Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

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Pharmacokinetics, Contraindications, Precautions, Interactions with Other Medicines, Adverse Effects Precautions, Adverse Effects, Dosage and Administration Precautions, Interactions with Other Medicines, Presentation Pharmacology, Interactions with Other Medicines, Adverse Effects Interactions with Other Medicines, Adverse Effects Precautions, Interactions with Other Medicines Pharmacokinetics, Precautions, Overdosage Clinical Trials, Precautions, Adverse Effects, Presentation Precautions, Adverse Effects, Interactions with Product Name
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Contraindications, Precautions, Adverse Effects, Dosage and Administration, Overdosage Precautions, Interactions with Other Medicines, Adverse Effects Pharmacokinetics, Precautions, Adverse Effects, Presentation Precautions, Pregnancy category change , Adverse Effects, Dosage and Administration Pharmacology, Pharmacokinetics, Clinical Trials, Precautions, Adverse Effects, Dosage and Administration, Storage Pharmacology, Precautions, Company address change Interactions with Other Medicines, Adverse Effects Revised Clorhexidine and Cetrimide Sponsor change Poisons Schedule change, Dosage and Administration

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