective Routes to Three-membered Rings” 15.00-15.15 Giuseppe Rulli
“Organocatalysts in Aldol Reactions: Chemoenzymatic Synthesis and Continuously-operating Processes” 15.15-15.30 Cristele Roux
“New Access to the Tetrahydropyran Core Through Organocatalyzed Desymmetrization of Meso Diols” 15.30-15.45 Jezabel Praz
“Evaluation of the Chiral DIANANE Backbone as Ligand for Organolithium 15.45-16.00 Samson Afewerki
“Highly Enantioselective Co-catalytic Michael/α-allylic Alkylation Cascades by Combination of Chiral Amine and Palladium Catalysts: Asymmetric Synthesis of Poly-substituted Cyclopentanes with an All-carbon Stereocenter” Poster Session
Saturday, November 3nd, 2012
09.00-09.45 Darren Dixon
“New High-Performance Multifunctional Organocatalysts and Their 09.45-10.15 Gabriela Guillena
"Binam-prolinamides, Increasing the Greenness of the Aldol Reaction" 10.15-10.30 Michael Haindl
“Enamine and Iminium Intermediates - Structural Diversity Revealed by 11.00-11.45 Keiji Maruoka
“Design of High-Performance Organocatalysts for the Efficient Synthesis of 11.45-12.15 Imre Papai
"Revised Mechanism for the Organocatalytic Michael Addition of Aldehydes 12.15-12.30 Albert Moyano
“Cooperative Effects in Amino acid–catalyzed Aldol Reactions” 14.00-14.30 Rita Ventura
“New Organocatalysts Derived from Tartaric and Glyceric Acids” 14.30.15.00 Eoghan McGarrigle
“Organocatalytic Glycosylations” 15.00-15.15 Benjamin Voigt
“Stereoselective Amine-Catalyzed Elongation of Unprotected Carbohydates” 15.15-15.30 Uxue Uria
“Aminocatalytic Conjugate Addition of Umpolung Reagents” 15.30-15.45 Konstantin Chernichenko
“FLP-catalyzed Hydrogenations: Advantages of Ansa-systems” 16.00-18.00 MC Meeting
Poster Session
Christoforos Kokotos
“Construction of Tertiary Alcohols Bearing Perfluoroalkyl Chains Catalyzed by Prolinamide-Thioureas” Giorgos Papadopoulos, Alexis Theodorou, Christoforos Kokotos
“Amino Acids as Organocatalysts for the Asymmetric α-Amination of Aldehydes” Michail Tsakos, Christoforos Kokotos, George Kokotos
“Primary Amine-Thiourea as an Efficient Organocatalyst for the Enantioselective Michael Addition of Aromatic Methyl Ketones to Nitroalkenes. Syntheses of Enantiopure (R)-Baclofen and (S)-Phenibut” Alice Lefranc, Adrien Quintard, Alexandre Alexakis
“Highly Enantioselective Direct Vinylogous Michael Addition of γ-Butenolide to Enals” Aikaterini Nikolaou, Victoria Magrioti, George Kokotos
“Efficient Microwave-Assisted Synthesis of Hydroxymethyl Ketones Using NHC Organocatalysts” Eduardo Gomez-Torres, Gabriel Stan, Diego Alonso, Enrique Gomez-
Bengoa, Carmen Najera

“Enantioselective Synthesis of Chiral Succinimides by Michael Addition of 1,3-Dicarbonyl aminobenzimidazole) Organocatalyst: Mechanistic Studies and Reaction Scope” Dimitris Limnios, Danai Spanou, Christoforos Kokotos, George Kokotos
“Primary Amine-Thioureas Based on Dipeptides as Efficient Organocatalysts for Michael Reactions” Sergei Zari, Marina Kudrjashova, Tonis Kanger
“Unsaturated 1,4-Dicarbonyl Compounds as Multifunctional Synthons” Panagiota Revelou, Christoforos Kokotos, Panagiota Moutevelis-
Minakakis
“Novel Ureas Based on Dipeptide Analogues as Organocatalysts for the Asymmetric Aldol Reaction” Zoe Ziaka, Savvas Vasileiadis Maria Anagnostakou
“Use of Organocatalysis of Ionic Liquids in Polymerization Reactions”

Source: https://www.jyu.fi/kemia/en/research/cm0905/eventsfolder/CM0905_Athens%20Programme.pdf

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