Medicamentsen-ligne vous propose les traitements dont vous avez besoin afin de prendre soin de votre santé sexuelle. Avec plus de 7 ans d'expérience et plus de 80.000 clients francophones, nous étions la première clinique fournissant du
**acheter viagra** original en France à vente en ligne et le premier vendeur en ligne de Levitra dans le monde. Pourquoi prendre des risques si vous pouvez être sûr avec Medicamentsen-ligne - Le service auquel vous pouvez faire confiance.

## Mas367.pdf

**Worksheet 1 MAS367**
**Sample Sizes, Allocation, Bias and Randomization**
1.

The Beck depression inventory score is often used as the outcome measure in trialsthat assess treatments for depression. It has standard deviation 8 (no units). Supposethat in a trial comparing two treatments there is interest in detecting a difference of 3.5between the mean Beck depression inventory scores in the two groups.

a) If the groups are of equal size and the power is 90% at the 5% level of
significance, how many patients need to be recruited in total?
b) How would this number change if the power were reduced to 80%?
c) I can recruit 100 patients: what is the largest power I can have to detect a mean
d) If the value used for the standard deviation for the Beck depression inventory score
should have been 10% larger, what would have been the effect on the numbers ina) and b)?
2.

Patients who contract bronchiolitis, a respiratory disease of infants, often suffer fromwheezing for some time after they have been ostensibly cured. In a trial to see if aninhaled steroid, budesonide, can alleviate this after-effect, patients were randomized toreceive budesonide or a placebo. The outcome was the presence of wheeze one yearafter the diagnosis of bronchiolitis.

a) It is thought that the proportion of children with wheeze at one year post-diagnosis
is 0.65. There is interest in reducing this to 0.25. How many infants would haveto be randomized to each of two equal-sized groups in order to have 80% powerto detect this difference at the 5% significance level?
b) Suppose that the initial estimate of 0.65 is too high, and it should be 0.55. How
many patients would be needed to detect a change to 0.15 (i.e. the same change inproportion) with 80% power?
c) If the initial estimate were too low and 0.75 was a more reasonable choice, how
many patients would be needed to detect a change to 0.35 (again the same change,0.4, in proportions) with 80% power? Comment on your answer.

The method for determining the sample size for a trial with binary outcome usesthe approximation:
arcsin(

*p *) ~

*N *(arcsin(

*π *1
where

*r* successes have been observed in

*n* trials and

*p*=

*r*/

*n*: the populationprobability of success is

*π*. Although no longer a standard method, this result canbe used as a basis for the analysis of binary data. If two groups are to becompared, with observed proportions of successes from

*n*1 and

*n*2 trials of,respectively,

*p*1 and

*p*2, then show that a statistic testing the null hypothesis that thetwo population proportions are equal is:
arcsin(

*p *) − arcsin(

*p *)
To which distribution would you compare this statistic in order to perform the test?Using the result
arcsin(

*p *) ≈ arcsin(

*π *) + (

*p *−

*π *)
and relate this to one of the more common ways of testing this hypothesis.

4. Ten patients are randomly allocated to treatments A and B in a clinical trial.

Unequal allocation is used, with Pr(Allocate to A) = 0.6. What is the probabilitythat two or fewer patients are allocated to treatment B?
5. Suppose you were designing the trial outlined in question 1 and had decided to opt
for 80% power. However it was thought appropriate that one treatment groupshould be twice the size of the other. What would be the sizes of the two groups?Suppose that allocation was to be made using random permuted blocks of length 6.

How many blocks are there? What is the disadvantage of using a single block size?How many blocks of length 9 are there?

Source: http://www.mas.ncl.ac.uk/~njnsm/mas367/egsht1.pdf

Municipalidad de Firmat www.firmat.gov.ar Paseo Ntra. Sra. de la Merced 1096 (2630) - Firmat (Santa Fe) LA MUNICIPALIDAD DE FIRMAT HA SANCIONADO LA ORDENANZA Nº 1448 La existencia en nuestra ciudad de piscinas de uso público, semi público; y, CONSIDERANDO: Que en nuestra ciudad la actividad antes puesta esta regulada por la Que Firmat creció no solo en l

http://www.cbr.gov.pk/newst/Sros/2002sro208st.htm GOVERNMENT OF PAKISTAN MINISTRY OF FINANCE, ECONOMIC AFFAIRS, STATISTICS & REVENUE REVENUE DIVISION NOTIFICATION (SALES TAX) Amended via SRO 432(I)/2002 S.R.O. 208(I)/2002 .¾ In exercise of the powers conferred under clause (a) of sub-section (2) of section 13 of the Sales Tax Act, 1990, the Federal Government is pleased t